Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Phing Chian Chai, Steeve Cruchet, Leonore Wigger, Richard Benton

ABSTRACT

Nervous systems exhibit myriad cell types, but understanding how this diversity arises is hampered by the difficulty to visualize and genetically-probe specific lineages, especially at early developmental stages prior to expression of unique molecular markers. Here, we use a genetic immortalization method to analyze the development of sensory neuron lineages in the Drosophila olfactory system, from their origin to terminal differentiation. We apply this approach to define a fate map of nearly all olfactory lineages and refine the model of temporal patterns of lineage divisions. Taking advantage of a selective marker for the lineage that gives rise to Or67d pheromone-sensing neurons and a genome-wide transcription factor RNAi screen, we identify the spatial and temporal requirements for Pointed, an ETS family member, in this developmental pathway. Transcriptomic analysis of wild-type and Pointed-depleted olfactory tissue reveals a universal requirement for this factor as a switch-like determinant of fates in these sensory lineages. More... »

PAGES

643

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-019-08345-4

    DOI

    http://dx.doi.org/10.1038/s41467-019-08345-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111979885

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30733440


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