C1 CAGE detects transcription start sites and enhancer activity at single-cell resolution View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Tsukasa Kouno, Jonathan Moody, Andrew Tae-Jun Kwon, Youtaro Shibayama, Sachi Kato, Yi Huang, Michael Böttcher, Efthymios Motakis, Mickaël Mendez, Jessica Severin, Joachim Luginbühl, Imad Abugessaisa, Akira Hasegawa, Satoshi Takizawa, Takahiro Arakawa, Masaaki Furuno, Naveen Ramalingam, Jay West, Harukazu Suzuki, Takeya Kasukawa, Timo Lassmann, Chung-Chau Hon, Erik Arner, Piero Carninci, Charles Plessy, Jay W. Shin

ABSTRACT

Single-cell transcriptomic profiling is a powerful tool to explore cellular heterogeneity. However, most of these methods focus on the 3'-end of polyadenylated transcripts and provide only a partial view of the transcriptome. We introduce C1 CAGE, a method for the detection of transcript 5'-ends with an original sample multiplexing strategy in the C1TM microfluidic system. We first quantifiy the performance of C1 CAGE and find it as accurate and sensitive as other methods in the C1 system. We then use it to profile promoter and enhancer activities in the cellular response to TGF-β of lung cancer cells and discover subpopulations of cells differing in their response. We also describe enhancer RNA dynamics revealing transcriptional bursts in subsets of cells with transcripts arising from either strand in a mutually exclusive manner, validated using single molecule fluorescence in situ hybridization. More... »

PAGES

360

References to SciGraph publications

  • 2016-04. Enhancers as non-coding RNA transcription units: recent insights and future perspectives in NATURE REVIEWS GENETICS
  • 2016-11. Revealing the vectors of cellular identity with single-cell genomics in NATURE BIOTECHNOLOGY
  • 2014. Detecting Expressed Genes Using CAGE in TRANSCRIPTION FACTOR REGULATORY NETWORKS
  • 2014-01. Quantitative assessment of single-cell RNA-sequencing methods in NATURE METHODS
  • 2013-08. The DREAM complex: master coordinator of cell cycle-dependent gene expression in NATURE REVIEWS CANCER
  • 2008-12. ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells in MOLECULAR CANCER
  • 2017-05. SC3: consensus clustering of single-cell RNA-seq data in NATURE METHODS
  • 2017. NanoCAGE: A Method for the Analysis of Coding and Noncoding 5′-Capped Transcriptomes in PROMOTER ASSOCIATED RNA
  • 2014-02. Quantitative single-cell RNA-seq with unique molecular identifiers in NATURE METHODS
  • 1999-01. Functional association of TGF-β receptor II with cyclin B in ONCOGENE
  • 2008-10. Imaging individual mRNA molecules using multiple singly labeled probes in NATURE METHODS
  • 2014-03. An atlas of active enhancers across human cell types and tissues in NATURE
  • 2016-12. Pooling across cells to normalize single-cell RNA sequencing data with many zero counts in GENOME BIOLOGY
  • 2017-03-01. An atlas of human long non-coding RNAs with accurate 5′ ends in NATURE
  • 2015-02. Genetic and epigenetic fine mapping of causal autoimmune disease variants in NATURE
  • 2008-12. WGCNA: an R package for weighted correlation network analysis in BMC BIOINFORMATICS
  • 2018-12. Single-cell full-length total RNA sequencing uncovers dynamics of recursive splicing and enhancer RNAs in NATURE COMMUNICATIONS
  • 2015-01. TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis in ONCOGENE
  • 2014-03. A promoter-level mammalian expression atlas in NATURE
  • 2012-09. An integrated encyclopedia of DNA elements in the human genome in NATURE
  • 2017. Visualization of Enhancer-Derived Noncoding RNA in ENHANCER RNAS
  • 2014-03. Interactive visualization and analysis of large-scale sequencing datasets using ZENBU in NATURE BIOTECHNOLOGY
  • 2015-02. Integrative analysis of 111 reference human epigenomes in NATURE
  • 2017-04. Power analysis of single-cell RNA-sequencing experiments in NATURE METHODS
  • 2006-06. Genome-wide analysis of mammalian promoter architecture and evolution in NATURE GENETICS
  • 2014-12. Assessing technical performance in differential gene expression experiments with external spike-in RNA control ratio mixtures in NATURE COMMUNICATIONS
  • 2015-12. TagDust2: a generic method to extract reads from sequencing data in BMC BIOINFORMATICS
  • 2017-12. Batch effects and the effective design of single-cell gene expression studies in SCIENTIFIC REPORTS
  • 2010-07. Linking promoters to functional transcripts in small samples with nanoCAGE and CAGEscan in NATURE METHODS
  • 2010-06. TGFβ signalling: a complex web in cancer progression in NATURE REVIEWS CANCER
  • 2015-10. Oscope identifies oscillatory genes in unsynchronized single-cell RNA-seq experiments in NATURE METHODS
  • 2010-02. Gene ontology analysis for RNA-seq: accounting for selection bias in GENOME BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-08126-5

    DOI

    http://dx.doi.org/10.1038/s41467-018-08126-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111571058

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30664627


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kouno", 
            "givenName": "Tsukasa", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moody", 
            "givenName": "Jonathan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kwon", 
            "givenName": "Andrew Tae-Jun", 
            "id": "sg:person.01263503002.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263503002.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shibayama", 
            "givenName": "Youtaro", 
            "id": "sg:person.01025467174.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025467174.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kato", 
            "givenName": "Sachi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan", 
                "ACT Genomics Co. Ltd., 3F., No. 345, Xinhu 2nd Rd, Neihu Dist., 114, Taipei City, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huang", 
            "givenName": "Yi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "B\u00f6ttcher", 
            "givenName": "Michael", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan", 
                "Yong Loo Lin School of Medicine MD6, #08-01, 14 Medical Drive, National University of Singapore, 117599, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Motakis", 
            "givenName": "Efthymios", 
            "id": "sg:person.01204243664.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204243664.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan", 
                "Princess Margaret Cancer Research Tower 11-401, 101 College Street, M5G 1L7, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mendez", 
            "givenName": "Micka\u00ebl", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Severin", 
            "givenName": "Jessica", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Luginb\u00fchl", 
            "givenName": "Joachim", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Abugessaisa", 
            "givenName": "Imad", 
            "id": "sg:person.01004363723.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004363723.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hasegawa", 
            "givenName": "Akira", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takizawa", 
            "givenName": "Satoshi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arakawa", 
            "givenName": "Takahiro", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Furuno", 
            "givenName": "Masaaki", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Fluidigm (United States)", 
              "id": "https://www.grid.ac/institutes/grid.481625.c", 
              "name": [
                "Single-Cell Research and Development, Fluidigm Corporation, 7000 Shoreline Court, Suite 100, 94080, South San Francisco, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ramalingam", 
            "givenName": "Naveen", 
            "id": "sg:person.0705032240.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705032240.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Fluidigm (United States)", 
              "id": "https://www.grid.ac/institutes/grid.481625.c", 
              "name": [
                "Single-Cell Research and Development, Fluidigm Corporation, 7000 Shoreline Court, Suite 100, 94080, South San Francisco, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "West", 
            "givenName": "Jay", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suzuki", 
            "givenName": "Harukazu", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kasukawa", 
            "givenName": "Takeya", 
            "id": "sg:person.0704002516.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704002516.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan", 
                "Telethon Kids Institute, The University of Western Australia, Perth Children\u2019s Hospital, 15 Hospital Ave, 6009, Nedlands, WA, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lassmann", 
            "givenName": "Timo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hon", 
            "givenName": "Chung-Chau", 
            "id": "sg:person.01324137450.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324137450.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arner", 
            "givenName": "Erik", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carninci", 
            "givenName": "Piero", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Okinawa Institute of Science and Technology", 
              "id": "https://www.grid.ac/institutes/grid.250464.1", 
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan", 
                "Okinawa Institute of Science and Technology Graduate University (OIST), 1919-1 Tancha, Onna-son, Kunigami-gun, 904-0495, Okinawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Plessy", 
            "givenName": "Charles", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shin", 
            "givenName": "Jay W.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/s13059-016-0947-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000759088", 
              "https://doi.org/10.1186/s13059-016-0947-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001417778", 
              "https://doi.org/10.1038/ng1789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001417778", 
              "https://doi.org/10.1038/ng1789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2015.01.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002038512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkw257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002966090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4939-0805-9_7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004176565", 
              "https://doi.org/10.1007/978-1-4939-0805-9_7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3549", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005273990", 
              "https://doi.org/10.1038/nmeth.3549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008016112", 
              "https://doi.org/10.1038/nmeth.2694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkw430", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008748288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2853", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010358767", 
              "https://doi.org/10.1038/nrc2853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2853", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010358767", 
              "https://doi.org/10.1038/nrc2853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-1759(93)90121-m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011001736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-1759(93)90121-m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011001736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1198817", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011656336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp698", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012031985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg.2016.4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012036012", 
              "https://doi.org/10.1038/nrg.2016.4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btw337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014185003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.06373-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015410397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016760496", 
              "https://doi.org/10.1038/nbt.3711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4939-4035-6_3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017610503", 
              "https://doi.org/10.1007/978-1-4939-4035-6_3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gks461", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018382972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-9-559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020312314", 
              "https://doi.org/10.1186/1471-2105-9-559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2009.290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020592916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2009.290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020592916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13835", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021809129", 
              "https://doi.org/10.1038/nature13835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022158752", 
              "https://doi.org/10.1038/nature12787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep39921", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022676626", 
              "https://doi.org/10.1038/srep39921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1253", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023537585", 
              "https://doi.org/10.1038/nmeth.1253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.190595.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024114097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cels.2015.12.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024709936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.280.5363.585", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024813644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gks1128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026036713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0804863106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026276921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026672996", 
              "https://doi.org/10.1038/sj.onc.1202263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026672996", 
              "https://doi.org/10.1038/sj.onc.1202263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.2136655100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028529038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029065430", 
              "https://doi.org/10.1038/nature11247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20081434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029271463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20081434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029271463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13182", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029370855", 
              "https://doi.org/10.1038/nature13182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2772", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029706604", 
              "https://doi.org/10.1038/nmeth.2772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aaa6090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030599272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2013.07.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030876564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms6125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031390242", 
              "https://doi.org/10.1038/ncomms6125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1259418", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031720295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031836937", 
              "https://doi.org/10.1038/nature14248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkv1176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034036004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2012.02.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035289424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2014.02.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035488202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-7-87", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036077250", 
              "https://doi.org/10.1186/1476-4598-7-87"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbamcr.2011.07.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041772216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2840", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046089872", 
              "https://doi.org/10.1038/nbt.2840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047168268", 
              "https://doi.org/10.1038/nrc3556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1470", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047181882", 
              "https://doi.org/10.1038/nmeth.1470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1470", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047181882", 
              "https://doi.org/10.1038/nmeth.1470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15476286.2016.1201618", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048328139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2015.06.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049505494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2015.06.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049505494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2013.569", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049831512", 
              "https://doi.org/10.1038/onc.2013.569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2010-11-2-r14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050171830", 
              "https://doi.org/10.1186/gb-2010-11-2-r14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcb.2013.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050764505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12859-015-0454-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052084842", 
              "https://doi.org/10.1186/s12859-015-0454-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12859-015-0454-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052084842", 
              "https://doi.org/10.1186/s12859-015-0454-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkw1220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059932140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.12688/f1000research.9501.2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064612874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2144/000114400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069096882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature21374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084128527", 
              "https://doi.org/10.1038/nature21374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.4220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129311", 
              "https://doi.org/10.1038/nmeth.4220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.4236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129325", 
              "https://doi.org/10.1038/nmeth.4236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.4236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129325", 
              "https://doi.org/10.1038/nmeth.4236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4939-6716-2_4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084507095", 
              "https://doi.org/10.1007/978-1-4939-6716-2_4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/088500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085115058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/088500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085115058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/088500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085115058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkx949", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092104202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkx1092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092368480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-02866-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100868022", 
              "https://doi.org/10.1038/s41467-018-02866-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/407932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106592672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/407932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106592672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/407932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106592672"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "Single-cell transcriptomic profiling is a powerful tool to explore cellular heterogeneity. However, most of these methods focus on the 3'-end of polyadenylated transcripts and provide only a partial view of the transcriptome. We introduce C1 CAGE, a method for the detection of transcript 5'-ends with an original sample multiplexing strategy in the C1TM microfluidic system. We first quantifiy the performance of C1 CAGE and find it as accurate and sensitive as other methods in the C1 system. We then use it to profile promoter and enhancer activities in the cellular response to TGF-\u03b2 of lung cancer cells and discover subpopulations of cells differing in their response. We also describe enhancer RNA dynamics revealing transcriptional bursts in subsets of cells with transcripts arising from either strand in a mutually exclusive manner, validated using single molecule fluorescence in situ hybridization.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41467-018-08126-5", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "C1 CAGE detects transcription start sites and enhancer activity at single-cell resolution", 
        "pagination": "360", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "a3f754d9557a2c1f321ff322f40367a74d84b9509fa499b2ff5dec6e888db310"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30664627"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101528555"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-018-08126-5"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111571058"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-018-08126-5", 
          "https://app.dimensions.ai/details/publication/pub.1111571058"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:55", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000325_0000000325/records_100779_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41467-018-08126-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-08126-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-08126-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-08126-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-08126-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    509 TRIPLES      21 PREDICATES      95 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-018-08126-5 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N1a3d1f9c9ced4661b3b4345f251dcbaf
    4 schema:citation sg:pub.10.1007/978-1-4939-0805-9_7
    5 sg:pub.10.1007/978-1-4939-4035-6_3
    6 sg:pub.10.1007/978-1-4939-6716-2_4
    7 sg:pub.10.1038/nature11247
    8 sg:pub.10.1038/nature12787
    9 sg:pub.10.1038/nature13182
    10 sg:pub.10.1038/nature13835
    11 sg:pub.10.1038/nature14248
    12 sg:pub.10.1038/nature21374
    13 sg:pub.10.1038/nbt.2840
    14 sg:pub.10.1038/nbt.3711
    15 sg:pub.10.1038/ncomms6125
    16 sg:pub.10.1038/ng1789
    17 sg:pub.10.1038/nmeth.1253
    18 sg:pub.10.1038/nmeth.1470
    19 sg:pub.10.1038/nmeth.2694
    20 sg:pub.10.1038/nmeth.2772
    21 sg:pub.10.1038/nmeth.3549
    22 sg:pub.10.1038/nmeth.4220
    23 sg:pub.10.1038/nmeth.4236
    24 sg:pub.10.1038/nrc2853
    25 sg:pub.10.1038/nrc3556
    26 sg:pub.10.1038/nrg.2016.4
    27 sg:pub.10.1038/onc.2013.569
    28 sg:pub.10.1038/s41467-018-02866-0
    29 sg:pub.10.1038/sj.onc.1202263
    30 sg:pub.10.1038/srep39921
    31 sg:pub.10.1186/1471-2105-9-559
    32 sg:pub.10.1186/1476-4598-7-87
    33 sg:pub.10.1186/gb-2010-11-2-r14
    34 sg:pub.10.1186/s12859-015-0454-y
    35 sg:pub.10.1186/s13059-016-0947-7
    36 https://doi.org/10.1016/0022-1759(93)90121-m
    37 https://doi.org/10.1016/j.bbamcr.2011.07.016
    38 https://doi.org/10.1016/j.cels.2015.12.004
    39 https://doi.org/10.1016/j.febslet.2012.02.037
    40 https://doi.org/10.1016/j.molcel.2013.07.022
    41 https://doi.org/10.1016/j.molcel.2015.01.027
    42 https://doi.org/10.1016/j.tcb.2013.06.001
    43 https://doi.org/10.1016/j.tibs.2014.02.007
    44 https://doi.org/10.1016/j.ymeth.2015.06.021
    45 https://doi.org/10.1038/emboj.2009.290
    46 https://doi.org/10.1042/bj20081434
    47 https://doi.org/10.1073/pnas.0804863106
    48 https://doi.org/10.1073/pnas.2136655100
    49 https://doi.org/10.1080/15476286.2016.1201618
    50 https://doi.org/10.1093/bioinformatics/btp698
    51 https://doi.org/10.1093/bioinformatics/btw337
    52 https://doi.org/10.1093/nar/gks1128
    53 https://doi.org/10.1093/nar/gks461
    54 https://doi.org/10.1093/nar/gkv1176
    55 https://doi.org/10.1093/nar/gkw1220
    56 https://doi.org/10.1093/nar/gkw257
    57 https://doi.org/10.1093/nar/gkw430
    58 https://doi.org/10.1093/nar/gkx1092
    59 https://doi.org/10.1093/nar/gkx949
    60 https://doi.org/10.1101/088500
    61 https://doi.org/10.1101/407932
    62 https://doi.org/10.1101/gr.190595.115
    63 https://doi.org/10.1126/science.1198817
    64 https://doi.org/10.1126/science.1259418
    65 https://doi.org/10.1126/science.280.5363.585
    66 https://doi.org/10.1126/science.aaa6090
    67 https://doi.org/10.1128/mcb.06373-11
    68 https://doi.org/10.12688/f1000research.9501.2
    69 https://doi.org/10.2144/000114400
    70 schema:datePublished 2019-12
    71 schema:datePublishedReg 2019-12-01
    72 schema:description Single-cell transcriptomic profiling is a powerful tool to explore cellular heterogeneity. However, most of these methods focus on the 3'-end of polyadenylated transcripts and provide only a partial view of the transcriptome. We introduce C1 CAGE, a method for the detection of transcript 5'-ends with an original sample multiplexing strategy in the C1<sup>TM</sup> microfluidic system. We first quantifiy the performance of C1 CAGE and find it as accurate and sensitive as other methods in the C1 system. We then use it to profile promoter and enhancer activities in the cellular response to TGF-β of lung cancer cells and discover subpopulations of cells differing in their response. We also describe enhancer RNA dynamics revealing transcriptional bursts in subsets of cells with transcripts arising from either strand in a mutually exclusive manner, validated using single molecule fluorescence in situ hybridization.
    73 schema:genre research_article
    74 schema:inLanguage en
    75 schema:isAccessibleForFree true
    76 schema:isPartOf N2db060bd3bbf49d28c917551cd534eed
    77 Nf826e5b617cd43e3804406a53555b25f
    78 sg:journal.1043282
    79 schema:name C1 CAGE detects transcription start sites and enhancer activity at single-cell resolution
    80 schema:pagination 360
    81 schema:productId N00d987b7a3c04c32a324eccf5581430d
    82 N3a5517919fe94aec941f82807ed9d966
    83 N613d2013e57b4f99884ef10e4865ccef
    84 N6f77e6fa6d09437eaf4b12035563f5ad
    85 Nce9d0d48b6a6418c984595dbeca2b571
    86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111571058
    87 https://doi.org/10.1038/s41467-018-08126-5
    88 schema:sdDatePublished 2019-04-11T08:55
    89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    90 schema:sdPublisher Nbce34e226b914ace9af5dcfddabac71e
    91 schema:url https://www.nature.com/articles/s41467-018-08126-5
    92 sgo:license sg:explorer/license/
    93 sgo:sdDataset articles
    94 rdf:type schema:ScholarlyArticle
    95 N00d987b7a3c04c32a324eccf5581430d schema:name dimensions_id
    96 schema:value pub.1111571058
    97 rdf:type schema:PropertyValue
    98 N01dbe866c5a046a7bac8620fe154a0f1 schema:name ACT Genomics Co. Ltd., 3F., No. 345, Xinhu 2nd Rd, Neihu Dist., 114, Taipei City, Taiwan
    99 RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    100 rdf:type schema:Organization
    101 N049e4f7f2cd74b299229c3981c724aca rdf:first sg:person.01263503002.13
    102 rdf:rest N7dfaec1d9f0b4154bdbccfd68e5c1f6e
    103 N06dfce7fa0ee41e4841bfefbe4b2c6c0 rdf:first Ndd8854b047da417bb834ae1ad06e5ef2
    104 rdf:rest N9da71b166a864bffa8355728d14ba8f7
    105 N0bb2de338fc1429089c598d3430fe924 rdf:first Na8e04766e5664fb59b0d0b063841ee58
    106 rdf:rest N54406084c3f145e5b60203424d48e63b
    107 N0fa886b12572481cad89feb90abfa71b schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    108 rdf:type schema:Organization
    109 N100755b2e72a4218a28ba34a136bfff8 schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    110 rdf:type schema:Organization
    111 N131d7b4198cc4408bdd30cc6d743fc8c schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    112 rdf:type schema:Organization
    113 N15fa2e1e0b8744cbb1e576f3ba83b2dd schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    114 rdf:type schema:Organization
    115 N17e39940aa7a4c60a5eb45b90908a18d schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    116 rdf:type schema:Organization
    117 N1818c8376c5d4b2c8e2ba54b067567ab rdf:first N77d1830647ca46848ec845ef973003ef
    118 rdf:rest Nfac962f8550e41599269d45b1d5a7c4b
    119 N1a3d1f9c9ced4661b3b4345f251dcbaf rdf:first Nb3c6da90cf204c3f98f98f1108abb3a3
    120 rdf:rest Nde9e8b6ae0c44fc3ab7cfca5a55af772
    121 N1b9a99bf08e24ec3857c676c2d8c6b58 schema:affiliation N15fa2e1e0b8744cbb1e576f3ba83b2dd
    122 schema:familyName Suzuki
    123 schema:givenName Harukazu
    124 rdf:type schema:Person
    125 N1d841d801b9245788f33451583288ee2 schema:affiliation N356ee0dd6af346758ebf886b49557574
    126 schema:familyName Arner
    127 schema:givenName Erik
    128 rdf:type schema:Person
    129 N1f76c4e45b724908b40b28f8dc22876a schema:affiliation N28da3bbe70fb4f86b0d264594114f2b8
    130 schema:familyName Carninci
    131 schema:givenName Piero
    132 rdf:type schema:Person
    133 N2850b48c59674f5a91440bbd1cb5bde6 rdf:first N53c5b386af8c4cd285ba5c3f51fcbeb5
    134 rdf:rest Nf370ddab20444054b3fa5c2fe8cdb091
    135 N28da3bbe70fb4f86b0d264594114f2b8 schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    136 rdf:type schema:Organization
    137 N2db060bd3bbf49d28c917551cd534eed schema:issueNumber 1
    138 rdf:type schema:PublicationIssue
    139 N2e961533d04d4cf7a75a33357991f583 rdf:first Nefea197e89064f5dbb9dcb98ca42ec2c
    140 rdf:rest Nfef78561939345a8b8f80d58ac494e8f
    141 N356ee0dd6af346758ebf886b49557574 schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    142 rdf:type schema:Organization
    143 N3a5517919fe94aec941f82807ed9d966 schema:name pubmed_id
    144 schema:value 30664627
    145 rdf:type schema:PropertyValue
    146 N40747fb65ead47e69303d67dff057a70 schema:affiliation N53dab12cbd874f618d4ab3b721ead91e
    147 schema:familyName Takizawa
    148 schema:givenName Satoshi
    149 rdf:type schema:Person
    150 N41125e15fece41a8a4e275faea0ad79d schema:affiliation N01dbe866c5a046a7bac8620fe154a0f1
    151 schema:familyName Huang
    152 schema:givenName Yi
    153 rdf:type schema:Person
    154 N419a6cecf7a241e094278b24e23ab5d3 rdf:first sg:person.0704002516.87
    155 rdf:rest N70b6f57676a24e9eab4d2dff97de0b07
    156 N49e9ac82cb4a4b9abfd415847e9f0054 rdf:first N61b04650521c4efeab6231ca2d079577
    157 rdf:rest Na6287c1cd5064773aea58716096ec0d1
    158 N4dfa2473ca9748cc868e9f715c0f8fbd schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    159 rdf:type schema:Organization
    160 N53c5b386af8c4cd285ba5c3f51fcbeb5 schema:affiliation N91f07d500df9486a8db43e36ec7fa52b
    161 schema:familyName Hasegawa
    162 schema:givenName Akira
    163 rdf:type schema:Person
    164 N53dab12cbd874f618d4ab3b721ead91e schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    165 rdf:type schema:Organization
    166 N54406084c3f145e5b60203424d48e63b rdf:first N70c641d011274fa7afcfb4ab8aca3138
    167 rdf:rest Nf7e3a22fcd2a425d924aafb175b76713
    168 N590e1a024c5a4835b9d6a40aade39532 schema:affiliation Ncf4f1aad75b2446a8490d29563343bc8
    169 schema:familyName Lassmann
    170 schema:givenName Timo
    171 rdf:type schema:Person
    172 N5d8be715b44745e69dcd2d398e101375 rdf:first Nc5807b59a2684f8c812bcedeaa1de8a6
    173 rdf:rest Nba5f1b9e932b41d4955ef0ff948defee
    174 N613d2013e57b4f99884ef10e4865ccef schema:name nlm_unique_id
    175 schema:value 101528555
    176 rdf:type schema:PropertyValue
    177 N61b04650521c4efeab6231ca2d079577 schema:affiliation N131d7b4198cc4408bdd30cc6d743fc8c
    178 schema:familyName Furuno
    179 schema:givenName Masaaki
    180 rdf:type schema:Person
    181 N63eae99fe6584621ac6f4a7b77c8d2ba rdf:first sg:person.01324137450.88
    182 rdf:rest N8236e9600d94427ca1adf1cc3e4112b1
    183 N6f77e6fa6d09437eaf4b12035563f5ad schema:name readcube_id
    184 schema:value a3f754d9557a2c1f321ff322f40367a74d84b9509fa499b2ff5dec6e888db310
    185 rdf:type schema:PropertyValue
    186 N70b6f57676a24e9eab4d2dff97de0b07 rdf:first N590e1a024c5a4835b9d6a40aade39532
    187 rdf:rest N63eae99fe6584621ac6f4a7b77c8d2ba
    188 N70c641d011274fa7afcfb4ab8aca3138 schema:affiliation Nd652986483434ef7be4f0aedfb8e3154
    189 schema:familyName Severin
    190 schema:givenName Jessica
    191 rdf:type schema:Person
    192 N76265ea7a47c43e0b0312950ba189380 schema:affiliation N4dfa2473ca9748cc868e9f715c0f8fbd
    193 schema:familyName Arakawa
    194 schema:givenName Takahiro
    195 rdf:type schema:Person
    196 N77d1830647ca46848ec845ef973003ef schema:affiliation https://www.grid.ac/institutes/grid.481625.c
    197 schema:familyName West
    198 schema:givenName Jay
    199 rdf:type schema:Person
    200 N7883ad20aceb49ac95f483de423bcde7 schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    201 rdf:type schema:Organization
    202 N7dfaec1d9f0b4154bdbccfd68e5c1f6e rdf:first sg:person.01025467174.16
    203 rdf:rest N5d8be715b44745e69dcd2d398e101375
    204 N812f63b90d9c48ed86eee140a50e0907 schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    205 rdf:type schema:Organization
    206 N8236e9600d94427ca1adf1cc3e4112b1 rdf:first N1d841d801b9245788f33451583288ee2
    207 rdf:rest Nf98001b7e94841baa4acd4bdba7c61e6
    208 N8aa77eaf6aa94e7f9504ed2a49ad0bf8 schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    209 rdf:type schema:Organization
    210 N91f07d500df9486a8db43e36ec7fa52b schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    211 rdf:type schema:Organization
    212 N9a9c3362f70748f180f082967f65f797 schema:affiliation Na87b02929dc94f4d939bbe290836af63
    213 schema:familyName Shin
    214 schema:givenName Jay W.
    215 rdf:type schema:Person
    216 N9da71b166a864bffa8355728d14ba8f7 rdf:first sg:person.01204243664.46
    217 rdf:rest N0bb2de338fc1429089c598d3430fe924
    218 Na6287c1cd5064773aea58716096ec0d1 rdf:first sg:person.0705032240.17
    219 rdf:rest N1818c8376c5d4b2c8e2ba54b067567ab
    220 Na87b02929dc94f4d939bbe290836af63 schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    221 rdf:type schema:Organization
    222 Na8e04766e5664fb59b0d0b063841ee58 schema:affiliation Nccddfb369bb849fda03bf43f9b153e8e
    223 schema:familyName Mendez
    224 schema:givenName Mickaël
    225 rdf:type schema:Person
    226 Naeb39635eb834058931108753c75833f schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    227 rdf:type schema:Organization
    228 Nb3c6da90cf204c3f98f98f1108abb3a3 schema:affiliation N812f63b90d9c48ed86eee140a50e0907
    229 schema:familyName Kouno
    230 schema:givenName Tsukasa
    231 rdf:type schema:Person
    232 Nb619082f2f6c4c7c9ff13ee02effa7d3 rdf:first N76265ea7a47c43e0b0312950ba189380
    233 rdf:rest N49e9ac82cb4a4b9abfd415847e9f0054
    234 Nb6d7cb26a1c5473abe3c13186e19ba57 schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    235 rdf:type schema:Organization
    236 Nba5f1b9e932b41d4955ef0ff948defee rdf:first N41125e15fece41a8a4e275faea0ad79d
    237 rdf:rest N06dfce7fa0ee41e4841bfefbe4b2c6c0
    238 Nbce34e226b914ace9af5dcfddabac71e schema:name Springer Nature - SN SciGraph project
    239 rdf:type schema:Organization
    240 Nc0338fdc934948a9aebc2ded60dcfe8a schema:affiliation N100755b2e72a4218a28ba34a136bfff8
    241 schema:familyName Moody
    242 schema:givenName Jonathan
    243 rdf:type schema:Person
    244 Nc20aa0e01a7f4a2991976b4c5868670a schema:affiliation Ndb90da76cbad438ca1f2ee21898f3ea9
    245 schema:familyName Luginbühl
    246 schema:givenName Joachim
    247 rdf:type schema:Person
    248 Nc5807b59a2684f8c812bcedeaa1de8a6 schema:affiliation N0fa886b12572481cad89feb90abfa71b
    249 schema:familyName Kato
    250 schema:givenName Sachi
    251 rdf:type schema:Person
    252 Nccddfb369bb849fda03bf43f9b153e8e schema:name Princess Margaret Cancer Research Tower 11-401, 101 College Street, M5G 1L7, Toronto, ON, Canada
    253 RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    254 rdf:type schema:Organization
    255 Nce9d0d48b6a6418c984595dbeca2b571 schema:name doi
    256 schema:value 10.1038/s41467-018-08126-5
    257 rdf:type schema:PropertyValue
    258 Ncf4f1aad75b2446a8490d29563343bc8 schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    259 Telethon Kids Institute, The University of Western Australia, Perth Children’s Hospital, 15 Hospital Ave, 6009, Nedlands, WA, Australia
    260 rdf:type schema:Organization
    261 Nd652986483434ef7be4f0aedfb8e3154 schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    262 rdf:type schema:Organization
    263 Ndb90da76cbad438ca1f2ee21898f3ea9 schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    264 rdf:type schema:Organization
    265 Ndd8854b047da417bb834ae1ad06e5ef2 schema:affiliation N8aa77eaf6aa94e7f9504ed2a49ad0bf8
    266 schema:familyName Böttcher
    267 schema:givenName Michael
    268 rdf:type schema:Person
    269 Ndd8dbf1075244db8ba376424c4777861 schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    270 rdf:type schema:Organization
    271 Nde9e8b6ae0c44fc3ab7cfca5a55af772 rdf:first Nc0338fdc934948a9aebc2ded60dcfe8a
    272 rdf:rest N049e4f7f2cd74b299229c3981c724aca
    273 Ne9674dcdaed547e5b35163ad602c7a4d rdf:first sg:person.01004363723.49
    274 rdf:rest N2850b48c59674f5a91440bbd1cb5bde6
    275 Nefea197e89064f5dbb9dcb98ca42ec2c schema:affiliation https://www.grid.ac/institutes/grid.250464.1
    276 schema:familyName Plessy
    277 schema:givenName Charles
    278 rdf:type schema:Person
    279 Nf370ddab20444054b3fa5c2fe8cdb091 rdf:first N40747fb65ead47e69303d67dff057a70
    280 rdf:rest Nb619082f2f6c4c7c9ff13ee02effa7d3
    281 Nf7e3a22fcd2a425d924aafb175b76713 rdf:first Nc20aa0e01a7f4a2991976b4c5868670a
    282 rdf:rest Ne9674dcdaed547e5b35163ad602c7a4d
    283 Nf826e5b617cd43e3804406a53555b25f schema:volumeNumber 10
    284 rdf:type schema:PublicationVolume
    285 Nf98001b7e94841baa4acd4bdba7c61e6 rdf:first N1f76c4e45b724908b40b28f8dc22876a
    286 rdf:rest N2e961533d04d4cf7a75a33357991f583
    287 Nfac962f8550e41599269d45b1d5a7c4b rdf:first N1b9a99bf08e24ec3857c676c2d8c6b58
    288 rdf:rest N419a6cecf7a241e094278b24e23ab5d3
    289 Nfef78561939345a8b8f80d58ac494e8f rdf:first N9a9c3362f70748f180f082967f65f797
    290 rdf:rest rdf:nil
    291 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    292 schema:name Biological Sciences
    293 rdf:type schema:DefinedTerm
    294 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    295 schema:name Biochemistry and Cell Biology
    296 rdf:type schema:DefinedTerm
    297 sg:journal.1043282 schema:issn 2041-1723
    298 schema:name Nature Communications
    299 rdf:type schema:Periodical
    300 sg:person.01004363723.49 schema:affiliation Naeb39635eb834058931108753c75833f
    301 schema:familyName Abugessaisa
    302 schema:givenName Imad
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004363723.49
    304 rdf:type schema:Person
    305 sg:person.01025467174.16 schema:affiliation Ndd8dbf1075244db8ba376424c4777861
    306 schema:familyName Shibayama
    307 schema:givenName Youtaro
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025467174.16
    309 rdf:type schema:Person
    310 sg:person.01204243664.46 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    311 schema:familyName Motakis
    312 schema:givenName Efthymios
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204243664.46
    314 rdf:type schema:Person
    315 sg:person.01263503002.13 schema:affiliation N17e39940aa7a4c60a5eb45b90908a18d
    316 schema:familyName Kwon
    317 schema:givenName Andrew Tae-Jun
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263503002.13
    319 rdf:type schema:Person
    320 sg:person.01324137450.88 schema:affiliation Nb6d7cb26a1c5473abe3c13186e19ba57
    321 schema:familyName Hon
    322 schema:givenName Chung-Chau
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324137450.88
    324 rdf:type schema:Person
    325 sg:person.0704002516.87 schema:affiliation N7883ad20aceb49ac95f483de423bcde7
    326 schema:familyName Kasukawa
    327 schema:givenName Takeya
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704002516.87
    329 rdf:type schema:Person
    330 sg:person.0705032240.17 schema:affiliation https://www.grid.ac/institutes/grid.481625.c
    331 schema:familyName Ramalingam
    332 schema:givenName Naveen
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705032240.17
    334 rdf:type schema:Person
    335 sg:pub.10.1007/978-1-4939-0805-9_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004176565
    336 https://doi.org/10.1007/978-1-4939-0805-9_7
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1007/978-1-4939-4035-6_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017610503
    339 https://doi.org/10.1007/978-1-4939-4035-6_3
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1007/978-1-4939-6716-2_4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084507095
    342 https://doi.org/10.1007/978-1-4939-6716-2_4
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1038/nature11247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029065430
    345 https://doi.org/10.1038/nature11247
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1038/nature12787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022158752
    348 https://doi.org/10.1038/nature12787
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/nature13182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029370855
    351 https://doi.org/10.1038/nature13182
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/nature13835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021809129
    354 https://doi.org/10.1038/nature13835
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/nature14248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031836937
    357 https://doi.org/10.1038/nature14248
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/nature21374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128527
    360 https://doi.org/10.1038/nature21374
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/nbt.2840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046089872
    363 https://doi.org/10.1038/nbt.2840
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/nbt.3711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016760496
    366 https://doi.org/10.1038/nbt.3711
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/ncomms6125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031390242
    369 https://doi.org/10.1038/ncomms6125
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/ng1789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001417778
    372 https://doi.org/10.1038/ng1789
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1038/nmeth.1253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023537585
    375 https://doi.org/10.1038/nmeth.1253
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1038/nmeth.1470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047181882
    378 https://doi.org/10.1038/nmeth.1470
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1038/nmeth.2694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008016112
    381 https://doi.org/10.1038/nmeth.2694
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1038/nmeth.2772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029706604
    384 https://doi.org/10.1038/nmeth.2772
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/nmeth.3549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005273990
    387 https://doi.org/10.1038/nmeth.3549
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/nmeth.4220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129311
    390 https://doi.org/10.1038/nmeth.4220
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1038/nmeth.4236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129325
    393 https://doi.org/10.1038/nmeth.4236
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1038/nrc2853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010358767
    396 https://doi.org/10.1038/nrc2853
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1038/nrc3556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047168268
    399 https://doi.org/10.1038/nrc3556
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/nrg.2016.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012036012
    402 https://doi.org/10.1038/nrg.2016.4
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1038/onc.2013.569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049831512
    405 https://doi.org/10.1038/onc.2013.569
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1038/s41467-018-02866-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100868022
    408 https://doi.org/10.1038/s41467-018-02866-0
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1038/sj.onc.1202263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026672996
    411 https://doi.org/10.1038/sj.onc.1202263
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1038/srep39921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022676626
    414 https://doi.org/10.1038/srep39921
    415 rdf:type schema:CreativeWork
    416 sg:pub.10.1186/1471-2105-9-559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020312314
    417 https://doi.org/10.1186/1471-2105-9-559
    418 rdf:type schema:CreativeWork
    419 sg:pub.10.1186/1476-4598-7-87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036077250
    420 https://doi.org/10.1186/1476-4598-7-87
    421 rdf:type schema:CreativeWork
    422 sg:pub.10.1186/gb-2010-11-2-r14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050171830
    423 https://doi.org/10.1186/gb-2010-11-2-r14
    424 rdf:type schema:CreativeWork
    425 sg:pub.10.1186/s12859-015-0454-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1052084842
    426 https://doi.org/10.1186/s12859-015-0454-y
    427 rdf:type schema:CreativeWork
    428 sg:pub.10.1186/s13059-016-0947-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000759088
    429 https://doi.org/10.1186/s13059-016-0947-7
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1016/0022-1759(93)90121-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1011001736
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1016/j.bbamcr.2011.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041772216
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1016/j.cels.2015.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024709936
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1016/j.febslet.2012.02.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035289424
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1016/j.molcel.2013.07.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030876564
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1016/j.molcel.2015.01.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002038512
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1016/j.tcb.2013.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050764505
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1016/j.tibs.2014.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035488202
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1016/j.ymeth.2015.06.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049505494
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1038/emboj.2009.290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020592916
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1042/bj20081434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029271463
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1073/pnas.0804863106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026276921
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1073/pnas.2136655100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028529038
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1080/15476286.2016.1201618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048328139
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1093/bioinformatics/btp698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012031985
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1093/bioinformatics/btw337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014185003
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1093/nar/gks1128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026036713
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1093/nar/gks461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018382972
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1093/nar/gkv1176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034036004
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1093/nar/gkw1220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059932140
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1093/nar/gkw257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002966090
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1093/nar/gkw430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008748288
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1093/nar/gkx1092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092368480
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1093/nar/gkx949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092104202
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1101/088500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085115058
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1101/407932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106592672
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1101/gr.190595.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024114097
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1126/science.1198817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011656336
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1126/science.1259418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031720295
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1126/science.280.5363.585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024813644
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1126/science.aaa6090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030599272
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1128/mcb.06373-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015410397
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.12688/f1000research.9501.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064612874
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.2144/000114400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069096882
    498 rdf:type schema:CreativeWork
    499 https://www.grid.ac/institutes/grid.250464.1 schema:alternateName Okinawa Institute of Science and Technology
    500 schema:name Okinawa Institute of Science and Technology Graduate University (OIST), 1919-1 Tancha, Onna-son, Kunigami-gun, 904-0495, Okinawa, Japan
    501 RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    502 rdf:type schema:Organization
    503 https://www.grid.ac/institutes/grid.4280.e schema:alternateName National University of Singapore
    504 schema:name RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Japan
    505 Yong Loo Lin School of Medicine MD6, #08-01, 14 Medical Drive, National University of Singapore, 117599, Singapore, Singapore
    506 rdf:type schema:Organization
    507 https://www.grid.ac/institutes/grid.481625.c schema:alternateName Fluidigm (United States)
    508 schema:name Single-Cell Research and Development, Fluidigm Corporation, 7000 Shoreline Court, Suite 100, 94080, South San Francisco, CA, USA
    509 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...