The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Robert M. Cleverley, Zoe J. Rutter, Jeanine Rismondo, Federico Corona, Ho-Ching Tiffany Tsui, Fuad A. Alatawi, Richard A. Daniel, Sven Halbedel, Orietta Massidda, Malcolm E. Winkler, Richard J. Lewis

ABSTRACT

Bacterial growth and cell division requires precise spatiotemporal regulation of the synthesis and remodelling of the peptidoglycan layer that surrounds the cytoplasmic membrane. GpsB is a cytosolic protein that affects cell wall synthesis by binding cytoplasmic mini-domains of peptidoglycan synthases to ensure their correct subcellular localisation. Here, we describe critical structural features for the interaction of GpsB with peptidoglycan synthases from three bacterial species (Bacillus subtilis, Listeria monocytogenes and Streptococcus pneumoniae) and suggest their importance for cell wall growth and viability in L. monocytogenes and S. pneumoniae. We use these structural motifs to identify novel partners of GpsB in B. subtilis and extend the members of the GpsB interactome in all three bacterial species. Our results support that GpsB functions as an adaptor protein that mediates the interaction between membrane proteins, scaffolding proteins, signalling proteins and enzymes to generate larger protein complexes at specific sites in a bacterial cell cycle-dependent manner. More... »

PAGES

261

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-08056-2

DOI

http://dx.doi.org/10.1038/s41467-018-08056-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111348230

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30651563


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467 schema:name FG11 Division of Enteropathogenic Bacteria and Legionella, Robert Koch Institute, Burgstrasse 37, 38855, Wernigerode, Germany
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469 https://www.grid.ac/institutes/grid.411377.7 schema:alternateName Indiana University Bloomington
470 schema:name Department of Biology, Indiana University Bloomington, 47405, Bloomington, IN, USA
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472 https://www.grid.ac/institutes/grid.7445.2 schema:alternateName Imperial College London
473 schema:name FG11 Division of Enteropathogenic Bacteria and Legionella, Robert Koch Institute, Burgstrasse 37, 38855, Wernigerode, Germany
474 Section of Microbiology and MRC Centre for Molecular Bacteriology and Infection, Imperial College London, SW7 2DD, London, UK
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