Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Jiangping He, Xiuling Fu, Meng Zhang, Fangfang He, Wenjuan Li, Mazid Md. Abdul, Jianguo Zhou, Li Sun, Chen Chang, Yuhao Li, He Liu, Kaixin Wu, Isaac A. Babarinde, Qiang Zhuang, Yuin-Han Loh, Jiekai Chen, Miguel A. Esteban, Andrew P. Hutchins

ABSTRACT

The majority of mammalian genomes are devoted to transposable elements (TEs). Whilst TEs are increasingly recognized for their important biological functions, they are a potential danger to genomic stability and are carefully regulated by the epigenetic system. However, the full complexity of this regulatory system is not understood. Here, using mouse embryonic stem cells, we show that TEs are suppressed by heterochromatic marks like H3K9me3, and are also labelled by all major types of chromatin modification in complex patterns, including bivalent activatory and repressive marks. We identified 29 epigenetic modifiers that significantly deregulated at least one type of TE. The loss of Setdb1, Ncor2, Rnf2, Kat5, Prmt5, Uhrf1, and Rrp8 caused widespread changes in TE expression and chromatin accessibility. These effects were context-specific, with different chromatin modifiers regulating the expression and chromatin accessibility of specific subsets of TEs. Our work reveals the complex patterns of epigenetic regulation of TEs. More... »

PAGES

34

References to SciGraph publications

  • 2010-04. Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET in NATURE
  • 2005-01. APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses in NATURE
  • 2010-06. Estimating enrichment of repetitive elements from high-throughput sequence data in GENOME BIOLOGY
  • 2017-10. LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo in NATURE GENETICS
  • 2017-06. Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons in NATURE GENETICS
  • 2015-08. Genomic analysis of LPS-stimulated myeloid cells identifies a common pro-inflammatory response but divergent IL-10 anti-inflammatory responses in SCIENTIFIC REPORTS
  • 2018-12. SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells in GENOME BIOLOGY
  • 2007-05-24. Stability and flexibility of epigenetic gene regulation in mammalian development in NATURE
  • 2013-06. The octamer is the major form of CENP-A nucleosomes at human centromeres in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-08. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells in NATURE
  • 2018-01. A molecular roadmap for the emergence of early-embryonic-like cells in culture in NATURE GENETICS
  • 2015-10. Transposable elements at the center of the crossroads between embryogenesis, embryonic stem cells, reprogramming, and long non-coding RNAs in SCIENCE BULLETIN
  • 2015-06. Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells in NATURE
  • 2012-04. Fast gapped-read alignment with Bowtie 2 in NATURE METHODS
  • 2011-12. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome in BMC BIOINFORMATICS
  • 2018-04. NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming in NATURE CELL BIOLOGY
  • 2017-02. Regulatory activities of transposable elements: from conflicts to benefits in NATURE REVIEWS GENETICS
  • 2012-07. Embryonic stem cell potency fluctuates with endogenous retrovirus activity in NATURE
  • 2016-06. The landscape of accessible chromatin in mammalian preimplantation embryos in NATURE
  • 2013-12. Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position in NATURE METHODS
  • 2013-12. Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells in EPIGENETICS & CHROMATIN
  • 2015-05. C2H2 zinc finger proteins greatly expand the human regulatory lexicon in NATURE BIOTECHNOLOGY
  • 2010-07. Transposable elements have rewired the core regulatory network of human embryonic stem cells in NATURE GENETICS
  • 2010-01. KAP1 controls endogenous retroviruses in embryonic stem cells in NATURE
  • 2014-12. glbase: a framework for combining, analyzing and displaying heterogeneous genomic and high-throughput sequencing data in CELL REGENERATION
  • 2013-03. Chromatin signatures and retrotransposon profiling in mouse embryos reveal regulation of LINE-1 by RNA in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-12. GC-Content Normalization for RNA-Seq Data in BMC BIOINFORMATICS
  • 2015-06. Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells in NATURE
  • 2010-02. Gene ontology analysis for RNA-seq: accounting for selection bias in GENOME BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-08006-y

    DOI

    http://dx.doi.org/10.1038/s41467-018-08006-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110955640

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30604769


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