Interferon lambda protects the female reproductive tract against Zika virus infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Elizabeth A. Caine, Suzanne M. Scheaffer, Nitin Arora, Konstantin Zaitsev, Maxim N. Artyomov, Carolyn B. Coyne, Kelle H. Moley, Michael S. Diamond

ABSTRACT

Although Zika virus (ZIKV) can be transmitted sexually and cause congenital birth defects, immune control mechanisms in the female reproductive tract (FRT) are not well characterized. Here we show that treatment of primary human vaginal and cervical epithelial cells with interferon (IFN)-α/β or IFN-λ induces host defense transcriptional signatures and inhibits ZIKV infection. We also assess the effects of IFNs on intravaginal infection of the FRT using ovariectomized mice treated with reproductive hormones. We find that mice receiving estradiol are protected against intravaginal ZIKV infection, independently of IFN-α/β or IFN-λ signaling. In contrast, mice lacking IFN-λ signaling sustain greater FRT infection when progesterone is administered. Exogenous IFN-λ treatment confers an antiviral effect when mice receive both estradiol and progesterone, but not progesterone alone. Our results identify a hormonal stage-dependent role for IFN-λ in controlling ZIKV infection in the FRT and suggest a path for minimizing sexual transmission of ZIKV in women. More... »

PAGES

280

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-07993-2

DOI

http://dx.doi.org/10.1038/s41467-018-07993-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111375451

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30655513


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Intravaginal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiviral Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cervix Uteri", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estradiol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Host-Pathogen Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Primary Cell Culture", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Progesterone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sexually Transmitted Diseases, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vagina", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virus Replication", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zika Virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zika Virus Infection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Departments of Medicine, Washington University School of Medicine, 63110, Saint Louis, MO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caine", 
        "givenName": "Elizabeth A.", 
        "id": "sg:person.016415566125.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016415566125.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Obstetrics and Gynecology, Washington University School of Medicine, 63110, Saint Louis, MO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scheaffer", 
        "givenName": "Suzanne M.", 
        "id": "sg:person.0635034417.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635034417.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Alabama at Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Departments of Pediatrics, University of Pittsburgh School of Medicine, 15224, Pittsburgh, PA, USA", 
            "The Center for Microbial Pathogenesis, Children\u2019s Hospital, University of Pittsburgh School of Medicine, 15224, Pittsburgh, PA, USA", 
            "Department of Pediatrics, The University of Alabama at Birmingham, 35233, Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arora", 
        "givenName": "Nitin", 
        "id": "sg:person.013473326567.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013473326567.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "ITMO University", 
          "id": "https://www.grid.ac/institutes/grid.35915.3b", 
          "name": [
            "Department of Pathology and Immunology, Washington University School of Medicine, 63110, Saint Louis, MO, USA", 
            "Computer Technologies Department, ITMO University, 197101, St. Petersburg, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zaitsev", 
        "givenName": "Konstantin", 
        "id": "sg:person.013507664054.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013507664054.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Pathology and Immunology, Washington University School of Medicine, 63110, Saint Louis, MO, USA", 
            "The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, 63110, Saint Louis, MO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Artyomov", 
        "givenName": "Maxim N.", 
        "id": "sg:person.01174550174.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174550174.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pittsburgh", 
          "id": "https://www.grid.ac/institutes/grid.21925.3d", 
          "name": [
            "Departments of Pediatrics, University of Pittsburgh School of Medicine, 15224, Pittsburgh, PA, USA", 
            "The Center for Microbial Pathogenesis, Children\u2019s Hospital, University of Pittsburgh School of Medicine, 15224, Pittsburgh, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coyne", 
        "givenName": "Carolyn B.", 
        "id": "sg:person.0643372735.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643372735.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Obstetrics and Gynecology, Washington University School of Medicine, 63110, Saint Louis, MO, USA", 
            "Department of Cell Biology and Physiology, Washington University School of Medicine, 63110, Saint Louis, MO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moley", 
        "givenName": "Kelle H.", 
        "id": "sg:person.01203460064.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203460064.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Departments of Medicine, Washington University School of Medicine, 63110, Saint Louis, MO, USA", 
            "Department of Pathology and Immunology, Washington University School of Medicine, 63110, Saint Louis, MO, USA", 
            "The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, 63110, Saint Louis, MO, USA", 
            "Department of Molecular Microbiology, Washington University School of Medicine, 63110, Saint Louis, MO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Diamond", 
        "givenName": "Michael S.", 
        "id": "sg:person.0757052535.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757052535.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmoa1600651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000811266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(16)30336-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004294049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00252-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014201874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-014-0550-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015222646", 
          "https://doi.org/10.1186/s13059-014-0550-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-014-0550-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015222646", 
          "https://doi.org/10.1186/s13059-014-0550-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0190-9622(99)70359-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015852108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.79.5.3107-3116.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017013645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2016.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019121050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.80.9.4501-4509.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021537247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/315776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022052026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2016.05.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022742596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/jir.2014.0064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023229296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-3653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023517367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature20556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025029060", 
          "https://doi.org/10.1038/nature20556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01703-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026247832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5858/arpa.2016-0401-oa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027444432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02897-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027948174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15252/embr.201642627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028165458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029923770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pd.4882", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030610998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2016.11.070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032789664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2015.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034884884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038061613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.11.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040313202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.11.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040313202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1100552108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040762426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0114824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041096271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.180.4.2474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041336388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mbio.01114-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042753672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.68.7.4207-4216.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046017277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1233321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046745440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.16-0111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047271815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.16-0111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047271815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.16-0111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047271815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.16-0111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047271815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.4193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047583755", 
          "https://doi.org/10.1038/nm.4193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20161289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049547937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mob.2000.108857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050517572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2016.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050875315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc1604449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051374791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6364382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052545661", 
          "https://doi.org/10.1038/sj.gene.6364382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-3542(90)90004-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052885767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-3542(90)90004-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052885767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053006462", 
          "https://doi.org/10.1038/nri3819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/jir.2006.26.804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059280827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/ciw692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059468163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/sciadv.1501462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062440022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02079-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062712986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15585/mmwr.mm6514a3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067984243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15585/mmwr.mm6528e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067984359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2017.01.056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083822556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/sciadv.1602899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083937916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1006219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084310348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00404-017-4361-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084770941", 
          "https://doi.org/10.1007/s00404-017-4361-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00404-017-4361-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084770941", 
          "https://doi.org/10.1007/s00404-017-4361-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virusres.2017.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090579236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1006537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090896903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1707513114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091089423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/icu.0000000000000420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091111074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/icu.0000000000000420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091111074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/icu.0000000000000420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091111074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(17)30444-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091307154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2017.08.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091687389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1006633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091879228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m117.800755", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093081553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m117.800755", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093081553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m117.800755", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093081553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2017.01707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099605247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1711038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103217108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2018.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103886683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2018.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103886683"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Although Zika virus (ZIKV) can be transmitted sexually and cause congenital birth defects, immune control mechanisms in the female reproductive tract (FRT) are not well characterized. Here we show that treatment of primary human vaginal and cervical epithelial cells with\u00a0interferon (IFN)-\u03b1/\u03b2 or IFN-\u03bb induces host defense transcriptional signatures and inhibits ZIKV infection. We also assess the effects of IFNs on intravaginal infection of the FRT using ovariectomized mice treated with reproductive hormones. We find that mice receiving estradiol are protected against intravaginal ZIKV infection, independently of IFN-\u03b1/\u03b2 or IFN-\u03bb signaling. In contrast, mice lacking IFN-\u03bb signaling sustain greater FRT infection when progesterone is administered. Exogenous IFN-\u03bb treatment confers an antiviral effect when mice receive both estradiol and progesterone, but not progesterone alone. Our results identify a hormonal stage-dependent role for IFN-\u03bb in controlling ZIKV infection in the FRT and suggest a path for minimizing sexual transmission of ZIKV in women.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-018-07993-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2681992", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2458569", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2528648", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6541511", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2457911", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4317555", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6618512", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4055070", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Interferon lambda protects the female reproductive tract against Zika virus infection", 
    "pagination": "280", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a24fe80180b7e15d7ed7ce5693332413e2ca94f230a04df95147544293533d74"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30655513"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-018-07993-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111375451"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-018-07993-2", 
      "https://app.dimensions.ai/details/publication/pub.1111375451"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70066_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-018-07993-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07993-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07993-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07993-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07993-2'


 

This table displays all metadata directly associated to this object as RDF triples.

425 TRIPLES      21 PREDICATES      111 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-018-07993-2 schema:about N00ce6ce58cdc4b7fa3135d866c147512
2 N0794791edeb64c8fbe35d9c62286410d
3 N26b8227ad01a4b7bb2baa6139d02e82d
4 N2dd8b66119544e3e9176bdd5d8aa8fdd
5 N4365cd59271a4e4c96711c50d914f003
6 N79f049737cfa488a8221e68f2b971062
7 N7e5ddf6e68714356a65e75c6dd9f3afb
8 N82acc3a3a82345e4a6270ce7cc71d276
9 N898857463f4843978c14649798a4cd50
10 N8c3db6ce23324753a73554ceb0673bad
11 N9dbd8c41787140a3864a4f362623a02d
12 Na710a62899c8437dbb25fe8ba67f2618
13 Nab3ae3bec21e4467b6bd7b794c323e93
14 Nad5f6c14376346cc9ae4f0869557aacf
15 Nb78ab11d930142e1a53878231b0bc0ec
16 Ndc7fa3aadf9c47cf9ff78b6f34dde70e
17 Ne5fcf5fcd5534288bf3d62301e177ca4
18 Nea8289ac3b8d4578af9bfa23ec0153a7
19 Nec52f207354f4ee49458067afde0f2dd
20 Nf2270f23416044f1826142db92ca2053
21 Nf8c00d7a17e94bd49b201b3883b0a38b
22 Nffdaf5a48b68429484a14b42c27a9f9e
23 anzsrc-for:11
24 anzsrc-for:1103
25 schema:author N46b9bb458c28430bb13046f0aa1d057c
26 schema:citation sg:pub.10.1007/s00404-017-4361-5
27 sg:pub.10.1038/nature20556
28 sg:pub.10.1038/nm.4193
29 sg:pub.10.1038/nri3819
30 sg:pub.10.1038/sj.gene.6364382
31 sg:pub.10.1186/s13059-014-0550-8
32 https://doi.org/10.1002/pd.4882
33 https://doi.org/10.1016/0166-3542(90)90004-q
34 https://doi.org/10.1016/j.cell.2016.08.004
35 https://doi.org/10.1016/j.cell.2016.11.016
36 https://doi.org/10.1016/j.celrep.2016.11.070
37 https://doi.org/10.1016/j.celrep.2017.01.056
38 https://doi.org/10.1016/j.chom.2016.03.008
39 https://doi.org/10.1016/j.chom.2016.03.010
40 https://doi.org/10.1016/j.chom.2016.05.009
41 https://doi.org/10.1016/j.chom.2017.08.012
42 https://doi.org/10.1016/j.chom.2018.04.003
43 https://doi.org/10.1016/j.immuni.2015.07.001
44 https://doi.org/10.1016/j.virusres.2017.07.011
45 https://doi.org/10.1016/s0190-9622(99)70359-2
46 https://doi.org/10.1016/s1473-3099(16)30336-x
47 https://doi.org/10.1016/s1473-3099(17)30444-9
48 https://doi.org/10.1056/nejmc1604449
49 https://doi.org/10.1056/nejmoa1600651
50 https://doi.org/10.1056/nejmoa1711038
51 https://doi.org/10.1067/mob.2000.108857
52 https://doi.org/10.1073/pnas.0506580102
53 https://doi.org/10.1073/pnas.1100552108
54 https://doi.org/10.1073/pnas.1707513114
55 https://doi.org/10.1074/jbc.m117.800755
56 https://doi.org/10.1084/jem.20161289
57 https://doi.org/10.1086/315776
58 https://doi.org/10.1089/jir.2006.26.804
59 https://doi.org/10.1089/jir.2014.0064
60 https://doi.org/10.1093/cid/ciw692
61 https://doi.org/10.1097/icu.0000000000000420
62 https://doi.org/10.1126/sciadv.1501462
63 https://doi.org/10.1126/sciadv.1602899
64 https://doi.org/10.1126/science.1233321
65 https://doi.org/10.1128/iai.68.7.4207-4216.2000
66 https://doi.org/10.1128/jvi.00252-16
67 https://doi.org/10.1128/jvi.01703-09
68 https://doi.org/10.1128/jvi.02079-16
69 https://doi.org/10.1128/jvi.02897-14
70 https://doi.org/10.1128/jvi.79.5.3107-3116.2005
71 https://doi.org/10.1128/jvi.80.9.4501-4509.2006
72 https://doi.org/10.1128/mbio.01114-16
73 https://doi.org/10.1158/0008-5472.can-05-3653
74 https://doi.org/10.1371/journal.pone.0114824
75 https://doi.org/10.1371/journal.ppat.1000017
76 https://doi.org/10.1371/journal.ppat.1006219
77 https://doi.org/10.1371/journal.ppat.1006537
78 https://doi.org/10.1371/journal.ppat.1006633
79 https://doi.org/10.15252/embr.201642627
80 https://doi.org/10.15585/mmwr.mm6514a3
81 https://doi.org/10.15585/mmwr.mm6528e2
82 https://doi.org/10.3389/fimmu.2017.01707
83 https://doi.org/10.4049/jimmunol.180.4.2474
84 https://doi.org/10.4269/ajtmh.16-0111
85 https://doi.org/10.5858/arpa.2016-0401-oa
86 schema:datePublished 2019-12
87 schema:datePublishedReg 2019-12-01
88 schema:description Although Zika virus (ZIKV) can be transmitted sexually and cause congenital birth defects, immune control mechanisms in the female reproductive tract (FRT) are not well characterized. Here we show that treatment of primary human vaginal and cervical epithelial cells with interferon (IFN)-α/β or IFN-λ induces host defense transcriptional signatures and inhibits ZIKV infection. We also assess the effects of IFNs on intravaginal infection of the FRT using ovariectomized mice treated with reproductive hormones. We find that mice receiving estradiol are protected against intravaginal ZIKV infection, independently of IFN-α/β or IFN-λ signaling. In contrast, mice lacking IFN-λ signaling sustain greater FRT infection when progesterone is administered. Exogenous IFN-λ treatment confers an antiviral effect when mice receive both estradiol and progesterone, but not progesterone alone. Our results identify a hormonal stage-dependent role for IFN-λ in controlling ZIKV infection in the FRT and suggest a path for minimizing sexual transmission of ZIKV in women.
89 schema:genre research_article
90 schema:inLanguage en
91 schema:isAccessibleForFree true
92 schema:isPartOf N258103e0698648c5b25560d02ecb4d36
93 N284bc6f7b1a24dc9b25eb0f374490634
94 sg:journal.1043282
95 schema:name Interferon lambda protects the female reproductive tract against Zika virus infection
96 schema:pagination 280
97 schema:productId N0fd17ed3b8ff4103afe7e8c45c5178e7
98 N6e82474b970242aea840cba6349dcc4d
99 N72e7b5fd1aab45c29df676f9a9ee31fa
100 N7f095ddb1a634017973b923d94bf2899
101 Ne2a635facde543b4ad4d5232c1c56ceb
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111375451
103 https://doi.org/10.1038/s41467-018-07993-2
104 schema:sdDatePublished 2019-04-11T12:44
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N1244a0933ae8418899d5f82a454826dd
107 schema:url https://www.nature.com/articles/s41467-018-07993-2
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N00ce6ce58cdc4b7fa3135d866c147512 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Interferon-beta
113 rdf:type schema:DefinedTerm
114 N0794791edeb64c8fbe35d9c62286410d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Cervix Uteri
116 rdf:type schema:DefinedTerm
117 N0fd17ed3b8ff4103afe7e8c45c5178e7 schema:name readcube_id
118 schema:value a24fe80180b7e15d7ed7ce5693332413e2ca94f230a04df95147544293533d74
119 rdf:type schema:PropertyValue
120 N1244a0933ae8418899d5f82a454826dd schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 N258103e0698648c5b25560d02ecb4d36 schema:volumeNumber 10
123 rdf:type schema:PublicationVolume
124 N26b8227ad01a4b7bb2baa6139d02e82d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Administration, Intravaginal
126 rdf:type schema:DefinedTerm
127 N284bc6f7b1a24dc9b25eb0f374490634 schema:issueNumber 1
128 rdf:type schema:PublicationIssue
129 N2dd8b66119544e3e9176bdd5d8aa8fdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Mice, Inbred C57BL
131 rdf:type schema:DefinedTerm
132 N2f1c145f391d43548f7b1a21ab34bac0 rdf:first sg:person.0643372735.88
133 rdf:rest Nd68fac4aa17a4440ba217f54eee5447b
134 N3ea216ff7ad649ee8f858dc5b2577f25 rdf:first sg:person.013507664054.78
135 rdf:rest N4e9b0887bf4b443ab5469d51087b6130
136 N3feb4e2ff3b0423ea6671e48fbea2c16 rdf:first sg:person.013473326567.27
137 rdf:rest N3ea216ff7ad649ee8f858dc5b2577f25
138 N4365cd59271a4e4c96711c50d914f003 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Disease Models, Animal
140 rdf:type schema:DefinedTerm
141 N46b9bb458c28430bb13046f0aa1d057c rdf:first sg:person.016415566125.53
142 rdf:rest Na92454f96caf4787b5509e181d4f5698
143 N4e9b0887bf4b443ab5469d51087b6130 rdf:first sg:person.01174550174.55
144 rdf:rest N2f1c145f391d43548f7b1a21ab34bac0
145 N6e82474b970242aea840cba6349dcc4d schema:name dimensions_id
146 schema:value pub.1111375451
147 rdf:type schema:PropertyValue
148 N72e7b5fd1aab45c29df676f9a9ee31fa schema:name doi
149 schema:value 10.1038/s41467-018-07993-2
150 rdf:type schema:PropertyValue
151 N79f049737cfa488a8221e68f2b971062 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Zika Virus
153 rdf:type schema:DefinedTerm
154 N7e5ddf6e68714356a65e75c6dd9f3afb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Virus Replication
156 rdf:type schema:DefinedTerm
157 N7f095ddb1a634017973b923d94bf2899 schema:name nlm_unique_id
158 schema:value 101528555
159 rdf:type schema:PropertyValue
160 N82acc3a3a82345e4a6270ce7cc71d276 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Animals
162 rdf:type schema:DefinedTerm
163 N898857463f4843978c14649798a4cd50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Progesterone
165 rdf:type schema:DefinedTerm
166 N8bd5c257bf034b1c91dec9733c2c3869 rdf:first sg:person.0757052535.15
167 rdf:rest rdf:nil
168 N8c3db6ce23324753a73554ceb0673bad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Estradiol
170 rdf:type schema:DefinedTerm
171 N9dbd8c41787140a3864a4f362623a02d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Vagina
173 rdf:type schema:DefinedTerm
174 Na710a62899c8437dbb25fe8ba67f2618 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Interleukins
176 rdf:type schema:DefinedTerm
177 Na92454f96caf4787b5509e181d4f5698 rdf:first sg:person.0635034417.46
178 rdf:rest N3feb4e2ff3b0423ea6671e48fbea2c16
179 Nab3ae3bec21e4467b6bd7b794c323e93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Primary Cell Culture
181 rdf:type schema:DefinedTerm
182 Nad5f6c14376346cc9ae4f0869557aacf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Mice
184 rdf:type schema:DefinedTerm
185 Nb78ab11d930142e1a53878231b0bc0ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Host-Pathogen Interactions
187 rdf:type schema:DefinedTerm
188 Nd68fac4aa17a4440ba217f54eee5447b rdf:first sg:person.01203460064.68
189 rdf:rest N8bd5c257bf034b1c91dec9733c2c3869
190 Ndc7fa3aadf9c47cf9ff78b6f34dde70e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Humans
192 rdf:type schema:DefinedTerm
193 Ne2a635facde543b4ad4d5232c1c56ceb schema:name pubmed_id
194 schema:value 30655513
195 rdf:type schema:PropertyValue
196 Ne5fcf5fcd5534288bf3d62301e177ca4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Female
198 rdf:type schema:DefinedTerm
199 Nea8289ac3b8d4578af9bfa23ec0153a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Zika Virus Infection
201 rdf:type schema:DefinedTerm
202 Nec52f207354f4ee49458067afde0f2dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Sexually Transmitted Diseases, Viral
204 rdf:type schema:DefinedTerm
205 Nf2270f23416044f1826142db92ca2053 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Interferon-alpha
207 rdf:type schema:DefinedTerm
208 Nf8c00d7a17e94bd49b201b3883b0a38b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Epithelial Cells
210 rdf:type schema:DefinedTerm
211 Nffdaf5a48b68429484a14b42c27a9f9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Antiviral Agents
213 rdf:type schema:DefinedTerm
214 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
215 schema:name Medical and Health Sciences
216 rdf:type schema:DefinedTerm
217 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
218 schema:name Clinical Sciences
219 rdf:type schema:DefinedTerm
220 sg:grant.2457911 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07993-2
221 rdf:type schema:MonetaryGrant
222 sg:grant.2458569 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07993-2
223 rdf:type schema:MonetaryGrant
224 sg:grant.2528648 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07993-2
225 rdf:type schema:MonetaryGrant
226 sg:grant.2681992 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07993-2
227 rdf:type schema:MonetaryGrant
228 sg:grant.4055070 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07993-2
229 rdf:type schema:MonetaryGrant
230 sg:grant.4317555 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07993-2
231 rdf:type schema:MonetaryGrant
232 sg:grant.6541511 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07993-2
233 rdf:type schema:MonetaryGrant
234 sg:grant.6618512 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07993-2
235 rdf:type schema:MonetaryGrant
236 sg:journal.1043282 schema:issn 2041-1723
237 schema:name Nature Communications
238 rdf:type schema:Periodical
239 sg:person.01174550174.55 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
240 schema:familyName Artyomov
241 schema:givenName Maxim N.
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174550174.55
243 rdf:type schema:Person
244 sg:person.01203460064.68 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
245 schema:familyName Moley
246 schema:givenName Kelle H.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203460064.68
248 rdf:type schema:Person
249 sg:person.013473326567.27 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
250 schema:familyName Arora
251 schema:givenName Nitin
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013473326567.27
253 rdf:type schema:Person
254 sg:person.013507664054.78 schema:affiliation https://www.grid.ac/institutes/grid.35915.3b
255 schema:familyName Zaitsev
256 schema:givenName Konstantin
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013507664054.78
258 rdf:type schema:Person
259 sg:person.016415566125.53 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
260 schema:familyName Caine
261 schema:givenName Elizabeth A.
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016415566125.53
263 rdf:type schema:Person
264 sg:person.0635034417.46 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
265 schema:familyName Scheaffer
266 schema:givenName Suzanne M.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635034417.46
268 rdf:type schema:Person
269 sg:person.0643372735.88 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
270 schema:familyName Coyne
271 schema:givenName Carolyn B.
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643372735.88
273 rdf:type schema:Person
274 sg:person.0757052535.15 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
275 schema:familyName Diamond
276 schema:givenName Michael S.
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757052535.15
278 rdf:type schema:Person
279 sg:pub.10.1007/s00404-017-4361-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084770941
280 https://doi.org/10.1007/s00404-017-4361-5
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nature20556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025029060
283 https://doi.org/10.1038/nature20556
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nm.4193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047583755
286 https://doi.org/10.1038/nm.4193
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nri3819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053006462
289 https://doi.org/10.1038/nri3819
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/sj.gene.6364382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052545661
292 https://doi.org/10.1038/sj.gene.6364382
293 rdf:type schema:CreativeWork
294 sg:pub.10.1186/s13059-014-0550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015222646
295 https://doi.org/10.1186/s13059-014-0550-8
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1002/pd.4882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030610998
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/0166-3542(90)90004-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1052885767
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.cell.2016.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038061613
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.cell.2016.11.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040313202
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.celrep.2016.11.070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032789664
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.celrep.2017.01.056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083822556
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.chom.2016.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019121050
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.chom.2016.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050875315
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.chom.2016.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022742596
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.chom.2017.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091687389
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.chom.2018.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103886683
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.immuni.2015.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034884884
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.virusres.2017.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090579236
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/s0190-9622(99)70359-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015852108
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/s1473-3099(16)30336-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004294049
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/s1473-3099(17)30444-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091307154
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1056/nejmc1604449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051374791
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1056/nejmoa1600651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000811266
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1056/nejmoa1711038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103217108
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1067/mob.2000.108857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050517572
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1073/pnas.1100552108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040762426
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1073/pnas.1707513114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091089423
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1074/jbc.m117.800755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093081553
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1084/jem.20161289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049547937
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1086/315776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022052026
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1089/jir.2006.26.804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059280827
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1089/jir.2014.0064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023229296
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1093/cid/ciw692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059468163
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1097/icu.0000000000000420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091111074
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1126/sciadv.1501462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062440022
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1126/sciadv.1602899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083937916
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1126/science.1233321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046745440
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1128/iai.68.7.4207-4216.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046017277
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1128/jvi.00252-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014201874
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1128/jvi.01703-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026247832
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1128/jvi.02079-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062712986
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1128/jvi.02897-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027948174
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1128/jvi.79.5.3107-3116.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017013645
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1128/jvi.80.9.4501-4509.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021537247
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1128/mbio.01114-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042753672
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1158/0008-5472.can-05-3653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023517367
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1371/journal.pone.0114824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041096271
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1371/journal.ppat.1000017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029923770
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1371/journal.ppat.1006219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084310348
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1371/journal.ppat.1006537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090896903
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1371/journal.ppat.1006633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091879228
390 rdf:type schema:CreativeWork
391 https://doi.org/10.15252/embr.201642627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028165458
392 rdf:type schema:CreativeWork
393 https://doi.org/10.15585/mmwr.mm6514a3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067984243
394 rdf:type schema:CreativeWork
395 https://doi.org/10.15585/mmwr.mm6528e2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067984359
396 rdf:type schema:CreativeWork
397 https://doi.org/10.3389/fimmu.2017.01707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099605247
398 rdf:type schema:CreativeWork
399 https://doi.org/10.4049/jimmunol.180.4.2474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041336388
400 rdf:type schema:CreativeWork
401 https://doi.org/10.4269/ajtmh.16-0111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047271815
402 rdf:type schema:CreativeWork
403 https://doi.org/10.5858/arpa.2016-0401-oa schema:sameAs https://app.dimensions.ai/details/publication/pub.1027444432
404 rdf:type schema:CreativeWork
405 https://www.grid.ac/institutes/grid.21925.3d schema:alternateName University of Pittsburgh
406 schema:name Departments of Pediatrics, University of Pittsburgh School of Medicine, 15224, Pittsburgh, PA, USA
407 The Center for Microbial Pathogenesis, Children’s Hospital, University of Pittsburgh School of Medicine, 15224, Pittsburgh, PA, USA
408 rdf:type schema:Organization
409 https://www.grid.ac/institutes/grid.265892.2 schema:alternateName University of Alabama at Birmingham
410 schema:name Department of Pediatrics, The University of Alabama at Birmingham, 35233, Birmingham, AL, USA
411 Departments of Pediatrics, University of Pittsburgh School of Medicine, 15224, Pittsburgh, PA, USA
412 The Center for Microbial Pathogenesis, Children’s Hospital, University of Pittsburgh School of Medicine, 15224, Pittsburgh, PA, USA
413 rdf:type schema:Organization
414 https://www.grid.ac/institutes/grid.35915.3b schema:alternateName ITMO University
415 schema:name Computer Technologies Department, ITMO University, 197101, St. Petersburg, Russia
416 Department of Pathology and Immunology, Washington University School of Medicine, 63110, Saint Louis, MO, USA
417 rdf:type schema:Organization
418 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
419 schema:name Department of Cell Biology and Physiology, Washington University School of Medicine, 63110, Saint Louis, MO, USA
420 Department of Molecular Microbiology, Washington University School of Medicine, 63110, Saint Louis, MO, USA
421 Department of Pathology and Immunology, Washington University School of Medicine, 63110, Saint Louis, MO, USA
422 Departments of Medicine, Washington University School of Medicine, 63110, Saint Louis, MO, USA
423 Obstetrics and Gynecology, Washington University School of Medicine, 63110, Saint Louis, MO, USA
424 The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, 63110, Saint Louis, MO, USA
425 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...