Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Yael Haberman, Rebekah Karns, Phillip J. Dexheimer, Melanie Schirmer, Judith Somekh, Ingrid Jurickova, Tzipi Braun, Elizabeth Novak, Laura Bauman, Margaret H. Collins, Angela Mo, Michael J. Rosen, Erin Bonkowski, Nathan Gotman, Alison Marquis, Mason Nistel, Paul A. Rufo, Susan S. Baker, Cary G. Sauer, James Markowitz, Marian D. Pfefferkorn, Joel R. Rosh, Brendan M. Boyle, David R. Mack, Robert N. Baldassano, Sapana Shah, Neal S. Leleiko, Melvin B. Heyman, Anne M. Grifiths, Ashish S. Patel, Joshua D. Noe, Bruce J. Aronow, Subra Kugathasan, Thomas D. Walters, Greg Gibson, Sonia Davis Thomas, Kevin Mollen, Shai Shen-Orr, Curtis Huttenhower, Ramnik J. Xavier, Jeffrey S. Hyams, Lee A. Denson

ABSTRACT

Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients receiving standardised therapy. We validate our key findings in adult and paediatric UC cohorts of 408 participants. We observe a marked suppression of mitochondrial genes and function across cohorts in active UC, and that increasing disease severity is notable for enrichment of adenoma/adenocarcinoma and innate immune genes. A subset of severity genes improves prediction of corticosteroid-induced remission in the discovery cohort; this gene signature is also associated with response to anti-TNFα and anti-α4β7 integrin in adults. The severity and therapeutic response gene signatures were in turn associated with shifts in microbes previously implicated in mucosal homeostasis. Our data provide insights into UC pathogenesis, and may prioritise future therapies for nonresponders to current approaches. More... »

PAGES

38

References to SciGraph publications

  • 2017-12. xCell: digitally portraying the tissue cellular heterogeneity landscape in GENOME BIOLOGY
  • 2017-06. Erratum: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease in NATURE MEDICINE
  • 2016-11-23. Altered intestinal microbiota–host mitochondria crosstalk in new onset Crohn’s disease in NATURE COMMUNICATIONS
  • 2012-03. An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea in THE ISME JOURNAL
  • 2017-04. Clonal evolution of colorectal cancer in IBD in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2009-02. Influence of Phenotype at Diagnosis and of Other Potential Prognostic Factors on the Course of Inflammatory Bowel Disease in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2017-05. Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease in NATURE MEDICINE
  • 2012. High-Resolution Respirometry: OXPHOS Protocols for Human Cells and Permeabilized Fibers from Small Biopsies of Human Muscle in MITOCHONDRIAL BIOENERGETICS
  • 2010-09. Mitochondrial respiratory chain in the colonic mucosal of patients with ulcerative colitis in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2017-07. Advances in the Development of Janus Kinase Inhibitors in Inflammatory Bowel Disease: Future Prospects in DRUGS
  • 2016-05. Near-optimal probabilistic RNA-seq quantification in NATURE BIOTECHNOLOGY
  • 2012-11. A travel guide to Cytoscape plugins in NATURE METHODS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-07841-3

    DOI

    http://dx.doi.org/10.1038/s41467-018-07841-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110955607

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30604764


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anti-Inflammatory Agents, Non-Steroidal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colitis, Ulcerative", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Feces", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Mitochondrial", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glucocorticoids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Integrins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intestinal Mucosa", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mesalamine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microbiota", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitochondria", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitochondrial Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Precision Medicine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rectum", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Remission Induction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Analysis, RNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Severity of Illness Index", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcriptome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Necrosis Factor-alpha", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Sheba Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.413795.d", 
              "name": [
                "Cincinnati Children\u2019s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA", 
                "Sheba Medical Center, Tel Hashomer, affiliated with the Tel Aviv University, 5265601, Tel Aviv, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Haberman", 
            "givenName": "Yael", 
            "id": "sg:person.01034142334.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034142334.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Cincinnati Children\u2019s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Karns", 
            "givenName": "Rebekah", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Cincinnati Children\u2019s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dexheimer", 
            "givenName": "Phillip J.", 
            "id": "sg:person.01153762210.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153762210.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute of MIT and Harvard University, 02142, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schirmer", 
            "givenName": "Melanie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Haifa", 
              "id": "https://www.grid.ac/institutes/grid.18098.38", 
              "name": [
                "Faculty of Medicine, Technion, 3109601, Haifa, Israel", 
                "Department of Information Systems, University of Haifa, 3498838, Haifa, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Somekh", 
            "givenName": "Judith", 
            "id": "sg:person.01366660604.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366660604.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Cincinnati Children\u2019s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jurickova", 
            "givenName": "Ingrid", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sheba Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.413795.d", 
              "name": [
                "Sheba Medical Center, Tel Hashomer, affiliated with the Tel Aviv University, 5265601, Tel Aviv, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Braun", 
            "givenName": "Tzipi", 
            "id": "sg:person.014027667613.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014027667613.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Children's Hospital of Pittsburgh", 
              "id": "https://www.grid.ac/institutes/grid.239553.b", 
              "name": [
                "Children\u2019s Hospital of Pittsburgh, 15224, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Novak", 
            "givenName": "Elizabeth", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Diego", 
              "id": "https://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Cincinnati Children\u2019s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA", 
                "Department of Pediatrics, University of California at San Diego, 92162, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bauman", 
            "givenName": "Laura", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Cincinnati Children\u2019s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Collins", 
            "givenName": "Margaret H.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Georgia Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.213917.f", 
              "name": [
                "Georgia Institute of Technology, 30332, Atlanta, GA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mo", 
            "givenName": "Angela", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Cincinnati Children\u2019s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rosen", 
            "givenName": "Michael J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Cincinnati Children\u2019s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bonkowski", 
            "givenName": "Erin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of North Carolina System", 
              "id": "https://www.grid.ac/institutes/grid.410711.2", 
              "name": [
                "Collaborative Studies Coordinating Center, University of North Carolina, 27516, Chapel Hill, NC, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gotman", 
            "givenName": "Nathan", 
            "id": "sg:person.01205365345.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205365345.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of North Carolina System", 
              "id": "https://www.grid.ac/institutes/grid.410711.2", 
              "name": [
                "Collaborative Studies Coordinating Center, University of North Carolina, 27516, Chapel Hill, NC, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marquis", 
            "givenName": "Alison", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Cincinnati Children\u2019s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nistel", 
            "givenName": "Mason", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Harvard\u2014Children\u2019s Hospital Boston, 02115, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rufo", 
            "givenName": "Paul A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Women & Children's Hospital of Buffalo", 
              "id": "https://www.grid.ac/institutes/grid.413993.5", 
              "name": [
                "Women & Children\u2019s Hospital of Buffalo WCHOB, 14222, Buffalo, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baker", 
            "givenName": "Susan S.", 
            "id": "sg:person.0773675772.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773675772.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Emory University", 
              "id": "https://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Emory University, 30322, Atlanta, GA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sauer", 
            "givenName": "Cary G.", 
            "id": "sg:person.01364523347.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364523347.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cohen Children's Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.415338.8", 
              "name": [
                "Cohen Children\u2019s Medical Center of New York, 11040, New Hyde Park, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Markowitz", 
            "givenName": "James", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Riley Hospital for Children", 
              "id": "https://www.grid.ac/institutes/grid.414923.9", 
              "name": [
                "Riley Hospital for Children, 46202, Indianapolis, IN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pfefferkorn", 
            "givenName": "Marian D.", 
            "id": "sg:person.013525540567.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013525540567.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Goryeb Children\u2019s Hospital\u2014Atlantic Health, 07960, Morristown, NJ, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rosh", 
            "givenName": "Joel R.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nationwide Children's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.240344.5", 
              "name": [
                "Nationwide Children\u2019s Hospital, 43205, Columbus, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boyle", 
            "givenName": "Brendan M.", 
            "id": "sg:person.01263671211.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263671211.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Children\u2019s Hospital of East Ontario, Ottawa, K1P 1J1, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mack", 
            "givenName": "David R.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Children's Hospital of Philadelphia", 
              "id": "https://www.grid.ac/institutes/grid.239552.a", 
              "name": [
                "The Children\u2019s Hospital of Philadelphia, 19104, Philadelphia, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baldassano", 
            "givenName": "Robert N.", 
            "id": "sg:person.0772340157.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772340157.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Children's Hospital of Pittsburgh", 
              "id": "https://www.grid.ac/institutes/grid.239553.b", 
              "name": [
                "Children\u2019s Hospital of Pittsburgh of UPMC, 15224, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shah", 
            "givenName": "Sapana", 
            "id": "sg:person.010432172377.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010432172377.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hasbro Children's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.414169.f", 
              "name": [
                "Hasbro Children\u2019s Hospital, 02903, Providence, RI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leleiko", 
            "givenName": "Neal S.", 
            "id": "sg:person.01355705324.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355705324.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Francisco", 
              "id": "https://www.grid.ac/institutes/grid.266102.1", 
              "name": [
                "University of California at San Francisco, 94143, San Francisco, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Heyman", 
            "givenName": "Melvin B.", 
            "id": "sg:person.0701734367.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701734367.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital for Sick Children", 
              "id": "https://www.grid.ac/institutes/grid.42327.30", 
              "name": [
                "Hospital for Sick Children, M5G 1X8, Toronto, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grifiths", 
            "givenName": "Anne M.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas Southwestern Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.267313.2", 
              "name": [
                "UT Southwestern, 75390, Dallas, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Patel", 
            "givenName": "Ashish S.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical College of Wisconsin", 
              "id": "https://www.grid.ac/institutes/grid.30760.32", 
              "name": [
                "Medical College of Wisconsin, 53226, Milwaukee, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Noe", 
            "givenName": "Joshua D.", 
            "id": "sg:person.01113420134.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113420134.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Cincinnati Children\u2019s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aronow", 
            "givenName": "Bruce J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Emory University", 
              "id": "https://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Emory University, 30322, Atlanta, GA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kugathasan", 
            "givenName": "Subra", 
            "id": "sg:person.01147172155.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147172155.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital for Sick Children", 
              "id": "https://www.grid.ac/institutes/grid.42327.30", 
              "name": [
                "Hospital for Sick Children, M5G 1X8, Toronto, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Walters", 
            "givenName": "Thomas D.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Georgia Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.213917.f", 
              "name": [
                "Georgia Institute of Technology, 30332, Atlanta, GA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gibson", 
            "givenName": "Greg", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "RTI International", 
              "id": "https://www.grid.ac/institutes/grid.62562.35", 
              "name": [
                "Collaborative Studies Coordinating Center, University of North Carolina, 27516, Chapel Hill, NC, USA", 
                "RTI International, 27709, Research Triangle Park, NC, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thomas", 
            "givenName": "Sonia Davis", 
            "id": "sg:person.016206760374.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016206760374.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Children's Hospital of Pittsburgh", 
              "id": "https://www.grid.ac/institutes/grid.239553.b", 
              "name": [
                "Children\u2019s Hospital of Pittsburgh, 15224, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mollen", 
            "givenName": "Kevin", 
            "id": "sg:person.01251467115.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251467115.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Technion \u2013 Israel Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.6451.6", 
              "name": [
                "Faculty of Medicine, Technion, 3109601, Haifa, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shen-Orr", 
            "givenName": "Shai", 
            "id": "sg:person.01213007720.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213007720.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Broad Institute of MIT and Harvard University, 02142, Cambridge, MA, USA", 
                "Harvard School of Public Health, 02115, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huttenhower", 
            "givenName": "Curtis", 
            "id": "sg:person.01214462502.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214462502.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Broad Institute of MIT and Harvard University, 02142, Cambridge, MA, USA", 
                "Massachusetts General Hospital, Harvard Medical School, 02114, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xavier", 
            "givenName": "Ramnik J.", 
            "id": "sg:person.0717130066.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717130066.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Connecticut Children's Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.414666.7", 
              "name": [
                "Connecticut Children\u2019s Medical Center, 06106, Hartford, CT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hyams", 
            "givenName": "Jeffrey S.", 
            "id": "sg:person.01101056755.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101056755.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Cincinnati Children\u2019s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Denson", 
            "givenName": "Lee A.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1053/j.gastro.2008.10.086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000121753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199011013231802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000157853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.20342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000380974"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.20342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000380974"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.20342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000380974"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-3476(96)70193-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001860348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001910376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2008.38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003848857", 
              "https://doi.org/10.1038/ajg.2008.38"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djt167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004244281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2010.02.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004519190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2012-303333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006858793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2016.10.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010214766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2015.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013295003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.parint.2011.04.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013295321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0071989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015576572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2012.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017400322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-61779-382-0_3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017755790", 
              "https://doi.org/10.1007/978-1-61779-382-0_3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms13419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017834073", 
              "https://doi.org/10.1038/ncomms13419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11010-010-0474-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019401146", 
              "https://doi.org/10.1007/s11010-010-0474-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11010-010-0474-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019401146", 
              "https://doi.org/10.1007/s11010-010-0474-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2014.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021097318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2014.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021097318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.0903816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021530352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.20110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023182499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.20110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023182499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mib.0000000000000535", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023887435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mib.0000000000000535", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023887435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mib.0000000000000535", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023887435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024493480", 
              "https://doi.org/10.1038/nbt.3519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026331197", 
              "https://doi.org/10.1038/nmeth.2212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2016.10.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027312466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2016.10.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027312466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0096153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027524338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkp427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027845966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkp427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027845966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2016.10.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027981992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.21393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028718417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.21393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028718417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.22926", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030837997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.22926", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030837997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mito.2016.09.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030873473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbalip.2016.07.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031221855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2005.12.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032910167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci75436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033973377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.3hi0515-189r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034831265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0007984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037870420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.48.4.526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039765228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.10-170027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041023319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq418", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041947444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ismej.2011.139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051863807", 
              "https://doi.org/10.1038/ismej.2011.139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m115.688812", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058214058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2016-312293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062813756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2202/1544-6115.1027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069289261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3969/j.issn.1673-5374.2013.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078970107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrgastro.2017.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083732766", 
              "https://doi.org/10.1038/nrgastro.2017.1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(17)30317-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084043501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084508963", 
              "https://doi.org/10.1038/nm.4307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084508963", 
              "https://doi.org/10.1038/nm.4307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aal3535", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085142091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pcbi.1005515", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085409246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40265-017-0755-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085444493", 
              "https://doi.org/10.1007/s40265-017-0755-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40265-017-0755-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085444493", 
              "https://doi.org/10.1007/s40265-017-0755-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0617-788d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085880786", 
              "https://doi.org/10.1038/nm0617-788d"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0617-788d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085880786", 
              "https://doi.org/10.1038/nm0617-788d"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpgi.00136.2017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086047756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.151142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091382105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000000939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091418408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000000939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091418408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000000939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091418408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s2468-1253(17)30252-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091877791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2017.10.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092187927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2017.10.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092187927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-017-1349-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092688878", 
              "https://doi.org/10.1186/s13059-017-1349-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btx754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093067522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2017-315494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103167849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2017-315494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103167849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2017-315494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103167849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2017-315494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103167849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2017-315494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103167849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2018.09.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107491985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2018.09.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107491985"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients receiving standardised therapy. We validate our key findings in adult and paediatric UC cohorts of 408 participants. We observe a marked suppression of mitochondrial genes and function across cohorts in active UC, and that increasing disease severity is notable for enrichment of adenoma/adenocarcinoma and innate immune genes. A subset of severity genes improves prediction of corticosteroid-induced remission in the discovery cohort; this gene signature is also associated with response to anti-TNF\u03b1 and anti-\u03b14\u03b27 integrin in adults. The severity and therapeutic response gene signatures were in turn associated with shifts in microbes previously implicated in mucosal homeostasis. Our data provide insights into UC pathogenesis, and may prioritise future therapies for nonresponders to current approaches.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41467-018-07841-3", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2690315", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2439002", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2683297", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7552884", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3624030", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7520434", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2439042", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6618860", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response", 
        "pagination": "38", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "53021b8f0f85e63c54aa80b2eb91c08d994ca674b1faa6e1163258648a0d376f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30604764"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101528555"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-018-07841-3"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1110955607"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-018-07841-3", 
          "https://app.dimensions.ai/details/publication/pub.1110955607"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78953_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41467-018-07841-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07841-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07841-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07841-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07841-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    744 TRIPLES      21 PREDICATES      115 URIs      48 LITERALS      36 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-018-07841-3 schema:about N07d1b3b282694313bdb032f7e9572799
    2 N0eb0d0c42ddc41adb944502e001cfe30
    3 N1144d487cd944da5bcc4ea986bf86b7d
    4 N232c623603f54853b0504d59a34556a5
    5 N2c2cdc349fe44d0aa0ec9ce7603a58b8
    6 N3301da56a6854d759028d0e8ed44b21e
    7 N33380dc5f3bc4b42a0373b101f47b0a7
    8 N35d52c6d40b54b57921ee202534542aa
    9 N35dc81754fec461ab7ea8338c636500c
    10 N3f27d18c39354d9a8edcaffac725b929
    11 N4073df4227604d229a6f48edda025e04
    12 N429e78a5fbec41b9801a3651930b2fcc
    13 N444b93d48340496b8dc9374e1f1daddd
    14 N7f58567707934867bb76558e208f43a6
    15 N93e83dbc5fdb4d2fb89783b13f94006f
    16 Nb615439c489f4182967236f4113c542d
    17 Nc430c4ac7774478a897704f4b3ebc607
    18 Nc451d8cd9ae642daa31db5d02658c7a2
    19 Nc93029932a4343fb84f606593c20796f
    20 Nd17f831140ce4704a386aba2dbc24dbd
    21 Ndc10ad65f54c488cb5f433a76f4d4841
    22 Ndf55e3949d35466699dd412456f6b7f7
    23 Ne1a9c2c03fc74a44a85d647bad6ceef8
    24 Ne1aa2bced270468aa9b7a9b65b807c67
    25 Ne8260d441ac24e14acd3c67f3d3fc7b9
    26 Nf2b558e73fb24789bdb71013ab359f5d
    27 Nf5a7c9038c0a4d33a987ebf04054143d
    28 anzsrc-for:06
    29 anzsrc-for:0604
    30 schema:author Ne03fce5a850e4ae2a9b7034975e6352b
    31 schema:citation sg:pub.10.1007/978-1-61779-382-0_3
    32 sg:pub.10.1007/s11010-010-0474-x
    33 sg:pub.10.1007/s40265-017-0755-8
    34 sg:pub.10.1038/ajg.2008.38
    35 sg:pub.10.1038/ismej.2011.139
    36 sg:pub.10.1038/nbt.3519
    37 sg:pub.10.1038/ncomms13419
    38 sg:pub.10.1038/nm.4307
    39 sg:pub.10.1038/nm0617-788d
    40 sg:pub.10.1038/nmeth.2212
    41 sg:pub.10.1038/nrgastro.2017.1
    42 sg:pub.10.1186/s13059-017-1349-1
    43 https://doi.org/10.1002/ibd.20110
    44 https://doi.org/10.1002/ibd.20342
    45 https://doi.org/10.1002/ibd.21393
    46 https://doi.org/10.1002/ibd.22926
    47 https://doi.org/10.1016/j.bbalip.2016.07.014
    48 https://doi.org/10.1016/j.chom.2015.03.005
    49 https://doi.org/10.1016/j.chom.2018.09.009
    50 https://doi.org/10.1016/j.cmet.2014.12.005
    51 https://doi.org/10.1016/j.mito.2016.09.003
    52 https://doi.org/10.1016/j.parint.2011.04.005
    53 https://doi.org/10.1016/s0022-3476(96)70193-2
    54 https://doi.org/10.1016/s0140-6736(17)30317-3
    55 https://doi.org/10.1016/s2468-1253(17)30252-2
    56 https://doi.org/10.1053/j.gastro.2005.12.035
    57 https://doi.org/10.1053/j.gastro.2008.10.086
    58 https://doi.org/10.1053/j.gastro.2010.02.047
    59 https://doi.org/10.1053/j.gastro.2012.08.002
    60 https://doi.org/10.1053/j.gastro.2016.10.012
    61 https://doi.org/10.1053/j.gastro.2016.10.018
    62 https://doi.org/10.1053/j.gastro.2016.10.020
    63 https://doi.org/10.1053/j.gastro.2017.10.007
    64 https://doi.org/10.1056/nejm199011013231802
    65 https://doi.org/10.1074/jbc.m115.688812
    66 https://doi.org/10.1093/bioinformatics/btp101
    67 https://doi.org/10.1093/bioinformatics/btx754
    68 https://doi.org/10.1093/jnci/djt167
    69 https://doi.org/10.1093/nar/gkp427
    70 https://doi.org/10.1093/nar/gkq418
    71 https://doi.org/10.1096/fj.10-170027
    72 https://doi.org/10.1097/mib.0000000000000535
    73 https://doi.org/10.1097/pas.0000000000000939
    74 https://doi.org/10.1126/science.aal3535
    75 https://doi.org/10.1136/gut.48.4.526
    76 https://doi.org/10.1136/gutjnl-2012-303333
    77 https://doi.org/10.1136/gutjnl-2016-312293
    78 https://doi.org/10.1136/gutjnl-2017-315494
    79 https://doi.org/10.1152/ajpgi.00136.2017
    80 https://doi.org/10.1172/jci75436
    81 https://doi.org/10.1189/jlb.3hi0515-189r
    82 https://doi.org/10.1242/dev.151142
    83 https://doi.org/10.1371/journal.pcbi.1005515
    84 https://doi.org/10.1371/journal.pone.0007984
    85 https://doi.org/10.1371/journal.pone.0071989
    86 https://doi.org/10.1371/journal.pone.0096153
    87 https://doi.org/10.2202/1544-6115.1027
    88 https://doi.org/10.3969/j.issn.1673-5374.2013.04.009
    89 https://doi.org/10.4049/jimmunol.0903816
    90 schema:datePublished 2019-12
    91 schema:datePublishedReg 2019-12-01
    92 schema:description Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients receiving standardised therapy. We validate our key findings in adult and paediatric UC cohorts of 408 participants. We observe a marked suppression of mitochondrial genes and function across cohorts in active UC, and that increasing disease severity is notable for enrichment of adenoma/adenocarcinoma and innate immune genes. A subset of severity genes improves prediction of corticosteroid-induced remission in the discovery cohort; this gene signature is also associated with response to anti-TNFα and anti-α<sub>4</sub>β<sub>7</sub> integrin in adults. The severity and therapeutic response gene signatures were in turn associated with shifts in microbes previously implicated in mucosal homeostasis. Our data provide insights into UC pathogenesis, and may prioritise future therapies for nonresponders to current approaches.
    93 schema:genre research_article
    94 schema:inLanguage en
    95 schema:isAccessibleForFree true
    96 schema:isPartOf N25f742651f784d03bf4e6b3aed4c8249
    97 N710d3b98665d4b89a8105416d3c1f617
    98 sg:journal.1043282
    99 schema:name Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response
    100 schema:pagination 38
    101 schema:productId N165c41d405fa4fc39ab343942f7eede2
    102 N4a5bbba90f31446a9a076bf4297ef22e
    103 N5d528caddd19469a8c2627ac7bee1f56
    104 N7acc07e74a0e445980b339e0946103d3
    105 Nc7feeb9ee2ae4b439e72f4e14800b43b
    106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110955607
    107 https://doi.org/10.1038/s41467-018-07841-3
    108 schema:sdDatePublished 2019-04-11T13:19
    109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    110 schema:sdPublisher N9ca8015ed7ce453c8d74b93124d9196a
    111 schema:url https://www.nature.com/articles/s41467-018-07841-3
    112 sgo:license sg:explorer/license/
    113 sgo:sdDataset articles
    114 rdf:type schema:ScholarlyArticle
    115 N05bda25a56254753936525dc4437dd53 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
    116 schema:familyName Grifiths
    117 schema:givenName Anne M.
    118 rdf:type schema:Person
    119 N076b49fe49f5479c9c506b25a22b0421 schema:name Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA
    120 rdf:type schema:Organization
    121 N07d1b3b282694313bdb032f7e9572799 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Mitochondrial Diseases
    123 rdf:type schema:DefinedTerm
    124 N0a88c17cd5d2430e802a019d19be6f34 schema:name Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA
    125 rdf:type schema:Organization
    126 N0b98c71f39bb4e07aa315b559f02e2b2 rdf:first Nfa2ebd053b77407582be187068461934
    127 rdf:rest Nb8211c92fc4949f7aba2b6c8018417bb
    128 N0c081edc6c0c4e0f8e04da36c10cf0c2 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
    129 schema:familyName Walters
    130 schema:givenName Thomas D.
    131 rdf:type schema:Person
    132 N0d4de4fe7d2246d6bcfa36bb43ecf74a rdf:first sg:person.01214462502.85
    133 rdf:rest Nd43df6427c38459a94dc596d30bdf54c
    134 N0eb0d0c42ddc41adb944502e001cfe30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Microbiota
    136 rdf:type schema:DefinedTerm
    137 N1144d487cd944da5bcc4ea986bf86b7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Gene Expression Profiling
    139 rdf:type schema:DefinedTerm
    140 N11f18abf829549d2b211c22bef0b5058 schema:name Goryeb Children’s Hospital—Atlantic Health, 07960, Morristown, NJ, USA
    141 rdf:type schema:Organization
    142 N165c41d405fa4fc39ab343942f7eede2 schema:name nlm_unique_id
    143 schema:value 101528555
    144 rdf:type schema:PropertyValue
    145 N1701dd8158694fd3aa26bc89d89c7b55 rdf:first N83cd7a58adbb4fcbb0e58eeb234dade1
    146 rdf:rest N9c0248c16efa40fb8dd94f05bcad1993
    147 N1c42fd5fe1004e4eb35a4780c644bd7e rdf:first sg:person.01263671211.03
    148 rdf:rest N7b9617fa145b42968a23ea0af80edb38
    149 N232c623603f54853b0504d59a34556a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Glucocorticoids
    151 rdf:type schema:DefinedTerm
    152 N24728d5eef40435184192ec7129d39b5 schema:name Children’s Hospital of East Ontario, Ottawa, K1P 1J1, Ontario, Canada
    153 rdf:type schema:Organization
    154 N255bbce274084f32b29c3a57bf461046 rdf:first sg:person.0773675772.82
    155 rdf:rest N61d62e62d6424fcaa262e65a99f23fd4
    156 N25f742651f784d03bf4e6b3aed4c8249 schema:volumeNumber 10
    157 rdf:type schema:PublicationVolume
    158 N2ab98ba2ceab40f7a7ea0e278848e1af rdf:first sg:person.014027667613.58
    159 rdf:rest N6696544ae5d34f758d86c44bbf39874c
    160 N2c2cdc349fe44d0aa0ec9ce7603a58b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Severity of Illness Index
    162 rdf:type schema:DefinedTerm
    163 N2fa9bfe024434a29ab87616fcdc5e695 rdf:first N72a6ffe6260d4b91ab5862daee3c0ea0
    164 rdf:rest Ndc6bbacd3d90461eae134bdbe08a6343
    165 N3124dc400893403cbd7189805879b345 schema:affiliation https://www.grid.ac/institutes/grid.415338.8
    166 schema:familyName Markowitz
    167 schema:givenName James
    168 rdf:type schema:Person
    169 N31edc26f810f4b7fb3d9a4459f3ad80a rdf:first sg:person.016206760374.52
    170 rdf:rest N61dc1efb9182491b952b306f5e2babd8
    171 N3301da56a6854d759028d0e8ed44b21e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Humans
    173 rdf:type schema:DefinedTerm
    174 N33380dc5f3bc4b42a0373b101f47b0a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Genes, Mitochondrial
    176 rdf:type schema:DefinedTerm
    177 N34cbc128d33a44e7a19e7fb16d1fbb0d rdf:first sg:person.01213007720.49
    178 rdf:rest N0d4de4fe7d2246d6bcfa36bb43ecf74a
    179 N35b279ff64174c7aafeb2e0a201c4c81 rdf:first Nad153f1ec14e49bf86a017ac78bc0c37
    180 rdf:rest rdf:nil
    181 N35d52c6d40b54b57921ee202534542aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Adult
    183 rdf:type schema:DefinedTerm
    184 N35dc81754fec461ab7ea8338c636500c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Prospective Studies
    186 rdf:type schema:DefinedTerm
    187 N3f27d18c39354d9a8edcaffac725b929 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Tumor Necrosis Factor-alpha
    189 rdf:type schema:DefinedTerm
    190 N4073df4227604d229a6f48edda025e04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Precision Medicine
    192 rdf:type schema:DefinedTerm
    193 N407a73b1577e4cd4a6ba265e0afe0891 schema:name Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA
    194 rdf:type schema:Organization
    195 N429e78a5fbec41b9801a3651930b2fcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Mesalamine
    197 rdf:type schema:DefinedTerm
    198 N4372bbd7e2374764b3185a7ec6a91211 rdf:first N0c081edc6c0c4e0f8e04da36c10cf0c2
    199 rdf:rest N4c22e7e5181c4174950bd4add347310f
    200 N444b93d48340496b8dc9374e1f1daddd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Transcriptome
    202 rdf:type schema:DefinedTerm
    203 N4a5bbba90f31446a9a076bf4297ef22e schema:name pubmed_id
    204 schema:value 30604764
    205 rdf:type schema:PropertyValue
    206 N4bcd224b7d05495cb2ab2316f7e84ad0 rdf:first Nac9a09edffad45638acde1356b141405
    207 rdf:rest N2ab98ba2ceab40f7a7ea0e278848e1af
    208 N4c22e7e5181c4174950bd4add347310f rdf:first N62642f1a86c94b9bba20125f2fdd64cc
    209 rdf:rest N31edc26f810f4b7fb3d9a4459f3ad80a
    210 N52b2e3e49bde4e0d8c6f016a54a11ef5 schema:affiliation https://www.grid.ac/institutes/grid.239553.b
    211 schema:familyName Novak
    212 schema:givenName Elizabeth
    213 rdf:type schema:Person
    214 N5b24a9d5aa124c66a2cbbce480cf0742 schema:affiliation N0a88c17cd5d2430e802a019d19be6f34
    215 schema:familyName Karns
    216 schema:givenName Rebekah
    217 rdf:type schema:Person
    218 N5b80e7feea9c4ea0b6464280ca9370a0 schema:name Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA
    219 rdf:type schema:Organization
    220 N5d528caddd19469a8c2627ac7bee1f56 schema:name readcube_id
    221 schema:value 53021b8f0f85e63c54aa80b2eb91c08d994ca674b1faa6e1163258648a0d376f
    222 rdf:type schema:PropertyValue
    223 N5eb8ca93ec61438c8c11e1da9edaba18 rdf:first N9d3c3f1e9a014f2a926347f2c3eae078
    224 rdf:rest Na5c3bbc928214bd7969d961630b5efbe
    225 N61d62e62d6424fcaa262e65a99f23fd4 rdf:first sg:person.01364523347.12
    226 rdf:rest Na1f29ae9e48e4fe1b88bdb79eb061744
    227 N61dc1efb9182491b952b306f5e2babd8 rdf:first sg:person.01251467115.20
    228 rdf:rest N34cbc128d33a44e7a19e7fb16d1fbb0d
    229 N62642f1a86c94b9bba20125f2fdd64cc schema:affiliation https://www.grid.ac/institutes/grid.213917.f
    230 schema:familyName Gibson
    231 schema:givenName Greg
    232 rdf:type schema:Person
    233 N6696544ae5d34f758d86c44bbf39874c rdf:first N52b2e3e49bde4e0d8c6f016a54a11ef5
    234 rdf:rest N76f8987289c946e6864a490730d78aaf
    235 N6770f0aa70c04988aabaa269230705e7 rdf:first sg:person.0772340157.54
    236 rdf:rest Nc2bfb793c8494ef4a61b8795f2642d67
    237 N6c6f53e42a1449a3b8a69d5e8081204d schema:affiliation N79f28ad8c920449fa4ec86a2c92056d5
    238 schema:familyName Rosen
    239 schema:givenName Michael J.
    240 rdf:type schema:Person
    241 N6d892db4327d4e1db6c12d2bc366790b schema:name Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA
    242 rdf:type schema:Organization
    243 N710d3b98665d4b89a8105416d3c1f617 schema:issueNumber 1
    244 rdf:type schema:PublicationIssue
    245 N72a6ffe6260d4b91ab5862daee3c0ea0 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    246 schema:familyName Schirmer
    247 schema:givenName Melanie
    248 rdf:type schema:Person
    249 N766e06963ea34db69e9b28d13dae9619 schema:affiliation https://www.grid.ac/institutes/grid.213917.f
    250 schema:familyName Mo
    251 schema:givenName Angela
    252 rdf:type schema:Person
    253 N76f8987289c946e6864a490730d78aaf rdf:first N7cb7eb961c504b84accc3f5d9f9c4aa7
    254 rdf:rest Nddb20f5657c24580b3ee15aaf5354329
    255 N794d30a1af414e94b8850f84860804f9 rdf:first Nd78b2dec092f4c609f5593eaa88b2cf0
    256 rdf:rest Nc1f750b3d9f84ac19111137e129937c1
    257 N79f28ad8c920449fa4ec86a2c92056d5 schema:name Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA
    258 rdf:type schema:Organization
    259 N7acc07e74a0e445980b339e0946103d3 schema:name dimensions_id
    260 schema:value pub.1110955607
    261 rdf:type schema:PropertyValue
    262 N7b9617fa145b42968a23ea0af80edb38 rdf:first Na7ea84d55170465995bd5412d94e066a
    263 rdf:rest N6770f0aa70c04988aabaa269230705e7
    264 N7cb7eb961c504b84accc3f5d9f9c4aa7 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
    265 schema:familyName Bauman
    266 schema:givenName Laura
    267 rdf:type schema:Person
    268 N7f58567707934867bb76558e208f43a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    269 schema:name Anti-Inflammatory Agents, Non-Steroidal
    270 rdf:type schema:DefinedTerm
    271 N83cd7a58adbb4fcbb0e58eeb234dade1 schema:affiliation Ncbfa10894bc4420fb1d716916a1e766d
    272 schema:familyName Bonkowski
    273 schema:givenName Erin
    274 rdf:type schema:Person
    275 N83d894ea49fa4e5c8f8ff0fd5273940d schema:name Harvard—Children’s Hospital Boston, 02115, Boston, MA, USA
    276 rdf:type schema:Organization
    277 N8ae8d009f18949a38d7f76a04d9dda84 rdf:first N5b24a9d5aa124c66a2cbbce480cf0742
    278 rdf:rest Nf4044fc359c64d1bb1cfa0ae377e41b0
    279 N8b9bac521b54404ba638ee80b115a468 rdf:first Nf921147f064c45778babdfc17f9f69fd
    280 rdf:rest N794d30a1af414e94b8850f84860804f9
    281 N8d97982a6888426e88867fcad4fa89b2 schema:name Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA
    282 rdf:type schema:Organization
    283 N93e83dbc5fdb4d2fb89783b13f94006f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    284 schema:name Sequence Analysis, RNA
    285 rdf:type schema:DefinedTerm
    286 N9c0248c16efa40fb8dd94f05bcad1993 rdf:first sg:person.01205365345.37
    287 rdf:rest N8b9bac521b54404ba638ee80b115a468
    288 N9ca8015ed7ce453c8d74b93124d9196a schema:name Springer Nature - SN SciGraph project
    289 rdf:type schema:Organization
    290 N9d3c3f1e9a014f2a926347f2c3eae078 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
    291 schema:familyName Patel
    292 schema:givenName Ashish S.
    293 rdf:type schema:Person
    294 Na03344e03412443caef759b97e817bcb schema:affiliation N8d97982a6888426e88867fcad4fa89b2
    295 schema:familyName Collins
    296 schema:givenName Margaret H.
    297 rdf:type schema:Person
    298 Na03c6b62c3df41109f3c6837f06a500d schema:name Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA
    299 rdf:type schema:Organization
    300 Na1f29ae9e48e4fe1b88bdb79eb061744 rdf:first N3124dc400893403cbd7189805879b345
    301 rdf:rest Ncaf648b806a848eda2120ea5c743c4ce
    302 Na5c3bbc928214bd7969d961630b5efbe rdf:first sg:person.01113420134.40
    303 rdf:rest N0b98c71f39bb4e07aa315b559f02e2b2
    304 Na7ea84d55170465995bd5412d94e066a schema:affiliation N24728d5eef40435184192ec7129d39b5
    305 schema:familyName Mack
    306 schema:givenName David R.
    307 rdf:type schema:Person
    308 Nac9a09edffad45638acde1356b141405 schema:affiliation N407a73b1577e4cd4a6ba265e0afe0891
    309 schema:familyName Jurickova
    310 schema:givenName Ingrid
    311 rdf:type schema:Person
    312 Nad153f1ec14e49bf86a017ac78bc0c37 schema:affiliation N5b80e7feea9c4ea0b6464280ca9370a0
    313 schema:familyName Denson
    314 schema:givenName Lee A.
    315 rdf:type schema:Person
    316 Nb21ad0d9bb504bd5969076377ff69408 rdf:first N05bda25a56254753936525dc4437dd53
    317 rdf:rest N5eb8ca93ec61438c8c11e1da9edaba18
    318 Nb4a5dd1018a1471dac39872395b81132 rdf:first Nbfe13154cf524e2985a05b03348aec37
    319 rdf:rest N1c42fd5fe1004e4eb35a4780c644bd7e
    320 Nb615439c489f4182967236f4113c542d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    321 schema:name Colitis, Ulcerative
    322 rdf:type schema:DefinedTerm
    323 Nb7caed60036e4dc59d4ed59fb2d5be52 schema:affiliation N83d894ea49fa4e5c8f8ff0fd5273940d
    324 schema:familyName Rufo
    325 schema:givenName Paul A.
    326 rdf:type schema:Person
    327 Nb8211c92fc4949f7aba2b6c8018417bb rdf:first sg:person.01147172155.49
    328 rdf:rest N4372bbd7e2374764b3185a7ec6a91211
    329 Nbfe13154cf524e2985a05b03348aec37 schema:affiliation N11f18abf829549d2b211c22bef0b5058
    330 schema:familyName Rosh
    331 schema:givenName Joel R.
    332 rdf:type schema:Person
    333 Nc1f750b3d9f84ac19111137e129937c1 rdf:first Nb7caed60036e4dc59d4ed59fb2d5be52
    334 rdf:rest N255bbce274084f32b29c3a57bf461046
    335 Nc2bfb793c8494ef4a61b8795f2642d67 rdf:first sg:person.010432172377.00
    336 rdf:rest Ndec3af4830164c149ff5b8faa941b67e
    337 Nc34d931b920b427081652adf7034ebd7 rdf:first N766e06963ea34db69e9b28d13dae9619
    338 rdf:rest Nc76489916fdb41cea728a2f69128c9b2
    339 Nc430c4ac7774478a897704f4b3ebc607 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    340 schema:name Feces
    341 rdf:type schema:DefinedTerm
    342 Nc451d8cd9ae642daa31db5d02658c7a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    343 schema:name Mitochondria
    344 rdf:type schema:DefinedTerm
    345 Nc76489916fdb41cea728a2f69128c9b2 rdf:first N6c6f53e42a1449a3b8a69d5e8081204d
    346 rdf:rest N1701dd8158694fd3aa26bc89d89c7b55
    347 Nc7feeb9ee2ae4b439e72f4e14800b43b schema:name doi
    348 schema:value 10.1038/s41467-018-07841-3
    349 rdf:type schema:PropertyValue
    350 Nc93029932a4343fb84f606593c20796f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    351 schema:name Treatment Outcome
    352 rdf:type schema:DefinedTerm
    353 Ncaf648b806a848eda2120ea5c743c4ce rdf:first sg:person.013525540567.22
    354 rdf:rest Nb4a5dd1018a1471dac39872395b81132
    355 Ncbfa10894bc4420fb1d716916a1e766d schema:name Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA
    356 rdf:type schema:Organization
    357 Nd17f831140ce4704a386aba2dbc24dbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    358 schema:name Remission Induction
    359 rdf:type schema:DefinedTerm
    360 Nd43df6427c38459a94dc596d30bdf54c rdf:first sg:person.0717130066.82
    361 rdf:rest Ne4a05095d6b04cf4ba901d4f1e8953b3
    362 Nd78b2dec092f4c609f5593eaa88b2cf0 schema:affiliation N6d892db4327d4e1db6c12d2bc366790b
    363 schema:familyName Nistel
    364 schema:givenName Mason
    365 rdf:type schema:Person
    366 Ndc10ad65f54c488cb5f433a76f4d4841 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    367 schema:name Integrins
    368 rdf:type schema:DefinedTerm
    369 Ndc6bbacd3d90461eae134bdbe08a6343 rdf:first sg:person.01366660604.57
    370 rdf:rest N4bcd224b7d05495cb2ab2316f7e84ad0
    371 Nddb20f5657c24580b3ee15aaf5354329 rdf:first Na03344e03412443caef759b97e817bcb
    372 rdf:rest Nc34d931b920b427081652adf7034ebd7
    373 Ndec3af4830164c149ff5b8faa941b67e rdf:first sg:person.01355705324.35
    374 rdf:rest Ndff4f228535e4c4eab02b077f62cf193
    375 Ndf55e3949d35466699dd412456f6b7f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    376 schema:name Male
    377 rdf:type schema:DefinedTerm
    378 Ndff4f228535e4c4eab02b077f62cf193 rdf:first sg:person.0701734367.07
    379 rdf:rest Nb21ad0d9bb504bd5969076377ff69408
    380 Ne03fce5a850e4ae2a9b7034975e6352b rdf:first sg:person.01034142334.13
    381 rdf:rest N8ae8d009f18949a38d7f76a04d9dda84
    382 Ne1a9c2c03fc74a44a85d647bad6ceef8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    383 schema:name Child
    384 rdf:type schema:DefinedTerm
    385 Ne1aa2bced270468aa9b7a9b65b807c67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    386 schema:name Intestinal Mucosa
    387 rdf:type schema:DefinedTerm
    388 Ne4a05095d6b04cf4ba901d4f1e8953b3 rdf:first sg:person.01101056755.25
    389 rdf:rest N35b279ff64174c7aafeb2e0a201c4c81
    390 Ne8260d441ac24e14acd3c67f3d3fc7b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    391 schema:name Adolescent
    392 rdf:type schema:DefinedTerm
    393 Nf2b558e73fb24789bdb71013ab359f5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    394 schema:name Rectum
    395 rdf:type schema:DefinedTerm
    396 Nf4044fc359c64d1bb1cfa0ae377e41b0 rdf:first sg:person.01153762210.70
    397 rdf:rest N2fa9bfe024434a29ab87616fcdc5e695
    398 Nf5a7c9038c0a4d33a987ebf04054143d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    399 schema:name Female
    400 rdf:type schema:DefinedTerm
    401 Nf921147f064c45778babdfc17f9f69fd schema:affiliation https://www.grid.ac/institutes/grid.410711.2
    402 schema:familyName Marquis
    403 schema:givenName Alison
    404 rdf:type schema:Person
    405 Nfa2ebd053b77407582be187068461934 schema:affiliation N076b49fe49f5479c9c506b25a22b0421
    406 schema:familyName Aronow
    407 schema:givenName Bruce J.
    408 rdf:type schema:Person
    409 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    410 schema:name Biological Sciences
    411 rdf:type schema:DefinedTerm
    412 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    413 schema:name Genetics
    414 rdf:type schema:DefinedTerm
    415 sg:grant.2439002 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07841-3
    416 rdf:type schema:MonetaryGrant
    417 sg:grant.2439042 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07841-3
    418 rdf:type schema:MonetaryGrant
    419 sg:grant.2683297 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07841-3
    420 rdf:type schema:MonetaryGrant
    421 sg:grant.2690315 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07841-3
    422 rdf:type schema:MonetaryGrant
    423 sg:grant.3624030 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07841-3
    424 rdf:type schema:MonetaryGrant
    425 sg:grant.6618860 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07841-3
    426 rdf:type schema:MonetaryGrant
    427 sg:grant.7520434 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07841-3
    428 rdf:type schema:MonetaryGrant
    429 sg:grant.7552884 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07841-3
    430 rdf:type schema:MonetaryGrant
    431 sg:journal.1043282 schema:issn 2041-1723
    432 schema:name Nature Communications
    433 rdf:type schema:Periodical
    434 sg:person.01034142334.13 schema:affiliation https://www.grid.ac/institutes/grid.413795.d
    435 schema:familyName Haberman
    436 schema:givenName Yael
    437 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034142334.13
    438 rdf:type schema:Person
    439 sg:person.010432172377.00 schema:affiliation https://www.grid.ac/institutes/grid.239553.b
    440 schema:familyName Shah
    441 schema:givenName Sapana
    442 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010432172377.00
    443 rdf:type schema:Person
    444 sg:person.01101056755.25 schema:affiliation https://www.grid.ac/institutes/grid.414666.7
    445 schema:familyName Hyams
    446 schema:givenName Jeffrey S.
    447 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101056755.25
    448 rdf:type schema:Person
    449 sg:person.01113420134.40 schema:affiliation https://www.grid.ac/institutes/grid.30760.32
    450 schema:familyName Noe
    451 schema:givenName Joshua D.
    452 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113420134.40
    453 rdf:type schema:Person
    454 sg:person.01147172155.49 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
    455 schema:familyName Kugathasan
    456 schema:givenName Subra
    457 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147172155.49
    458 rdf:type schema:Person
    459 sg:person.01153762210.70 schema:affiliation Na03c6b62c3df41109f3c6837f06a500d
    460 schema:familyName Dexheimer
    461 schema:givenName Phillip J.
    462 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153762210.70
    463 rdf:type schema:Person
    464 sg:person.01205365345.37 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
    465 schema:familyName Gotman
    466 schema:givenName Nathan
    467 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205365345.37
    468 rdf:type schema:Person
    469 sg:person.01213007720.49 schema:affiliation https://www.grid.ac/institutes/grid.6451.6
    470 schema:familyName Shen-Orr
    471 schema:givenName Shai
    472 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213007720.49
    473 rdf:type schema:Person
    474 sg:person.01214462502.85 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    475 schema:familyName Huttenhower
    476 schema:givenName Curtis
    477 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214462502.85
    478 rdf:type schema:Person
    479 sg:person.01251467115.20 schema:affiliation https://www.grid.ac/institutes/grid.239553.b
    480 schema:familyName Mollen
    481 schema:givenName Kevin
    482 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251467115.20
    483 rdf:type schema:Person
    484 sg:person.01263671211.03 schema:affiliation https://www.grid.ac/institutes/grid.240344.5
    485 schema:familyName Boyle
    486 schema:givenName Brendan M.
    487 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263671211.03
    488 rdf:type schema:Person
    489 sg:person.013525540567.22 schema:affiliation https://www.grid.ac/institutes/grid.414923.9
    490 schema:familyName Pfefferkorn
    491 schema:givenName Marian D.
    492 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013525540567.22
    493 rdf:type schema:Person
    494 sg:person.01355705324.35 schema:affiliation https://www.grid.ac/institutes/grid.414169.f
    495 schema:familyName Leleiko
    496 schema:givenName Neal S.
    497 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355705324.35
    498 rdf:type schema:Person
    499 sg:person.01364523347.12 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
    500 schema:familyName Sauer
    501 schema:givenName Cary G.
    502 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364523347.12
    503 rdf:type schema:Person
    504 sg:person.01366660604.57 schema:affiliation https://www.grid.ac/institutes/grid.18098.38
    505 schema:familyName Somekh
    506 schema:givenName Judith
    507 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366660604.57
    508 rdf:type schema:Person
    509 sg:person.014027667613.58 schema:affiliation https://www.grid.ac/institutes/grid.413795.d
    510 schema:familyName Braun
    511 schema:givenName Tzipi
    512 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014027667613.58
    513 rdf:type schema:Person
    514 sg:person.016206760374.52 schema:affiliation https://www.grid.ac/institutes/grid.62562.35
    515 schema:familyName Thomas
    516 schema:givenName Sonia Davis
    517 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016206760374.52
    518 rdf:type schema:Person
    519 sg:person.0701734367.07 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
    520 schema:familyName Heyman
    521 schema:givenName Melvin B.
    522 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701734367.07
    523 rdf:type schema:Person
    524 sg:person.0717130066.82 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
    525 schema:familyName Xavier
    526 schema:givenName Ramnik J.
    527 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717130066.82
    528 rdf:type schema:Person
    529 sg:person.0772340157.54 schema:affiliation https://www.grid.ac/institutes/grid.239552.a
    530 schema:familyName Baldassano
    531 schema:givenName Robert N.
    532 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772340157.54
    533 rdf:type schema:Person
    534 sg:person.0773675772.82 schema:affiliation https://www.grid.ac/institutes/grid.413993.5
    535 schema:familyName Baker
    536 schema:givenName Susan S.
    537 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773675772.82
    538 rdf:type schema:Person
    539 sg:pub.10.1007/978-1-61779-382-0_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017755790
    540 https://doi.org/10.1007/978-1-61779-382-0_3
    541 rdf:type schema:CreativeWork
    542 sg:pub.10.1007/s11010-010-0474-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019401146
    543 https://doi.org/10.1007/s11010-010-0474-x
    544 rdf:type schema:CreativeWork
    545 sg:pub.10.1007/s40265-017-0755-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085444493
    546 https://doi.org/10.1007/s40265-017-0755-8
    547 rdf:type schema:CreativeWork
    548 sg:pub.10.1038/ajg.2008.38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003848857
    549 https://doi.org/10.1038/ajg.2008.38
    550 rdf:type schema:CreativeWork
    551 sg:pub.10.1038/ismej.2011.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051863807
    552 https://doi.org/10.1038/ismej.2011.139
    553 rdf:type schema:CreativeWork
    554 sg:pub.10.1038/nbt.3519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024493480
    555 https://doi.org/10.1038/nbt.3519
    556 rdf:type schema:CreativeWork
    557 sg:pub.10.1038/ncomms13419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017834073
    558 https://doi.org/10.1038/ncomms13419
    559 rdf:type schema:CreativeWork
    560 sg:pub.10.1038/nm.4307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084508963
    561 https://doi.org/10.1038/nm.4307
    562 rdf:type schema:CreativeWork
    563 sg:pub.10.1038/nm0617-788d schema:sameAs https://app.dimensions.ai/details/publication/pub.1085880786
    564 https://doi.org/10.1038/nm0617-788d
    565 rdf:type schema:CreativeWork
    566 sg:pub.10.1038/nmeth.2212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026331197
    567 https://doi.org/10.1038/nmeth.2212
    568 rdf:type schema:CreativeWork
    569 sg:pub.10.1038/nrgastro.2017.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083732766
    570 https://doi.org/10.1038/nrgastro.2017.1
    571 rdf:type schema:CreativeWork
    572 sg:pub.10.1186/s13059-017-1349-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092688878
    573 https://doi.org/10.1186/s13059-017-1349-1
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1002/ibd.20110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023182499
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.1002/ibd.20342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000380974
    578 rdf:type schema:CreativeWork
    579 https://doi.org/10.1002/ibd.21393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028718417
    580 rdf:type schema:CreativeWork
    581 https://doi.org/10.1002/ibd.22926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030837997
    582 rdf:type schema:CreativeWork
    583 https://doi.org/10.1016/j.bbalip.2016.07.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031221855
    584 rdf:type schema:CreativeWork
    585 https://doi.org/10.1016/j.chom.2015.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013295003
    586 rdf:type schema:CreativeWork
    587 https://doi.org/10.1016/j.chom.2018.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107491985
    588 rdf:type schema:CreativeWork
    589 https://doi.org/10.1016/j.cmet.2014.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021097318
    590 rdf:type schema:CreativeWork
    591 https://doi.org/10.1016/j.mito.2016.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030873473
    592 rdf:type schema:CreativeWork
    593 https://doi.org/10.1016/j.parint.2011.04.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013295321
    594 rdf:type schema:CreativeWork
    595 https://doi.org/10.1016/s0022-3476(96)70193-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001860348
    596 rdf:type schema:CreativeWork
    597 https://doi.org/10.1016/s0140-6736(17)30317-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084043501
    598 rdf:type schema:CreativeWork
    599 https://doi.org/10.1016/s2468-1253(17)30252-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091877791
    600 rdf:type schema:CreativeWork
    601 https://doi.org/10.1053/j.gastro.2005.12.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032910167
    602 rdf:type schema:CreativeWork
    603 https://doi.org/10.1053/j.gastro.2008.10.086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000121753
    604 rdf:type schema:CreativeWork
    605 https://doi.org/10.1053/j.gastro.2010.02.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004519190
    606 rdf:type schema:CreativeWork
    607 https://doi.org/10.1053/j.gastro.2012.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017400322
    608 rdf:type schema:CreativeWork
    609 https://doi.org/10.1053/j.gastro.2016.10.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027981992
    610 rdf:type schema:CreativeWork
    611 https://doi.org/10.1053/j.gastro.2016.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027312466
    612 rdf:type schema:CreativeWork
    613 https://doi.org/10.1053/j.gastro.2016.10.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010214766
    614 rdf:type schema:CreativeWork
    615 https://doi.org/10.1053/j.gastro.2017.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092187927
    616 rdf:type schema:CreativeWork
    617 https://doi.org/10.1056/nejm199011013231802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000157853
    618 rdf:type schema:CreativeWork
    619 https://doi.org/10.1074/jbc.m115.688812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058214058
    620 rdf:type schema:CreativeWork
    621 https://doi.org/10.1093/bioinformatics/btp101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001910376
    622 rdf:type schema:CreativeWork
    623 https://doi.org/10.1093/bioinformatics/btx754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093067522
    624 rdf:type schema:CreativeWork
    625 https://doi.org/10.1093/jnci/djt167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004244281
    626 rdf:type schema:CreativeWork
    627 https://doi.org/10.1093/nar/gkp427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027845966
    628 rdf:type schema:CreativeWork
    629 https://doi.org/10.1093/nar/gkq418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041947444
    630 rdf:type schema:CreativeWork
    631 https://doi.org/10.1096/fj.10-170027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041023319
    632 rdf:type schema:CreativeWork
    633 https://doi.org/10.1097/mib.0000000000000535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023887435
    634 rdf:type schema:CreativeWork
    635 https://doi.org/10.1097/pas.0000000000000939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091418408
    636 rdf:type schema:CreativeWork
    637 https://doi.org/10.1126/science.aal3535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085142091
    638 rdf:type schema:CreativeWork
    639 https://doi.org/10.1136/gut.48.4.526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039765228
    640 rdf:type schema:CreativeWork
    641 https://doi.org/10.1136/gutjnl-2012-303333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006858793
    642 rdf:type schema:CreativeWork
    643 https://doi.org/10.1136/gutjnl-2016-312293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062813756
    644 rdf:type schema:CreativeWork
    645 https://doi.org/10.1136/gutjnl-2017-315494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103167849
    646 rdf:type schema:CreativeWork
    647 https://doi.org/10.1152/ajpgi.00136.2017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086047756
    648 rdf:type schema:CreativeWork
    649 https://doi.org/10.1172/jci75436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033973377
    650 rdf:type schema:CreativeWork
    651 https://doi.org/10.1189/jlb.3hi0515-189r schema:sameAs https://app.dimensions.ai/details/publication/pub.1034831265
    652 rdf:type schema:CreativeWork
    653 https://doi.org/10.1242/dev.151142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091382105
    654 rdf:type schema:CreativeWork
    655 https://doi.org/10.1371/journal.pcbi.1005515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085409246
    656 rdf:type schema:CreativeWork
    657 https://doi.org/10.1371/journal.pone.0007984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037870420
    658 rdf:type schema:CreativeWork
    659 https://doi.org/10.1371/journal.pone.0071989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015576572
    660 rdf:type schema:CreativeWork
    661 https://doi.org/10.1371/journal.pone.0096153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027524338
    662 rdf:type schema:CreativeWork
    663 https://doi.org/10.2202/1544-6115.1027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069289261
    664 rdf:type schema:CreativeWork
    665 https://doi.org/10.3969/j.issn.1673-5374.2013.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078970107
    666 rdf:type schema:CreativeWork
    667 https://doi.org/10.4049/jimmunol.0903816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021530352
    668 rdf:type schema:CreativeWork
    669 https://www.grid.ac/institutes/grid.18098.38 schema:alternateName University of Haifa
    670 schema:name Department of Information Systems, University of Haifa, 3498838, Haifa, Israel
    671 Faculty of Medicine, Technion, 3109601, Haifa, Israel
    672 rdf:type schema:Organization
    673 https://www.grid.ac/institutes/grid.189967.8 schema:alternateName Emory University
    674 schema:name Emory University, 30322, Atlanta, GA, USA
    675 rdf:type schema:Organization
    676 https://www.grid.ac/institutes/grid.213917.f schema:alternateName Georgia Institute of Technology
    677 schema:name Georgia Institute of Technology, 30332, Atlanta, GA, USA
    678 rdf:type schema:Organization
    679 https://www.grid.ac/institutes/grid.239552.a schema:alternateName Children's Hospital of Philadelphia
    680 schema:name The Children’s Hospital of Philadelphia, 19104, Philadelphia, PA, USA
    681 rdf:type schema:Organization
    682 https://www.grid.ac/institutes/grid.239553.b schema:alternateName Children's Hospital of Pittsburgh
    683 schema:name Children’s Hospital of Pittsburgh of UPMC, 15224, Pittsburgh, PA, USA
    684 Children’s Hospital of Pittsburgh, 15224, Pittsburgh, PA, USA
    685 rdf:type schema:Organization
    686 https://www.grid.ac/institutes/grid.240344.5 schema:alternateName Nationwide Children's Hospital
    687 schema:name Nationwide Children’s Hospital, 43205, Columbus, OH, USA
    688 rdf:type schema:Organization
    689 https://www.grid.ac/institutes/grid.266100.3 schema:alternateName University of California, San Diego
    690 schema:name Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA
    691 Department of Pediatrics, University of California at San Diego, 92162, La Jolla, CA, USA
    692 rdf:type schema:Organization
    693 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
    694 schema:name University of California at San Francisco, 94143, San Francisco, CA, USA
    695 rdf:type schema:Organization
    696 https://www.grid.ac/institutes/grid.267313.2 schema:alternateName The University of Texas Southwestern Medical Center
    697 schema:name UT Southwestern, 75390, Dallas, TX, USA
    698 rdf:type schema:Organization
    699 https://www.grid.ac/institutes/grid.30760.32 schema:alternateName Medical College of Wisconsin
    700 schema:name Medical College of Wisconsin, 53226, Milwaukee, WI, USA
    701 rdf:type schema:Organization
    702 https://www.grid.ac/institutes/grid.32224.35 schema:alternateName Massachusetts General Hospital
    703 schema:name Broad Institute of MIT and Harvard University, 02142, Cambridge, MA, USA
    704 Massachusetts General Hospital, Harvard Medical School, 02114, Boston, MA, USA
    705 rdf:type schema:Organization
    706 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
    707 schema:name Broad Institute of MIT and Harvard University, 02142, Cambridge, MA, USA
    708 Harvard School of Public Health, 02115, Boston, MA, USA
    709 rdf:type schema:Organization
    710 https://www.grid.ac/institutes/grid.410711.2 schema:alternateName University of North Carolina System
    711 schema:name Collaborative Studies Coordinating Center, University of North Carolina, 27516, Chapel Hill, NC, USA
    712 rdf:type schema:Organization
    713 https://www.grid.ac/institutes/grid.413795.d schema:alternateName Sheba Medical Center
    714 schema:name Cincinnati Children’s Hospital Medical Center, and the University of Cincinnati College of Medicine, 45229, Cincinnati, OH, USA
    715 Sheba Medical Center, Tel Hashomer, affiliated with the Tel Aviv University, 5265601, Tel Aviv, Israel
    716 rdf:type schema:Organization
    717 https://www.grid.ac/institutes/grid.413993.5 schema:alternateName Women & Children's Hospital of Buffalo
    718 schema:name Women & Children’s Hospital of Buffalo WCHOB, 14222, Buffalo, NY, USA
    719 rdf:type schema:Organization
    720 https://www.grid.ac/institutes/grid.414169.f schema:alternateName Hasbro Children's Hospital
    721 schema:name Hasbro Children’s Hospital, 02903, Providence, RI, USA
    722 rdf:type schema:Organization
    723 https://www.grid.ac/institutes/grid.414666.7 schema:alternateName Connecticut Children's Medical Center
    724 schema:name Connecticut Children’s Medical Center, 06106, Hartford, CT, USA
    725 rdf:type schema:Organization
    726 https://www.grid.ac/institutes/grid.414923.9 schema:alternateName Riley Hospital for Children
    727 schema:name Riley Hospital for Children, 46202, Indianapolis, IN, USA
    728 rdf:type schema:Organization
    729 https://www.grid.ac/institutes/grid.415338.8 schema:alternateName Cohen Children's Medical Center
    730 schema:name Cohen Children’s Medical Center of New York, 11040, New Hyde Park, NY, USA
    731 rdf:type schema:Organization
    732 https://www.grid.ac/institutes/grid.42327.30 schema:alternateName Hospital for Sick Children
    733 schema:name Hospital for Sick Children, M5G 1X8, Toronto, Canada
    734 rdf:type schema:Organization
    735 https://www.grid.ac/institutes/grid.62562.35 schema:alternateName RTI International
    736 schema:name Collaborative Studies Coordinating Center, University of North Carolina, 27516, Chapel Hill, NC, USA
    737 RTI International, 27709, Research Triangle Park, NC, USA
    738 rdf:type schema:Organization
    739 https://www.grid.ac/institutes/grid.6451.6 schema:alternateName Technion – Israel Institute of Technology
    740 schema:name Faculty of Medicine, Technion, 3109601, Haifa, Israel
    741 rdf:type schema:Organization
    742 https://www.grid.ac/institutes/grid.66859.34 schema:alternateName Broad Institute
    743 schema:name Broad Institute of MIT and Harvard University, 02142, Cambridge, MA, USA
    744 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...