Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12-21

AUTHORS

Hong-Yeoul Ryu, Francesc López-Giráldez, James Knight, Soo Seok Hwang, Christina Renner, Stefan G. Kreft, Mark Hochstrasser

ABSTRACT

In response to acute loss of the Ulp2 SUMO-specific protease, yeast become disomic for chromosome I (ChrI) and ChrXII. Here we report that ChrI disomy, which creates an adaptive advantage in part by increasing the dosage of the Ccr4 deadenylase, was eliminated by extended passaging. Loss of aneuploidy is often accompanied by mutations in essential SUMO-ligating enzymes, which reduced polySUMO-conjugate accumulation. The mRNA levels for almost all ribosomal proteins increase transiently upon initial loss of Ulp2, but elevated Ccr4 levels limit excess ribosome formation. Notably, extended passaging leads to increased levels of many small nucleolar RNAs (snoRNAs) involved in ribosome biogenesis, and higher dosage of three linked ChrXII snoRNA genes suppressed ChrXII disomy in ulp2Δ cells. Our data reveal that aneuploidy allows rapid adaptation to Ulp2 loss, but long-term adaptation restores euploidy. Cellular evolution restores homeostasis through countervailing mutations in SUMO-modification pathways and regulatory shifts in ribosome biogenesis. More... »

PAGES

5417

References to SciGraph publications

  • 2012-01-24. Causes and consequences of aneuploidy in cancer in NATURE REVIEWS GENETICS
  • 2009-11-15. An auxin-based degron system for the rapid depletion of proteins in nonplant cells in NATURE METHODS
  • 2016-04-05. Regulated cell death and adaptive stress responses in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2011-02-14. The genetic interaction network of CCW12, a Saccharomyces cerevisiae gene required for cell wall integrity during budding and formation of mating projections in BMC GENOMICS
  • 2000-06. SUMO conjugation and deconjugation in MOLECULAR GENETICS AND GENOMICS
  • 2012-01-19. Are snoRNAs and snoRNA host genes new players in cancer? in NATURE REVIEWS CANCER
  • 2017-07-17. Evolutionary biology through the lens of budding yeast comparative genomics in NATURE REVIEWS GENETICS
  • 2001-07. Evolving responsively: adaptive mutation in NATURE REVIEWS GENETICS
  • 2014-09-24. Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic ribosomal DNA condensation in BMC BIOLOGY
  • 2013-07-01. Adaptive laboratory evolution – principles and applications for biotechnology in MICROBIAL CELL FACTORIES
  • 1999-03-18. A new protease required for cell-cycle progression in yeast in NATURE
  • 2010-10-20. Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast in NATURE
  • 2008-02-03. A systematic library for comprehensive overexpression screens in Saccharomyces cerevisiae in NATURE METHODS
  • 2008-06-05. Analyzing real-time PCR data by the comparative CT method in NATURE PROTOCOLS
  • 2010-05-02. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation in NATURE BIOTECHNOLOGY
  • 2012-11-23. Function and regulation of SUMO proteases in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2015-07-23. Short- and long-term effects of chromosome mis-segregation and aneuploidy in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-07836-0

    DOI

    http://dx.doi.org/10.1038/s41467-018-07836-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110718621

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30575729


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adaptation, Biological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aneuploidy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endopeptidases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Point Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Small Nucleolar", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ribosomal Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Saccharomyces cerevisiae", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Saccharomyces cerevisiae Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Small Ubiquitin-Related Modifier Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ubiquitin-Conjugating Enzymes", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biophysics & Biochemistry, Yale University, 06520, New Haven, CT, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Department of Molecular Biophysics & Biochemistry, Yale University, 06520, New Haven, CT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ryu", 
            "givenName": "Hong-Yeoul", 
            "id": "sg:person.0645610415.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645610415.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Yale Center for Genome Analysis, Yale University, 06520, New Haven, CT, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Yale Center for Genome Analysis, Yale University, 06520, New Haven, CT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "L\u00f3pez-Gir\u00e1ldez", 
            "givenName": "Francesc", 
            "id": "sg:person.0640367377.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640367377.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Yale Center for Genome Analysis, Yale University, 06520, New Haven, CT, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Yale Center for Genome Analysis, Yale University, 06520, New Haven, CT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Knight", 
            "givenName": "James", 
            "id": "sg:person.011001355253.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011001355253.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Immunobiology, Yale University, 06520, New Haven, CT, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Department of Immunobiology, Yale University, 06520, New Haven, CT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hwang", 
            "givenName": "Soo Seok", 
            "id": "sg:person.0763506102.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763506102.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biology, Molecular Microbiology, University of Konstanz, Universitaetsstrasse 10, 78457, Konstanz, Germany", 
              "id": "http://www.grid.ac/institutes/grid.9811.1", 
              "name": [
                "Department of Biology, Molecular Microbiology, University of Konstanz, Universitaetsstrasse 10, 78457, Konstanz, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Renner", 
            "givenName": "Christina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biology, Molecular Microbiology, University of Konstanz, Universitaetsstrasse 10, 78457, Konstanz, Germany", 
              "id": "http://www.grid.ac/institutes/grid.9811.1", 
              "name": [
                "Department of Biology, Molecular Microbiology, University of Konstanz, Universitaetsstrasse 10, 78457, Konstanz, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kreft", 
            "givenName": "Stefan G.", 
            "id": "sg:person.0730671135.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730671135.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biophysics & Biochemistry, Yale University, 06520, New Haven, CT, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Department of Molecular Biophysics & Biochemistry, Yale University, 06520, New Haven, CT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hochstrasser", 
            "givenName": "Mark", 
            "id": "sg:person.01143566242.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143566242.49"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nbt.1621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031035095", 
              "https://doi.org/10.1038/nbt.1621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2859-12-64", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014684190", 
              "https://doi.org/10.1186/1475-2859-12-64"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3478", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038519524", 
              "https://doi.org/10.1038/nrm3478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004380000254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050428758", 
              "https://doi.org/10.1007/s004380000254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35080556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002349427", 
              "https://doi.org/10.1038/35080556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036025299", 
              "https://doi.org/10.1038/nature09529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/18457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005715451", 
              "https://doi.org/10.1038/18457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2008.73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005355981", 
              "https://doi.org/10.1038/nprot.2008.73"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038812086", 
              "https://doi.org/10.1038/nmeth.1401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024273311", 
              "https://doi.org/10.1038/nmeth.1181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg.2017.49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090738950", 
              "https://doi.org/10.1038/nrg.2017.49"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-12-107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024365079", 
              "https://doi.org/10.1186/1471-2164-12-107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm4025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003767537", 
              "https://doi.org/10.1038/nrm4025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023417946", 
              "https://doi.org/10.1038/nrg3123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-016-2209-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000176078", 
              "https://doi.org/10.1007/s00018-016-2209-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12915-014-0075-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051112058", 
              "https://doi.org/10.1186/s12915-014-0075-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051234090", 
              "https://doi.org/10.1038/nrc3195"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12-21", 
        "datePublishedReg": "2018-12-21", 
        "description": "In response to acute loss of the Ulp2 SUMO-specific protease, yeast become disomic for chromosome I (ChrI) and ChrXII. Here we report that ChrI disomy, which creates an adaptive advantage in part by increasing the dosage of the Ccr4 deadenylase, was eliminated by extended passaging. Loss of aneuploidy is often accompanied by mutations in essential SUMO-ligating enzymes, which reduced polySUMO-conjugate accumulation. The mRNA levels for almost all ribosomal proteins increase transiently upon initial loss of Ulp2, but elevated Ccr4 levels limit excess ribosome formation. Notably, extended passaging leads to increased levels of many small nucleolar RNAs (snoRNAs) involved in ribosome biogenesis, and higher dosage of three linked ChrXII snoRNA genes suppressed ChrXII disomy in ulp2\u0394 cells. Our data reveal that aneuploidy allows rapid adaptation to Ulp2 loss, but long-term adaptation restores euploidy. Cellular evolution restores homeostasis through countervailing mutations in SUMO-modification pathways and regulatory shifts in ribosome biogenesis.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41467-018-07836-0", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.4177401", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2514890", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "keywords": [
          "ribosome biogenesis", 
          "SUMO modification pathway", 
          "Ulp2 SUMO protease", 
          "small nucleolar RNAs", 
          "SUMO-specific proteases", 
          "snoRNA genes", 
          "CCR4 deadenylase", 
          "distinct adaptive mechanisms", 
          "ribosomal proteins", 
          "chromosome I", 
          "cellular evolution", 
          "nucleolar RNAs", 
          "ribosome formation", 
          "SUMO protease", 
          "adaptive advantage", 
          "extended passaging", 
          "rapid adaptation", 
          "long-term adaptation", 
          "biogenesis", 
          "adaptive mechanisms", 
          "mutations", 
          "protease", 
          "aneuploidy", 
          "disomy", 
          "regulatory shift", 
          "Ulp2", 
          "deadenylase", 
          "yeast", 
          "genes", 
          "adaptation", 
          "RNA", 
          "protein", 
          "enzyme", 
          "mRNA", 
          "pathway", 
          "passaging", 
          "acute loss", 
          "cells", 
          "accumulation", 
          "loss", 
          "evolution", 
          "initial loss", 
          "mechanism", 
          "levels", 
          "response", 
          "formation", 
          "shift", 
          "part", 
          "lead", 
          "high dosage", 
          "data", 
          "dosage", 
          "recovery", 
          "advantages"
        ], 
        "name": "Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease", 
        "pagination": "5417", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1110718621"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-018-07836-0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30575729"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-018-07836-0", 
          "https://app.dimensions.ai/details/publication/pub.1110718621"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:37", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_770.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41467-018-07836-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07836-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07836-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07836-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07836-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    274 TRIPLES      21 PREDICATES      106 URIs      81 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-018-07836-0 schema:about N3ab3dbc8f65a4ca6a3fd09a9ddf72913
    2 N433ffb0cf4bb40e7850fde7cedb6743f
    3 N48d7a830966b46c094f64a04b1ef07af
    4 N75c902d505614988b52495dec452c303
    5 N839c0bcf21a54ff58f8ca199d1ade5b8
    6 N86446317a6584a5f9bfc02ab0804caef
    7 N9d27cc6dff9e40788b1189f754caf08e
    8 Ncbcbf9f1c12348849834f9de4b286c80
    9 Ne2f45454514e4294829637d16039dfb2
    10 Nf5dcb16fe9da4cc5b5f7ace42bf0532b
    11 anzsrc-for:06
    12 anzsrc-for:0601
    13 schema:author Na9a99e5c29de4768b2c0d54991b49db2
    14 schema:citation sg:pub.10.1007/s00018-016-2209-y
    15 sg:pub.10.1007/s004380000254
    16 sg:pub.10.1038/18457
    17 sg:pub.10.1038/35080556
    18 sg:pub.10.1038/nature09529
    19 sg:pub.10.1038/nbt.1621
    20 sg:pub.10.1038/nmeth.1181
    21 sg:pub.10.1038/nmeth.1401
    22 sg:pub.10.1038/nprot.2008.73
    23 sg:pub.10.1038/nrc3195
    24 sg:pub.10.1038/nrg.2017.49
    25 sg:pub.10.1038/nrg3123
    26 sg:pub.10.1038/nrm3478
    27 sg:pub.10.1038/nrm4025
    28 sg:pub.10.1186/1471-2164-12-107
    29 sg:pub.10.1186/1475-2859-12-64
    30 sg:pub.10.1186/s12915-014-0075-3
    31 schema:datePublished 2018-12-21
    32 schema:datePublishedReg 2018-12-21
    33 schema:description In response to acute loss of the Ulp2 SUMO-specific protease, yeast become disomic for chromosome I (ChrI) and ChrXII. Here we report that ChrI disomy, which creates an adaptive advantage in part by increasing the dosage of the Ccr4 deadenylase, was eliminated by extended passaging. Loss of aneuploidy is often accompanied by mutations in essential SUMO-ligating enzymes, which reduced polySUMO-conjugate accumulation. The mRNA levels for almost all ribosomal proteins increase transiently upon initial loss of Ulp2, but elevated Ccr4 levels limit excess ribosome formation. Notably, extended passaging leads to increased levels of many small nucleolar RNAs (snoRNAs) involved in ribosome biogenesis, and higher dosage of three linked ChrXII snoRNA genes suppressed ChrXII disomy in ulp2Δ cells. Our data reveal that aneuploidy allows rapid adaptation to Ulp2 loss, but long-term adaptation restores euploidy. Cellular evolution restores homeostasis through countervailing mutations in SUMO-modification pathways and regulatory shifts in ribosome biogenesis.
    34 schema:genre article
    35 schema:isAccessibleForFree true
    36 schema:isPartOf N5769801f4fe34692bdb5a8aa62e922a9
    37 N89c247956f7143b68ab11885bd266787
    38 sg:journal.1043282
    39 schema:keywords CCR4 deadenylase
    40 RNA
    41 SUMO modification pathway
    42 SUMO protease
    43 SUMO-specific proteases
    44 Ulp2
    45 Ulp2 SUMO protease
    46 accumulation
    47 acute loss
    48 adaptation
    49 adaptive advantage
    50 adaptive mechanisms
    51 advantages
    52 aneuploidy
    53 biogenesis
    54 cells
    55 cellular evolution
    56 chromosome I
    57 data
    58 deadenylase
    59 disomy
    60 distinct adaptive mechanisms
    61 dosage
    62 enzyme
    63 evolution
    64 extended passaging
    65 formation
    66 genes
    67 high dosage
    68 initial loss
    69 lead
    70 levels
    71 long-term adaptation
    72 loss
    73 mRNA
    74 mechanism
    75 mutations
    76 nucleolar RNAs
    77 part
    78 passaging
    79 pathway
    80 protease
    81 protein
    82 rapid adaptation
    83 recovery
    84 regulatory shift
    85 response
    86 ribosomal proteins
    87 ribosome biogenesis
    88 ribosome formation
    89 shift
    90 small nucleolar RNAs
    91 snoRNA genes
    92 yeast
    93 schema:name Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease
    94 schema:pagination 5417
    95 schema:productId N40fc1003aa5540cb992d3367189cc792
    96 N593ba5fb2f904207bcb4b619636c1871
    97 N844c87efea164c9b97744f6578cbd49f
    98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110718621
    99 https://doi.org/10.1038/s41467-018-07836-0
    100 schema:sdDatePublished 2022-12-01T06:37
    101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    102 schema:sdPublisher N428211fcfd5d4a0487b949edfeba1d56
    103 schema:url https://doi.org/10.1038/s41467-018-07836-0
    104 sgo:license sg:explorer/license/
    105 sgo:sdDataset articles
    106 rdf:type schema:ScholarlyArticle
    107 N082ed1a382cb44958851a46fc0fd7e2e schema:affiliation grid-institutes:grid.9811.1
    108 schema:familyName Renner
    109 schema:givenName Christina
    110 rdf:type schema:Person
    111 N1f37977f14094d95b634ae957099b5d2 rdf:first sg:person.0730671135.08
    112 rdf:rest Nb91e30a6e39c450da845b2f2b9274609
    113 N3ab3dbc8f65a4ca6a3fd09a9ddf72913 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Small Ubiquitin-Related Modifier Proteins
    115 rdf:type schema:DefinedTerm
    116 N40fc1003aa5540cb992d3367189cc792 schema:name pubmed_id
    117 schema:value 30575729
    118 rdf:type schema:PropertyValue
    119 N428211fcfd5d4a0487b949edfeba1d56 schema:name Springer Nature - SN SciGraph project
    120 rdf:type schema:Organization
    121 N433ffb0cf4bb40e7850fde7cedb6743f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Point Mutation
    123 rdf:type schema:DefinedTerm
    124 N48d7a830966b46c094f64a04b1ef07af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name RNA, Small Nucleolar
    126 rdf:type schema:DefinedTerm
    127 N533858aff22040b9b5c5607200d6d628 rdf:first N082ed1a382cb44958851a46fc0fd7e2e
    128 rdf:rest N1f37977f14094d95b634ae957099b5d2
    129 N5769801f4fe34692bdb5a8aa62e922a9 schema:issueNumber 1
    130 rdf:type schema:PublicationIssue
    131 N593ba5fb2f904207bcb4b619636c1871 schema:name dimensions_id
    132 schema:value pub.1110718621
    133 rdf:type schema:PropertyValue
    134 N75c902d505614988b52495dec452c303 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Aneuploidy
    136 rdf:type schema:DefinedTerm
    137 N781312d8da0443249a4590dccf70d072 rdf:first sg:person.011001355253.42
    138 rdf:rest Nd80d8ee7873543c69c62990f34975ab9
    139 N839c0bcf21a54ff58f8ca199d1ade5b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Endopeptidases
    141 rdf:type schema:DefinedTerm
    142 N844c87efea164c9b97744f6578cbd49f schema:name doi
    143 schema:value 10.1038/s41467-018-07836-0
    144 rdf:type schema:PropertyValue
    145 N86446317a6584a5f9bfc02ab0804caef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Ubiquitin-Conjugating Enzymes
    147 rdf:type schema:DefinedTerm
    148 N89c247956f7143b68ab11885bd266787 schema:volumeNumber 9
    149 rdf:type schema:PublicationVolume
    150 N8db5e1268428492d84577e5910f667f6 rdf:first sg:person.0640367377.05
    151 rdf:rest N781312d8da0443249a4590dccf70d072
    152 N9d27cc6dff9e40788b1189f754caf08e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Saccharomyces cerevisiae
    154 rdf:type schema:DefinedTerm
    155 Na9a99e5c29de4768b2c0d54991b49db2 rdf:first sg:person.0645610415.05
    156 rdf:rest N8db5e1268428492d84577e5910f667f6
    157 Nb91e30a6e39c450da845b2f2b9274609 rdf:first sg:person.01143566242.49
    158 rdf:rest rdf:nil
    159 Ncbcbf9f1c12348849834f9de4b286c80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Saccharomyces cerevisiae Proteins
    161 rdf:type schema:DefinedTerm
    162 Nd80d8ee7873543c69c62990f34975ab9 rdf:first sg:person.0763506102.38
    163 rdf:rest N533858aff22040b9b5c5607200d6d628
    164 Ne2f45454514e4294829637d16039dfb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Ribosomal Proteins
    166 rdf:type schema:DefinedTerm
    167 Nf5dcb16fe9da4cc5b5f7ace42bf0532b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Adaptation, Biological
    169 rdf:type schema:DefinedTerm
    170 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    171 schema:name Biological Sciences
    172 rdf:type schema:DefinedTerm
    173 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    174 schema:name Biochemistry and Cell Biology
    175 rdf:type schema:DefinedTerm
    176 sg:grant.2514890 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07836-0
    177 rdf:type schema:MonetaryGrant
    178 sg:grant.4177401 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07836-0
    179 rdf:type schema:MonetaryGrant
    180 sg:journal.1043282 schema:issn 2041-1723
    181 schema:name Nature Communications
    182 schema:publisher Springer Nature
    183 rdf:type schema:Periodical
    184 sg:person.011001355253.42 schema:affiliation grid-institutes:grid.47100.32
    185 schema:familyName Knight
    186 schema:givenName James
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011001355253.42
    188 rdf:type schema:Person
    189 sg:person.01143566242.49 schema:affiliation grid-institutes:grid.47100.32
    190 schema:familyName Hochstrasser
    191 schema:givenName Mark
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143566242.49
    193 rdf:type schema:Person
    194 sg:person.0640367377.05 schema:affiliation grid-institutes:grid.47100.32
    195 schema:familyName López-Giráldez
    196 schema:givenName Francesc
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640367377.05
    198 rdf:type schema:Person
    199 sg:person.0645610415.05 schema:affiliation grid-institutes:grid.47100.32
    200 schema:familyName Ryu
    201 schema:givenName Hong-Yeoul
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645610415.05
    203 rdf:type schema:Person
    204 sg:person.0730671135.08 schema:affiliation grid-institutes:grid.9811.1
    205 schema:familyName Kreft
    206 schema:givenName Stefan G.
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730671135.08
    208 rdf:type schema:Person
    209 sg:person.0763506102.38 schema:affiliation grid-institutes:grid.47100.32
    210 schema:familyName Hwang
    211 schema:givenName Soo Seok
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763506102.38
    213 rdf:type schema:Person
    214 sg:pub.10.1007/s00018-016-2209-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1000176078
    215 https://doi.org/10.1007/s00018-016-2209-y
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1007/s004380000254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050428758
    218 https://doi.org/10.1007/s004380000254
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/18457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005715451
    221 https://doi.org/10.1038/18457
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/35080556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002349427
    224 https://doi.org/10.1038/35080556
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/nature09529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036025299
    227 https://doi.org/10.1038/nature09529
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/nbt.1621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031035095
    230 https://doi.org/10.1038/nbt.1621
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/nmeth.1181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024273311
    233 https://doi.org/10.1038/nmeth.1181
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/nmeth.1401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038812086
    236 https://doi.org/10.1038/nmeth.1401
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/nprot.2008.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005355981
    239 https://doi.org/10.1038/nprot.2008.73
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/nrc3195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051234090
    242 https://doi.org/10.1038/nrc3195
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/nrg.2017.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090738950
    245 https://doi.org/10.1038/nrg.2017.49
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/nrg3123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023417946
    248 https://doi.org/10.1038/nrg3123
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/nrm3478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038519524
    251 https://doi.org/10.1038/nrm3478
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/nrm4025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003767537
    254 https://doi.org/10.1038/nrm4025
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1186/1471-2164-12-107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024365079
    257 https://doi.org/10.1186/1471-2164-12-107
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1186/1475-2859-12-64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014684190
    260 https://doi.org/10.1186/1475-2859-12-64
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1186/s12915-014-0075-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051112058
    263 https://doi.org/10.1186/s12915-014-0075-3
    264 rdf:type schema:CreativeWork
    265 grid-institutes:grid.47100.32 schema:alternateName Department of Immunobiology, Yale University, 06520, New Haven, CT, USA
    266 Department of Molecular Biophysics & Biochemistry, Yale University, 06520, New Haven, CT, USA
    267 Yale Center for Genome Analysis, Yale University, 06520, New Haven, CT, USA
    268 schema:name Department of Immunobiology, Yale University, 06520, New Haven, CT, USA
    269 Department of Molecular Biophysics & Biochemistry, Yale University, 06520, New Haven, CT, USA
    270 Yale Center for Genome Analysis, Yale University, 06520, New Haven, CT, USA
    271 rdf:type schema:Organization
    272 grid-institutes:grid.9811.1 schema:alternateName Department of Biology, Molecular Microbiology, University of Konstanz, Universitaetsstrasse 10, 78457, Konstanz, Germany
    273 schema:name Department of Biology, Molecular Microbiology, University of Konstanz, Universitaetsstrasse 10, 78457, Konstanz, Germany
    274 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...