Genome-wide association meta-analysis yields 20 loci associated with gallstone disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Egil Ferkingstad, Asmundur Oddsson, Solveig Gretarsdottir, Stefania Benonisdottir, Gudmar Thorleifsson, Aimee M. Deaton, Stefan Jonsson, Olafur A. Stefansson, Gudmundur L. Norddahl, Florian Zink, Gudny A. Arnadottir, Bjarni Gunnarsson, Gisli H. Halldorsson, Anna Helgadottir, Brynjar O. Jensson, Ragnar P. Kristjansson, Gardar Sveinbjornsson, David A. Sverrisson, Gisli Masson, Isleifur Olafsson, Gudmundur I. Eyjolfsson, Olof Sigurdardottir, Hilma Holm, Ingileif Jonsdottir, Sigurdur Olafsson, Thora Steingrimsdottir, Thorunn Rafnar, Einar S. Bjornsson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Patrick Sulem, Kari Stefansson

ABSTRACT

Gallstones are responsible for one of the most common diseases in the Western world and are commonly treated with cholecystectomy. We perform a meta-analysis of two genome-wide association studies of gallstone disease in Iceland and the UK, totaling 27,174 cases and 736,838 controls, uncovering 21 novel gallstone-associated variants at 20 loci. Two distinct low frequency missense variants in SLC10A2, encoding the apical sodium-dependent bile acid transporter (ASBT), associate with an increased risk of gallstone disease (Pro290Ser: OR = 1.36 [1.25-1.49], P = 2.1 × 10-12, MAF = 1%; Val98Ile: OR = 1.15 [1.10-1.20], P = 1.8 × 10-10, MAF = 4%). We demonstrate that lower bile acid transport by ASBT is accompanied by greater risk of gallstone disease and highlight the role of the intestinal compartment of the enterohepatic circulation of bile acids in gallstone disease susceptibility. Additionally, two low frequency missense variants in SERPINA1 and HNF4A and 17 common variants represent novel associations with gallstone disease. More... »

PAGES

5101

References to SciGraph publications

  • 2015-05. Large-scale whole-genome sequencing of the Icelandic population in NATURE GENETICS
  • 2011-12. Effects of SLC10A2 variant rs9514089 on gallstone risk and serum cholesterol levels- meta-analysis of three independent cohorts in BMC MEDICAL GENETICS
  • 2003-04. T130I mutation in HNF-4α gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects in DIABETOLOGIA
  • 2015-03-25. Sequence variants from whole genome sequencing a large group of Icelanders in SCIENTIFIC DATA
  • 2017-12. Comparison of DNA quantification methodology used in the DNA extraction protocol for the UK Biobank cohort in BMC GENOMICS
  • 2018-06. A novel variant associated with HDL-C levels by modifying DAGLB expression levels: An annotation-based genome-wide association study in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2006-03. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 2006-11. Identification of a hormonal basis for gallbladder filling in NATURE MEDICINE
  • 2018-12. Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study in NATURE COMMUNICATIONS
  • 2016-03. Weighting sequence variants based on their annotation increases power of whole-genome association studies in NATURE GENETICS
  • 2013-11. Discovery and refinement of loci associated with lipid levels in NATURE GENETICS
  • 2014-11. The contribution of genetic variants to disease depends on the ruler in NATURE REVIEWS GENETICS
  • 2008-10. Common variants of FUT2 are associated with plasma vitamin B12 levels in NATURE GENETICS
  • 2007-08. A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease in NATURE GENETICS
  • 2001-04. Hepatocyte nuclear factor-1α is an essential regulator of bile acid and plasma cholesterol metabolism in NATURE GENETICS
  • 2017-12. Exome-wide association study of plasma lipids in >300,000 individuals in NATURE GENETICS
  • 2018-10. The UK Biobank resource with deep phenotyping and genomic data in NATURE
  • 2016-01. Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array in EUROPEAN JOURNAL OF HUMAN GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-07460-y

    DOI

    http://dx.doi.org/10.1038/s41467-018-07460-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110204810

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30504769


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferkingstad", 
            "givenName": "Egil", 
            "id": "sg:person.01302730542.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302730542.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oddsson", 
            "givenName": "Asmundur", 
            "id": "sg:person.0610550316.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610550316.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gretarsdottir", 
            "givenName": "Solveig", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Benonisdottir", 
            "givenName": "Stefania", 
            "id": "sg:person.0620625167.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620625167.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thorleifsson", 
            "givenName": "Gudmar", 
            "id": "sg:person.01247426430.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247426430.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deaton", 
            "givenName": "Aimee M.", 
            "id": "sg:person.01366537405.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366537405.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jonsson", 
            "givenName": "Stefan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stefansson", 
            "givenName": "Olafur A.", 
            "id": "sg:person.01346127620.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346127620.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Norddahl", 
            "givenName": "Gudmundur L.", 
            "id": "sg:person.0771421022.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771421022.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zink", 
            "givenName": "Florian", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arnadottir", 
            "givenName": "Gudny A.", 
            "id": "sg:person.0777325667.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777325667.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gunnarsson", 
            "givenName": "Bjarni", 
            "id": "sg:person.011574450425.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011574450425.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Halldorsson", 
            "givenName": "Gisli H.", 
            "id": "sg:person.01334675114.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334675114.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Helgadottir", 
            "givenName": "Anna", 
            "id": "sg:person.01242432070.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242432070.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jensson", 
            "givenName": "Brynjar O.", 
            "id": "sg:person.01045441067.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045441067.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kristjansson", 
            "givenName": "Ragnar P.", 
            "id": "sg:person.01340370167.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340370167.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sveinbjornsson", 
            "givenName": "Gardar", 
            "id": "sg:person.0700374216.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700374216.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sverrisson", 
            "givenName": "David A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Masson", 
            "givenName": "Gisli", 
            "id": "sg:person.013573442774.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013573442774.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University Hospital of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.410540.4", 
              "name": [
                "Department of Clinical Biochemistry, Landsp\u00edtali University Hospital, 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Olafsson", 
            "givenName": "Isleifur", 
            "id": "sg:person.01352712313.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352712313.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Laboratory in Mj\u00f3dd (RAM), 109, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eyjolfsson", 
            "givenName": "Gudmundur I.", 
            "id": "sg:person.01170350513.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170350513.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Akureyri Hospital", 
              "id": "https://www.grid.ac/institutes/grid.440311.3", 
              "name": [
                "Department of Clinical Biochemistry, Akureyri Hospital, 600, Akureyri, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sigurdardottir", 
            "givenName": "Olof", 
            "id": "sg:person.016621360067.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016621360067.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Holm", 
            "givenName": "Hilma", 
            "id": "sg:person.01225441541.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225441541.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University Hospital of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.410540.4", 
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland", 
                "Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland", 
                "Department of Immunology, Landspitali University Hospital, 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jonsdottir", 
            "givenName": "Ingileif", 
            "id": "sg:person.01220643160.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220643160.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University Hospital of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.410540.4", 
              "name": [
                "Department of Internal Medicine, Landspitali University Hospital, 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Olafsson", 
            "givenName": "Sigurdur", 
            "id": "sg:person.01263601536.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263601536.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University Hospital of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.410540.4", 
              "name": [
                "Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland", 
                "Department of Obstetrics and Gynecology, Landspitali University Hospital, 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Steingrimsdottir", 
            "givenName": "Thora", 
            "id": "sg:person.0724231652.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724231652.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rafnar", 
            "givenName": "Thorunn", 
            "id": "sg:person.0651363747.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651363747.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University Hospital of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.410540.4", 
              "name": [
                "Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland", 
                "Department of Internal Medicine, Landspitali University Hospital, 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bjornsson", 
            "givenName": "Einar S.", 
            "id": "sg:person.01342765226.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342765226.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.14013.37", 
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland", 
                "Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thorsteinsdottir", 
            "givenName": "Unnur", 
            "id": "sg:person.01277776417.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277776417.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.14013.37", 
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland", 
                "School of Engineering and Natural Sciences, University of Iceland, 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gudbjartsson", 
            "givenName": "Daniel F.", 
            "id": "sg:person.0637651205.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637651205.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sulem", 
            "givenName": "Patrick", 
            "id": "sg:person.0773127601.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773127601.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.14013.37", 
              "name": [
                "CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland", 
                "Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stefansson", 
            "givenName": "Kari", 
            "id": "sg:person.0723426172.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723426172.10"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/86871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000259771", 
              "https://doi.org/10.1038/86871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/86871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000259771", 
              "https://doi.org/10.1038/86871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(06)69044-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000408558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jhep.2012.08.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001967705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/molbev/msp108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002242347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/molbev/msp108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002242347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005206876", 
              "https://doi.org/10.1038/nrg3786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1194/jlr.r900012-jlr200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005775402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2004.08.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007030006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/joim.12082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007773470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hq1201.100262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007833669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/meg.0b013e3283477cc9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008537693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/meg.0b013e3283477cc9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008537693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2016.04.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008633442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/joim.12239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009001224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpendo.00323.2011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010602649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01894-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014215382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.10-0746", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014324314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0007321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014480759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.270.45.27228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015537399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/00365520903296669", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017819119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.201108-1428ci", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019082112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.79.24.15351-15355.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019542733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000000925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019811959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000000925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019811959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020692466", 
              "https://doi.org/10.1038/ng.3247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coph.2010.08.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023537539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.26009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025292549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sdata.2015.11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026621968", 
              "https://doi.org/10.1038/sdata.2015.11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.2004.022541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027032066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.2004.022541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027032066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkp427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027845966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkp427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027845966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.20654", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028099054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0002-9343(83)90615-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031572795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2797", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031899225", 
              "https://doi.org/10.1038/ng.2797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2015.63", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032851902", 
              "https://doi.org/10.1038/ejhg.2015.63"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.1001779", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033632930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/00365590903151479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033735209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci119355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035827653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00210-006-0043-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035843485", 
              "https://doi.org/10.1007/s00210-006-0043-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00210-006-0043-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035843485", 
              "https://doi.org/10.1007/s00210-006-0043-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/glycob/cwi089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039681339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s2213-2600(15)00283-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040230125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/jhep.2001.24373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040843077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-5793(93)80199-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040867474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-003-1067-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040876036", 
              "https://doi.org/10.1007/s00125-003-1067-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-003-1067-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040876036", 
              "https://doi.org/10.1007/s00125-003-1067-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2350-12-149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041152662", 
              "https://doi.org/10.1186/1471-2350-12-149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci105794", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042580315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwp411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042920391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwp411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042920391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3507", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043168111", 
              "https://doi.org/10.1038/ng.3507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-016-3391-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043593875", 
              "https://doi.org/10.1186/s12864-016-3391-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-016-3391-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043593875", 
              "https://doi.org/10.1186/s12864-016-3391-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1746.2011.06805.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044904067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046301553", 
              "https://doi.org/10.1038/nm1501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046301553", 
              "https://doi.org/10.1038/nm1501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047719697", 
              "https://doi.org/10.1038/ng.210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0016-5085(94)90712-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049339404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2796.2007.01783.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049998206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bpg.2006.05.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051503380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng2101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052131615", 
              "https://doi.org/10.1038/ng2101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000431071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053289325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1003530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053489788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2004-2159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064288156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2741/a699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070917482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v21.i24.7436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071372659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074834161", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074874180", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/22.4.719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075910802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078316026", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079450293", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddx062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083931991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092440097", 
              "https://doi.org/10.1038/ng.3977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092440097", 
              "https://doi.org/10.1038/ng.3977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.117.312086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099613660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.117.312086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099613660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/eurheartj/ehy068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100679758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41431-018-0108-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101190281", 
              "https://doi.org/10.1038/s41431-018-0108-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41431-018-0108-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101190281", 
              "https://doi.org/10.1038/s41431-018-0108-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41431-018-0108-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101190281", 
              "https://doi.org/10.1038/s41431-018-0108-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-03910-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103541272", 
              "https://doi.org/10.1038/s41467-018-03910-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-03910-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103541272", 
              "https://doi.org/10.1038/s41467-018-03910-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2018.04.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104040437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2018.04.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104040437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2018.04.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104040437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0579-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107363293", 
              "https://doi.org/10.1038/s41586-018-0579-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0579-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107363293", 
              "https://doi.org/10.1038/s41586-018-0579-z"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "Gallstones are responsible for one of the most common diseases in the Western world and are commonly treated with cholecystectomy. We perform a meta-analysis of two genome-wide association studies of gallstone disease in Iceland and the UK, totaling 27,174 cases and 736,838 controls, uncovering 21 novel gallstone-associated variants\u00a0at 20 loci. Two distinct low frequency missense variants in SLC10A2, encoding the apical sodium-dependent bile acid transporter (ASBT), associate with an increased risk of gallstone disease (Pro290Ser: OR\u2009=\u20091.36 [1.25-1.49], P\u2009=\u20092.1\u2009\u00d7\u200910-12, MAF\u2009=\u20091%; Val98Ile: OR\u2009=\u20091.15 [1.10-1.20], P\u2009=\u20091.8\u2009\u00d7\u200910-10, MAF\u2009=\u20094%). We demonstrate that lower bile acid transport by ASBT is accompanied by greater risk of gallstone disease and highlight the role of the intestinal compartment of the enterohepatic circulation of bile acids in gallstone disease susceptibility. Additionally, two low frequency missense variants in SERPINA1 and HNF4A and 17 common variants represent novel associations with gallstone disease.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41467-018-07460-y", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Genome-wide association meta-analysis yields 20 loci associated with gallstone disease", 
        "pagination": "5101", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "1f9ef588276978a534f24f40d890406e5711b55d3bf59a18c644638632191c6a"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30504769"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101528555"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-018-07460-y"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1110204810"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-018-07460-y", 
          "https://app.dimensions.ai/details/publication/pub.1110204810"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:18", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000281_0000000281/records_9848_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41467-018-07460-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07460-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07460-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07460-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07460-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    564 TRIPLES      21 PREDICATES      99 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-018-07460-y schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N4a676adecf7e4b2d934ff8c7a3d59463
    4 schema:citation sg:pub.10.1007/s00125-003-1067-y
    5 sg:pub.10.1007/s00210-006-0043-8
    6 sg:pub.10.1038/86871
    7 sg:pub.10.1038/ejhg.2015.63
    8 sg:pub.10.1038/ng.210
    9 sg:pub.10.1038/ng.2797
    10 sg:pub.10.1038/ng.3247
    11 sg:pub.10.1038/ng.3507
    12 sg:pub.10.1038/ng.3977
    13 sg:pub.10.1038/ng2101
    14 sg:pub.10.1038/nm1501
    15 sg:pub.10.1038/nrg3786
    16 sg:pub.10.1038/s41431-018-0108-4
    17 sg:pub.10.1038/s41467-018-03910-9
    18 sg:pub.10.1038/s41586-018-0579-z
    19 sg:pub.10.1038/sdata.2015.11
    20 sg:pub.10.1186/1471-2350-12-149
    21 sg:pub.10.1186/s12864-016-3391-x
    22 https://app.dimensions.ai/details/publication/pub.1074834161
    23 https://app.dimensions.ai/details/publication/pub.1074874180
    24 https://app.dimensions.ai/details/publication/pub.1078316026
    25 https://app.dimensions.ai/details/publication/pub.1079450293
    26 https://doi.org/10.1002/hep.20654
    27 https://doi.org/10.1002/hep.26009
    28 https://doi.org/10.1016/0002-9343(83)90615-0
    29 https://doi.org/10.1016/0014-5793(93)80199-5
    30 https://doi.org/10.1016/0016-5085(94)90712-9
    31 https://doi.org/10.1016/j.bpg.2006.05.004
    32 https://doi.org/10.1016/j.cell.2018.04.032
    33 https://doi.org/10.1016/j.coph.2010.08.010
    34 https://doi.org/10.1016/j.humpath.2004.08.013
    35 https://doi.org/10.1016/j.jhep.2012.08.013
    36 https://doi.org/10.1016/s0140-6736(06)69044-2
    37 https://doi.org/10.1016/s2213-2600(15)00283-0
    38 https://doi.org/10.1053/j.gastro.2016.04.007
    39 https://doi.org/10.1053/jhep.2001.24373
    40 https://doi.org/10.1074/jbc.270.45.27228
    41 https://doi.org/10.1093/aje/kwp411
    42 https://doi.org/10.1093/eurheartj/ehy068
    43 https://doi.org/10.1093/glycob/cwi089
    44 https://doi.org/10.1093/hmg/ddx062
    45 https://doi.org/10.1093/jnci/22.4.719
    46 https://doi.org/10.1093/molbev/msp108
    47 https://doi.org/10.1093/nar/gkp427
    48 https://doi.org/10.1097/md.0000000000000925
    49 https://doi.org/10.1097/meg.0b013e3283477cc9
    50 https://doi.org/10.1111/j.1365-2796.2007.01783.x
    51 https://doi.org/10.1111/j.1440-1746.2011.06805.x
    52 https://doi.org/10.1111/joim.12082
    53 https://doi.org/10.1111/joim.12239
    54 https://doi.org/10.1128/jvi.79.24.15351-15355.2005
    55 https://doi.org/10.1128/mcb.01894-06
    56 https://doi.org/10.1136/thx.2004.022541
    57 https://doi.org/10.1152/ajpendo.00323.2011
    58 https://doi.org/10.1159/000431071
    59 https://doi.org/10.1161/circresaha.117.312086
    60 https://doi.org/10.1161/hq1201.100262
    61 https://doi.org/10.1164/rccm.201108-1428ci
    62 https://doi.org/10.1172/jci105794
    63 https://doi.org/10.1172/jci119355
    64 https://doi.org/10.1194/jlr.r900012-jlr200
    65 https://doi.org/10.1210/jc.2004-2159
    66 https://doi.org/10.1371/journal.pgen.1003530
    67 https://doi.org/10.1371/journal.pmed.1001779
    68 https://doi.org/10.1371/journal.pone.0007321
    69 https://doi.org/10.1378/chest.10-0746
    70 https://doi.org/10.2741/a699
    71 https://doi.org/10.3109/00365520903296669
    72 https://doi.org/10.3109/00365590903151479
    73 https://doi.org/10.3748/wjg.v21.i24.7436
    74 schema:datePublished 2018-12
    75 schema:datePublishedReg 2018-12-01
    76 schema:description Gallstones are responsible for one of the most common diseases in the Western world and are commonly treated with cholecystectomy. We perform a meta-analysis of two genome-wide association studies of gallstone disease in Iceland and the UK, totaling 27,174 cases and 736,838 controls, uncovering 21 novel gallstone-associated variants at 20 loci. Two distinct low frequency missense variants in SLC10A2, encoding the apical sodium-dependent bile acid transporter (ASBT), associate with an increased risk of gallstone disease (Pro290Ser: OR = 1.36 [1.25-1.49], P = 2.1 × 10<sup>-12</sup>, MAF = 1%; Val98Ile: OR = 1.15 [1.10-1.20], P = 1.8 × 10<sup>-10</sup>, MAF = 4%). We demonstrate that lower bile acid transport by ASBT is accompanied by greater risk of gallstone disease and highlight the role of the intestinal compartment of the enterohepatic circulation of bile acids in gallstone disease susceptibility. Additionally, two low frequency missense variants in SERPINA1 and HNF4A and 17 common variants represent novel associations with gallstone disease.
    77 schema:genre research_article
    78 schema:inLanguage en
    79 schema:isAccessibleForFree true
    80 schema:isPartOf N8b574183d33b41139944ef7d7ee271f2
    81 Nddba826054404bd2bd7e4f8c15370c4b
    82 sg:journal.1043282
    83 schema:name Genome-wide association meta-analysis yields 20 loci associated with gallstone disease
    84 schema:pagination 5101
    85 schema:productId N402a0844645e4143bde9dd618e6353da
    86 N51e263e1be9f4fac9d4b8f90392ae6b8
    87 N58a899ffb05d44208ab736eed3e29c9a
    88 N5a8a27a6fc7f4727a8143e53293840dd
    89 Ncd7fd006a1b6438a955f20d52ffb9f16
    90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110204810
    91 https://doi.org/10.1038/s41467-018-07460-y
    92 schema:sdDatePublished 2019-04-11T08:18
    93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    94 schema:sdPublisher Nd0a168e7ba2f44459773fa9d99dab74e
    95 schema:url https://www.nature.com/articles/s41467-018-07460-y
    96 sgo:license sg:explorer/license/
    97 sgo:sdDataset articles
    98 rdf:type schema:ScholarlyArticle
    99 N0233005ccb94404f99a9f6390ccf9801 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    100 rdf:type schema:Organization
    101 N02ef400e508b475384251fd5bf69eae4 rdf:first sg:person.016621360067.59
    102 rdf:rest Nd9e063f6f2cb4cf4bc6ef80392977e6f
    103 N040dd8aeba0245cea50fc03e8c09f383 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    104 rdf:type schema:Organization
    105 N044637716e194b86a4837ad733f963a1 rdf:first sg:person.01277776417.51
    106 rdf:rest N145103ed010b4cf6a100a5ade55b9c06
    107 N0ad48cadd5b74028b77def53a7a16d4c schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    108 rdf:type schema:Organization
    109 N0def11e0db024420bb11ae0c74fd5255 rdf:first sg:person.01220643160.06
    110 rdf:rest Nfd347e3a73aa41238b2e41a179bb2cce
    111 N145103ed010b4cf6a100a5ade55b9c06 rdf:first sg:person.0637651205.48
    112 rdf:rest N43ab0669ace34b76a5262296a25f2756
    113 N1d6fff15770b42df8ecdb46014917561 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    114 rdf:type schema:Organization
    115 N1ff52e441f9f40eebb55e57aa2d1fc03 rdf:first sg:person.0700374216.54
    116 rdf:rest N4f6f12b31ebd41689237fe2e578cbd9e
    117 N21566db0b8c545898d0d3c7c1f5a383e rdf:first sg:person.0771421022.72
    118 rdf:rest N78e962196f254af2a736e58d419c8647
    119 N233653239c154188ad6a0c09aa9ca69d schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    120 rdf:type schema:Organization
    121 N2ceedabf12a0402b95b54179d7a209d1 rdf:first sg:person.0723426172.10
    122 rdf:rest rdf:nil
    123 N2d566c32d45d45baabde08bc20f2a818 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    124 rdf:type schema:Organization
    125 N32f6f3988ec54fe1b278d65ae3f1bbe5 schema:affiliation N233653239c154188ad6a0c09aa9ca69d
    126 schema:familyName Zink
    127 schema:givenName Florian
    128 rdf:type schema:Person
    129 N402a0844645e4143bde9dd618e6353da schema:name pubmed_id
    130 schema:value 30504769
    131 rdf:type schema:PropertyValue
    132 N43ab0669ace34b76a5262296a25f2756 rdf:first sg:person.0773127601.34
    133 rdf:rest N2ceedabf12a0402b95b54179d7a209d1
    134 N473384f779ce4f6a95db2da0d8f31298 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    135 rdf:type schema:Organization
    136 N4a676adecf7e4b2d934ff8c7a3d59463 rdf:first sg:person.01302730542.76
    137 rdf:rest Nced1bfc725774bccb0daac1a1dd3a420
    138 N4f6f12b31ebd41689237fe2e578cbd9e rdf:first N6dd2e596cf1b46319c75f05a1abad453
    139 rdf:rest Nb5994ec3d1444ffb9f53565f178d86f5
    140 N51e263e1be9f4fac9d4b8f90392ae6b8 schema:name doi
    141 schema:value 10.1038/s41467-018-07460-y
    142 rdf:type schema:PropertyValue
    143 N5352950559594fa8a2809ea6e99e3a92 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    144 rdf:type schema:Organization
    145 N58a899ffb05d44208ab736eed3e29c9a schema:name readcube_id
    146 schema:value 1f9ef588276978a534f24f40d890406e5711b55d3bf59a18c644638632191c6a
    147 rdf:type schema:PropertyValue
    148 N59bc9f99be8245a19aa25fb40aa0e60f rdf:first sg:person.0651363747.00
    149 rdf:rest N892bc0fc98ed4d4a88e8370009eb45e8
    150 N5a8a27a6fc7f4727a8143e53293840dd schema:name dimensions_id
    151 schema:value pub.1110204810
    152 rdf:type schema:PropertyValue
    153 N5b00098aa0e94d718471ca0ddef2abc7 schema:affiliation N2d566c32d45d45baabde08bc20f2a818
    154 schema:familyName Gretarsdottir
    155 schema:givenName Solveig
    156 rdf:type schema:Person
    157 N635bdaf1afdb415e9e2951a88060deb8 rdf:first sg:person.01045441067.97
    158 rdf:rest N994e30871f4f4bed885be26416d643d0
    159 N63e00cf6ebd141e487266d06dc041a2c rdf:first sg:person.01247426430.47
    160 rdf:rest Nc1b618352022425aa8accbf99595c826
    161 N698eff73a595429f8be63ae12efe7bbe rdf:first sg:person.0724231652.79
    162 rdf:rest N59bc9f99be8245a19aa25fb40aa0e60f
    163 N6a497617c9884774a0aff53dcf843011 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    164 rdf:type schema:Organization
    165 N6dd2e596cf1b46319c75f05a1abad453 schema:affiliation N473384f779ce4f6a95db2da0d8f31298
    166 schema:familyName Sverrisson
    167 schema:givenName David A.
    168 rdf:type schema:Person
    169 N6e3910d646104e809b81d676ea55ddbd rdf:first sg:person.01170350513.24
    170 rdf:rest N02ef400e508b475384251fd5bf69eae4
    171 N71f5743c023548a4b0f2348b8852ac6c rdf:first sg:person.01242432070.38
    172 rdf:rest N635bdaf1afdb415e9e2951a88060deb8
    173 N78e962196f254af2a736e58d419c8647 rdf:first N32f6f3988ec54fe1b278d65ae3f1bbe5
    174 rdf:rest Naafcd0a09a304786a79bef9c3b58ca89
    175 N7a419308bfd044c9b9fd24bdc116ea60 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    176 rdf:type schema:Organization
    177 N7cc08ea680ed46248147c93a079c8209 schema:name Laboratory in Mjódd (RAM), 109, Reykjavik, Iceland
    178 rdf:type schema:Organization
    179 N892bc0fc98ed4d4a88e8370009eb45e8 rdf:first sg:person.01342765226.91
    180 rdf:rest N044637716e194b86a4837ad733f963a1
    181 N8b574183d33b41139944ef7d7ee271f2 schema:issueNumber 1
    182 rdf:type schema:PublicationIssue
    183 N994e30871f4f4bed885be26416d643d0 rdf:first sg:person.01340370167.51
    184 rdf:rest N1ff52e441f9f40eebb55e57aa2d1fc03
    185 N9c211ff1c3474abb9d3cc97a33a88f3e rdf:first sg:person.01334675114.72
    186 rdf:rest N71f5743c023548a4b0f2348b8852ac6c
    187 Na8271291e03145b294898fd59285b7af schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    188 rdf:type schema:Organization
    189 Naa4a47ec616040ae8edcaf95d22f2dfe schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    190 rdf:type schema:Organization
    191 Naafcd0a09a304786a79bef9c3b58ca89 rdf:first sg:person.0777325667.55
    192 rdf:rest Neadfd98aa0464587b377657857f53bfb
    193 Nac0e9989830448e393dfad15e57d8d06 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    194 rdf:type schema:Organization
    195 Naf6ad0179edf485eb97bfff1f6018783 rdf:first sg:person.01352712313.86
    196 rdf:rest N6e3910d646104e809b81d676ea55ddbd
    197 Nb03e53542fdf44cd926fa1b831adc365 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    198 rdf:type schema:Organization
    199 Nb2bbb94a3e3d4d6eb629934fea44eb3d schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    200 rdf:type schema:Organization
    201 Nb55fb6624ecb46c695243f239150d6bd schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    202 rdf:type schema:Organization
    203 Nb5994ec3d1444ffb9f53565f178d86f5 rdf:first sg:person.013573442774.25
    204 rdf:rest Naf6ad0179edf485eb97bfff1f6018783
    205 Nba28220cc1e149cf842ddf088b7fddac rdf:first Nfa7b4b2b82054552815ba7c7766bb3c6
    206 rdf:rest Nd71550962e3b428fb0354a6f6d97c43f
    207 Nbaf65263f65b42aa93fefc0847361e21 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    208 rdf:type schema:Organization
    209 Nc1b618352022425aa8accbf99595c826 rdf:first sg:person.01366537405.35
    210 rdf:rest Nba28220cc1e149cf842ddf088b7fddac
    211 Nc7b777a51fcf4523b0a7c089a44d65b8 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    212 rdf:type schema:Organization
    213 Ncd7fd006a1b6438a955f20d52ffb9f16 schema:name nlm_unique_id
    214 schema:value 101528555
    215 rdf:type schema:PropertyValue
    216 Nce2f42c5ab1c4f66a618cbaf1d43c38b rdf:first N5b00098aa0e94d718471ca0ddef2abc7
    217 rdf:rest Nd8a6de4ee2f94cbc8bd10eb9603e9bb7
    218 Nced1bfc725774bccb0daac1a1dd3a420 rdf:first sg:person.0610550316.44
    219 rdf:rest Nce2f42c5ab1c4f66a618cbaf1d43c38b
    220 Nd0a168e7ba2f44459773fa9d99dab74e schema:name Springer Nature - SN SciGraph project
    221 rdf:type schema:Organization
    222 Nd71550962e3b428fb0354a6f6d97c43f rdf:first sg:person.01346127620.28
    223 rdf:rest N21566db0b8c545898d0d3c7c1f5a383e
    224 Nd8a6de4ee2f94cbc8bd10eb9603e9bb7 rdf:first sg:person.0620625167.81
    225 rdf:rest N63e00cf6ebd141e487266d06dc041a2c
    226 Nd9e063f6f2cb4cf4bc6ef80392977e6f rdf:first sg:person.01225441541.34
    227 rdf:rest N0def11e0db024420bb11ae0c74fd5255
    228 Nddba826054404bd2bd7e4f8c15370c4b schema:volumeNumber 9
    229 rdf:type schema:PublicationVolume
    230 Nde60d70afcb24ae8a9f3b77114196972 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    231 rdf:type schema:Organization
    232 Ne219cd37b2f04ff4a3b6e5426bf351b0 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    233 rdf:type schema:Organization
    234 Neadfd98aa0464587b377657857f53bfb rdf:first sg:person.011574450425.45
    235 rdf:rest N9c211ff1c3474abb9d3cc97a33a88f3e
    236 Nec1146e2d01743e5b47fa16364085d4c schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    237 rdf:type schema:Organization
    238 Nfa7b4b2b82054552815ba7c7766bb3c6 schema:affiliation Nb55fb6624ecb46c695243f239150d6bd
    239 schema:familyName Jonsson
    240 schema:givenName Stefan
    241 rdf:type schema:Person
    242 Nfd347e3a73aa41238b2e41a179bb2cce rdf:first sg:person.01263601536.27
    243 rdf:rest N698eff73a595429f8be63ae12efe7bbe
    244 Nfdeba7ebdafe4024a162b4260de7977b schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    245 rdf:type schema:Organization
    246 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    247 schema:name Biological Sciences
    248 rdf:type schema:DefinedTerm
    249 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    250 schema:name Genetics
    251 rdf:type schema:DefinedTerm
    252 sg:journal.1043282 schema:issn 2041-1723
    253 schema:name Nature Communications
    254 rdf:type schema:Periodical
    255 sg:person.01045441067.97 schema:affiliation N5352950559594fa8a2809ea6e99e3a92
    256 schema:familyName Jensson
    257 schema:givenName Brynjar O.
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045441067.97
    259 rdf:type schema:Person
    260 sg:person.011574450425.45 schema:affiliation N0ad48cadd5b74028b77def53a7a16d4c
    261 schema:familyName Gunnarsson
    262 schema:givenName Bjarni
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011574450425.45
    264 rdf:type schema:Person
    265 sg:person.01170350513.24 schema:affiliation N7cc08ea680ed46248147c93a079c8209
    266 schema:familyName Eyjolfsson
    267 schema:givenName Gudmundur I.
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170350513.24
    269 rdf:type schema:Person
    270 sg:person.01220643160.06 schema:affiliation https://www.grid.ac/institutes/grid.410540.4
    271 schema:familyName Jonsdottir
    272 schema:givenName Ingileif
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220643160.06
    274 rdf:type schema:Person
    275 sg:person.01225441541.34 schema:affiliation N7a419308bfd044c9b9fd24bdc116ea60
    276 schema:familyName Holm
    277 schema:givenName Hilma
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225441541.34
    279 rdf:type schema:Person
    280 sg:person.01242432070.38 schema:affiliation Nbaf65263f65b42aa93fefc0847361e21
    281 schema:familyName Helgadottir
    282 schema:givenName Anna
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242432070.38
    284 rdf:type schema:Person
    285 sg:person.01247426430.47 schema:affiliation Nec1146e2d01743e5b47fa16364085d4c
    286 schema:familyName Thorleifsson
    287 schema:givenName Gudmar
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247426430.47
    289 rdf:type schema:Person
    290 sg:person.01263601536.27 schema:affiliation https://www.grid.ac/institutes/grid.410540.4
    291 schema:familyName Olafsson
    292 schema:givenName Sigurdur
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263601536.27
    294 rdf:type schema:Person
    295 sg:person.01277776417.51 schema:affiliation https://www.grid.ac/institutes/grid.14013.37
    296 schema:familyName Thorsteinsdottir
    297 schema:givenName Unnur
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277776417.51
    299 rdf:type schema:Person
    300 sg:person.01302730542.76 schema:affiliation N040dd8aeba0245cea50fc03e8c09f383
    301 schema:familyName Ferkingstad
    302 schema:givenName Egil
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302730542.76
    304 rdf:type schema:Person
    305 sg:person.01334675114.72 schema:affiliation Nde60d70afcb24ae8a9f3b77114196972
    306 schema:familyName Halldorsson
    307 schema:givenName Gisli H.
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334675114.72
    309 rdf:type schema:Person
    310 sg:person.01340370167.51 schema:affiliation Nb03e53542fdf44cd926fa1b831adc365
    311 schema:familyName Kristjansson
    312 schema:givenName Ragnar P.
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340370167.51
    314 rdf:type schema:Person
    315 sg:person.01342765226.91 schema:affiliation https://www.grid.ac/institutes/grid.410540.4
    316 schema:familyName Bjornsson
    317 schema:givenName Einar S.
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342765226.91
    319 rdf:type schema:Person
    320 sg:person.01346127620.28 schema:affiliation N1d6fff15770b42df8ecdb46014917561
    321 schema:familyName Stefansson
    322 schema:givenName Olafur A.
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346127620.28
    324 rdf:type schema:Person
    325 sg:person.01352712313.86 schema:affiliation https://www.grid.ac/institutes/grid.410540.4
    326 schema:familyName Olafsson
    327 schema:givenName Isleifur
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352712313.86
    329 rdf:type schema:Person
    330 sg:person.013573442774.25 schema:affiliation Na8271291e03145b294898fd59285b7af
    331 schema:familyName Masson
    332 schema:givenName Gisli
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013573442774.25
    334 rdf:type schema:Person
    335 sg:person.01366537405.35 schema:affiliation Nac0e9989830448e393dfad15e57d8d06
    336 schema:familyName Deaton
    337 schema:givenName Aimee M.
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366537405.35
    339 rdf:type schema:Person
    340 sg:person.016621360067.59 schema:affiliation https://www.grid.ac/institutes/grid.440311.3
    341 schema:familyName Sigurdardottir
    342 schema:givenName Olof
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016621360067.59
    344 rdf:type schema:Person
    345 sg:person.0610550316.44 schema:affiliation Ne219cd37b2f04ff4a3b6e5426bf351b0
    346 schema:familyName Oddsson
    347 schema:givenName Asmundur
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610550316.44
    349 rdf:type schema:Person
    350 sg:person.0620625167.81 schema:affiliation Naa4a47ec616040ae8edcaf95d22f2dfe
    351 schema:familyName Benonisdottir
    352 schema:givenName Stefania
    353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620625167.81
    354 rdf:type schema:Person
    355 sg:person.0637651205.48 schema:affiliation https://www.grid.ac/institutes/grid.14013.37
    356 schema:familyName Gudbjartsson
    357 schema:givenName Daniel F.
    358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637651205.48
    359 rdf:type schema:Person
    360 sg:person.0651363747.00 schema:affiliation N0233005ccb94404f99a9f6390ccf9801
    361 schema:familyName Rafnar
    362 schema:givenName Thorunn
    363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651363747.00
    364 rdf:type schema:Person
    365 sg:person.0700374216.54 schema:affiliation N6a497617c9884774a0aff53dcf843011
    366 schema:familyName Sveinbjornsson
    367 schema:givenName Gardar
    368 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700374216.54
    369 rdf:type schema:Person
    370 sg:person.0723426172.10 schema:affiliation https://www.grid.ac/institutes/grid.14013.37
    371 schema:familyName Stefansson
    372 schema:givenName Kari
    373 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723426172.10
    374 rdf:type schema:Person
    375 sg:person.0724231652.79 schema:affiliation https://www.grid.ac/institutes/grid.410540.4
    376 schema:familyName Steingrimsdottir
    377 schema:givenName Thora
    378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724231652.79
    379 rdf:type schema:Person
    380 sg:person.0771421022.72 schema:affiliation Nfdeba7ebdafe4024a162b4260de7977b
    381 schema:familyName Norddahl
    382 schema:givenName Gudmundur L.
    383 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771421022.72
    384 rdf:type schema:Person
    385 sg:person.0773127601.34 schema:affiliation Nb2bbb94a3e3d4d6eb629934fea44eb3d
    386 schema:familyName Sulem
    387 schema:givenName Patrick
    388 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773127601.34
    389 rdf:type schema:Person
    390 sg:person.0777325667.55 schema:affiliation Nc7b777a51fcf4523b0a7c089a44d65b8
    391 schema:familyName Arnadottir
    392 schema:givenName Gudny A.
    393 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777325667.55
    394 rdf:type schema:Person
    395 sg:pub.10.1007/s00125-003-1067-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1040876036
    396 https://doi.org/10.1007/s00125-003-1067-y
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1007/s00210-006-0043-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035843485
    399 https://doi.org/10.1007/s00210-006-0043-8
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/86871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000259771
    402 https://doi.org/10.1038/86871
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1038/ejhg.2015.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032851902
    405 https://doi.org/10.1038/ejhg.2015.63
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1038/ng.210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047719697
    408 https://doi.org/10.1038/ng.210
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1038/ng.2797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031899225
    411 https://doi.org/10.1038/ng.2797
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1038/ng.3247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020692466
    414 https://doi.org/10.1038/ng.3247
    415 rdf:type schema:CreativeWork
    416 sg:pub.10.1038/ng.3507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043168111
    417 https://doi.org/10.1038/ng.3507
    418 rdf:type schema:CreativeWork
    419 sg:pub.10.1038/ng.3977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092440097
    420 https://doi.org/10.1038/ng.3977
    421 rdf:type schema:CreativeWork
    422 sg:pub.10.1038/ng2101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052131615
    423 https://doi.org/10.1038/ng2101
    424 rdf:type schema:CreativeWork
    425 sg:pub.10.1038/nm1501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046301553
    426 https://doi.org/10.1038/nm1501
    427 rdf:type schema:CreativeWork
    428 sg:pub.10.1038/nrg3786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005206876
    429 https://doi.org/10.1038/nrg3786
    430 rdf:type schema:CreativeWork
    431 sg:pub.10.1038/s41431-018-0108-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101190281
    432 https://doi.org/10.1038/s41431-018-0108-4
    433 rdf:type schema:CreativeWork
    434 sg:pub.10.1038/s41467-018-03910-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103541272
    435 https://doi.org/10.1038/s41467-018-03910-9
    436 rdf:type schema:CreativeWork
    437 sg:pub.10.1038/s41586-018-0579-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1107363293
    438 https://doi.org/10.1038/s41586-018-0579-z
    439 rdf:type schema:CreativeWork
    440 sg:pub.10.1038/sdata.2015.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026621968
    441 https://doi.org/10.1038/sdata.2015.11
    442 rdf:type schema:CreativeWork
    443 sg:pub.10.1186/1471-2350-12-149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041152662
    444 https://doi.org/10.1186/1471-2350-12-149
    445 rdf:type schema:CreativeWork
    446 sg:pub.10.1186/s12864-016-3391-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043593875
    447 https://doi.org/10.1186/s12864-016-3391-x
    448 rdf:type schema:CreativeWork
    449 https://app.dimensions.ai/details/publication/pub.1074834161 schema:CreativeWork
    450 https://app.dimensions.ai/details/publication/pub.1074874180 schema:CreativeWork
    451 https://app.dimensions.ai/details/publication/pub.1078316026 schema:CreativeWork
    452 https://app.dimensions.ai/details/publication/pub.1079450293 schema:CreativeWork
    453 https://doi.org/10.1002/hep.20654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028099054
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1002/hep.26009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025292549
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1016/0002-9343(83)90615-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031572795
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1016/0014-5793(93)80199-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040867474
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1016/0016-5085(94)90712-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049339404
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1016/j.bpg.2006.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051503380
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1016/j.cell.2018.04.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104040437
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1016/j.coph.2010.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023537539
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1016/j.humpath.2004.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007030006
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1016/j.jhep.2012.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001967705
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1016/s0140-6736(06)69044-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000408558
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1016/s2213-2600(15)00283-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040230125
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1053/j.gastro.2016.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008633442
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1053/jhep.2001.24373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040843077
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1074/jbc.270.45.27228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015537399
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1093/aje/kwp411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042920391
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1093/eurheartj/ehy068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100679758
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1093/glycob/cwi089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039681339
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1093/hmg/ddx062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083931991
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1093/jnci/22.4.719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075910802
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1093/molbev/msp108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002242347
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1093/nar/gkp427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027845966
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1097/md.0000000000000925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019811959
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1097/meg.0b013e3283477cc9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008537693
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1111/j.1365-2796.2007.01783.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049998206
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1111/j.1440-1746.2011.06805.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044904067
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1111/joim.12082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007773470
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1111/joim.12239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009001224
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1128/jvi.79.24.15351-15355.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019542733
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1128/mcb.01894-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014215382
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1136/thx.2004.022541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027032066
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1152/ajpendo.00323.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010602649
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1159/000431071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053289325
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1161/circresaha.117.312086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099613660
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1161/hq1201.100262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007833669
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1164/rccm.201108-1428ci schema:sameAs https://app.dimensions.ai/details/publication/pub.1019082112
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1172/jci105794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042580315
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1172/jci119355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035827653
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1194/jlr.r900012-jlr200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005775402
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1210/jc.2004-2159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064288156
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1371/journal.pgen.1003530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053489788
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1371/journal.pmed.1001779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033632930
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.1371/journal.pone.0007321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014480759
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.1378/chest.10-0746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014324314
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.2741/a699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070917482
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.3109/00365520903296669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017819119
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.3109/00365590903151479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033735209
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.3748/wjg.v21.i24.7436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071372659
    548 rdf:type schema:CreativeWork
    549 https://www.grid.ac/institutes/grid.14013.37 schema:alternateName University of Iceland
    550 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    551 Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland
    552 School of Engineering and Natural Sciences, University of Iceland, 101, Reykjavik, Iceland
    553 rdf:type schema:Organization
    554 https://www.grid.ac/institutes/grid.410540.4 schema:alternateName National University Hospital of Iceland
    555 schema:name CODE Genetics/Amgen, Inc., 101, Reykjavik, Iceland
    556 Department of Clinical Biochemistry, Landspítali University Hospital, 101, Reykjavik, Iceland
    557 Department of Immunology, Landspitali University Hospital, 101, Reykjavik, Iceland
    558 Department of Internal Medicine, Landspitali University Hospital, 101, Reykjavik, Iceland
    559 Department of Obstetrics and Gynecology, Landspitali University Hospital, 101, Reykjavik, Iceland
    560 Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland
    561 rdf:type schema:Organization
    562 https://www.grid.ac/institutes/grid.440311.3 schema:alternateName Akureyri Hospital
    563 schema:name Department of Clinical Biochemistry, Akureyri Hospital, 600, Akureyri, Iceland
    564 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...