Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-11-26

AUTHORS

Vanessa Pellegrinelli, Vivian J. Peirce, Laura Howard, Samuel Virtue, Dénes Türei, Martina Senzacqua, Andrea Frontini, Jeffrey W. Dalley, Antony R. Horton, Guillaume Bidault, Ilenia Severi, Andrew Whittle, Kamal Rahmouni, Julio Saez-Rodriguez, Saverio Cinti, Alun M. Davies, Antonio Vidal-Puig

ABSTRACT

Activation of brown adipose tissue-mediated thermogenesis is a strategy for tackling obesity and promoting metabolic health. BMP8b is secreted by brown/beige adipocytes and enhances energy dissipation. Here we show that adipocyte-secreted BMP8b contributes to adrenergic-induced remodeling of the neuro-vascular network in adipose tissue (AT). Overexpression of bmp8b in AT enhances browning of the subcutaneous depot and maximal thermogenic capacity. Moreover, BMP8b-induced browning, increased sympathetic innervation and vascularization of AT were maintained at 28 °C, a condition of low adrenergic output. This reinforces the local trophic effect of BMP8b. Innervation and vascular remodeling effects required BMP8b signaling through the adipocytes to 1) secrete neuregulin-4 (NRG4), which promotes sympathetic axon growth and branching in vitro, and 2) induce a pro-angiogenic transcriptional and secretory profile that promotes vascular sprouting. Thus, BMP8b and NRG4 can be considered as interconnected regulators of neuro-vascular remodeling in AT and are potential therapeutic targets in obesity. More... »

PAGES

4974

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-07453-x

DOI

http://dx.doi.org/10.1038/s41467-018-07453-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110065941

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30478315


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "3T3-L1 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipocytes, Brown", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipose Tissue, Brown", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenergic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Morphogenetic Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Physiologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuregulins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Subcutaneous Fat", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thermogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Endothelial Growth Factor A", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke\u2019s Hospital, University of Cambridge, Cambridge, CB2 0QQ UK", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke\u2019s Hospital, University of Cambridge, Cambridge, CB2 0QQ UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pellegrinelli", 
        "givenName": "Vanessa", 
        "id": "sg:person.01171770232.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171770232.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke\u2019s Hospital, University of Cambridge, Cambridge, CB2 0QQ UK", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke\u2019s Hospital, University of Cambridge, Cambridge, CB2 0QQ UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peirce", 
        "givenName": "Vivian J.", 
        "id": "sg:person.0631701206.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631701206.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AT UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AT UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Howard", 
        "givenName": "Laura", 
        "id": "sg:person.014525050265.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014525050265.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke\u2019s Hospital, University of Cambridge, Cambridge, CB2 0QQ UK", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke\u2019s Hospital, University of Cambridge, Cambridge, CB2 0QQ UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Virtue", 
        "givenName": "Samuel", 
        "id": "sg:person.015537336047.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015537336047.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine, MTI2 Wendlingweg 2, D-52074 Aachen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.1957.a", 
          "name": [
            "European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit, Meyerhofstrasse 1, D-69117 Heidelberg, Germany", 
            "European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI), Cambridge, CB10 1SD UK", 
            "RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine, MTI2 Wendlingweg 2, D-52074 Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "T\u00fcrei", 
        "givenName": "D\u00e9nes", 
        "id": "sg:person.01211245177.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211245177.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Experimental and Clinical Medicine, Center of Obesity, Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7010.6", 
          "name": [
            "Department of Experimental and Clinical Medicine, Center of Obesity, Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Senzacqua", 
        "givenName": "Martina", 
        "id": "sg:person.01015432624.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015432624.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy", 
          "id": "http://www.grid.ac/institutes/grid.8982.b", 
          "name": [
            "Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frontini", 
        "givenName": "Andrea", 
        "id": "sg:person.0710143405.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710143405.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, CB2 0QQ UK", 
          "id": "http://www.grid.ac/institutes/grid.120073.7", 
          "name": [
            "Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB UK", 
            "Department of Psychiatry, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, CB2 0QQ UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dalley", 
        "givenName": "Jeffrey W.", 
        "id": "sg:person.01207720551.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207720551.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AT UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AT UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horton", 
        "givenName": "Antony R.", 
        "id": "sg:person.01275522613.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275522613.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke\u2019s Hospital, University of Cambridge, Cambridge, CB2 0QQ UK", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke\u2019s Hospital, University of Cambridge, Cambridge, CB2 0QQ UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bidault", 
        "givenName": "Guillaume", 
        "id": "sg:person.01031667746.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031667746.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Experimental and Clinical Medicine, Center of Obesity, Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7010.6", 
          "name": [
            "Department of Experimental and Clinical Medicine, Center of Obesity, Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Severi", 
        "givenName": "Ilenia", 
        "id": "sg:person.01120771263.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120771263.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke\u2019s Hospital, University of Cambridge, Cambridge, CB2 0QQ UK", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke\u2019s Hospital, University of Cambridge, Cambridge, CB2 0QQ UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Whittle", 
        "givenName": "Andrew", 
        "id": "sg:person.01346647546.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346647546.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, University of Iowa, Iowa City, IA 52242 USA", 
          "id": "http://www.grid.ac/institutes/grid.214572.7", 
          "name": [
            "Department of Pharmacology, University of Iowa, Iowa City, IA 52242 USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rahmouni", 
        "givenName": "Kamal", 
        "id": "sg:person.01223331472.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223331472.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine, MTI2 Wendlingweg 2, D-52074 Aachen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.1957.a", 
          "name": [
            "European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI), Cambridge, CB10 1SD UK", 
            "RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine, MTI2 Wendlingweg 2, D-52074 Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saez-Rodriguez", 
        "givenName": "Julio", 
        "id": "sg:person.01307552567.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307552567.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Experimental and Clinical Medicine, Center of Obesity, Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7010.6", 
          "name": [
            "Department of Experimental and Clinical Medicine, Center of Obesity, Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cinti", 
        "givenName": "Saverio", 
        "id": "sg:person.0600061345.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600061345.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AT UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AT UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davies", 
        "givenName": "Alun M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA UK", 
          "id": "http://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke\u2019s Hospital, University of Cambridge, Cambridge, CB2 0QQ UK", 
            "Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vidal-Puig", 
        "givenName": "Antonio", 
        "id": "sg:person.015024501017.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015024501017.64"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/978-1-59745-241-0_10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013091367", 
          "https://doi.org/10.1007/978-1-59745-241-0_10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.4077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040324914", 
          "https://doi.org/10.1038/nmeth.4077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051519114", 
          "https://doi.org/10.1038/nm.3713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034212815", 
          "https://doi.org/10.1038/nrn1805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.3396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029543733", 
          "https://doi.org/10.1038/nmeth.3396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.4031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015376337", 
          "https://doi.org/10.1038/nm.4031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2013.158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006178520", 
          "https://doi.org/10.1038/cr.2013.158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-013-2931-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039327534", 
          "https://doi.org/10.1007/s00125-013-2931-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006017302", 
          "https://doi.org/10.1038/nature13477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/75556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044135237", 
          "https://doi.org/10.1038/75556"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-11-26", 
    "datePublishedReg": "2018-11-26", 
    "description": "Activation of brown adipose tissue-mediated thermogenesis is a strategy for tackling obesity and promoting metabolic health. BMP8b is secreted by brown/beige adipocytes and enhances energy dissipation. Here we show that adipocyte-secreted BMP8b contributes to adrenergic-induced remodeling of the neuro-vascular network in adipose tissue (AT). Overexpression of bmp8b in AT enhances browning of the subcutaneous depot and maximal thermogenic capacity. Moreover, BMP8b-induced browning, increased sympathetic innervation and vascularization of AT were maintained at 28\u2009\u00b0C, a condition of low adrenergic output. This reinforces the local trophic effect of BMP8b. Innervation and vascular remodeling effects required BMP8b signaling through the adipocytes to 1) secrete neuregulin-4 (NRG4), which promotes sympathetic axon growth and branching in vitro, and 2) induce a pro-angiogenic transcriptional and secretory profile that promotes vascular sprouting. Thus, BMP8b and NRG4 can be considered as interconnected regulators of neuro-vascular remodeling in AT and are potential therapeutic targets in obesity.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41467-018-07453-x", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3560141", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8470218", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2758718", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2437040", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2762296", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8470187", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4579503", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.100065959", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5137078", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3641652", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3559965", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.9462536", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2752738", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2783446", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5141564", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2763827", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "keywords": [
      "neuregulin 4", 
      "adipose tissue", 
      "local trophic effects", 
      "sympathetic axon growth", 
      "brown/beige adipocytes", 
      "potential therapeutic target", 
      "sympathetic innervation", 
      "metabolic health", 
      "secretory profile", 
      "therapeutic target", 
      "trophic effects", 
      "beige adipocytes", 
      "subcutaneous depot", 
      "maximal thermogenic capacity", 
      "axon growth", 
      "thermogenic capacity", 
      "obesity", 
      "innervation", 
      "adipocytes", 
      "remodeling", 
      "vascular sprouting", 
      "Bmp8b", 
      "tissue", 
      "thermogenesis", 
      "vascularization", 
      "health", 
      "activation", 
      "overexpression", 
      "effect", 
      "sprouting", 
      "depots", 
      "contributes", 
      "target", 
      "browning", 
      "regulator", 
      "profile", 
      "strategies", 
      "capacity", 
      "growth", 
      "conditions", 
      "output", 
      "network", 
      "dissipation", 
      "energy dissipation", 
      "brown adipose tissue-mediated thermogenesis", 
      "adipose tissue-mediated thermogenesis", 
      "tissue-mediated thermogenesis", 
      "adipocyte-secreted BMP8b contributes", 
      "BMP8b contributes", 
      "adrenergic-induced remodeling", 
      "neuro-vascular network", 
      "Overexpression of bmp8b", 
      "AT enhances browning", 
      "enhances browning", 
      "vascularization of AT", 
      "low adrenergic output", 
      "adrenergic output", 
      "secrete neuregulin-4", 
      "neuro-vascular remodeling"
    ], 
    "name": "Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue", 
    "pagination": "4974", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110065941"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-018-07453-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30478315"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-018-07453-x", 
      "https://app.dimensions.ai/details/publication/pub.1110065941"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_790.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41467-018-07453-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07453-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07453-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07453-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07453-x'


 

This table displays all metadata directly associated to this object as RDF triples.

400 TRIPLES      22 PREDICATES      113 URIs      95 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-018-07453-x schema:about N0f7cca0cbab249bcb3bd32613e0444fe
2 N1354e08a80a24303b87272cd23aef2f6
3 N1bb33e9652434eef90c081d097aeace1
4 N1d3389f0ae044731aeab87a0519d1905
5 N4d10e1f5d44e43ee94e9dd43164e63b6
6 N6d1441947e2146dd89663a1f0d5b85fa
7 N74e11e99a0eb4238a603c661b53326b6
8 N811e79436dce405da2d9d1e6565bceae
9 N91f173e830a24a1491e3d51455ab2588
10 Na2c8ecc9b5ae4a288552d83454775b16
11 Nb9790cc2f3c143ae967afae7e206fe31
12 Nbe2640e2233742bf92134e77d7852537
13 Nd241d441dc4746ac95fcfd058abf7dd0
14 Nea7a43ea05114af8894be1474f679376
15 Neb5212f042ba433085a38acac05e540c
16 Nec43da19c160487a8c26c03eab7e878b
17 Nf18f8d1741dd407bb010542c1bdc6e4e
18 Nfe5f5d7f438b4a16ac74c7c5ba544806
19 anzsrc-for:11
20 anzsrc-for:1116
21 schema:author N8ab484e102474b4e8248d99e0ea0fbc3
22 schema:citation sg:pub.10.1007/978-1-59745-241-0_10
23 sg:pub.10.1007/s00125-013-2931-z
24 sg:pub.10.1038/75556
25 sg:pub.10.1038/cr.2013.158
26 sg:pub.10.1038/nature13477
27 sg:pub.10.1038/nm.3713
28 sg:pub.10.1038/nm.4031
29 sg:pub.10.1038/nmeth.3396
30 sg:pub.10.1038/nmeth.4077
31 sg:pub.10.1038/nrn1805
32 schema:datePublished 2018-11-26
33 schema:datePublishedReg 2018-11-26
34 schema:description Activation of brown adipose tissue-mediated thermogenesis is a strategy for tackling obesity and promoting metabolic health. BMP8b is secreted by brown/beige adipocytes and enhances energy dissipation. Here we show that adipocyte-secreted BMP8b contributes to adrenergic-induced remodeling of the neuro-vascular network in adipose tissue (AT). Overexpression of bmp8b in AT enhances browning of the subcutaneous depot and maximal thermogenic capacity. Moreover, BMP8b-induced browning, increased sympathetic innervation and vascularization of AT were maintained at 28 °C, a condition of low adrenergic output. This reinforces the local trophic effect of BMP8b. Innervation and vascular remodeling effects required BMP8b signaling through the adipocytes to 1) secrete neuregulin-4 (NRG4), which promotes sympathetic axon growth and branching in vitro, and 2) induce a pro-angiogenic transcriptional and secretory profile that promotes vascular sprouting. Thus, BMP8b and NRG4 can be considered as interconnected regulators of neuro-vascular remodeling in AT and are potential therapeutic targets in obesity.
35 schema:genre article
36 schema:inLanguage en
37 schema:isAccessibleForFree true
38 schema:isPartOf N33153139b8fc499989f6343abc68bc2e
39 Ncb1f99f6a3d741a297c5b2d392a736aa
40 sg:journal.1043282
41 schema:keywords AT enhances browning
42 BMP8b contributes
43 Bmp8b
44 Overexpression of bmp8b
45 activation
46 adipocyte-secreted BMP8b contributes
47 adipocytes
48 adipose tissue
49 adipose tissue-mediated thermogenesis
50 adrenergic output
51 adrenergic-induced remodeling
52 axon growth
53 beige adipocytes
54 brown adipose tissue-mediated thermogenesis
55 brown/beige adipocytes
56 browning
57 capacity
58 conditions
59 contributes
60 depots
61 dissipation
62 effect
63 energy dissipation
64 enhances browning
65 growth
66 health
67 innervation
68 local trophic effects
69 low adrenergic output
70 maximal thermogenic capacity
71 metabolic health
72 network
73 neuregulin 4
74 neuro-vascular network
75 neuro-vascular remodeling
76 obesity
77 output
78 overexpression
79 potential therapeutic target
80 profile
81 regulator
82 remodeling
83 secrete neuregulin-4
84 secretory profile
85 sprouting
86 strategies
87 subcutaneous depot
88 sympathetic axon growth
89 sympathetic innervation
90 target
91 therapeutic target
92 thermogenesis
93 thermogenic capacity
94 tissue
95 tissue-mediated thermogenesis
96 trophic effects
97 vascular sprouting
98 vascularization
99 vascularization of AT
100 schema:name Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue
101 schema:pagination 4974
102 schema:productId Na394cae3cae84ae284092125615e65bf
103 Na6261c9eba2941b693d2b00b6cfe3753
104 Na77b84db5a604355b4d11b1cecef54fa
105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110065941
106 https://doi.org/10.1038/s41467-018-07453-x
107 schema:sdDatePublished 2021-12-01T19:42
108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
109 schema:sdPublisher N0bbc3e2350184ad3a8bea0c81175bcd3
110 schema:url https://doi.org/10.1038/s41467-018-07453-x
111 sgo:license sg:explorer/license/
112 sgo:sdDataset articles
113 rdf:type schema:ScholarlyArticle
114 N01562b8e012c4dfd8573a6b976175932 rdf:first sg:person.0710143405.33
115 rdf:rest Ne05aa209a0b94bd2aa70c58b06f5c1a5
116 N0bbc3e2350184ad3a8bea0c81175bcd3 schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 N0f7cca0cbab249bcb3bd32613e0444fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Vascular Endothelial Growth Factor A
120 rdf:type schema:DefinedTerm
121 N11e77ba8c8114ab7a8e9730c37755175 rdf:first sg:person.01307552567.91
122 rdf:rest Na807017ffa0a4047b19798e50ce3889d
123 N1354e08a80a24303b87272cd23aef2f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Signal Transduction
125 rdf:type schema:DefinedTerm
126 N1bb33e9652434eef90c081d097aeace1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name 3T3-L1 Cells
128 rdf:type schema:DefinedTerm
129 N1d3389f0ae044731aeab87a0519d1905 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Bone Morphogenetic Proteins
131 rdf:type schema:DefinedTerm
132 N22e551b71b214d9fbe6682a2ffeca40f rdf:first sg:person.01031667746.15
133 rdf:rest N62dbdf6cc7674c68b05464e72af63e6b
134 N2486cf370af44edc9dc005c79481260e rdf:first sg:person.01223331472.89
135 rdf:rest N11e77ba8c8114ab7a8e9730c37755175
136 N33153139b8fc499989f6343abc68bc2e schema:volumeNumber 9
137 rdf:type schema:PublicationVolume
138 N352ba79c7fb44eccaa95c3345dda56db rdf:first sg:person.01275522613.35
139 rdf:rest N22e551b71b214d9fbe6682a2ffeca40f
140 N4d10e1f5d44e43ee94e9dd43164e63b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Mice, Inbred C57BL
142 rdf:type schema:DefinedTerm
143 N5ce7df1ea84a4c1dbfa14f885e5bd836 schema:affiliation grid-institutes:grid.5600.3
144 schema:familyName Davies
145 schema:givenName Alun M.
146 rdf:type schema:Person
147 N62dbdf6cc7674c68b05464e72af63e6b rdf:first sg:person.01120771263.63
148 rdf:rest Ncb308a53bec04a84bf5246a02ef45790
149 N6d1441947e2146dd89663a1f0d5b85fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Adipose Tissue, Brown
151 rdf:type schema:DefinedTerm
152 N74e11e99a0eb4238a603c661b53326b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Subcutaneous Fat
154 rdf:type schema:DefinedTerm
155 N811e79436dce405da2d9d1e6565bceae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Neovascularization, Physiologic
157 rdf:type schema:DefinedTerm
158 N8ab484e102474b4e8248d99e0ea0fbc3 rdf:first sg:person.01171770232.62
159 rdf:rest Na21240ca1b6f4f00a7beb90eea5b5940
160 N91f173e830a24a1491e3d51455ab2588 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Neuregulins
162 rdf:type schema:DefinedTerm
163 Na21240ca1b6f4f00a7beb90eea5b5940 rdf:first sg:person.0631701206.50
164 rdf:rest Nfb47be181ca944dbb87f7a4d8c5346b1
165 Na2c8ecc9b5ae4a288552d83454775b16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Adipocytes, Brown
167 rdf:type schema:DefinedTerm
168 Na394cae3cae84ae284092125615e65bf schema:name pubmed_id
169 schema:value 30478315
170 rdf:type schema:PropertyValue
171 Na6261c9eba2941b693d2b00b6cfe3753 schema:name dimensions_id
172 schema:value pub.1110065941
173 rdf:type schema:PropertyValue
174 Na77b84db5a604355b4d11b1cecef54fa schema:name doi
175 schema:value 10.1038/s41467-018-07453-x
176 rdf:type schema:PropertyValue
177 Na807017ffa0a4047b19798e50ce3889d rdf:first sg:person.0600061345.48
178 rdf:rest Nad337c88b43e4595a83fb866249dda44
179 Nad337c88b43e4595a83fb866249dda44 rdf:first N5ce7df1ea84a4c1dbfa14f885e5bd836
180 rdf:rest Nbdcb009864024e7baf2005c84003b47b
181 Nae738cea1e344613bef03da15a14f736 rdf:first sg:person.015537336047.86
182 rdf:rest Nb9ba87cc478247b5bf3fd625aba9c98d
183 Nb9790cc2f3c143ae967afae7e206fe31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Female
185 rdf:type schema:DefinedTerm
186 Nb9ba87cc478247b5bf3fd625aba9c98d rdf:first sg:person.01211245177.40
187 rdf:rest Nffcc49b2f32241b4a9bf34387e5b3499
188 Nbdcb009864024e7baf2005c84003b47b rdf:first sg:person.015024501017.64
189 rdf:rest rdf:nil
190 Nbe2640e2233742bf92134e77d7852537 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Mice
192 rdf:type schema:DefinedTerm
193 Ncb1f99f6a3d741a297c5b2d392a736aa schema:issueNumber 1
194 rdf:type schema:PublicationIssue
195 Ncb308a53bec04a84bf5246a02ef45790 rdf:first sg:person.01346647546.24
196 rdf:rest N2486cf370af44edc9dc005c79481260e
197 Nd241d441dc4746ac95fcfd058abf7dd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Animals
199 rdf:type schema:DefinedTerm
200 Ne05aa209a0b94bd2aa70c58b06f5c1a5 rdf:first sg:person.01207720551.23
201 rdf:rest N352ba79c7fb44eccaa95c3345dda56db
202 Nea7a43ea05114af8894be1474f679376 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Mice, Transgenic
204 rdf:type schema:DefinedTerm
205 Neb5212f042ba433085a38acac05e540c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Adrenergic Agents
207 rdf:type schema:DefinedTerm
208 Nec43da19c160487a8c26c03eab7e878b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Proteomics
210 rdf:type schema:DefinedTerm
211 Nf18f8d1741dd407bb010542c1bdc6e4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Thermogenesis
213 rdf:type schema:DefinedTerm
214 Nfb47be181ca944dbb87f7a4d8c5346b1 rdf:first sg:person.014525050265.72
215 rdf:rest Nae738cea1e344613bef03da15a14f736
216 Nfe5f5d7f438b4a16ac74c7c5ba544806 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Models, Biological
218 rdf:type schema:DefinedTerm
219 Nffcc49b2f32241b4a9bf34387e5b3499 rdf:first sg:person.01015432624.03
220 rdf:rest N01562b8e012c4dfd8573a6b976175932
221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
222 schema:name Medical and Health Sciences
223 rdf:type schema:DefinedTerm
224 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
225 schema:name Medical Physiology
226 rdf:type schema:DefinedTerm
227 sg:grant.100065959 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
228 rdf:type schema:MonetaryGrant
229 sg:grant.2437040 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
230 rdf:type schema:MonetaryGrant
231 sg:grant.2752738 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
232 rdf:type schema:MonetaryGrant
233 sg:grant.2758718 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
234 rdf:type schema:MonetaryGrant
235 sg:grant.2762296 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
236 rdf:type schema:MonetaryGrant
237 sg:grant.2763827 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
238 rdf:type schema:MonetaryGrant
239 sg:grant.2783446 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
240 rdf:type schema:MonetaryGrant
241 sg:grant.3559965 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
242 rdf:type schema:MonetaryGrant
243 sg:grant.3560141 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
244 rdf:type schema:MonetaryGrant
245 sg:grant.3641652 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
246 rdf:type schema:MonetaryGrant
247 sg:grant.4579503 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
248 rdf:type schema:MonetaryGrant
249 sg:grant.5137078 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
250 rdf:type schema:MonetaryGrant
251 sg:grant.5141564 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
252 rdf:type schema:MonetaryGrant
253 sg:grant.8470187 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
254 rdf:type schema:MonetaryGrant
255 sg:grant.8470218 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
256 rdf:type schema:MonetaryGrant
257 sg:grant.9462536 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-07453-x
258 rdf:type schema:MonetaryGrant
259 sg:journal.1043282 schema:issn 2041-1723
260 schema:name Nature Communications
261 schema:publisher Springer Nature
262 rdf:type schema:Periodical
263 sg:person.01015432624.03 schema:affiliation grid-institutes:grid.7010.6
264 schema:familyName Senzacqua
265 schema:givenName Martina
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015432624.03
267 rdf:type schema:Person
268 sg:person.01031667746.15 schema:affiliation grid-institutes:None
269 schema:familyName Bidault
270 schema:givenName Guillaume
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031667746.15
272 rdf:type schema:Person
273 sg:person.01120771263.63 schema:affiliation grid-institutes:grid.7010.6
274 schema:familyName Severi
275 schema:givenName Ilenia
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120771263.63
277 rdf:type schema:Person
278 sg:person.01171770232.62 schema:affiliation grid-institutes:None
279 schema:familyName Pellegrinelli
280 schema:givenName Vanessa
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171770232.62
282 rdf:type schema:Person
283 sg:person.01207720551.23 schema:affiliation grid-institutes:grid.120073.7
284 schema:familyName Dalley
285 schema:givenName Jeffrey W.
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207720551.23
287 rdf:type schema:Person
288 sg:person.01211245177.40 schema:affiliation grid-institutes:grid.1957.a
289 schema:familyName Türei
290 schema:givenName Dénes
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211245177.40
292 rdf:type schema:Person
293 sg:person.01223331472.89 schema:affiliation grid-institutes:grid.214572.7
294 schema:familyName Rahmouni
295 schema:givenName Kamal
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223331472.89
297 rdf:type schema:Person
298 sg:person.01275522613.35 schema:affiliation grid-institutes:grid.5600.3
299 schema:familyName Horton
300 schema:givenName Antony R.
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275522613.35
302 rdf:type schema:Person
303 sg:person.01307552567.91 schema:affiliation grid-institutes:grid.1957.a
304 schema:familyName Saez-Rodriguez
305 schema:givenName Julio
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307552567.91
307 rdf:type schema:Person
308 sg:person.01346647546.24 schema:affiliation grid-institutes:None
309 schema:familyName Whittle
310 schema:givenName Andrew
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346647546.24
312 rdf:type schema:Person
313 sg:person.014525050265.72 schema:affiliation grid-institutes:grid.5600.3
314 schema:familyName Howard
315 schema:givenName Laura
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014525050265.72
317 rdf:type schema:Person
318 sg:person.015024501017.64 schema:affiliation grid-institutes:grid.10306.34
319 schema:familyName Vidal-Puig
320 schema:givenName Antonio
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015024501017.64
322 rdf:type schema:Person
323 sg:person.015537336047.86 schema:affiliation grid-institutes:None
324 schema:familyName Virtue
325 schema:givenName Samuel
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015537336047.86
327 rdf:type schema:Person
328 sg:person.0600061345.48 schema:affiliation grid-institutes:grid.7010.6
329 schema:familyName Cinti
330 schema:givenName Saverio
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600061345.48
332 rdf:type schema:Person
333 sg:person.0631701206.50 schema:affiliation grid-institutes:None
334 schema:familyName Peirce
335 schema:givenName Vivian J.
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631701206.50
337 rdf:type schema:Person
338 sg:person.0710143405.33 schema:affiliation grid-institutes:grid.8982.b
339 schema:familyName Frontini
340 schema:givenName Andrea
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710143405.33
342 rdf:type schema:Person
343 sg:pub.10.1007/978-1-59745-241-0_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013091367
344 https://doi.org/10.1007/978-1-59745-241-0_10
345 rdf:type schema:CreativeWork
346 sg:pub.10.1007/s00125-013-2931-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1039327534
347 https://doi.org/10.1007/s00125-013-2931-z
348 rdf:type schema:CreativeWork
349 sg:pub.10.1038/75556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044135237
350 https://doi.org/10.1038/75556
351 rdf:type schema:CreativeWork
352 sg:pub.10.1038/cr.2013.158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006178520
353 https://doi.org/10.1038/cr.2013.158
354 rdf:type schema:CreativeWork
355 sg:pub.10.1038/nature13477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006017302
356 https://doi.org/10.1038/nature13477
357 rdf:type schema:CreativeWork
358 sg:pub.10.1038/nm.3713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051519114
359 https://doi.org/10.1038/nm.3713
360 rdf:type schema:CreativeWork
361 sg:pub.10.1038/nm.4031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015376337
362 https://doi.org/10.1038/nm.4031
363 rdf:type schema:CreativeWork
364 sg:pub.10.1038/nmeth.3396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029543733
365 https://doi.org/10.1038/nmeth.3396
366 rdf:type schema:CreativeWork
367 sg:pub.10.1038/nmeth.4077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040324914
368 https://doi.org/10.1038/nmeth.4077
369 rdf:type schema:CreativeWork
370 sg:pub.10.1038/nrn1805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034212815
371 https://doi.org/10.1038/nrn1805
372 rdf:type schema:CreativeWork
373 grid-institutes:None schema:alternateName Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, University of Cambridge, Cambridge, CB2 0QQ UK
374 schema:name Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, University of Cambridge, Cambridge, CB2 0QQ UK
375 rdf:type schema:Organization
376 grid-institutes:grid.10306.34 schema:alternateName Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA UK
377 schema:name Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, University of Cambridge, Cambridge, CB2 0QQ UK
378 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA UK
379 rdf:type schema:Organization
380 grid-institutes:grid.120073.7 schema:alternateName Department of Psychiatry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, CB2 0QQ UK
381 schema:name Department of Psychiatry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, CB2 0QQ UK
382 Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB UK
383 rdf:type schema:Organization
384 grid-institutes:grid.1957.a schema:alternateName RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine, MTI2 Wendlingweg 2, D-52074 Aachen, Germany
385 schema:name European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI), Cambridge, CB10 1SD UK
386 European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
387 RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine, MTI2 Wendlingweg 2, D-52074 Aachen, Germany
388 rdf:type schema:Organization
389 grid-institutes:grid.214572.7 schema:alternateName Department of Pharmacology, University of Iowa, Iowa City, IA 52242 USA
390 schema:name Department of Pharmacology, University of Iowa, Iowa City, IA 52242 USA
391 rdf:type schema:Organization
392 grid-institutes:grid.5600.3 schema:alternateName School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AT UK
393 schema:name School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AT UK
394 rdf:type schema:Organization
395 grid-institutes:grid.7010.6 schema:alternateName Department of Experimental and Clinical Medicine, Center of Obesity, Università Politecnica delle Marche, 60126 Ancona, Italy
396 schema:name Department of Experimental and Clinical Medicine, Center of Obesity, Università Politecnica delle Marche, 60126 Ancona, Italy
397 rdf:type schema:Organization
398 grid-institutes:grid.8982.b schema:alternateName Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy
399 schema:name Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy
400 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...