Ontology type: schema:ScholarlyArticle Open Access: True
2018-12
AUTHORSAnna Aulicino, Kevin C. Rue-Albrecht, Lorena Preciado-Llanes, Giorgio Napolitani, Neil Ashley, Adam Cribbs, Jana Koth, B. Christoffer Lagerholm, Tim Ambrose, Melita A. Gordon, David Sims, Alison Simmons
ABSTRACTNon-typhoidal Salmonella (NTS) are highly prevalent food-borne pathogens. Recently, a highly invasive, multi-drug resistant S. Typhimurium, ST313, emerged as a major cause of bacteraemia in children and immunosuppressed adults, however the pathogenic mechanisms remain unclear. Here, we utilize invasive and non-invasive Salmonella strains combined with single-cell RNA-sequencing to study the transcriptome of individual infected and bystander monocyte-derived dendritic cells (MoDCs) implicated in disseminating invasive ST313. Compared with non-invasive Salmonella, ST313 directs a highly heterogeneous innate immune response. Bystander MoDCs exhibit a hyper-activated profile potentially diverting adaptive immunity away from infected cells. MoDCs harbouring invasive Salmonella display higher expression of IL10 and MARCH1 concomitant with lower expression of CD83 to evade adaptive immune detection. Finally, we demonstrate how these mechanisms conjointly restrain MoDC-mediated activation of Salmonella-specific CD4+ T cell clones. Here, we show how invasive ST313 exploits discrete evasion strategies within infected and bystander MoDCs to mediate its dissemination in vivo. More... »
PAGES4883
http://scigraph.springernature.com/pub.10.1038/s41467-018-07329-0
DOIhttp://dx.doi.org/10.1038/s41467-018-07329-0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1109934318
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30451854
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adaptive Immunity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antigens, CD",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bystander Effect",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "CD4-Positive T-Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Differentiation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Lineage",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dendritic Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Profiling",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immune Evasion",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunity, Innate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunoglobulins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Interleukin-10",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Membrane Glycoproteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Monocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Primary Cell Culture",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Salmonella typhimurium",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Signal Transduction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Single-Cell Analysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ubiquitin-Protein Ligases",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "John Radcliffe Hospital",
"id": "https://www.grid.ac/institutes/grid.8348.7",
"name": [
"MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS, Oxford, UK",
"Translational Gastroenterology Unit, John Radcliffe Hospital, Headington, OX3 9DU, Oxford, UK"
],
"type": "Organization"
},
"familyName": "Aulicino",
"givenName": "Anna",
"id": "sg:person.01306760660.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306760660.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Oxford",
"id": "https://www.grid.ac/institutes/grid.4991.5",
"name": [
"Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Headington, OX3 7FY, Oxford, UK"
],
"type": "Organization"
},
"familyName": "Rue-Albrecht",
"givenName": "Kevin C.",
"id": "sg:person.0655304214.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655304214.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "John Radcliffe Hospital",
"id": "https://www.grid.ac/institutes/grid.8348.7",
"name": [
"MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS, Oxford, UK",
"Translational Gastroenterology Unit, John Radcliffe Hospital, Headington, OX3 9DU, Oxford, UK"
],
"type": "Organization"
},
"familyName": "Preciado-Llanes",
"givenName": "Lorena",
"id": "sg:person.010610566051.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010610566051.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Oxford",
"id": "https://www.grid.ac/institutes/grid.4991.5",
"name": [
"MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS, Oxford, UK"
],
"type": "Organization"
},
"familyName": "Napolitani",
"givenName": "Giorgio",
"id": "sg:person.01266475744.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266475744.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Weatherall Institute of Molecular Medicine",
"id": "https://www.grid.ac/institutes/grid.421962.a",
"name": [
"MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford and BRC Blood Theme, NIHR Oxford Biomedical Centre, OX3 9DS, Oxford, UK"
],
"type": "Organization"
},
"familyName": "Ashley",
"givenName": "Neil",
"id": "sg:person.01031734313.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031734313.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Oxford",
"id": "https://www.grid.ac/institutes/grid.4991.5",
"name": [
"MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular medicine, University of Oxford, OX3 9DS, Oxford, UK"
],
"type": "Organization"
},
"familyName": "Cribbs",
"givenName": "Adam",
"id": "sg:person.0604273024.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604273024.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Oxford",
"id": "https://www.grid.ac/institutes/grid.4991.5",
"name": [
"MRC Human Immunology Unit and Wolfson Imaging Centre, MRC Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS, Oxford, UK"
],
"type": "Organization"
},
"familyName": "Koth",
"givenName": "Jana",
"id": "sg:person.015027002455.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015027002455.38"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Oxford",
"id": "https://www.grid.ac/institutes/grid.4991.5",
"name": [
"MRC Human Immunology Unit and Wolfson Imaging Centre, MRC Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS, Oxford, UK"
],
"type": "Organization"
},
"familyName": "Lagerholm",
"givenName": "B. Christoffer",
"id": "sg:person.0675113324.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675113324.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "John Radcliffe Hospital",
"id": "https://www.grid.ac/institutes/grid.8348.7",
"name": [
"MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS, Oxford, UK",
"Translational Gastroenterology Unit, John Radcliffe Hospital, Headington, OX3 9DU, Oxford, UK"
],
"type": "Organization"
},
"familyName": "Ambrose",
"givenName": "Tim",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Liverpool",
"id": "https://www.grid.ac/institutes/grid.10025.36",
"name": [
"Institute of Infection and Global Health, University of Liverpool, 8 W Derby St, L7 3EA, Liverpool, UK",
"Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi"
],
"type": "Organization"
},
"familyName": "Gordon",
"givenName": "Melita A.",
"id": "sg:person.0654763303.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654763303.80"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Oxford",
"id": "https://www.grid.ac/institutes/grid.4991.5",
"name": [
"MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular medicine, University of Oxford, OX3 9DS, Oxford, UK"
],
"type": "Organization"
},
"familyName": "Sims",
"givenName": "David",
"type": "Person"
},
{
"affiliation": {
"alternateName": "John Radcliffe Hospital",
"id": "https://www.grid.ac/institutes/grid.8348.7",
"name": [
"MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS, Oxford, UK",
"Translational Gastroenterology Unit, John Radcliffe Hospital, Headington, OX3 9DU, Oxford, UK"
],
"type": "Organization"
},
"familyName": "Simmons",
"givenName": "Alison",
"id": "sg:person.01065421251.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065421251.40"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1128/iai.72.3.1568-1579.2004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000307105"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/jvi.74.15.7127-7136.2000",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001480804"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gr.091017.109",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004356368"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3389/fcimb.2013.00024",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004470070"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20092203",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005169333"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0011453",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006768325"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrmicro3029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007428269",
"https://doi.org/10.1038/nrmicro3029"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmicrobiol.2016.206",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008457589",
"https://doi.org/10.1038/nmicrobiol.2016.206"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/sj.emboj.7601556",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008701720"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrmicro1126",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009188643",
"https://doi.org/10.1038/nrmicro1126"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrmicro1126",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009188643",
"https://doi.org/10.1038/nrmicro1126"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrmicro1126",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009188643",
"https://doi.org/10.1038/nrmicro1126"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/eji.200737902",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009469644"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/jvi.78.3.1109-1120.2004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012280627"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.immuni.2004.12.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012291843"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2015.08.027",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013931026"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13059-014-0550-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015222646",
"https://doi.org/10.1186/s13059-014-0550-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13059-014-0550-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015222646",
"https://doi.org/10.1186/s13059-014-0550-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/iai.70.10.5759-5769.2002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015836575"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.2967",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015866289",
"https://doi.org/10.1038/nmeth.2967"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.200906110",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016178317"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijmm.2016.10.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016229143"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04768",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016282305",
"https://doi.org/10.1038/nature04768"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04768",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016282305",
"https://doi.org/10.1038/nature04768"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1600-0463.2006.apm_465.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016604434"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nprot.2014.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017950805",
"https://doi.org/10.1038/nprot.2014.006"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2003-12-4350",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018679525"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gku555",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019442037"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/jvi.02327-06",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021757788"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/650733",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022147211"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1111959108",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022987444"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.immunol.18.1.767",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023617086"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri1745",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023688846",
"https://doi.org/10.1038/nri1745"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri1745",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023688846",
"https://doi.org/10.1038/nri1745"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.imlet.2007.05.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024302411"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0029968",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024350277"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1111/j.1440-1711.2006.01461.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026289158",
"https://doi.org/10.1111/j.1440-1711.2006.01461.x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.179.6.3622",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027640934"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35101614",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028123916",
"https://doi.org/10.1038/35101614"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35101614",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028123916",
"https://doi.org/10.1038/35101614"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.chom.2016.10.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028329548"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0056705",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028564578"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0906735106",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028652768"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(11)61752-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029095686"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev-genet-102209-163607",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030772154"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20122695",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030836574"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev-immunol-020711-074929",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031897463"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1521-4141(199910)29:10<3245::aid-immu3245>3.0.co;2-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034886875"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1521-4141(199910)29:10<3245::aid-immu3245>3.0.co;2-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034886875"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12172",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035006736",
"https://doi.org/10.1038/nature12172"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.ppat.1004049",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036028422"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.chom.2012.09.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036784529"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2567.2012.03614.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040978830"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cyto.2012.03.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041532123"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m211285200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045707829"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature13437",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048753935",
"https://doi.org/10.1038/nature13437"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/fpd.2010.0787",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059262014"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/bioinformatics/btv715",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059414589"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/hmg/ddt570",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059645590"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.12688/f1000research.9501.2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064612874"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3855/jidc.3328",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071482623"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074525187",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074558492",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.165.3.1506",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074670873"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.169.9.4770",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1075178036"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.169.10.5638",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1075187647"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.173.3.1934",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1076868457"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.174.5.2892",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077011888"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.176.5.3000",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077192111"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.178.1.338",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077339975"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.178.9.5454",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077405642"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3389/fmicb.2017.00119",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083407005"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.chom.2017.01.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083737678"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/icb.2017.44",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085727901",
"https://doi.org/10.1038/icb.2017.44"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri.2017.76",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091079764",
"https://doi.org/10.1038/nri.2017.76"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13059-017-1340-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092409644",
"https://doi.org/10.1186/s13059-017-1340-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41590-018-0133-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1104611824",
"https://doi.org/10.1038/s41590-018-0133-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41590-018-0133-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1104611824",
"https://doi.org/10.1038/s41590-018-0133-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41590-018-0133-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1104611824",
"https://doi.org/10.1038/s41590-018-0133-z"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-12",
"datePublishedReg": "2018-12-01",
"description": "Non-typhoidal Salmonella (NTS) are highly prevalent food-borne pathogens. Recently, a highly invasive, multi-drug resistant S. Typhimurium, ST313, emerged as a major cause of bacteraemia in children and immunosuppressed adults, however the pathogenic mechanisms remain unclear. Here, we utilize invasive and non-invasive Salmonella strains combined with single-cell RNA-sequencing to study the transcriptome of individual infected and bystander monocyte-derived dendritic cells (MoDCs) implicated in disseminating invasive ST313. Compared with non-invasive Salmonella, ST313 directs a highly heterogeneous innate immune response. Bystander MoDCs exhibit a hyper-activated profile potentially diverting adaptive immunity away from infected cells. MoDCs harbouring invasive Salmonella display higher expression of IL10 and MARCH1 concomitant with lower expression of CD83 to evade adaptive immune detection. Finally, we demonstrate how these mechanisms conjointly restrain MoDC-mediated activation of Salmonella-specific CD4+ T cell clones. Here, we show how invasive ST313 exploits discrete evasion strategies within infected and bystander MoDCs to mediate its dissemination in vivo.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41467-018-07329-0",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.4599153",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.4598877",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2768229",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.4106871",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.7158981",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2762985",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1043282",
"issn": [
"2041-1723"
],
"name": "Nature Communications",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "9"
}
],
"name": "Invasive Salmonella exploits divergent immune evasion strategies in infected and bystander dendritic cell subsets",
"pagination": "4883",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"8a1c9b527c8f48cf8e264744fb7e3a0d9a72917694bf32ec12e8b9f9ebce7b89"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30451854"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101528555"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41467-018-07329-0"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1109934318"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41467-018-07329-0",
"https://app.dimensions.ai/details/publication/pub.1109934318"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T11:05",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000352_0000000352/records_60367_00000003.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41467-018-07329-0"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07329-0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07329-0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07329-0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07329-0'
This table displays all metadata directly associated to this object as RDF triples.
477 TRIPLES
21 PREDICATES
120 URIs
42 LITERALS
30 BLANK NODES