Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Etienne Boulter, Soline Estrach, Floriane S. Tissot, Marco L. Hennrich, Lionel Tosello, Laurence Cailleteau, Laura R. de la Ballina, Sabrina Pisano, Anne-Claude Gavin, Chloé C. Féral

ABSTRACT

Mechanical and metabolic cues independently contribute to the regulation of cell and tissue homeostasis. However, how they cross-regulate each other during this process remains largely unknown. Here, we show that cellular metabolism can regulate integrin rigidity-sensing via the sphingolipid metabolic pathway controlled by the amino acid transporter and integrin coreceptor CD98hc (SLC3A2). Genetic invalidation of CD98hc in dermal cells and tissue impairs rigidity sensing and mechanical signaling downstream of integrins, including RhoA activation, resulting in aberrant tissue mechanical homeostasis. Unexpectedly, we found that this regulation does not occur directly through regulation of integrins by CD98hc but indirectly, via the regulation of sphingolipid synthesis and the delta-4-desaturase DES2. Loss of CD98hc decreases sphingolipid availability preventing proper membrane recruitment, shuttling and activation of upstream regulators of RhoA including Src kinases and GEF-H1. Altogether, our results unravel a novel cross-talk regulation between integrin mechanosensing and cellular metabolism which may constitute an important new regulatory framework contributing to mechanical homeostasis. More... »

PAGES

4862

References to SciGraph publications

  • 2017-11-22. Sphingolipids and their metabolism in physiology and disease in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2015-05. YAP is essential for tissue tension to ensure vertebrate 3D body shape in NATURE
  • 2014-07. The Nano-Scale Mechanical Properties of the Extracellular Matrix Regulate Dermal Fibroblast Function in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2016-08. Changes in membrane sphingolipid composition modulate dynamics and adhesion of integrin nanoclusters in SCIENTIFIC REPORTS
  • 2013-06. β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments in NATURE CELL BIOLOGY
  • 2011-06. The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins in NATURE CELL BIOLOGY
  • 2009-02. A tense situation: forcing tumour progression in NATURE REVIEWS CANCER
  • 2009-01. Environmental sensing through focal adhesions in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2009-01. Mechanotransduction gone awry in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2010-07. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics in NATURE
  • 2004-02. CATs and HATs: the SLC7 family of amino acid transporters in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2002-04. Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton in NATURE CELL BIOLOGY
  • 2015-07. Traction microscopy to identify force modulation in subresolution adhesions in NATURE METHODS
  • 2014-04. Metabolic control of YAP and TAZ by the mevalonate pathway in NATURE CELL BIOLOGY
  • 2011-06. Role of YAP/TAZ in mechanotransduction in NATURE
  • 1998-09. Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family in NATURE
  • 2011-07. Dynamic molecular processes mediate cellular mechanotransduction in NATURE
  • 2017-06. Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK in NATURE CELL BIOLOGY
  • 2017-12. Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol in SCIENTIFIC REPORTS
  • 1997-11. Complementation of dominant suppression implicates CD98 in integrin activation in NATURE
  • 2014-04. The integrin adhesome: from genes and proteins to human disease in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2011-05. Balancing forces: architectural control of mechanotransduction in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-07268-w

    DOI

    http://dx.doi.org/10.1038/s41467-018-07268-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1109934302

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30451822


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