Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-11-07

AUTHORS

A. N. Niemeijer, D. Leung, M. C. Huisman, I. Bahce, O. S. Hoekstra, G. A. M. S. van Dongen, R. Boellaard, S. Du, W. Hayes, R. Smith, A. D. Windhorst, N. H. Hendrikse, A. Poot, D. J. Vugts, E. Thunnissen, P. Morin, D. Lipovsek, D. J. Donnelly, S. J. Bonacorsi, L. M. Velasquez, T. D. de Gruijl, E. F. Smit, A. J. de Langen

ABSTRACT

PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L)1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor lesions. More... »

PAGES

4664

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-07131-y

DOI

http://dx.doi.org/10.1038/s41467-018-07131-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107969592

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30405135


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