Tissue-resident memory T cells populate the human brain View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Joost Smolders, Kirstin M. Heutinck, Nina L. Fransen, Ester B. M. Remmerswaal, Pleun Hombrink, Ineke J. M. ten Berge, René A. W. van Lier, Inge Huitinga, Jörg Hamann

ABSTRACT

Most tissues are populated by tissue-resident memory T cells (TRM cells), which are adapted to their niche and appear to be indispensable for local protection against pathogens. Here we show that human white matter-derived brain CD8+ T cells can be subsetted into CD103-CD69+ and CD103+CD69+ T cells both with a phenotypic and transcription factor profile consistent with TRM cells. Specifically, CD103 expression in brain CD8+ T cells correlates with reduced expression of differentiation markers, increased expression of tissue-homing chemokine receptors, intermediate and low expression of the transcription factors T-bet and eomes, increased expression of PD-1 and CTLA-4, and low expression of cytolytic enzymes with preserved polyfunctionality upon activation. Brain CD4+ T cells also display TRM cell-associated markers but have low CD103 expression. We conclude that the human brain is surveilled by TRM cells, providing protection against neurotropic virus reactivation, whilst being under tight control of key immune checkpoint molecules. More... »

PAGES

4593

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-07053-9

DOI

http://dx.doi.org/10.1038/s41467-018-07053-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107912915

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30389931


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Canisius-Wilhelmina Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.413327.0", 
          "name": [
            "Department of Neuroimmunology, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105BA, Amsterdam, The Netherlands", 
            "Department of Neurology, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532SZ, Nijmegen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smolders", 
        "givenName": "Joost", 
        "id": "sg:person.01221545470.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221545470.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heutinck", 
        "givenName": "Kirstin M.", 
        "id": "sg:person.0715562371.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715562371.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Netherlands Institute for Neuroscience", 
          "id": "https://www.grid.ac/institutes/grid.419918.c", 
          "name": [
            "Department of Neuroimmunology, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105BA, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fransen", 
        "givenName": "Nina L.", 
        "id": "sg:person.0762622630.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762622630.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands", 
            "Renal Transplant Unit, Department of Internal Medicine, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Remmerswaal", 
        "givenName": "Ester B. M.", 
        "id": "sg:person.012005771227.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012005771227.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hombrink", 
        "givenName": "Pleun", 
        "id": "sg:person.0602622044.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602622044.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands", 
            "Renal Transplant Unit, Department of Internal Medicine, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berge", 
        "givenName": "Ineke J. M. ten", 
        "id": "sg:person.010717653025.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010717653025.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Lier", 
        "givenName": "Ren\u00e9 A. W.", 
        "id": "sg:person.013000452177.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013000452177.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Netherlands Institute for Neuroscience", 
          "id": "https://www.grid.ac/institutes/grid.419918.c", 
          "name": [
            "Department of Neuroimmunology, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105BA, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huitinga", 
        "givenName": "Inge", 
        "id": "sg:person.0743474773.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743474773.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Department of Neuroimmunology, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105BA, Amsterdam, The Netherlands", 
            "Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamann", 
        "givenName": "J\u00f6rg", 
        "id": "sg:person.01202175473.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202175473.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/356063a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001855171", 
          "https://doi.org/10.1038/356063a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1100943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004871446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1201305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004937477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005772959", 
          "https://doi.org/10.1038/nm.3883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2012.09.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007515041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.24715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007516209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009352257", 
          "https://doi.org/10.1038/nri2971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(03)00112-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010322205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1301390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011171761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2016.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011368175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1249547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011751463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci44675", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014252008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.22370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014857410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1254803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015059253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1254803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015059253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cr.7310017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015913411", 
          "https://doi.org/10.1038/sj.cr.7310017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cr.7310017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015913411", 
          "https://doi.org/10.1038/sj.cr.7310017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016124947", 
          "https://doi.org/10.1038/nri3307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.03478-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016175363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mi.2013.67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017330938", 
          "https://doi.org/10.1038/mi.2013.67"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.171.1.368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018540161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.3589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018745068", 
          "https://doi.org/10.1038/ni.3589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1101612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018877885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018921903", 
          "https://doi.org/10.1038/nprot.2006.268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018921903", 
          "https://doi.org/10.1038/nprot.2006.268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2015.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021550062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.168.11.5954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021655786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1433000100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023553864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2015.12.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023640634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1403243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024201442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.173.3.1834", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025697950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026706357", 
          "https://doi.org/10.1038/nmeth.2019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri.2015.3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028021210", 
          "https://doi.org/10.1038/nri.2015.3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1010201107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028187076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031134420", 
          "https://doi.org/10.1038/nri3265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.21158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031457597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2016.10.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032076002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20121517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033092638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2014.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033776903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-9-268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034460137", 
          "https://doi.org/10.1186/1742-2094-9-268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.09.082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034669747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.09.082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034669747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.03.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035995346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2326-6066.cir-15-0035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036095267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038410936", 
          "https://doi.org/10.1038/nri3108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20142237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038520844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.2744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039054258", 
          "https://doi.org/10.1038/ni.2744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-013-1155-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043485029", 
          "https://doi.org/10.1007/s00401-013-1155-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2015.05.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043501297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0610847104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043508369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20151916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043851746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aad2035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043917777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2011.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046304867", 
          "https://doi.org/10.1038/cdd.2011.5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.05-5022fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047459485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00702-014-1353-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048322950", 
          "https://doi.org/10.1007/s00702-014-1353-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00702-014-1353-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048322950", 
          "https://doi.org/10.1007/s00702-014-1353-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00702-014-1353-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048322950", 
          "https://doi.org/10.1007/s00702-014-1353-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0211092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048608679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.186.9.1407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058438620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.jnen.0000173894.09553.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060330599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2326-6066.cir-15-0141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063282524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000002594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064353492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000002594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064353492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000002594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064353492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.164.4.1705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074584600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2017.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083830276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2017.00335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084433109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1006318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084842087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-017-1744-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086070526", 
          "https://doi.org/10.1007/s00401-017-1744-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-017-1744-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086070526", 
          "https://doi.org/10.1007/s00401-017-1744-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-06352-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090754925", 
          "https://doi.org/10.1038/s41598-017-06352-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-06352-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090754925", 
          "https://doi.org/10.1038/s41598-017-06352-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaneurol.2017.1912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091545241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2017.08.078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091858541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mi.2017.94", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092689584", 
          "https://doi.org/10.1038/mi.2017.94"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-017-01689-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092756079", 
          "https://doi.org/10.1038/s41467-017-01689-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12859-017-1934-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093055870", 
          "https://doi.org/10.1186/s12859-017-1934-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-444-63639-3.00005-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101220435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.201847526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101319043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.201847526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101319043"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Most tissues are populated by tissue-resident memory T cells (TRM cells), which are adapted to their niche and appear to be indispensable for local protection against pathogens. Here we show that human white matter-derived brain CD8+ T cells can be subsetted into CD103-CD69+ and CD103+CD69+ T cells both with a phenotypic and transcription factor profile consistent with TRM cells. Specifically, CD103 expression in brain CD8+ T cells correlates with reduced expression of differentiation markers, increased expression of tissue-homing chemokine receptors, intermediate and low expression of the transcription factors T-bet and eomes, increased expression of PD-1 and CTLA-4, and low expression of cytolytic enzymes with preserved polyfunctionality upon activation. Brain CD4+ T cells also display TRM cell-associated markers but have low CD103 expression. We conclude that the human brain is surveilled by TRM cells, providing protection against neurotropic virus reactivation, whilst being under tight control of key immune checkpoint molecules.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-018-07053-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Tissue-resident memory T cells populate the human brain", 
    "pagination": "4593", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bf0ec837bad1d2d9785cacb5ac3874c8438350561356e99a43e09a7e6dab7c87"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30389931"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-018-07053-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107912915"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-018-07053-9", 
      "https://app.dimensions.ai/details/publication/pub.1107912915"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000610.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-018-07053-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07053-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07053-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07053-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-07053-9'


 

This table displays all metadata directly associated to this object as RDF triples.

363 TRIPLES      21 PREDICATES      98 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-018-07053-9 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author Nb5f3405046a44db4ad8f257166a5c901
4 schema:citation sg:pub.10.1007/s00401-013-1155-0
5 sg:pub.10.1007/s00401-017-1744-4
6 sg:pub.10.1007/s00702-014-1353-5
7 sg:pub.10.1038/356063a0
8 sg:pub.10.1038/cdd.2011.5
9 sg:pub.10.1038/mi.2013.67
10 sg:pub.10.1038/mi.2017.94
11 sg:pub.10.1038/ni.2744
12 sg:pub.10.1038/ni.3589
13 sg:pub.10.1038/nm.3883
14 sg:pub.10.1038/nmeth.2019
15 sg:pub.10.1038/nprot.2006.268
16 sg:pub.10.1038/nri.2015.3
17 sg:pub.10.1038/nri2971
18 sg:pub.10.1038/nri3108
19 sg:pub.10.1038/nri3265
20 sg:pub.10.1038/nri3307
21 sg:pub.10.1038/s41467-017-01689-9
22 sg:pub.10.1038/s41598-017-06352-3
23 sg:pub.10.1038/sj.cr.7310017
24 sg:pub.10.1186/1742-2094-9-268
25 sg:pub.10.1186/s12859-017-1934-z
26 https://doi.org/10.1001/jamaneurol.2017.1912
27 https://doi.org/10.1002/ana.24715
28 https://doi.org/10.1002/eji.201847526
29 https://doi.org/10.1002/glia.21158
30 https://doi.org/10.1002/glia.22370
31 https://doi.org/10.1016/b978-0-444-63639-3.00005-0
32 https://doi.org/10.1016/j.cell.2015.03.031
33 https://doi.org/10.1016/j.celrep.2015.09.082
34 https://doi.org/10.1016/j.celrep.2017.08.078
35 https://doi.org/10.1016/j.immuni.2012.09.020
36 https://doi.org/10.1016/j.immuni.2014.12.007
37 https://doi.org/10.1016/j.immuni.2015.05.023
38 https://doi.org/10.1016/j.immuni.2015.11.008
39 https://doi.org/10.1016/j.immuni.2016.07.007
40 https://doi.org/10.1016/j.immuni.2016.10.026
41 https://doi.org/10.1016/j.immuni.2017.01.009
42 https://doi.org/10.1016/j.it.2015.12.008
43 https://doi.org/10.1016/s1074-7613(03)00112-2
44 https://doi.org/10.1073/pnas.0610847104
45 https://doi.org/10.1073/pnas.1010201107
46 https://doi.org/10.1073/pnas.1433000100
47 https://doi.org/10.1084/jem.186.9.1407
48 https://doi.org/10.1084/jem.20121517
49 https://doi.org/10.1084/jem.20142237
50 https://doi.org/10.1084/jem.20151916
51 https://doi.org/10.1096/fj.05-5022fje
52 https://doi.org/10.1097/01.jnen.0000173894.09553.13
53 https://doi.org/10.1126/science.1249547
54 https://doi.org/10.1126/science.1254803
55 https://doi.org/10.1126/science.aad2035
56 https://doi.org/10.1128/jvi.03478-14
57 https://doi.org/10.1158/2326-6066.cir-15-0035
58 https://doi.org/10.1158/2326-6066.cir-15-0141
59 https://doi.org/10.1172/jci44675
60 https://doi.org/10.1189/jlb.0211092
61 https://doi.org/10.1212/wnl.0000000000002594
62 https://doi.org/10.1371/journal.ppat.1006318
63 https://doi.org/10.3389/fimmu.2017.00335
64 https://doi.org/10.4049/jimmunol.1100943
65 https://doi.org/10.4049/jimmunol.1101612
66 https://doi.org/10.4049/jimmunol.1201305
67 https://doi.org/10.4049/jimmunol.1301390
68 https://doi.org/10.4049/jimmunol.1403243
69 https://doi.org/10.4049/jimmunol.164.4.1705
70 https://doi.org/10.4049/jimmunol.168.11.5954
71 https://doi.org/10.4049/jimmunol.171.1.368
72 https://doi.org/10.4049/jimmunol.173.3.1834
73 schema:datePublished 2018-12
74 schema:datePublishedReg 2018-12-01
75 schema:description Most tissues are populated by tissue-resident memory T cells (T<sub>RM</sub> cells), which are adapted to their niche and appear to be indispensable for local protection against pathogens. Here we show that human white matter-derived brain CD8<sup>+</sup> T cells can be subsetted into CD103<sup>-</sup>CD69<sup>+</sup> and CD103<sup>+</sup>CD69<sup>+</sup> T cells both with a phenotypic and transcription factor profile consistent with T<sub>RM</sub> cells. Specifically, CD103 expression in brain CD8<sup>+</sup> T cells correlates with reduced expression of differentiation markers, increased expression of tissue-homing chemokine receptors, intermediate and low expression of the transcription factors T-bet and eomes, increased expression of PD-1 and CTLA-4, and low expression of cytolytic enzymes with preserved polyfunctionality upon activation. Brain CD4<sup>+</sup> T cells also display T<sub>RM</sub> cell-associated markers but have low CD103 expression. We conclude that the human brain is surveilled by T<sub>RM</sub> cells, providing protection against neurotropic virus reactivation, whilst being under tight control of key immune checkpoint molecules.
76 schema:genre research_article
77 schema:inLanguage en
78 schema:isAccessibleForFree true
79 schema:isPartOf N0cf1f224edbd4a8398912bbed40fb086
80 N12096c9f82d9463697d670fff662d6b6
81 sg:journal.1043282
82 schema:name Tissue-resident memory T cells populate the human brain
83 schema:pagination 4593
84 schema:productId N0d7375c1655b49afb4575ec3c9b754f4
85 N56a42990489e45f9aff648ea744f865a
86 N6b55f3a4611b4a35a2ae7194b38bb426
87 Nafa8d6961c0c475d9bcfe84b5556ef20
88 Nf58ae5fda3f44b32a5634c07cb93b876
89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107912915
90 https://doi.org/10.1038/s41467-018-07053-9
91 schema:sdDatePublished 2019-04-10T15:15
92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
93 schema:sdPublisher N09d862ab9ae841e5b535e1ab0ca42ce2
94 schema:url https://www.nature.com/articles/s41467-018-07053-9
95 sgo:license sg:explorer/license/
96 sgo:sdDataset articles
97 rdf:type schema:ScholarlyArticle
98 N09d862ab9ae841e5b535e1ab0ca42ce2 schema:name Springer Nature - SN SciGraph project
99 rdf:type schema:Organization
100 N0cf1f224edbd4a8398912bbed40fb086 schema:issueNumber 1
101 rdf:type schema:PublicationIssue
102 N0d7375c1655b49afb4575ec3c9b754f4 schema:name dimensions_id
103 schema:value pub.1107912915
104 rdf:type schema:PropertyValue
105 N12096c9f82d9463697d670fff662d6b6 schema:volumeNumber 9
106 rdf:type schema:PublicationVolume
107 N1225222a792541919c6efa329f12736e rdf:first sg:person.0602622044.44
108 rdf:rest N51d7f26543e94fa2a10d3cd6c05d4e2a
109 N2d0c5778302e4224969a09e3addc9f8f rdf:first sg:person.013000452177.04
110 rdf:rest N537087ec88ec4c8bbaffb6ce7b416f74
111 N51d7f26543e94fa2a10d3cd6c05d4e2a rdf:first sg:person.010717653025.76
112 rdf:rest N2d0c5778302e4224969a09e3addc9f8f
113 N537087ec88ec4c8bbaffb6ce7b416f74 rdf:first sg:person.0743474773.54
114 rdf:rest Nb2db75a6d495486781259c7b3a4b2fdf
115 N56a42990489e45f9aff648ea744f865a schema:name nlm_unique_id
116 schema:value 101528555
117 rdf:type schema:PropertyValue
118 N6b55f3a4611b4a35a2ae7194b38bb426 schema:name readcube_id
119 schema:value bf0ec837bad1d2d9785cacb5ac3874c8438350561356e99a43e09a7e6dab7c87
120 rdf:type schema:PropertyValue
121 Nafa8d6961c0c475d9bcfe84b5556ef20 schema:name pubmed_id
122 schema:value 30389931
123 rdf:type schema:PropertyValue
124 Nb2db75a6d495486781259c7b3a4b2fdf rdf:first sg:person.01202175473.50
125 rdf:rest rdf:nil
126 Nb39ecc35c4284ffb9794d01c04759714 rdf:first sg:person.0715562371.94
127 rdf:rest Nc8d162d8043f4057b8304063794d3562
128 Nb5f3405046a44db4ad8f257166a5c901 rdf:first sg:person.01221545470.88
129 rdf:rest Nb39ecc35c4284ffb9794d01c04759714
130 Nc8d162d8043f4057b8304063794d3562 rdf:first sg:person.0762622630.20
131 rdf:rest Nf8e014ec17e644c28a418bddb6ce49be
132 Nf58ae5fda3f44b32a5634c07cb93b876 schema:name doi
133 schema:value 10.1038/s41467-018-07053-9
134 rdf:type schema:PropertyValue
135 Nf8e014ec17e644c28a418bddb6ce49be rdf:first sg:person.012005771227.05
136 rdf:rest N1225222a792541919c6efa329f12736e
137 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
138 schema:name Medical and Health Sciences
139 rdf:type schema:DefinedTerm
140 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
141 schema:name Immunology
142 rdf:type schema:DefinedTerm
143 sg:journal.1043282 schema:issn 2041-1723
144 schema:name Nature Communications
145 rdf:type schema:Periodical
146 sg:person.010717653025.76 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
147 schema:familyName Berge
148 schema:givenName Ineke J. M. ten
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010717653025.76
150 rdf:type schema:Person
151 sg:person.012005771227.05 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
152 schema:familyName Remmerswaal
153 schema:givenName Ester B. M.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012005771227.05
155 rdf:type schema:Person
156 sg:person.01202175473.50 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
157 schema:familyName Hamann
158 schema:givenName Jörg
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202175473.50
160 rdf:type schema:Person
161 sg:person.01221545470.88 schema:affiliation https://www.grid.ac/institutes/grid.413327.0
162 schema:familyName Smolders
163 schema:givenName Joost
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221545470.88
165 rdf:type schema:Person
166 sg:person.013000452177.04 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
167 schema:familyName van Lier
168 schema:givenName René A. W.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013000452177.04
170 rdf:type schema:Person
171 sg:person.0602622044.44 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
172 schema:familyName Hombrink
173 schema:givenName Pleun
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602622044.44
175 rdf:type schema:Person
176 sg:person.0715562371.94 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
177 schema:familyName Heutinck
178 schema:givenName Kirstin M.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715562371.94
180 rdf:type schema:Person
181 sg:person.0743474773.54 schema:affiliation https://www.grid.ac/institutes/grid.419918.c
182 schema:familyName Huitinga
183 schema:givenName Inge
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743474773.54
185 rdf:type schema:Person
186 sg:person.0762622630.20 schema:affiliation https://www.grid.ac/institutes/grid.419918.c
187 schema:familyName Fransen
188 schema:givenName Nina L.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762622630.20
190 rdf:type schema:Person
191 sg:pub.10.1007/s00401-013-1155-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043485029
192 https://doi.org/10.1007/s00401-013-1155-0
193 rdf:type schema:CreativeWork
194 sg:pub.10.1007/s00401-017-1744-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086070526
195 https://doi.org/10.1007/s00401-017-1744-4
196 rdf:type schema:CreativeWork
197 sg:pub.10.1007/s00702-014-1353-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048322950
198 https://doi.org/10.1007/s00702-014-1353-5
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/356063a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001855171
201 https://doi.org/10.1038/356063a0
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/cdd.2011.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046304867
204 https://doi.org/10.1038/cdd.2011.5
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/mi.2013.67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017330938
207 https://doi.org/10.1038/mi.2013.67
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/mi.2017.94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092689584
210 https://doi.org/10.1038/mi.2017.94
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/ni.2744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039054258
213 https://doi.org/10.1038/ni.2744
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/ni.3589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018745068
216 https://doi.org/10.1038/ni.3589
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/nm.3883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005772959
219 https://doi.org/10.1038/nm.3883
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/nmeth.2019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026706357
222 https://doi.org/10.1038/nmeth.2019
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/nprot.2006.268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018921903
225 https://doi.org/10.1038/nprot.2006.268
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/nri.2015.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028021210
228 https://doi.org/10.1038/nri.2015.3
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/nri2971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009352257
231 https://doi.org/10.1038/nri2971
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/nri3108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038410936
234 https://doi.org/10.1038/nri3108
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/nri3265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031134420
237 https://doi.org/10.1038/nri3265
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/nri3307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016124947
240 https://doi.org/10.1038/nri3307
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/s41467-017-01689-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092756079
243 https://doi.org/10.1038/s41467-017-01689-9
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/s41598-017-06352-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090754925
246 https://doi.org/10.1038/s41598-017-06352-3
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/sj.cr.7310017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015913411
249 https://doi.org/10.1038/sj.cr.7310017
250 rdf:type schema:CreativeWork
251 sg:pub.10.1186/1742-2094-9-268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034460137
252 https://doi.org/10.1186/1742-2094-9-268
253 rdf:type schema:CreativeWork
254 sg:pub.10.1186/s12859-017-1934-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1093055870
255 https://doi.org/10.1186/s12859-017-1934-z
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1001/jamaneurol.2017.1912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091545241
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1002/ana.24715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007516209
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1002/eji.201847526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101319043
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1002/glia.21158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031457597
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/glia.22370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014857410
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/b978-0-444-63639-3.00005-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101220435
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.cell.2015.03.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035995346
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.celrep.2015.09.082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034669747
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.celrep.2017.08.078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091858541
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.immuni.2012.09.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007515041
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.immuni.2014.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033776903
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.immuni.2015.05.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043501297
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.immuni.2015.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021550062
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.immuni.2016.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011368175
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.immuni.2016.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032076002
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.immuni.2017.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083830276
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.it.2015.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023640634
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/s1074-7613(03)00112-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010322205
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1073/pnas.0610847104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043508369
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1073/pnas.1010201107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028187076
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1073/pnas.1433000100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023553864
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1084/jem.186.9.1407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058438620
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1084/jem.20121517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033092638
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1084/jem.20142237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038520844
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1084/jem.20151916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043851746
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1096/fj.05-5022fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1047459485
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1097/01.jnen.0000173894.09553.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060330599
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1126/science.1249547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011751463
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1126/science.1254803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015059253
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1126/science.aad2035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043917777
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1128/jvi.03478-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016175363
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1158/2326-6066.cir-15-0035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036095267
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1158/2326-6066.cir-15-0141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063282524
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1172/jci44675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014252008
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1189/jlb.0211092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048608679
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1212/wnl.0000000000002594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064353492
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1371/journal.ppat.1006318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084842087
330 rdf:type schema:CreativeWork
331 https://doi.org/10.3389/fimmu.2017.00335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084433109
332 rdf:type schema:CreativeWork
333 https://doi.org/10.4049/jimmunol.1100943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004871446
334 rdf:type schema:CreativeWork
335 https://doi.org/10.4049/jimmunol.1101612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018877885
336 rdf:type schema:CreativeWork
337 https://doi.org/10.4049/jimmunol.1201305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004937477
338 rdf:type schema:CreativeWork
339 https://doi.org/10.4049/jimmunol.1301390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011171761
340 rdf:type schema:CreativeWork
341 https://doi.org/10.4049/jimmunol.1403243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024201442
342 rdf:type schema:CreativeWork
343 https://doi.org/10.4049/jimmunol.164.4.1705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074584600
344 rdf:type schema:CreativeWork
345 https://doi.org/10.4049/jimmunol.168.11.5954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021655786
346 rdf:type schema:CreativeWork
347 https://doi.org/10.4049/jimmunol.171.1.368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018540161
348 rdf:type schema:CreativeWork
349 https://doi.org/10.4049/jimmunol.173.3.1834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025697950
350 rdf:type schema:CreativeWork
351 https://www.grid.ac/institutes/grid.413327.0 schema:alternateName Canisius-Wilhelmina Ziekenhuis
352 schema:name Department of Neuroimmunology, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105BA, Amsterdam, The Netherlands
353 Department of Neurology, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532SZ, Nijmegen, The Netherlands
354 rdf:type schema:Organization
355 https://www.grid.ac/institutes/grid.419918.c schema:alternateName Netherlands Institute for Neuroscience
356 schema:name Department of Neuroimmunology, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105BA, Amsterdam, The Netherlands
357 rdf:type schema:Organization
358 https://www.grid.ac/institutes/grid.7177.6 schema:alternateName University of Amsterdam
359 schema:name Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands
360 Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands
361 Department of Neuroimmunology, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105BA, Amsterdam, The Netherlands
362 Renal Transplant Unit, Department of Internal Medicine, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands
363 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...