Programming molecular topologies from single-stranded nucleic acids View Full Text


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Article Info

DATE

2018-11-02

AUTHORS

Xiaodong Qi, Fei Zhang, Zhaoming Su, Shuoxing Jiang, Dongran Han, Baoquan Ding, Yan Liu, Wah Chiu, Peng Yin, Hao Yan

ABSTRACT

Molecular knots represent one of the most extraordinary topological structures in biological polymers. Creating highly knotted nanostructures with well-defined and sophisticated geometries and topologies remains challenging. Here, we demonstrate a general strategy to design and construct highly knotted nucleic acid nanostructures, each weaved from a single-stranded DNA or RNA chain by hierarchical folding in a prescribed order. Sets of DNA and RNA knots of two- or three-dimensional shapes have been designed and constructed (ranging from 1700 to 7500 nucleotides), and they exhibit complex topological features, with high crossing numbers (from 9 up to 57). These single-stranded DNA/RNA knots can be replicated and amplified enzymatically in vitro and in vivo. This work establishes a general platform for constructing nucleic acid nanostructures with complex molecular topologies. More... »

PAGES

4579

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-07039-7

DOI

http://dx.doi.org/10.1038/s41467-018-07039-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107912911

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30389935


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