A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Shin Murai, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Mai Yamagishi, Ryodai Shindo, Joanne M. Hildebrand, Ryosuke Miura, Osamu Nakabayashi, Mamoru Totsuka, Taichiro Tomida, Satomi Adachi-Akahane, Sotaro Uemura, John Silke, Hideo Yagita, Masayuki Miura, Hiroyasu Nakano

ABSTRACT

Necroptosis is a regulated form of necrosis that depends on receptor-interacting protein kinase (RIPK)3 and mixed lineage kinase domain-like (MLKL). While danger-associated molecular pattern (DAMP)s are involved in various pathological conditions and released from dead cells, the underlying mechanisms are not fully understood. Here we develop a fluorescence resonance energy transfer (FRET) biosensor, termed SMART (a sensor for MLKL activation by RIPK3 based on FRET). SMART is composed of a fragment of MLKL and monitors necroptosis, but not apoptosis or necrosis. Mechanistically, SMART monitors plasma membrane translocation of oligomerized MLKL, which is induced by RIPK3 or mutational activation. SMART in combination with imaging of the release of nuclear DAMPs and Live-Cell Imaging for Secretion activity (LCI-S) reveals two different modes of the release of High Mobility Group Box 1 from necroptotic cells. Thus, SMART and LCI-S uncover novel regulation of the release of DAMPs during necroptosis. More... »

PAGES

4457

References to SciGraph publications

  • 2015-01. Necroptosis and its role in inflammation in NATURE
  • 2015-08. Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells in SCIENTIFIC REPORTS
  • 2015-10. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling in NATURE
  • 2012-01. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 in CELL DEATH & DIFFERENTIATION
  • 2014-12. Mechanism of Ca2+-triggered ESCRT assembly and regulation of cell membrane repair in NATURE COMMUNICATIONS
  • 2017-01-03. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death in NATURE COMMUNICATIONS
  • 2002-07. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation in NATURE
  • 2007-03. HMGB1 modulates inflammatory responses in LPS-activated macrophages in INFLAMMATION RESEARCH
  • 2001-02. Imaging FRET between spectrally similar GFP molecules in single cells in NATURE BIOTECHNOLOGY
  • 2016-01. Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis in CELL DEATH & DIFFERENTIATION
  • 2015-10. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death in NATURE
  • 2011-06. Interleukin-33 biology with potential insights into human diseases in NATURE REVIEWS RHEUMATOLOGY
  • 2017-07. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin in NATURE
  • 2015-05. Real-time single-cell imaging of protein secretion in SCIENTIFIC REPORTS
  • 2015. Cellular FLICE-Inhibitory Protein Regulates Tissue Homeostasis in APOPTOTIC AND NON-APOPTOTIC CELL DEATH
  • 2018-12. Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis in NATURE COMMUNICATIONS
  • 2016-02. Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it in CELL DEATH & DIFFERENTIATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-06985-6

    DOI

    http://dx.doi.org/10.1038/s41467-018-06985-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107771864

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30367066


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