Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Julius Gudmundsson, Jon K. Sigurdsson, Lilja Stefansdottir, Bjarni A. Agnarsson, Helgi J. Isaksson, Olafur A. Stefansson, Sigurjon A. Gudjonsson, Daniel F. Gudbjartsson, Gisli Masson, Michael L. Frigge, Simon N. Stacey, Patrick Sulem, Gisli H. Halldorsson, Vinicius Tragante, Hilma Holm, Gudmundur I. Eyjolfsson, Olof Sigurdardottir, Isleifur Olafsson, Thorvaldur Jonsson, Eirikur Jonsson, Rosa B. Barkardottir, Rafn Hilmarsson, Folkert W. Asselbergs, Gudmundur Geirsson, Unnur Thorsteinsdottir, Thorunn Rafnar, Gudmar Thorleifsson, Kari Stefansson

ABSTRACT

Benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS) are common conditions affecting the majority of elderly males. Here we report the results of a genome-wide association study of symptomatic BPH/LUTS in 20,621 patients and 280,541 controls of European ancestry, from Iceland and the UK. We discovered 23 genome-wide significant variants, located at 14 loci. There is little or no overlap between the BPH/LUTS variants and published prostate cancer risk variants. However, 15 of the variants reported here also associate with serum levels of prostate specific antigen (PSA) (at a Bonferroni corrected P < 0.0022). Furthermore, there is a strong genetic correlation, rg = 0.77 (P = 2.6 × 10-11), between PSA and BPH/LUTS, and one standard deviation increase in a polygenic risk score (PRS) for BPH/LUTS increases PSA levels by 12.9% (P = 1.6×10-55). These results shed a light on the genetic background of BPH/LUTS and its substantial influence on PSA levels. More... »

PAGES

4568

References to SciGraph publications

  • 2014-03. A promoter-level mammalian expression atlas in NATURE
  • 2015-05. Large-scale whole-genome sequencing of the Icelandic population in NATURE GENETICS
  • 2010-12. Benign Prostatic Hyperplasia and Male Lower Urinary Tract Symptoms: Epidemiology and Risk Factors in CURRENT BLADDER DYSFUNCTION REPORTS
  • 2015-03. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies in NATURE GENETICS
  • 2017-02. Correlation between prostate volume and single nucleotide polymorphisms implicated in the steroid pathway in WORLD JOURNAL OF UROLOGY
  • 2011-09. Urological aspects of the metabolic syndrome in NATURE REVIEWS UROLOGY
  • 1997-07. Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome in NATURE GENETICS
  • 2013-04. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array in NATURE GENETICS
  • 2016-03. Weighting sequence variants based on their annotation increases power of whole-genome association studies in NATURE GENETICS
  • 2007-08. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes in NATURE GENETICS
  • 2012-04. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits in NATURE GENETICS
  • 2010-10-28. Fine-scale recombination rate differences between sexes, populations and individuals in NATURE
  • 2017-12. Comparison of DNA quantification methodology used in the DNA extraction protocol for the UK Biobank cohort in BMC GENOMICS
  • 2017-01-31. Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer in NATURE COMMUNICATIONS
  • 2008-09. Detection of sharing by descent, long-range phasing and haplotype imputation in NATURE GENETICS
  • 2015-03. Efficient Bayesian mixed-model analysis increases association power in large cohorts in NATURE GENETICS
  • 2017-10. Reconstruction of enhancer-target networks in 935 samples of human primary cells, tissues and cell lines in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-06920-9

    DOI

    http://dx.doi.org/10.1038/s41467-018-06920-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107871600

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30410027


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