Epigenetic profiling for the molecular classification of metastatic brain tumors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-11-06

AUTHORS

Javier I. J. Orozco, Theo A. Knijnenburg, Ayla O. Manughian-Peter, Matthew P. Salomon, Garni Barkhoudarian, John R. Jalas, James S. Wilmott, Parvinder Hothi, Xiaowen Wang, Yuki Takasumi, Michael E. Buckland, John F. Thompson, Georgina V. Long, Charles S. Cobbs, Ilya Shmulevich, Daniel F. Kelly, Richard A. Scolyer, Dave S. B. Hoon, Diego M. Marzese

ABSTRACT

Optimal treatment of brain metastases is often hindered by limitations in diagnostic capabilities. To meet this challenge, here we profile DNA methylomes of the three most frequent types of brain metastases: melanoma, breast, and lung cancers (n = 96). Using supervised machine learning and integration of DNA methylomes from normal, primary, and metastatic tumor specimens (n = 1860), we unravel epigenetic signatures specific to each type of metastatic brain tumor and constructed a three-step DNA methylation-based classifier (BrainMETH) that categorizes brain metastases according to the tissue of origin and therapeutically relevant subtypes. BrainMETH predictions are supported by routine histopathologic evaluation. We further characterize and validate the most predictive genomic regions in a large cohort of brain tumors (n = 165) using quantitative-methylation-specific PCR. Our study highlights the importance of brain tumor-defining epigenetic alterations, which can be utilized to further develop DNA methylation profiling as a critical tool in the histomolecular stratification of patients with brain metastases. More... »

PAGES

4627

References to SciGraph publications

  • 2012-06-15. SWAN: Subset-quantile Within Array Normalization for Illumina Infinium HumanMethylation450 BeadChips in GENOME BIOLOGY
  • 2018-02-27. Holocene geochemical footprint from Semi-arid alpine wetlands in southern Spain in SCIENTIFIC DATA
  • 2015-04-07. Differentiation of solitary brain metastasis from glioblastoma multiforme: a predictive multiparametric approach using combined MR diffusion and perfusion in NEURORADIOLOGY
  • 2010-11-12. Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists in MODERN PATHOLOGY
  • 2001-10. Random Forests in MACHINE LEARNING
  • 2016-11-22. Histopathologic diagnosis of brain metastases: current trends in management and future considerations in BRAIN TUMOR PATHOLOGY
  • 2017-10-03. Discrepancies between biomarkers of primary breast cancer and subsequent brain metastases: an international multicenter study in BREAST CANCER RESEARCH AND TREATMENT
  • 2018-03-14. DNA methylation-based classification of central nervous system tumours in NATURE
  • 2015-10-24. Brain metastasis: clinical characteristics, pathological findings and molecular subtyping for therapeutic implications in BRAIN TUMOR PATHOLOGY
  • 2016-02-23. Changing molecular profile of brain metastases compared with matched breast primary cancers and impact on clinical outcomes in BRITISH JOURNAL OF CANCER
  • 2005-10. Brain metastases: epidemiology and pathophysiology in JOURNAL OF NEURO-ONCOLOGY
  • 2010-05-02. GREAT improves functional interpretation of cis-regulatory regions in NATURE BIOTECHNOLOGY
  • 2009-08. Mammary development meets cancer genomics in NATURE MEDICINE
  • 2017-06-21. Same-day genomic and epigenomic diagnosis of brain tumors using real-time nanopore sequencing in ACTA NEUROPATHOLOGICA
  • 2009. MethyLight in DNA METHYLATION
  • 2015-12-04. Systematic pan-cancer analysis of tumour purity in NATURE COMMUNICATIONS
  • 2012-09-23. Comprehensive molecular portraits of human breast tumors in NATURE
  • Journal

    TITLE

    Nature Communications

    ISSUE

    1

    VOLUME

    9

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-06715-y

    DOI

    http://dx.doi.org/10.1038/s41467-018-06715-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107954768

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30401823


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