Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Stefan Schoenfelder, Borbala Mifsud, Claire E. Senner, Christopher D. Todd, Stephanie Chrysanthou, Elodie Darbo, Myriam Hemberger, Miguel R. Branco

ABSTRACT

The establishment of the embryonic and trophoblast lineages is a developmental decision underpinned by dramatic differences in the epigenetic landscape of the two compartments. However, it remains unknown how epigenetic information and transcription factor networks map to the 3D arrangement of the genome, which in turn may mediate transcriptional divergence between the two cell lineages. Here, we perform promoter capture Hi-C experiments in mouse trophoblast (TSC) and embryonic (ESC) stem cells to understand how chromatin conformation relates to cell-specific transcriptional programmes. We find that key TSC genes that are kept repressed in ESCs exhibit interactions between H3K27me3-marked regions in ESCs that depend on Polycomb repressive complex 1. Interactions that are prominent in TSCs are enriched for enhancer-gene contacts involving key TSC transcription factors, as well as TET1, which helps to maintain the expression of TSC-relevant genes. Our work shows that the first developmental cell fate decision results in distinct chromatin conformation patterns establishing lineage-specific contexts involving both repressive and active interactions. More... »

PAGES

4189

References to SciGraph publications

  • 1984-01. Cell lineage-specific undermethylation of mouse repetitive DNA in NATURE
  • 2014-12. Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast in NATURE COMMUNICATIONS
  • 2015-12. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells in NATURE COMMUNICATIONS
  • 2015-10. Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome in NATURE GENETICS
  • 2013-03. Endogenous retroviruses function as species-specific enhancer elements in the placenta in NATURE GENETICS
  • 2016-12. CHiCAGO: robust detection of DNA looping interactions in Capture Hi-C data in GENOME BIOLOGY
  • 2015-06. Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C in NATURE GENETICS
  • 2008-11. Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5 in NATURE CELL BIOLOGY
  • 2018-01. Dynamic epigenomic landscapes during early lineage specification in mouse embryos in NATURE GENETICS
  • 2009-12. ERG-associated protein with SET domain (ESET)-Oct4 interaction regulates pluripotency and represses the trophectoderm lineage in EPIGENETICS & CHROMATIN
  • 2009-08. Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2015-12. Comparison of Hi-C results using in-solution versus in-nucleus ligation in GENOME BIOLOGY
  • 2017-07. Allelic reprogramming of 3D chromatin architecture during early mammalian development in NATURE
  • 2007-09. Epigenetic landscape required for placental development in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2004-08. Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops in NATURE GENETICS
  • 2016-01. Insulator dysfunction and oncogene activation in IDH mutant gliomas in NATURE
  • 2008-11. Model-based Analysis of ChIP-Seq (MACS) in GENOME BIOLOGY
  • 2000-03. Eomesodermin is required for mouse trophoblast development and mesoderm formation in NATURE
  • 2016-09. Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos in NATURE
  • 2013-10. Single-cell Hi-C reveals cell-to-cell variability in chromosome structure in NATURE
  • 2012-04. Fast gapped-read alignment with Bowtie 2 in NATURE METHODS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-06666-4

    DOI

    http://dx.doi.org/10.1038/s41467-018-06666-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107415011

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30305613


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Nuclear Dynamics Programme, Babraham Institute, CB22 3AT, Cambridge, UK", 
                "Epigenetics Programme, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schoenfelder", 
            "givenName": "Stefan", 
            "id": "sg:person.01120403414.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120403414.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hamad bin Khalifa University", 
              "id": "https://www.grid.ac/institutes/grid.452146.0", 
              "name": [
                "William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, QMUL, EC1M 6BQ, London, UK", 
                "College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Doha, Qatar"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mifsud", 
            "givenName": "Borbala", 
            "id": "sg:person.01016015762.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016015762.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Cambridge", 
              "id": "https://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "Epigenetics Programme, Babraham Institute, CB22 3AT, Cambridge, UK", 
                "Centre for Trophoblast Research, University of Cambridge, CB2 3EG, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Senner", 
            "givenName": "Claire E.", 
            "id": "sg:person.01272471056.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272471056.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Queen Mary University of London", 
              "id": "https://www.grid.ac/institutes/grid.4868.2", 
              "name": [
                "Blizard Institute, Barts and The London School of Medicine and Dentistry, QMUL, E1 2AT, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Todd", 
            "givenName": "Christopher D.", 
            "id": "sg:person.016365777761.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016365777761.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Epigenetics Programme, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chrysanthou", 
            "givenName": "Stephanie", 
            "id": "sg:person.0713534260.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713534260.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Bergoni\u00e9", 
              "id": "https://www.grid.ac/institutes/grid.476460.7", 
              "name": [
                "Bordeaux Bioinformatics Center, 33076, Bordeaux, France", 
                "INSERM ACTION U1218, Institut Bergoni\u00e9, 33076, Bordeaux, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Darbo", 
            "givenName": "Elodie", 
            "id": "sg:person.01206135236.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206135236.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Cambridge", 
              "id": "https://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "Epigenetics Programme, Babraham Institute, CB22 3AT, Cambridge, UK", 
                "Centre for Trophoblast Research, University of Cambridge, CB2 3EG, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hemberger", 
            "givenName": "Myriam", 
            "id": "sg:person.01122441016.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122441016.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Queen Mary University of London", 
              "id": "https://www.grid.ac/institutes/grid.4868.2", 
              "name": [
                "Blizard Institute, Barts and The London School of Medicine and Dentistry, QMUL, E1 2AT, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Branco", 
            "givenName": "Miguel R.", 
            "id": "sg:person.01201145045.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201145045.88"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/s13059-015-0753-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001431580", 
              "https://doi.org/10.1186/s13059-015-0753-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-016-0992-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001813860", 
              "https://doi.org/10.1186/s13059-016-0992-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-016-0992-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001813860", 
              "https://doi.org/10.1186/s13059-016-0992-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0914507107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005497647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006541515", 
              "https://doi.org/10.1038/nmeth.1923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.048363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008248516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddg180", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008338421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.133462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008596482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/307284a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012125480", 
              "https://doi.org/10.1038/307284a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2014.08.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012328498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012425816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.01801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012426693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.05.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012506529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2013.09.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012987709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2015.12.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013387101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013387569", 
              "https://doi.org/10.1038/ncb1786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-007-7113-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013887529", 
              "https://doi.org/10.1007/s00018-007-7113-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature16490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017311368", 
              "https://doi.org/10.1038/nature16490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/dbio.2001.0501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018213002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.12688/f1000research.7334.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018290070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/stem.1249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021892213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022035194", 
              "https://doi.org/10.1038/nature12593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022811939", 
              "https://doi.org/10.1038/nrm2727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022811939", 
              "https://doi.org/10.1038/nrm2727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1831909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023158710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cels.2016.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024198101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.185272.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025208660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.268821.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026583018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3286", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026830910", 
              "https://doi.org/10.1038/ng.3286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2008-9-9-r137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027608848", 
              "https://doi.org/10.1186/gb-2008-9-9-r137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(92)90611-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028643561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.02.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030427346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature19362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030701084", 
              "https://doi.org/10.1038/nature19362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mod.2007.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031197939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.096511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034220384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms8776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034553610", 
              "https://doi.org/10.1038/ncomms8776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034813975", 
              "https://doi.org/10.1038/ng.3393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1019007108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034974922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2016.09.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035198067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms6538", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036128427", 
              "https://doi.org/10.1038/ncomms6538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btn480", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041228481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35003601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042251707", 
              "https://doi.org/10.1038/35003601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35003601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042251707", 
              "https://doi.org/10.1038/35003601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0600326103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047265972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049552487", 
              "https://doi.org/10.1038/ng1402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049552487", 
              "https://doi.org/10.1038/ng1402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-8935-2-12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049661431", 
              "https://doi.org/10.1186/1756-8935-2-12"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2015.11.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049745221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2553", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050701683", 
              "https://doi.org/10.1038/ng.2553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.038828", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051203513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.21.13.4330-4336.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051446414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.282.5396.2072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062563523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079749551", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.21926", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084485295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0174744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084624231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature23263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090610956", 
              "https://doi.org/10.1038/nature23263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature23263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090610956", 
              "https://doi.org/10.1038/nature23263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2017.09.043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092293106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-017-0003-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093139703", 
              "https://doi.org/10.1038/s41588-017-0003-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.227272.117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100799888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.227272.117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100799888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stemcr.2018.02.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101699829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stemcr.2018.02.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101699829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15592294.2018.1504592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105904193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15592294.2018.1504592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105904193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15592294.2018.1504592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105904193"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "The establishment of the embryonic and trophoblast lineages is a developmental decision underpinned by dramatic differences in the epigenetic landscape of the two compartments. However, it remains unknown how epigenetic information and transcription factor networks map to the 3D arrangement of the genome, which in turn may mediate transcriptional divergence between the two cell lineages. Here, we perform promoter capture Hi-C experiments in mouse trophoblast (TSC) and embryonic (ESC) stem cells to understand how chromatin conformation relates to cell-specific transcriptional programmes. We find that key TSC genes that are kept repressed in ESCs exhibit interactions between H3K27me3-marked regions in ESCs that depend on Polycomb repressive complex 1. Interactions that are prominent in TSCs are enriched for enhancer-gene contacts involving key TSC transcription factors, as well as TET1, which helps to maintain the expression of TSC-relevant genes. Our work shows that the first developmental cell fate decision results in distinct chromatin conformation patterns establishing lineage-specific contexts involving both repressive and active interactions.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41467-018-06666-4", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3637479", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3862932", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages", 
        "pagination": "4189", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "bf670fd31eed8254573459d72639704d67449dacd981e3ec47510ffd738eb375"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30305613"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101528555"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-018-06666-4"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1107415011"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-018-06666-4", 
          "https://app.dimensions.ai/details/publication/pub.1107415011"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T21:46", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000566.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41467-018-06666-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06666-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06666-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06666-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06666-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    328 TRIPLES      21 PREDICATES      86 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-018-06666-4 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N7dc3cb23f70249b99dc523925e047d86
    4 schema:citation sg:pub.10.1007/s00018-007-7113-z
    5 sg:pub.10.1038/307284a0
    6 sg:pub.10.1038/35003601
    7 sg:pub.10.1038/nature12593
    8 sg:pub.10.1038/nature16490
    9 sg:pub.10.1038/nature19362
    10 sg:pub.10.1038/nature23263
    11 sg:pub.10.1038/ncb1786
    12 sg:pub.10.1038/ncomms6538
    13 sg:pub.10.1038/ncomms8776
    14 sg:pub.10.1038/ng.2553
    15 sg:pub.10.1038/ng.3286
    16 sg:pub.10.1038/ng.3393
    17 sg:pub.10.1038/ng1402
    18 sg:pub.10.1038/nmeth.1923
    19 sg:pub.10.1038/nrm2727
    20 sg:pub.10.1038/s41588-017-0003-x
    21 sg:pub.10.1186/1756-8935-2-12
    22 sg:pub.10.1186/gb-2008-9-9-r137
    23 sg:pub.10.1186/s13059-015-0753-7
    24 sg:pub.10.1186/s13059-016-0992-2
    25 https://app.dimensions.ai/details/publication/pub.1079749551
    26 https://doi.org/10.1002/stem.1249
    27 https://doi.org/10.1006/dbio.2001.0501
    28 https://doi.org/10.1016/0092-8674(92)90611-f
    29 https://doi.org/10.1016/j.cell.2006.02.041
    30 https://doi.org/10.1016/j.cell.2014.05.004
    31 https://doi.org/10.1016/j.cell.2016.09.037
    32 https://doi.org/10.1016/j.cell.2017.09.043
    33 https://doi.org/10.1016/j.cels.2016.07.002
    34 https://doi.org/10.1016/j.devcel.2015.12.027
    35 https://doi.org/10.1016/j.mod.2007.11.002
    36 https://doi.org/10.1016/j.molcel.2013.09.002
    37 https://doi.org/10.1016/j.molcel.2014.08.026
    38 https://doi.org/10.1016/j.stem.2015.11.010
    39 https://doi.org/10.1016/j.stemcr.2018.02.014
    40 https://doi.org/10.1073/pnas.0600326103
    41 https://doi.org/10.1073/pnas.0914507107
    42 https://doi.org/10.1073/pnas.1019007108
    43 https://doi.org/10.1080/15592294.2018.1504592
    44 https://doi.org/10.1093/bioinformatics/btn480
    45 https://doi.org/10.1093/bioinformatics/btp120
    46 https://doi.org/10.1093/hmg/ddg180
    47 https://doi.org/10.1101/gad.1831909
    48 https://doi.org/10.1101/gad.268821.115
    49 https://doi.org/10.1101/gr.185272.114
    50 https://doi.org/10.1101/gr.227272.117
    51 https://doi.org/10.1126/science.282.5396.2072
    52 https://doi.org/10.1128/mcb.21.13.4330-4336.2001
    53 https://doi.org/10.1242/dev.01801
    54 https://doi.org/10.1242/dev.038828
    55 https://doi.org/10.1242/dev.048363
    56 https://doi.org/10.1242/dev.096511
    57 https://doi.org/10.1242/dev.133462
    58 https://doi.org/10.12688/f1000research.7334.1
    59 https://doi.org/10.1371/journal.pone.0174744
    60 https://doi.org/10.7554/elife.21926
    61 schema:datePublished 2018-12
    62 schema:datePublishedReg 2018-12-01
    63 schema:description The establishment of the embryonic and trophoblast lineages is a developmental decision underpinned by dramatic differences in the epigenetic landscape of the two compartments. However, it remains unknown how epigenetic information and transcription factor networks map to the 3D arrangement of the genome, which in turn may mediate transcriptional divergence between the two cell lineages. Here, we perform promoter capture Hi-C experiments in mouse trophoblast (TSC) and embryonic (ESC) stem cells to understand how chromatin conformation relates to cell-specific transcriptional programmes. We find that key TSC genes that are kept repressed in ESCs exhibit interactions between H3K27me3-marked regions in ESCs that depend on Polycomb repressive complex 1. Interactions that are prominent in TSCs are enriched for enhancer-gene contacts involving key TSC transcription factors, as well as TET1, which helps to maintain the expression of TSC-relevant genes. Our work shows that the first developmental cell fate decision results in distinct chromatin conformation patterns establishing lineage-specific contexts involving both repressive and active interactions.
    64 schema:genre research_article
    65 schema:inLanguage en
    66 schema:isAccessibleForFree true
    67 schema:isPartOf N3b3e82707cd841f2a2494848b1983988
    68 Na601e9f5f2c049e490ea30e5263d0dcd
    69 sg:journal.1043282
    70 schema:name Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages
    71 schema:pagination 4189
    72 schema:productId N19be2d5baa5f4b138a723c8dac756fb7
    73 N4872fa98f7a244a9977d13cf8e231f8d
    74 Nad36d7436f34479abaf6ff84cb9093f6
    75 Nd806284735cc4e10b5c6d10daf3c831a
    76 Nea3f7b9ea708415eb95aae08b381c5c8
    77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107415011
    78 https://doi.org/10.1038/s41467-018-06666-4
    79 schema:sdDatePublished 2019-04-10T21:46
    80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    81 schema:sdPublisher N4f7bfdb02f384138a4f552ab5af64f41
    82 schema:url https://www.nature.com/articles/s41467-018-06666-4
    83 sgo:license sg:explorer/license/
    84 sgo:sdDataset articles
    85 rdf:type schema:ScholarlyArticle
    86 N18944b3f0eaf4f68b25edaeb74102543 rdf:first sg:person.01016015762.15
    87 rdf:rest Nbeb81330371343f4b76d1549dc6e1c3e
    88 N19be2d5baa5f4b138a723c8dac756fb7 schema:name doi
    89 schema:value 10.1038/s41467-018-06666-4
    90 rdf:type schema:PropertyValue
    91 N3b3e82707cd841f2a2494848b1983988 schema:issueNumber 1
    92 rdf:type schema:PublicationIssue
    93 N486c0155be404ff8b559f0e870b56545 rdf:first sg:person.016365777761.37
    94 rdf:rest N6beab9a1fcbf4c15b1aa8912747fa0ca
    95 N4872fa98f7a244a9977d13cf8e231f8d schema:name readcube_id
    96 schema:value bf670fd31eed8254573459d72639704d67449dacd981e3ec47510ffd738eb375
    97 rdf:type schema:PropertyValue
    98 N4f7bfdb02f384138a4f552ab5af64f41 schema:name Springer Nature - SN SciGraph project
    99 rdf:type schema:Organization
    100 N60deb15a2e5e4d888236d4169ab07c70 rdf:first sg:person.01206135236.18
    101 rdf:rest Nce52be9094d14279921e9cef0d0a9339
    102 N6beab9a1fcbf4c15b1aa8912747fa0ca rdf:first sg:person.0713534260.86
    103 rdf:rest N60deb15a2e5e4d888236d4169ab07c70
    104 N7dc3cb23f70249b99dc523925e047d86 rdf:first sg:person.01120403414.36
    105 rdf:rest N18944b3f0eaf4f68b25edaeb74102543
    106 Na601e9f5f2c049e490ea30e5263d0dcd schema:volumeNumber 9
    107 rdf:type schema:PublicationVolume
    108 Nad36d7436f34479abaf6ff84cb9093f6 schema:name dimensions_id
    109 schema:value pub.1107415011
    110 rdf:type schema:PropertyValue
    111 Nb04c1a25917d45399eadc229946eea6a rdf:first sg:person.01201145045.88
    112 rdf:rest rdf:nil
    113 Nbeb81330371343f4b76d1549dc6e1c3e rdf:first sg:person.01272471056.38
    114 rdf:rest N486c0155be404ff8b559f0e870b56545
    115 Nce52be9094d14279921e9cef0d0a9339 rdf:first sg:person.01122441016.75
    116 rdf:rest Nb04c1a25917d45399eadc229946eea6a
    117 Nd806284735cc4e10b5c6d10daf3c831a schema:name pubmed_id
    118 schema:value 30305613
    119 rdf:type schema:PropertyValue
    120 Nea3f7b9ea708415eb95aae08b381c5c8 schema:name nlm_unique_id
    121 schema:value 101528555
    122 rdf:type schema:PropertyValue
    123 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    124 schema:name Biological Sciences
    125 rdf:type schema:DefinedTerm
    126 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    127 schema:name Genetics
    128 rdf:type schema:DefinedTerm
    129 sg:grant.3637479 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-06666-4
    130 rdf:type schema:MonetaryGrant
    131 sg:grant.3862932 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-06666-4
    132 rdf:type schema:MonetaryGrant
    133 sg:journal.1043282 schema:issn 2041-1723
    134 schema:name Nature Communications
    135 rdf:type schema:Periodical
    136 sg:person.01016015762.15 schema:affiliation https://www.grid.ac/institutes/grid.452146.0
    137 schema:familyName Mifsud
    138 schema:givenName Borbala
    139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016015762.15
    140 rdf:type schema:Person
    141 sg:person.01120403414.36 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    142 schema:familyName Schoenfelder
    143 schema:givenName Stefan
    144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120403414.36
    145 rdf:type schema:Person
    146 sg:person.01122441016.75 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
    147 schema:familyName Hemberger
    148 schema:givenName Myriam
    149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122441016.75
    150 rdf:type schema:Person
    151 sg:person.01201145045.88 schema:affiliation https://www.grid.ac/institutes/grid.4868.2
    152 schema:familyName Branco
    153 schema:givenName Miguel R.
    154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201145045.88
    155 rdf:type schema:Person
    156 sg:person.01206135236.18 schema:affiliation https://www.grid.ac/institutes/grid.476460.7
    157 schema:familyName Darbo
    158 schema:givenName Elodie
    159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206135236.18
    160 rdf:type schema:Person
    161 sg:person.01272471056.38 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
    162 schema:familyName Senner
    163 schema:givenName Claire E.
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272471056.38
    165 rdf:type schema:Person
    166 sg:person.016365777761.37 schema:affiliation https://www.grid.ac/institutes/grid.4868.2
    167 schema:familyName Todd
    168 schema:givenName Christopher D.
    169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016365777761.37
    170 rdf:type schema:Person
    171 sg:person.0713534260.86 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    172 schema:familyName Chrysanthou
    173 schema:givenName Stephanie
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713534260.86
    175 rdf:type schema:Person
    176 sg:pub.10.1007/s00018-007-7113-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1013887529
    177 https://doi.org/10.1007/s00018-007-7113-z
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.1038/307284a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012125480
    180 https://doi.org/10.1038/307284a0
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1038/35003601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042251707
    183 https://doi.org/10.1038/35003601
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1038/nature12593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022035194
    186 https://doi.org/10.1038/nature12593
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1038/nature16490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017311368
    189 https://doi.org/10.1038/nature16490
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1038/nature19362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030701084
    192 https://doi.org/10.1038/nature19362
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1038/nature23263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090610956
    195 https://doi.org/10.1038/nature23263
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1038/ncb1786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013387569
    198 https://doi.org/10.1038/ncb1786
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1038/ncomms6538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036128427
    201 https://doi.org/10.1038/ncomms6538
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/ncomms8776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034553610
    204 https://doi.org/10.1038/ncomms8776
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/ng.2553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050701683
    207 https://doi.org/10.1038/ng.2553
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/ng.3286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026830910
    210 https://doi.org/10.1038/ng.3286
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/ng.3393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034813975
    213 https://doi.org/10.1038/ng.3393
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/ng1402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049552487
    216 https://doi.org/10.1038/ng1402
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/nmeth.1923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006541515
    219 https://doi.org/10.1038/nmeth.1923
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/nrm2727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022811939
    222 https://doi.org/10.1038/nrm2727
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/s41588-017-0003-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1093139703
    225 https://doi.org/10.1038/s41588-017-0003-x
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1186/1756-8935-2-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049661431
    228 https://doi.org/10.1186/1756-8935-2-12
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1186/gb-2008-9-9-r137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027608848
    231 https://doi.org/10.1186/gb-2008-9-9-r137
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1186/s13059-015-0753-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001431580
    234 https://doi.org/10.1186/s13059-015-0753-7
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1186/s13059-016-0992-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001813860
    237 https://doi.org/10.1186/s13059-016-0992-2
    238 rdf:type schema:CreativeWork
    239 https://app.dimensions.ai/details/publication/pub.1079749551 schema:CreativeWork
    240 https://doi.org/10.1002/stem.1249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021892213
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1006/dbio.2001.0501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018213002
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1016/0092-8674(92)90611-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1028643561
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/j.cell.2006.02.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030427346
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.cell.2014.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012506529
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.cell.2016.09.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035198067
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/j.cell.2017.09.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092293106
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/j.cels.2016.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024198101
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/j.devcel.2015.12.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013387101
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/j.mod.2007.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031197939
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/j.molcel.2013.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012987709
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1016/j.molcel.2014.08.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012328498
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/j.stem.2015.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049745221
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/j.stemcr.2018.02.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101699829
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1073/pnas.0600326103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047265972
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1073/pnas.0914507107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005497647
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1073/pnas.1019007108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034974922
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1080/15592294.2018.1504592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105904193
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1093/bioinformatics/btn480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041228481
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1093/bioinformatics/btp120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012425816
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1093/hmg/ddg180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008338421
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1101/gad.1831909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023158710
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1101/gad.268821.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026583018
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1101/gr.185272.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025208660
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1101/gr.227272.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100799888
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1126/science.282.5396.2072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062563523
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1128/mcb.21.13.4330-4336.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051446414
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1242/dev.01801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012426693
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1242/dev.038828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051203513
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1242/dev.048363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008248516
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1242/dev.096511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034220384
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1242/dev.133462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008596482
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.12688/f1000research.7334.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018290070
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1371/journal.pone.0174744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084624231
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.7554/elife.21926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084485295
    309 rdf:type schema:CreativeWork
    310 https://www.grid.ac/institutes/grid.418195.0 schema:alternateName Babraham Institute
    311 schema:name Epigenetics Programme, Babraham Institute, CB22 3AT, Cambridge, UK
    312 Nuclear Dynamics Programme, Babraham Institute, CB22 3AT, Cambridge, UK
    313 rdf:type schema:Organization
    314 https://www.grid.ac/institutes/grid.452146.0 schema:alternateName Hamad bin Khalifa University
    315 schema:name College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Doha, Qatar
    316 William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, QMUL, EC1M 6BQ, London, UK
    317 rdf:type schema:Organization
    318 https://www.grid.ac/institutes/grid.476460.7 schema:alternateName Institut Bergonié
    319 schema:name Bordeaux Bioinformatics Center, 33076, Bordeaux, France
    320 INSERM ACTION U1218, Institut Bergonié, 33076, Bordeaux, France
    321 rdf:type schema:Organization
    322 https://www.grid.ac/institutes/grid.4868.2 schema:alternateName Queen Mary University of London
    323 schema:name Blizard Institute, Barts and The London School of Medicine and Dentistry, QMUL, E1 2AT, London, UK
    324 rdf:type schema:Organization
    325 https://www.grid.ac/institutes/grid.5335.0 schema:alternateName University of Cambridge
    326 schema:name Centre for Trophoblast Research, University of Cambridge, CB2 3EG, Cambridge, UK
    327 Epigenetics Programme, Babraham Institute, CB22 3AT, Cambridge, UK
    328 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...