The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Laura C. Zanetti-Domingues, Dimitrios Korovesis, Sarah R. Needham, Christopher J. Tynan, Shiori Sagawa, Selene K. Roberts, Antonija Kuzmanic, Elena Ortiz-Zapater, Purvi Jain, Rob C. Roovers, Alireza Lajevardipour, Paul M. P. van Bergen en Henegouwen, George Santis, Andrew H. A. Clayton, David T. Clarke, Francesco L. Gervasio, Yibing Shan, David E. Shaw, Daniel J. Rolfe, Peter J. Parker, Marisa L. Martin-Fernandez

ABSTRACT

Our current understanding of epidermal growth factor receptor (EGFR) autoinhibition is based on X-ray structural data of monomer and dimer receptor fragments and does not explain how mutations achieve ligand-independent phosphorylation. Using a repertoire of imaging technologies and simulations we reveal an extracellular head-to-head interaction through which ligand-free receptor polymer chains of various lengths assemble. The architecture of the head-to-head interaction prevents kinase-mediated dimerisation. The latter, afforded by mutation or intracellular treatments, splits the autoinhibited head-to-head polymers to form stalk-to-stalk flexible non-extended dimers structurally coupled across the plasma membrane to active asymmetric tyrosine kinase dimers, and extended dimers coupled to inactive symmetric kinase dimers. Contrary to the previously proposed main autoinhibitory function of the inactive symmetric kinase dimer, our data suggest that only dysregulated species bear populations of symmetric and asymmetric kinase dimers that coexist in equilibrium at the plasma membrane under the modulation of the C-terminal domain. More... »

PAGES

4325

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-06632-0

DOI

http://dx.doi.org/10.1038/s41467-018-06632-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107590384

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30337523


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CHO Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cricetinae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cricetulus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ErbB Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracellular Matrix", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorescent Dyes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ligands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Photobleaching", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Domains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Multimerization", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Rutherford Appleton Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.76978.37", 
          "name": [
            "Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot, OX11 0QX, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zanetti-Domingues", 
        "givenName": "Laura C.", 
        "id": "sg:person.01073047014.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073047014.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rutherford Appleton Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.76978.37", 
          "name": [
            "Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot, OX11 0QX, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Korovesis", 
        "givenName": "Dimitrios", 
        "id": "sg:person.0676050733.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676050733.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rutherford Appleton Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.76978.37", 
          "name": [
            "Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot, OX11 0QX, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Needham", 
        "givenName": "Sarah R.", 
        "id": "sg:person.01207275414.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207275414.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rutherford Appleton Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.76978.37", 
          "name": [
            "Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot, OX11 0QX, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tynan", 
        "givenName": "Christopher J.", 
        "id": "sg:person.0771276772.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771276772.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D. E. Shaw Research", 
          "id": "https://www.grid.ac/institutes/grid.417724.3", 
          "name": [
            "D. E. Shaw Research, 10036, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sagawa", 
        "givenName": "Shiori", 
        "id": "sg:person.013024511366.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013024511366.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rutherford Appleton Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.76978.37", 
          "name": [
            "Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot, OX11 0QX, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roberts", 
        "givenName": "Selene K.", 
        "id": "sg:person.01154633455.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154633455.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Chemistry, Faculty of Maths & Physical Sciences, University College London, WC1H 0AJ, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuzmanic", 
        "givenName": "Antonija", 
        "id": "sg:person.0722311156.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722311156.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Peter Gore Department of Immunobiology, School of Immunology & Microbial Sciences, Kings College London, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ortiz-Zapater", 
        "givenName": "Elena", 
        "id": "sg:person.01203344423.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203344423.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Utrecht University", 
          "id": "https://www.grid.ac/institutes/grid.5477.1", 
          "name": [
            "Division of Cell Biology, Science Faculty, Department of Biology, Utrecht University, 3584 CH, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jain", 
        "givenName": "Purvi", 
        "id": "sg:person.011466772521.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011466772521.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Merus, LSI, Yalelaan 62, 3584 CM, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roovers", 
        "givenName": "Rob C.", 
        "id": "sg:person.01316516647.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316516647.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Swinburne University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.1027.4", 
          "name": [
            "Centre for Micro-Photonics, Faculty of Science, Engineering and Technology, Swinburne University of Technology, 3122, Hawthorn, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lajevardipour", 
        "givenName": "Alireza", 
        "id": "sg:person.0661345127.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661345127.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Utrecht University", 
          "id": "https://www.grid.ac/institutes/grid.5477.1", 
          "name": [
            "Division of Cell Biology, Science Faculty, Department of Biology, Utrecht University, 3584 CH, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Bergen en Henegouwen", 
        "givenName": "Paul M. P.", 
        "id": "sg:person.07562536207.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07562536207.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Peter Gore Department of Immunobiology, School of Immunology & Microbial Sciences, Kings College London, SE1 9RT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santis", 
        "givenName": "George", 
        "id": "sg:person.0655051032.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655051032.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Swinburne University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.1027.4", 
          "name": [
            "Centre for Micro-Photonics, Faculty of Science, Engineering and Technology, Swinburne University of Technology, 3122, Hawthorn, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clayton", 
        "givenName": "Andrew H. A.", 
        "id": "sg:person.016255307132.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016255307132.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rutherford Appleton Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.76978.37", 
          "name": [
            "Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot, OX11 0QX, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clarke", 
        "givenName": "David T.", 
        "id": "sg:person.01033253567.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033253567.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Chemistry, Faculty of Maths & Physical Sciences, University College London, WC1H 0AJ, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gervasio", 
        "givenName": "Francesco L.", 
        "id": "sg:person.01112362314.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112362314.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D. E. Shaw Research", 
          "id": "https://www.grid.ac/institutes/grid.417724.3", 
          "name": [
            "D. E. Shaw Research, 10036, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shan", 
        "givenName": "Yibing", 
        "id": "sg:person.01136650361.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136650361.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "D. E. Shaw Research, 10036, New York, NY, USA", 
            "Department of Biochemistry and Molecular Biophysics, Columbia University, 10032, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shaw", 
        "givenName": "David E.", 
        "id": "sg:person.0642320761.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642320761.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rutherford Appleton Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.76978.37", 
          "name": [
            "Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot, OX11 0QX, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rolfe", 
        "givenName": "Daniel J.", 
        "id": "sg:person.01105525372.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105525372.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Protein Phosphorylation Laboratory, The Francis Crick Institute, 1 Midland Road, NW 1 1AT, London, UK", 
            "School of Cancer and Pharmaceutical Sciences, King\u2019s College London, New Hunt\u2019s House, Guy\u2019s Campus, SE1 1UL, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parker", 
        "givenName": "Peter J.", 
        "id": "sg:person.01111564441.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111564441.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rutherford Appleton Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.76978.37", 
          "name": [
            "Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot, OX11 0QX, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martin-Fernandez", 
        "givenName": "Marisa L.", 
        "id": "sg:person.0660711472.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660711472.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.m304332200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001183336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.05.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001670196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2014.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002991958", 
          "https://doi.org/10.1038/cr.2014.89"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(03)00047-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003071711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.2001.4923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003343011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1221953110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003387065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.04.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006916301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0062331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007398137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.02.063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009103049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.02.063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009103049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2012.11.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010128049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.07.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010981514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.12.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011371017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0707080105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011853433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms13307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013280320", 
          "https://doi.org/10.1038/ncomms13307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m207135200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015395356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.01-08-0411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016538588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1529/biophysj.106.102087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018028868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.028753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018860260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00249-011-0747-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018961076", 
          "https://doi.org/10.1007/s00249-011-0747-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1005025107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019213036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2013.08.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019251014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jp973084f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019311063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jp973084f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019311063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m504770200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019798618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m504770200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019798618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.414391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020194245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms8380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020778522", 
          "https://doi.org/10.1038/ncomms8380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pbiomolbio.2015.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022579829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01431-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023764240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e15-05-0269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024027080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2013.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025605900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025713856", 
          "https://doi.org/10.1038/nsmb.2135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.12.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025926106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamcr.2005.08.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026454548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamcr.2005.08.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026454548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026706357", 
          "https://doi.org/10.1038/nmeth.2019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.jctc.5b00255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027172688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027694871", 
          "https://doi.org/10.1038/onc.2010.313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00940-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028118590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.softx.2015.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028157022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymeth.2015.05.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030009088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymeth.2015.05.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030009088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1529/biophysj.107.105494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030199221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00248-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030218128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2013.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030267301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1993.1626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030443070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0709662105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030668301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m208327200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031202474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c3mb70073a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031529611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.21123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033216981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1099314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033538744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/1478-3975/8/6/066002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033868912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.06.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036327574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(90)90801-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037771370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14728222.2011.648617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038394005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkm047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040239983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040786335", 
          "https://doi.org/10.1038/nature08827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040786335", 
          "https://doi.org/10.1038/nature08827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.10688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041756186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.04.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044215429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.001487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045166493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00963-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046457415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2014.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047774332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.14107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048243978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cpc.2013.09.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049416945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1096-987x(20010415)22:5<501::aid-jcc1021>3.0.co;2-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050457221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.20660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050792187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.20660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050792187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.10.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050861868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.22862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053366075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi700002b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055206936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi700002b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055206936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja062463w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055842172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja062463w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055842172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jacs.6b05602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055875773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst20140318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056717852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst20140318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056717852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.445869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058023889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.467468", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058045473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.481505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058079325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physreva.31.1695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060473124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physreva.31.1695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060473124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1364/ol.31.002157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1065224062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1389450053765879", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069180255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3934/biophy.2015.1.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071731030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082432622", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/cancers9050052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085425076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/cells6020013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085745575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/sc.2014.9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093875572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.32271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103694671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.32271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103694671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.32271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103694671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.32271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103694671"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Our current understanding of epidermal growth factor receptor (EGFR) autoinhibition is based on X-ray structural data of monomer and dimer receptor fragments and does not explain how mutations achieve ligand-independent phosphorylation. Using a repertoire of imaging technologies and simulations we reveal an extracellular head-to-head interaction through which ligand-free receptor polymer chains of various lengths assemble. The architecture of the head-to-head interaction prevents kinase-mediated dimerisation. The latter, afforded by mutation or intracellular treatments, splits the autoinhibited head-to-head polymers to form stalk-to-stalk flexible non-extended dimers structurally coupled across the plasma membrane to active asymmetric tyrosine kinase dimers, and extended dimers coupled to inactive symmetric kinase dimers. Contrary to the previously proposed main autoinhibitory function of the inactive symmetric kinase dimer, our data suggest that only dysregulated species bear populations of symmetric and asymmetric kinase dimers that coexist in equilibrium at the plasma membrane under the modulation of the C-terminal domain.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-018-06632-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3560415", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2787832", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6621655", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3959602", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6620764", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2777051", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3497493", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "The architecture of EGFR\u2019s basal complexes reveals autoinhibition mechanisms in dimers and oligomers", 
    "pagination": "4325", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "561a5cd90cba8010de29952a5e31f39de241b75f5f26a87d62702c7e68794f68"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30337523"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-018-06632-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107590384"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-018-06632-0", 
      "https://app.dimensions.ai/details/publication/pub.1107590384"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78972_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-018-06632-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06632-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06632-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06632-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06632-0'


 

This table displays all metadata directly associated to this object as RDF triples.

556 TRIPLES      21 PREDICATES      125 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-018-06632-0 schema:about N04d5d9e216b549d49271973bd773fc57
2 N08f051a711ec492daf3d4bab4819f6a5
3 N0b48307689804568b90ef303f0927ff3
4 N130914e54904450186a8f928c83335a4
5 N1df26b644ea149f19545dad6843ebacb
6 N2035cd18c0ea4c03aa1d311afa384f20
7 N219388bfa28a45d287c968b0e2d32773
8 N2c915bfd49f74adfa6e4d8fd562930ba
9 N4b9ce374c3964eea86a5181df9cb2eea
10 N56dc53730ab743feb8576ac18488269c
11 N572d17f39e4a4dab8361809700d632b7
12 N84f74eb84f334fc1b01b3f6e24cb01a4
13 N96390027fe5f410bbf770d71b63e4dd1
14 Na98f1881f43449f48b6f3094833c34dc
15 Nb7570d75603d436097f581a8550ad3a8
16 Nb78fbf20ed19436cb3c906554bf1fc0c
17 anzsrc-for:06
18 anzsrc-for:0601
19 schema:author Nd5e7092ff6ab4787929747d12618558e
20 schema:citation sg:pub.10.1007/s00249-011-0747-7
21 sg:pub.10.1038/cr.2014.89
22 sg:pub.10.1038/nature08827
23 sg:pub.10.1038/ncomms13307
24 sg:pub.10.1038/ncomms8380
25 sg:pub.10.1038/nmeth.2019
26 sg:pub.10.1038/nsmb.2135
27 sg:pub.10.1038/onc.2010.313
28 https://app.dimensions.ai/details/publication/pub.1082432622
29 https://doi.org/10.1002/1096-987x(20010415)22:5<501::aid-jcc1021>3.0.co;2-v
30 https://doi.org/10.1002/prot.20660
31 https://doi.org/10.1002/prot.21123
32 https://doi.org/10.1002/prot.22862
33 https://doi.org/10.1006/jmbi.1993.1626
34 https://doi.org/10.1006/jmbi.2001.4923
35 https://doi.org/10.1016/0092-8674(90)90801-k
36 https://doi.org/10.1016/j.bbamcr.2005.08.008
37 https://doi.org/10.1016/j.bpj.2013.01.009
38 https://doi.org/10.1016/j.cell.2006.05.013
39 https://doi.org/10.1016/j.cell.2009.04.025
40 https://doi.org/10.1016/j.cell.2010.06.011
41 https://doi.org/10.1016/j.cell.2010.07.015
42 https://doi.org/10.1016/j.cell.2012.02.063
43 https://doi.org/10.1016/j.cell.2012.12.030
44 https://doi.org/10.1016/j.cell.2012.12.032
45 https://doi.org/10.1016/j.cell.2016.10.038
46 https://doi.org/10.1016/j.celrep.2014.10.010
47 https://doi.org/10.1016/j.cpc.2013.09.018
48 https://doi.org/10.1016/j.molcel.2009.04.034
49 https://doi.org/10.1016/j.pbiomolbio.2015.04.002
50 https://doi.org/10.1016/j.softx.2015.06.001
51 https://doi.org/10.1016/j.str.2012.11.014
52 https://doi.org/10.1016/j.str.2013.05.008
53 https://doi.org/10.1016/j.str.2013.08.020
54 https://doi.org/10.1016/j.ymeth.2015.05.009
55 https://doi.org/10.1016/s0092-8674(02)00940-6
56 https://doi.org/10.1016/s0092-8674(02)00963-7
57 https://doi.org/10.1016/s1097-2765(03)00047-9
58 https://doi.org/10.1021/acs.jctc.5b00255
59 https://doi.org/10.1021/bi700002b
60 https://doi.org/10.1021/ja062463w
61 https://doi.org/10.1021/jacs.6b05602
62 https://doi.org/10.1021/jp973084f
63 https://doi.org/10.1039/c3mb70073a
64 https://doi.org/10.1042/bst20140318
65 https://doi.org/10.1063/1.445869
66 https://doi.org/10.1063/1.467468
67 https://doi.org/10.1063/1.481505
68 https://doi.org/10.1073/pnas.0707080105
69 https://doi.org/10.1073/pnas.0709662105
70 https://doi.org/10.1073/pnas.1005025107
71 https://doi.org/10.1073/pnas.1221953110
72 https://doi.org/10.1074/jbc.m109.001487
73 https://doi.org/10.1074/jbc.m112.414391
74 https://doi.org/10.1074/jbc.m207135200
75 https://doi.org/10.1074/jbc.m208327200
76 https://doi.org/10.1074/jbc.m304332200
77 https://doi.org/10.1074/jbc.m504770200
78 https://doi.org/10.1088/1478-3975/8/6/066002
79 https://doi.org/10.1091/mbc.01-08-0411
80 https://doi.org/10.1091/mbc.e15-05-0269
81 https://doi.org/10.1093/nar/gkm047
82 https://doi.org/10.1103/physreva.31.1695
83 https://doi.org/10.1109/sc.2014.9
84 https://doi.org/10.1126/science.1099314
85 https://doi.org/10.1128/mcb.00248-15
86 https://doi.org/10.1128/mcb.01431-10
87 https://doi.org/10.1242/jcs.028753
88 https://doi.org/10.1364/ol.31.002157
89 https://doi.org/10.1371/journal.pone.0062331
90 https://doi.org/10.1517/14728222.2011.648617
91 https://doi.org/10.1529/biophysj.106.102087
92 https://doi.org/10.1529/biophysj.107.105494
93 https://doi.org/10.1593/neo.10688
94 https://doi.org/10.2174/1389450053765879
95 https://doi.org/10.3390/cancers9050052
96 https://doi.org/10.3390/cells6020013
97 https://doi.org/10.3934/biophy.2015.1.1
98 https://doi.org/10.7554/elife.14107
99 https://doi.org/10.7554/elife.32271
100 schema:datePublished 2018-12
101 schema:datePublishedReg 2018-12-01
102 schema:description Our current understanding of epidermal growth factor receptor (EGFR) autoinhibition is based on X-ray structural data of monomer and dimer receptor fragments and does not explain how mutations achieve ligand-independent phosphorylation. Using a repertoire of imaging technologies and simulations we reveal an extracellular head-to-head interaction through which ligand-free receptor polymer chains of various lengths assemble. The architecture of the head-to-head interaction prevents kinase-mediated dimerisation. The latter, afforded by mutation or intracellular treatments, splits the autoinhibited head-to-head polymers to form stalk-to-stalk flexible non-extended dimers structurally coupled across the plasma membrane to active asymmetric tyrosine kinase dimers, and extended dimers coupled to inactive symmetric kinase dimers. Contrary to the previously proposed main autoinhibitory function of the inactive symmetric kinase dimer, our data suggest that only dysregulated species bear populations of symmetric and asymmetric kinase dimers that coexist in equilibrium at the plasma membrane under the modulation of the C-terminal domain.
103 schema:genre research_article
104 schema:inLanguage en
105 schema:isAccessibleForFree true
106 schema:isPartOf N8b6b5eb031124762b840e597eb86992e
107 Nf60cc3d2ea844850ba1e5dc6f9d3c974
108 sg:journal.1043282
109 schema:name The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers
110 schema:pagination 4325
111 schema:productId N06700fe8c417469585bd039908090643
112 N9bc1b4ad741947a3933c8fb26746cbf7
113 Nd91f856f69e043d18a95fdc78cac5d20
114 Ne177adf98a3f46ea8d3d47521f4fbb0f
115 Nf67f636a4a28417f97755616b69253a8
116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107590384
117 https://doi.org/10.1038/s41467-018-06632-0
118 schema:sdDatePublished 2019-04-11T13:21
119 schema:sdLicense https://scigraph.springernature.com/explorer/license/
120 schema:sdPublisher N24b71e5cd59c424c8a47d5df95bc31dd
121 schema:url https://www.nature.com/articles/s41467-018-06632-0
122 sgo:license sg:explorer/license/
123 sgo:sdDataset articles
124 rdf:type schema:ScholarlyArticle
125 N04d5d9e216b549d49271973bd773fc57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Protein Multimerization
127 rdf:type schema:DefinedTerm
128 N06700fe8c417469585bd039908090643 schema:name doi
129 schema:value 10.1038/s41467-018-06632-0
130 rdf:type schema:PropertyValue
131 N08f051a711ec492daf3d4bab4819f6a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Polymers
133 rdf:type schema:DefinedTerm
134 N0b48307689804568b90ef303f0927ff3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Models, Biological
136 rdf:type schema:DefinedTerm
137 N0df1b670c97f4ef78322fd38d949c539 rdf:first sg:person.011466772521.20
138 rdf:rest N1a26b15c1fd44f8ebf2398fefeccfdfa
139 N130914e54904450186a8f928c83335a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Protein Kinases
141 rdf:type schema:DefinedTerm
142 N1a26b15c1fd44f8ebf2398fefeccfdfa rdf:first sg:person.01316516647.03
143 rdf:rest N4a38d4ff90724016842a09f08031cc63
144 N1be4f21949034dbbbd8807611f00b6d5 rdf:first sg:person.0722311156.12
145 rdf:rest Nd6297eb74d7f473ab691a1e969e6856c
146 N1df26b644ea149f19545dad6843ebacb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Animals
148 rdf:type schema:DefinedTerm
149 N2035cd18c0ea4c03aa1d311afa384f20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Cricetulus
151 rdf:type schema:DefinedTerm
152 N219388bfa28a45d287c968b0e2d32773 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Fluorescent Dyes
154 rdf:type schema:DefinedTerm
155 N24b71e5cd59c424c8a47d5df95bc31dd schema:name Springer Nature - SN SciGraph project
156 rdf:type schema:Organization
157 N2c915bfd49f74adfa6e4d8fd562930ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name ErbB Receptors
159 rdf:type schema:DefinedTerm
160 N3a8d889601a449f1b22d2563f67cd51a rdf:first sg:person.01033253567.34
161 rdf:rest N89bc4ad53e5c4ed8834c0fed359c7610
162 N420b6c02e4524adba81b0a760ec0cf3d schema:name Merus, LSI, Yalelaan 62, 3584 CM, Utrecht, The Netherlands
163 rdf:type schema:Organization
164 N4a38d4ff90724016842a09f08031cc63 rdf:first sg:person.0661345127.10
165 rdf:rest Nb1b5f82848d841ae9c3d0db92519152a
166 N4b9ce374c3964eea86a5181df9cb2eea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Extracellular Matrix
168 rdf:type schema:DefinedTerm
169 N56dc53730ab743feb8576ac18488269c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Photobleaching
171 rdf:type schema:DefinedTerm
172 N572d17f39e4a4dab8361809700d632b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Cricetinae
174 rdf:type schema:DefinedTerm
175 N76ad7999e58a4db98d4d54c79f1f0b94 rdf:first sg:person.0771276772.59
176 rdf:rest Na352c4948dc14790bbc910fde8c46c8e
177 N7b8f88c836ba47e0accb942e569e6a40 rdf:first sg:person.0660711472.96
178 rdf:rest rdf:nil
179 N84f74eb84f334fc1b01b3f6e24cb01a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Ligands
181 rdf:type schema:DefinedTerm
182 N89bc4ad53e5c4ed8834c0fed359c7610 rdf:first sg:person.01112362314.31
183 rdf:rest Nd9fd087ed84a4011a6e16c56d72fb908
184 N8b6b5eb031124762b840e597eb86992e schema:issueNumber 1
185 rdf:type schema:PublicationIssue
186 N96390027fe5f410bbf770d71b63e4dd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Protein Domains
188 rdf:type schema:DefinedTerm
189 N9865e6d4105e4d2f90b5aeab00a46359 rdf:first sg:person.01207275414.29
190 rdf:rest N76ad7999e58a4db98d4d54c79f1f0b94
191 N9bc1b4ad741947a3933c8fb26746cbf7 schema:name nlm_unique_id
192 schema:value 101528555
193 rdf:type schema:PropertyValue
194 Na0657499fef04ff08b17972c5df2e4de rdf:first sg:person.01111564441.81
195 rdf:rest N7b8f88c836ba47e0accb942e569e6a40
196 Na352c4948dc14790bbc910fde8c46c8e rdf:first sg:person.013024511366.64
197 rdf:rest Ndfe81a65bf4845ba9bd1f4f3c20bf507
198 Na98f1881f43449f48b6f3094833c34dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Cell Membrane
200 rdf:type schema:DefinedTerm
201 Nb1b5f82848d841ae9c3d0db92519152a rdf:first sg:person.07562536207.91
202 rdf:rest Nc9be47d852114dd2bf4fb2c4fda46d1a
203 Nb6d72accd90c42aba62c22d64e029979 rdf:first sg:person.016255307132.40
204 rdf:rest N3a8d889601a449f1b22d2563f67cd51a
205 Nb7570d75603d436097f581a8550ad3a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Models, Molecular
207 rdf:type schema:DefinedTerm
208 Nb78fbf20ed19436cb3c906554bf1fc0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name CHO Cells
210 rdf:type schema:DefinedTerm
211 Nc9be47d852114dd2bf4fb2c4fda46d1a rdf:first sg:person.0655051032.75
212 rdf:rest Nb6d72accd90c42aba62c22d64e029979
213 Ncbd47c12f1bf49628864aae4ddb78a68 rdf:first sg:person.0676050733.75
214 rdf:rest N9865e6d4105e4d2f90b5aeab00a46359
215 Nd5e7092ff6ab4787929747d12618558e rdf:first sg:person.01073047014.12
216 rdf:rest Ncbd47c12f1bf49628864aae4ddb78a68
217 Nd6297eb74d7f473ab691a1e969e6856c rdf:first sg:person.01203344423.35
218 rdf:rest N0df1b670c97f4ef78322fd38d949c539
219 Nd91f856f69e043d18a95fdc78cac5d20 schema:name dimensions_id
220 schema:value pub.1107590384
221 rdf:type schema:PropertyValue
222 Nd9fd087ed84a4011a6e16c56d72fb908 rdf:first sg:person.01136650361.84
223 rdf:rest Ndc8ad8f1374746edab5ba7c0178e0cd1
224 Ndbb955b6ff7a4c589ba3c16ecd2b3d00 rdf:first sg:person.01105525372.24
225 rdf:rest Na0657499fef04ff08b17972c5df2e4de
226 Ndc8ad8f1374746edab5ba7c0178e0cd1 rdf:first sg:person.0642320761.13
227 rdf:rest Ndbb955b6ff7a4c589ba3c16ecd2b3d00
228 Ndfe81a65bf4845ba9bd1f4f3c20bf507 rdf:first sg:person.01154633455.09
229 rdf:rest N1be4f21949034dbbbd8807611f00b6d5
230 Ne177adf98a3f46ea8d3d47521f4fbb0f schema:name pubmed_id
231 schema:value 30337523
232 rdf:type schema:PropertyValue
233 Nf60cc3d2ea844850ba1e5dc6f9d3c974 schema:volumeNumber 9
234 rdf:type schema:PublicationVolume
235 Nf67f636a4a28417f97755616b69253a8 schema:name readcube_id
236 schema:value 561a5cd90cba8010de29952a5e31f39de241b75f5f26a87d62702c7e68794f68
237 rdf:type schema:PropertyValue
238 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
239 schema:name Biological Sciences
240 rdf:type schema:DefinedTerm
241 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
242 schema:name Biochemistry and Cell Biology
243 rdf:type schema:DefinedTerm
244 sg:grant.2777051 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-06632-0
245 rdf:type schema:MonetaryGrant
246 sg:grant.2787832 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-06632-0
247 rdf:type schema:MonetaryGrant
248 sg:grant.3497493 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-06632-0
249 rdf:type schema:MonetaryGrant
250 sg:grant.3560415 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-06632-0
251 rdf:type schema:MonetaryGrant
252 sg:grant.3959602 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-06632-0
253 rdf:type schema:MonetaryGrant
254 sg:grant.6620764 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-06632-0
255 rdf:type schema:MonetaryGrant
256 sg:grant.6621655 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-06632-0
257 rdf:type schema:MonetaryGrant
258 sg:journal.1043282 schema:issn 2041-1723
259 schema:name Nature Communications
260 rdf:type schema:Periodical
261 sg:person.01033253567.34 schema:affiliation https://www.grid.ac/institutes/grid.76978.37
262 schema:familyName Clarke
263 schema:givenName David T.
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033253567.34
265 rdf:type schema:Person
266 sg:person.01073047014.12 schema:affiliation https://www.grid.ac/institutes/grid.76978.37
267 schema:familyName Zanetti-Domingues
268 schema:givenName Laura C.
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073047014.12
270 rdf:type schema:Person
271 sg:person.01105525372.24 schema:affiliation https://www.grid.ac/institutes/grid.76978.37
272 schema:familyName Rolfe
273 schema:givenName Daniel J.
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105525372.24
275 rdf:type schema:Person
276 sg:person.01111564441.81 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
277 schema:familyName Parker
278 schema:givenName Peter J.
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111564441.81
280 rdf:type schema:Person
281 sg:person.01112362314.31 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
282 schema:familyName Gervasio
283 schema:givenName Francesco L.
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112362314.31
285 rdf:type schema:Person
286 sg:person.01136650361.84 schema:affiliation https://www.grid.ac/institutes/grid.417724.3
287 schema:familyName Shan
288 schema:givenName Yibing
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136650361.84
290 rdf:type schema:Person
291 sg:person.011466772521.20 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
292 schema:familyName Jain
293 schema:givenName Purvi
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011466772521.20
295 rdf:type schema:Person
296 sg:person.01154633455.09 schema:affiliation https://www.grid.ac/institutes/grid.76978.37
297 schema:familyName Roberts
298 schema:givenName Selene K.
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154633455.09
300 rdf:type schema:Person
301 sg:person.01203344423.35 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
302 schema:familyName Ortiz-Zapater
303 schema:givenName Elena
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203344423.35
305 rdf:type schema:Person
306 sg:person.01207275414.29 schema:affiliation https://www.grid.ac/institutes/grid.76978.37
307 schema:familyName Needham
308 schema:givenName Sarah R.
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207275414.29
310 rdf:type schema:Person
311 sg:person.013024511366.64 schema:affiliation https://www.grid.ac/institutes/grid.417724.3
312 schema:familyName Sagawa
313 schema:givenName Shiori
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013024511366.64
315 rdf:type schema:Person
316 sg:person.01316516647.03 schema:affiliation N420b6c02e4524adba81b0a760ec0cf3d
317 schema:familyName Roovers
318 schema:givenName Rob C.
319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316516647.03
320 rdf:type schema:Person
321 sg:person.016255307132.40 schema:affiliation https://www.grid.ac/institutes/grid.1027.4
322 schema:familyName Clayton
323 schema:givenName Andrew H. A.
324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016255307132.40
325 rdf:type schema:Person
326 sg:person.0642320761.13 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
327 schema:familyName Shaw
328 schema:givenName David E.
329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642320761.13
330 rdf:type schema:Person
331 sg:person.0655051032.75 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
332 schema:familyName Santis
333 schema:givenName George
334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655051032.75
335 rdf:type schema:Person
336 sg:person.0660711472.96 schema:affiliation https://www.grid.ac/institutes/grid.76978.37
337 schema:familyName Martin-Fernandez
338 schema:givenName Marisa L.
339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660711472.96
340 rdf:type schema:Person
341 sg:person.0661345127.10 schema:affiliation https://www.grid.ac/institutes/grid.1027.4
342 schema:familyName Lajevardipour
343 schema:givenName Alireza
344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661345127.10
345 rdf:type schema:Person
346 sg:person.0676050733.75 schema:affiliation https://www.grid.ac/institutes/grid.76978.37
347 schema:familyName Korovesis
348 schema:givenName Dimitrios
349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676050733.75
350 rdf:type schema:Person
351 sg:person.0722311156.12 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
352 schema:familyName Kuzmanic
353 schema:givenName Antonija
354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722311156.12
355 rdf:type schema:Person
356 sg:person.07562536207.91 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
357 schema:familyName van Bergen en Henegouwen
358 schema:givenName Paul M. P.
359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07562536207.91
360 rdf:type schema:Person
361 sg:person.0771276772.59 schema:affiliation https://www.grid.ac/institutes/grid.76978.37
362 schema:familyName Tynan
363 schema:givenName Christopher J.
364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771276772.59
365 rdf:type schema:Person
366 sg:pub.10.1007/s00249-011-0747-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018961076
367 https://doi.org/10.1007/s00249-011-0747-7
368 rdf:type schema:CreativeWork
369 sg:pub.10.1038/cr.2014.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002991958
370 https://doi.org/10.1038/cr.2014.89
371 rdf:type schema:CreativeWork
372 sg:pub.10.1038/nature08827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040786335
373 https://doi.org/10.1038/nature08827
374 rdf:type schema:CreativeWork
375 sg:pub.10.1038/ncomms13307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013280320
376 https://doi.org/10.1038/ncomms13307
377 rdf:type schema:CreativeWork
378 sg:pub.10.1038/ncomms8380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020778522
379 https://doi.org/10.1038/ncomms8380
380 rdf:type schema:CreativeWork
381 sg:pub.10.1038/nmeth.2019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026706357
382 https://doi.org/10.1038/nmeth.2019
383 rdf:type schema:CreativeWork
384 sg:pub.10.1038/nsmb.2135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025713856
385 https://doi.org/10.1038/nsmb.2135
386 rdf:type schema:CreativeWork
387 sg:pub.10.1038/onc.2010.313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027694871
388 https://doi.org/10.1038/onc.2010.313
389 rdf:type schema:CreativeWork
390 https://app.dimensions.ai/details/publication/pub.1082432622 schema:CreativeWork
391 https://doi.org/10.1002/1096-987x(20010415)22:5<501::aid-jcc1021>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1050457221
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1002/prot.20660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050792187
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1002/prot.21123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033216981
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1002/prot.22862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053366075
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1006/jmbi.1993.1626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030443070
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1006/jmbi.2001.4923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003343011
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1016/0092-8674(90)90801-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1037771370
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1016/j.bbamcr.2005.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026454548
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1016/j.bpj.2013.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025605900
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1016/j.cell.2006.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001670196
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1016/j.cell.2009.04.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044215429
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1016/j.cell.2010.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036327574
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1016/j.cell.2010.07.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010981514
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1016/j.cell.2012.02.063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009103049
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1016/j.cell.2012.12.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025926106
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1016/j.cell.2012.12.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011371017
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1016/j.cell.2016.10.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050861868
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1016/j.celrep.2014.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047774332
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1016/j.cpc.2013.09.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049416945
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1016/j.molcel.2009.04.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006916301
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1016/j.pbiomolbio.2015.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022579829
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1016/j.softx.2015.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028157022
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1016/j.str.2012.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010128049
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1016/j.str.2013.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030267301
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1016/j.str.2013.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019251014
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1016/j.ymeth.2015.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030009088
442 rdf:type schema:CreativeWork
443 https://doi.org/10.1016/s0092-8674(02)00940-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028118590
444 rdf:type schema:CreativeWork
445 https://doi.org/10.1016/s0092-8674(02)00963-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046457415
446 rdf:type schema:CreativeWork
447 https://doi.org/10.1016/s1097-2765(03)00047-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003071711
448 rdf:type schema:CreativeWork
449 https://doi.org/10.1021/acs.jctc.5b00255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027172688
450 rdf:type schema:CreativeWork
451 https://doi.org/10.1021/bi700002b schema:sameAs https://app.dimensions.ai/details/publication/pub.1055206936
452 rdf:type schema:CreativeWork
453 https://doi.org/10.1021/ja062463w schema:sameAs https://app.dimensions.ai/details/publication/pub.1055842172
454 rdf:type schema:CreativeWork
455 https://doi.org/10.1021/jacs.6b05602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055875773
456 rdf:type schema:CreativeWork
457 https://doi.org/10.1021/jp973084f schema:sameAs https://app.dimensions.ai/details/publication/pub.1019311063
458 rdf:type schema:CreativeWork
459 https://doi.org/10.1039/c3mb70073a schema:sameAs https://app.dimensions.ai/details/publication/pub.1031529611
460 rdf:type schema:CreativeWork
461 https://doi.org/10.1042/bst20140318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056717852
462 rdf:type schema:CreativeWork
463 https://doi.org/10.1063/1.445869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058023889
464 rdf:type schema:CreativeWork
465 https://doi.org/10.1063/1.467468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058045473
466 rdf:type schema:CreativeWork
467 https://doi.org/10.1063/1.481505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058079325
468 rdf:type schema:CreativeWork
469 https://doi.org/10.1073/pnas.0707080105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011853433
470 rdf:type schema:CreativeWork
471 https://doi.org/10.1073/pnas.0709662105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030668301
472 rdf:type schema:CreativeWork
473 https://doi.org/10.1073/pnas.1005025107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019213036
474 rdf:type schema:CreativeWork
475 https://doi.org/10.1073/pnas.1221953110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003387065
476 rdf:type schema:CreativeWork
477 https://doi.org/10.1074/jbc.m109.001487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045166493
478 rdf:type schema:CreativeWork
479 https://doi.org/10.1074/jbc.m112.414391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020194245
480 rdf:type schema:CreativeWork
481 https://doi.org/10.1074/jbc.m207135200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015395356
482 rdf:type schema:CreativeWork
483 https://doi.org/10.1074/jbc.m208327200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031202474
484 rdf:type schema:CreativeWork
485 https://doi.org/10.1074/jbc.m304332200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001183336
486 rdf:type schema:CreativeWork
487 https://doi.org/10.1074/jbc.m504770200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019798618
488 rdf:type schema:CreativeWork
489 https://doi.org/10.1088/1478-3975/8/6/066002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033868912
490 rdf:type schema:CreativeWork
491 https://doi.org/10.1091/mbc.01-08-0411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016538588
492 rdf:type schema:CreativeWork
493 https://doi.org/10.1091/mbc.e15-05-0269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024027080
494 rdf:type schema:CreativeWork
495 https://doi.org/10.1093/nar/gkm047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040239983
496 rdf:type schema:CreativeWork
497 https://doi.org/10.1103/physreva.31.1695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060473124
498 rdf:type schema:CreativeWork
499 https://doi.org/10.1109/sc.2014.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093875572
500 rdf:type schema:CreativeWork
501 https://doi.org/10.1126/science.1099314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033538744
502 rdf:type schema:CreativeWork
503 https://doi.org/10.1128/mcb.00248-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030218128
504 rdf:type schema:CreativeWork
505 https://doi.org/10.1128/mcb.01431-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023764240
506 rdf:type schema:CreativeWork
507 https://doi.org/10.1242/jcs.028753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018860260
508 rdf:type schema:CreativeWork
509 https://doi.org/10.1364/ol.31.002157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1065224062
510 rdf:type schema:CreativeWork
511 https://doi.org/10.1371/journal.pone.0062331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007398137
512 rdf:type schema:CreativeWork
513 https://doi.org/10.1517/14728222.2011.648617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038394005
514 rdf:type schema:CreativeWork
515 https://doi.org/10.1529/biophysj.106.102087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018028868
516 rdf:type schema:CreativeWork
517 https://doi.org/10.1529/biophysj.107.105494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030199221
518 rdf:type schema:CreativeWork
519 https://doi.org/10.1593/neo.10688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041756186
520 rdf:type schema:CreativeWork
521 https://doi.org/10.2174/1389450053765879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069180255
522 rdf:type schema:CreativeWork
523 https://doi.org/10.3390/cancers9050052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085425076
524 rdf:type schema:CreativeWork
525 https://doi.org/10.3390/cells6020013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085745575
526 rdf:type schema:CreativeWork
527 https://doi.org/10.3934/biophy.2015.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071731030
528 rdf:type schema:CreativeWork
529 https://doi.org/10.7554/elife.14107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048243978
530 rdf:type schema:CreativeWork
531 https://doi.org/10.7554/elife.32271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103694671
532 rdf:type schema:CreativeWork
533 https://www.grid.ac/institutes/grid.1027.4 schema:alternateName Swinburne University of Technology
534 schema:name Centre for Micro-Photonics, Faculty of Science, Engineering and Technology, Swinburne University of Technology, 3122, Hawthorn, VIC, Australia
535 rdf:type schema:Organization
536 https://www.grid.ac/institutes/grid.13097.3c schema:alternateName King's College London
537 schema:name Peter Gore Department of Immunobiology, School of Immunology & Microbial Sciences, Kings College London, SE1 9RT, London, UK
538 Protein Phosphorylation Laboratory, The Francis Crick Institute, 1 Midland Road, NW 1 1AT, London, UK
539 School of Cancer and Pharmaceutical Sciences, King’s College London, New Hunt’s House, Guy’s Campus, SE1 1UL, London, UK
540 rdf:type schema:Organization
541 https://www.grid.ac/institutes/grid.21729.3f schema:alternateName Columbia University
542 schema:name D. E. Shaw Research, 10036, New York, NY, USA
543 Department of Biochemistry and Molecular Biophysics, Columbia University, 10032, New York, NY, USA
544 rdf:type schema:Organization
545 https://www.grid.ac/institutes/grid.417724.3 schema:alternateName D. E. Shaw Research
546 schema:name D. E. Shaw Research, 10036, New York, NY, USA
547 rdf:type schema:Organization
548 https://www.grid.ac/institutes/grid.5477.1 schema:alternateName Utrecht University
549 schema:name Division of Cell Biology, Science Faculty, Department of Biology, Utrecht University, 3584 CH, Utrecht, The Netherlands
550 rdf:type schema:Organization
551 https://www.grid.ac/institutes/grid.76978.37 schema:alternateName Rutherford Appleton Laboratory
552 schema:name Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot, OX11 0QX, Oxford, UK
553 rdf:type schema:Organization
554 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
555 schema:name Department of Chemistry, Faculty of Maths & Physical Sciences, University College London, WC1H 0AJ, London, UK
556 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...