Clonal dynamics in osteosarcoma defined by RGB marking View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Stefano Gambera, Ander Abarrategi, Fernando González-Camacho, Álvaro Morales-Molina, Josep Roma, Arantzazu Alfranca, Javier García-Castro

ABSTRACT

Osteosarcoma is a type of bone tumour characterized by considerable levels of phenotypic heterogeneity, aneuploidy, and a high mutational rate. The life expectancy of osteosarcoma patients has not changed during the last three decades and thus much remains to be learned about the disease biology. Here, we employ a RGB-based single-cell tracking system to study the clonal dynamics occurring in a de novo-induced murine osteosarcoma model. We show that osteosarcoma cells present initial polyclonal dynamics, followed by clonal dominance associated with adaptation to the microenvironment. Interestingly, the dominant clones are composed of subclones with a similar tumour generation potential when they are re-implanted in mice. Moreover, individual spontaneous metastases are clonal or oligoclonal, but they have a different cellular origin than the dominant clones present in primary tumours. In summary, we present evidence that osteosarcomagenesis can follow a neutral evolution model, in which different cancer clones coexist and propagate simultaneously. More... »

PAGES

3994

References to SciGraph publications

  • 2015-03. A Big Bang model of human colorectal tumor growth in NATURE GENETICS
  • 2015-05. In-vivo RGB marking and multicolour single-cell tracking in the adult brain in SCIENTIFIC REPORTS
  • 2012-05. RGB marking with lentiviral vectors for multicolor clonal cell tracking in NATURE PROTOCOLS
  • 2017-03-24. Germline and somatic genetics of osteosarcoma — connecting aetiology, biology and therapy in NATURE REVIEWS ENDOCRINOLOGY
  • 2016-03. Identification of neutral tumor evolution across cancer types in NATURE GENETICS
  • 2015-09. A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity in NATURE
  • 2012-08. Classifying collective cancer cell invasion in NATURE CELL BIOLOGY
  • 2012-01. Clonal evolution in cancer in NATURE
  • 2013-06. viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia in NATURE BIOTECHNOLOGY
  • 2011-10. Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE in NATURE BIOTECHNOLOGY
  • 1997-07. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell in NATURE MEDICINE
  • 2010-04. Lentiviral gene ontology (LeGO) vectors equipped with novel drug-selectable fluorescent proteins: new building blocks for cell marking and multi-gene analysis in GENE THERAPY
  • 2012-06. The Pediatric Cancer Genome Project in NATURE GENETICS
  • 2011-04. RGB marking facilitates multicolor clonal cell tracking in NATURE MEDICINE
  • 2017-12. Resource competition promotes tumour expansion in experimentally evolved cancer in BMC EVOLUTIONARY BIOLOGY
  • 2015-08. Tumorigenesis: it takes a village in NATURE REVIEWS CANCER
  • 2014-03. Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing in NATURE GENETICS
  • 2008-12. Efficient tumour formation by single human melanoma cells in NATURE
  • 2018-12. Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution in NATURE COMMUNICATIONS
  • 2015-12. Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency in NATURE COMMUNICATIONS
  • 2009-08-12. Current Concepts on the Molecular Biology of Osteosarcoma in PEDIATRIC AND ADOLESCENT OSTEOSARCOMA
  • 2017-12. Human Cancer Cells Signal Their Competitive Fitness Through MYC Activity in SCIENTIFIC REPORTS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-06401-z

    DOI

    http://dx.doi.org/10.1038/s41467-018-06401-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107235070

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30266933


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