Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-09-24

AUTHORS

Shuying Yi, Jing Zhai, Rui Niu, Guangming Zhu, Meixiang Wang, Jianguo Liu, Hua Huang, Yaping Wang, Xiuli Jing, Li Kang, Wengang Song, Yufang Shi, Hua Tang

ABSTRACT

Eosinophil infiltration, a hallmark of allergic asthma, is essential for type 2 immune responses. How the initial eosinophil recruitment is regulated by lung dendritic cell (DC) subsets during the memory stage after allergen challenge is unclear. Here, we show that the initial eosinophil infiltration is dependent on lung cDC1s, which require nitric oxide (NO) produced by inducible NO synthase from lung CD24-CD11b+ DC2s for inducing CCL17 and CCL22 to attract eosinophils. During late phase responses after allergen challenge, lung CD24+ cDC2s inhibit eosinophil recruitment through secretion of TGF-β1, which impairs the expression of CCL17 and CCL22. Our data suggest that different lung antigen-presenting cells modulate lung cDC1-mediated eosinophil recruitment dynamically, through secreting distinct soluble factors during the memory stage of chronic asthma after allergen challenge in the mouse. More... »

PAGES

3879

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-06316-9

DOI

http://dx.doi.org/10.1038/s41467-018-06316-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107094000

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30250029


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35 schema:description Eosinophil infiltration, a hallmark of allergic asthma, is essential for type 2 immune responses. How the initial eosinophil recruitment is regulated by lung dendritic cell (DC) subsets during the memory stage after allergen challenge is unclear. Here, we show that the initial eosinophil infiltration is dependent on lung cDC1s, which require nitric oxide (NO) produced by inducible NO synthase from lung CD24<sup>-</sup>CD11b<sup>+</sup> DC2s for inducing CCL17 and CCL22 to attract eosinophils. During late phase responses after allergen challenge, lung CD24<sup>+</sup> cDC2s inhibit eosinophil recruitment through secretion of TGF-β1, which impairs the expression of CCL17 and CCL22. Our data suggest that different lung antigen-presenting cells modulate lung cDC1-mediated eosinophil recruitment dynamically, through secreting distinct soluble factors during the memory stage of chronic asthma after allergen challenge in the mouse.
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43 CCL22
44 CD11b
45 CD24
46 DC2s
47 Lung Dendritic Cell Subsets
48 NO synthase
49 TGF-β1
50 allergen challenge
51 allergic asthma
52 antigen-presenting cells
53 asthma
54 cDC1
55 cDC1s
56 cell subsets
57 cells
58 challenges
59 chronic asthma
60 data
61 dendritic cell subsets
62 different lung antigen-presenting cells
63 distinct soluble factors
64 eosinophil infiltration
65 eosinophil recruitment
66 eosinophils
67 expression
68 expression of CCL17
69 factors
70 hallmark
71 immune response
72 inducible NO synthase
73 infiltration
74 initial eosinophil infiltration
75 initial eosinophil recruitment
76 interplay
77 late-phase response
78 lung CD24
79 lung antigen-presenting cells
80 lung cDC1
81 lung cDC1s
82 memory stages
83 mice
84 nitric oxide
85 oxide
86 phase response
87 recruitment
88 response
89 secretion
90 soluble factors
91 stage
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93 synthase
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