Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Benjamin M. Janus, Nydia van Dyk, Xuelian Zhao, Katie A. Howell, Cinque Soto, M. Javad Aman, Yuxing Li, Thomas R. Fuerst, Gilad Ofek

ABSTRACT

The severity of the 2014-2016 ebolavirus outbreak in West Africa expedited clinical development of therapeutics and vaccines though the countermeasures on hand were largely monospecific and lacked efficacy against other ebolavirus species that previously emerged. Recent studies indicate that ebolavirus glycoprotein (GP) fusion loops are targets for cross-protective antibodies. Here we report the 3.72 Å resolution crystal structure of one such cross-protective antibody, CA45, bound to the ectodomain of Ebola virus (EBOV) GP. The CA45 epitope spans multiple faces of the fusion loop stem, across both GP1 and GP2 subunits, with ~68% of residues identical across > 99.5% of known ebolavirus isolates. Extensive antibody interactions within a pan-ebolavirus small-molecule inhibitor binding cavity on GP define this cavity as a novel site of immune vulnerability. The structure elucidates broad ebolavirus neutralization through a highly conserved epitope on GP and further enables rational design and development of broadly protective vaccines and therapeutics. More... »

PAGES

3934

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-06113-4

DOI

http://dx.doi.org/10.1038/s41467-018-06113-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107129351

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30258051


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Maryland, College Park", 
          "id": "https://www.grid.ac/institutes/grid.164295.d", 
          "name": [
            "Institute for Bioscience and Biotechnology Research, University of Maryland, 20850, Rockville, MD, USA", 
            "Department of Cell Biology and Molecular Genetics, University of Maryland, 20742, College Park, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Janus", 
        "givenName": "Benjamin M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universities at Shady Grove", 
          "id": "https://www.grid.ac/institutes/grid.440664.4", 
          "name": [
            "Institute for Bioscience and Biotechnology Research, University of Maryland, 20850, Rockville, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Dyk", 
        "givenName": "Nydia", 
        "id": "sg:person.0616047031.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616047031.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universities at Shady Grove", 
          "id": "https://www.grid.ac/institutes/grid.440664.4", 
          "name": [
            "Institute for Bioscience and Biotechnology Research, University of Maryland, 20850, Rockville, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Xuelian", 
        "id": "sg:person.01123361413.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123361413.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Integrated BioTherapeutics (United States)", 
          "id": "https://www.grid.ac/institutes/grid.420253.2", 
          "name": [
            "Integrated BioTherapeutics, 20850, Rockville, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Howell", 
        "givenName": "Katie A.", 
        "id": "sg:person.0713521477.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713521477.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, 37232, Nashville, TN, USA", 
            "Department of Pediatrics, Vanderbilt University Medical Center, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soto", 
        "givenName": "Cinque", 
        "id": "sg:person.01131453372.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131453372.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Integrated BioTherapeutics (United States)", 
          "id": "https://www.grid.ac/institutes/grid.420253.2", 
          "name": [
            "Integrated BioTherapeutics, 20850, Rockville, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aman", 
        "givenName": "M. Javad", 
        "id": "sg:person.0715152765.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715152765.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Maryland, Baltimore", 
          "id": "https://www.grid.ac/institutes/grid.411024.2", 
          "name": [
            "Institute for Bioscience and Biotechnology Research, University of Maryland, 20850, Rockville, MD, USA", 
            "Department of Microbiology and Immunology, University of Maryland School of Medicine, 21201, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Yuxing", 
        "id": "sg:person.013247615607.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013247615607.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Maryland, College Park", 
          "id": "https://www.grid.ac/institutes/grid.164295.d", 
          "name": [
            "Institute for Bioscience and Biotechnology Research, University of Maryland, 20850, Rockville, MD, USA", 
            "Department of Cell Biology and Molecular Genetics, University of Maryland, 20742, College Park, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fuerst", 
        "givenName": "Thomas R.", 
        "id": "sg:person.013734217351.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013734217351.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Maryland, College Park", 
          "id": "https://www.grid.ac/institutes/grid.164295.d", 
          "name": [
            "Institute for Bioscience and Biotechnology Research, University of Maryland, 20850, Rockville, MD, USA", 
            "Department of Cell Biology and Molecular Genetics, University of Maryland, 20742, College Park, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ofek", 
        "givenName": "Gilad", 
        "id": "sg:person.0603046752.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603046752.25"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1128/jvi.00396-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000353096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1414164111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001076275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444910045749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002186240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002525629", 
          "https://doi.org/10.1038/nature07082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2015.03.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008778114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2016.04.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011055310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmsr1513109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012639471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.antiviral.2016.11.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015319697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.849004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016890117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.12.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019397797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.12.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019397797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444904019158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020281098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909052925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020777046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909052925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020777046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkw1065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021631519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40249-015-0055-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022737189", 
          "https://doi.org/10.1186/s40249-015-0055-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40249-015-0055-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022737189", 
          "https://doi.org/10.1186/s40249-015-0055-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aad6117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023349511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkr898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024121568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027461829", 
          "https://doi.org/10.1038/nsmb.2150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.10.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028033221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.10.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028033221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909047337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032162623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909047337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032162623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature18615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032182701", 
          "https://doi.org/10.1038/nature18615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.10.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035326707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037242940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037242940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02151-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038864290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2007.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042204379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80159-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042793681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmicrobiol.2016.128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043365156", 
          "https://doi.org/10.1038/nmicrobiol.2016.128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmicrobiol.2016.199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046144185", 
          "https://doi.org/10.1038/nmicrobiol.2016.199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02172-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048233929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01956-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048535130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aae0474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048767271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aae0474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048767271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444902016657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051282549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.3067010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057907404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3005471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062687842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2017.04.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085441537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2017.04.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085441537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2017.04.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085444291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2017.04.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085444291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00652-17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085918933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00652-17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085918933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1708052114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091494524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.jmedchem.7b01249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099903744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.jmedchem.7b01249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099903744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.jmedchem.7b01249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099903744"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "The severity of the 2014-2016 ebolavirus outbreak in West Africa expedited clinical development of therapeutics and vaccines\u00a0though the countermeasures on hand were largely monospecific and lacked efficacy against other ebolavirus species that previously emerged. Recent studies indicate that ebolavirus glycoprotein (GP) fusion loops are targets for cross-protective antibodies. Here we report the 3.72\u2009\u00c5 resolution crystal structure of one such cross-protective antibody, CA45, bound to the ectodomain of Ebola virus (EBOV) GP. The CA45 epitope spans multiple faces of the fusion loop stem, across both GP1 and GP2 subunits, with ~68% of residues identical across >\u200999.5% of known ebolavirus isolates. Extensive antibody interactions within a pan-ebolavirus\u00a0small-molecule inhibitor\u00a0binding cavity on GP define this cavity as a novel site of immune vulnerability. The structure elucidates broad ebolavirus neutralization through a highly conserved epitope on GP and further enables rational design and development of broadly protective vaccines and therapeutics.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-018-06113-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6618971", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop", 
    "pagination": "3934", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6cd55d90fabccce445e2c187344ac85a9d0edea06444a2577903248a336a9114"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30258051"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-018-06113-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107129351"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-018-06113-4", 
      "https://app.dimensions.ai/details/publication/pub.1107129351"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000555.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-018-06113-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06113-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06113-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06113-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06113-4'


 

This table displays all metadata directly associated to this object as RDF triples.

260 TRIPLES      21 PREDICATES      67 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-018-06113-4 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N2a78e3171e584a65b8c1f79fac88018a
4 schema:citation sg:pub.10.1038/nature07082
5 sg:pub.10.1038/nature18615
6 sg:pub.10.1038/nmicrobiol.2016.128
7 sg:pub.10.1038/nmicrobiol.2016.199
8 sg:pub.10.1038/nsmb.2150
9 sg:pub.10.1186/s40249-015-0055-z
10 https://doi.org/10.1016/j.antiviral.2016.11.017
11 https://doi.org/10.1016/j.cell.2015.12.044
12 https://doi.org/10.1016/j.cell.2016.05.022
13 https://doi.org/10.1016/j.cell.2016.10.013
14 https://doi.org/10.1016/j.cell.2016.10.014
15 https://doi.org/10.1016/j.cell.2017.04.037
16 https://doi.org/10.1016/j.cell.2017.04.038
17 https://doi.org/10.1016/j.celrep.2016.04.026
18 https://doi.org/10.1016/j.jmb.2007.05.022
19 https://doi.org/10.1016/j.virol.2015.03.043
20 https://doi.org/10.1016/s1097-2765(00)80159-8
21 https://doi.org/10.1021/acs.jmedchem.7b01249
22 https://doi.org/10.1056/nejmsr1513109
23 https://doi.org/10.1063/1.3067010
24 https://doi.org/10.1073/pnas.1414164111
25 https://doi.org/10.1073/pnas.1708052114
26 https://doi.org/10.1093/nar/gkr898
27 https://doi.org/10.1093/nar/gkw1065
28 https://doi.org/10.1101/gr.849004
29 https://doi.org/10.1107/s0907444902016657
30 https://doi.org/10.1107/s0907444904019158
31 https://doi.org/10.1107/s0907444909047337
32 https://doi.org/10.1107/s0907444909052925
33 https://doi.org/10.1107/s0907444910045749
34 https://doi.org/10.1126/science.aad6117
35 https://doi.org/10.1126/science.aae0474
36 https://doi.org/10.1126/scitranslmed.3005471
37 https://doi.org/10.1128/jvi.00396-14
38 https://doi.org/10.1128/jvi.00652-17
39 https://doi.org/10.1128/jvi.01956-08
40 https://doi.org/10.1128/jvi.02151-09
41 https://doi.org/10.1128/jvi.02172-15
42 schema:datePublished 2018-12
43 schema:datePublishedReg 2018-12-01
44 schema:description The severity of the 2014-2016 ebolavirus outbreak in West Africa expedited clinical development of therapeutics and vaccines though the countermeasures on hand were largely monospecific and lacked efficacy against other ebolavirus species that previously emerged. Recent studies indicate that ebolavirus glycoprotein (GP) fusion loops are targets for cross-protective antibodies. Here we report the 3.72 Å resolution crystal structure of one such cross-protective antibody, CA45, bound to the ectodomain of Ebola virus (EBOV) GP. The CA45 epitope spans multiple faces of the fusion loop stem, across both GP1 and GP2 subunits, with ~68% of residues identical across > 99.5% of known ebolavirus isolates. Extensive antibody interactions within a pan-ebolavirus small-molecule inhibitor binding cavity on GP define this cavity as a novel site of immune vulnerability. The structure elucidates broad ebolavirus neutralization through a highly conserved epitope on GP and further enables rational design and development of broadly protective vaccines and therapeutics.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree true
48 schema:isPartOf N88ffa9ba4f964442b8f5850cd754fe7d
49 Nffc42f886ee246568f5a1eca9ee46bd0
50 sg:journal.1043282
51 schema:name Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop
52 schema:pagination 3934
53 schema:productId N32fe799fdc5643be9c50fe8c04ab8baf
54 N5d149871e0bd46b6983cdde577df7cb9
55 N5f5e4c28ab994b299d416db1583a4788
56 Neeb8321da1c64d248204821c91fc70e2
57 Nfd40d9cd0abf4015ac9c0606ab296c3b
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107129351
59 https://doi.org/10.1038/s41467-018-06113-4
60 schema:sdDatePublished 2019-04-10T20:04
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N783ad31a394b477495fc33582932226b
63 schema:url https://www.nature.com/articles/s41467-018-06113-4
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N0fa40909756848539a4ace4758109801 rdf:first sg:person.01131453372.26
68 rdf:rest Nb212575c530d447096b9538b11f1041b
69 N1df81b2b72a7450ba913c8c61ab71908 rdf:first sg:person.0713521477.98
70 rdf:rest N0fa40909756848539a4ace4758109801
71 N2a78e3171e584a65b8c1f79fac88018a rdf:first Nc4b60d7ee5614fa3b98dce4cb5919cec
72 rdf:rest Ne580216adbb54d439c1ad06cf12edd32
73 N319cacef0fdf436c91d5f24d992709d2 rdf:first sg:person.013734217351.67
74 rdf:rest N6e80fa4790d64507ae951f095971e1a7
75 N32fe799fdc5643be9c50fe8c04ab8baf schema:name nlm_unique_id
76 schema:value 101528555
77 rdf:type schema:PropertyValue
78 N5d149871e0bd46b6983cdde577df7cb9 schema:name pubmed_id
79 schema:value 30258051
80 rdf:type schema:PropertyValue
81 N5f5e4c28ab994b299d416db1583a4788 schema:name dimensions_id
82 schema:value pub.1107129351
83 rdf:type schema:PropertyValue
84 N6e80fa4790d64507ae951f095971e1a7 rdf:first sg:person.0603046752.25
85 rdf:rest rdf:nil
86 N783ad31a394b477495fc33582932226b schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N7b2cd21752444ef9a6dc003c7fb4bfe9 rdf:first sg:person.01123361413.74
89 rdf:rest N1df81b2b72a7450ba913c8c61ab71908
90 N88ffa9ba4f964442b8f5850cd754fe7d schema:issueNumber 1
91 rdf:type schema:PublicationIssue
92 Nb212575c530d447096b9538b11f1041b rdf:first sg:person.0715152765.37
93 rdf:rest Ncc970102c06c41b2836c2b335be6c46d
94 Nc4b60d7ee5614fa3b98dce4cb5919cec schema:affiliation https://www.grid.ac/institutes/grid.164295.d
95 schema:familyName Janus
96 schema:givenName Benjamin M.
97 rdf:type schema:Person
98 Ncc970102c06c41b2836c2b335be6c46d rdf:first sg:person.013247615607.85
99 rdf:rest N319cacef0fdf436c91d5f24d992709d2
100 Ne580216adbb54d439c1ad06cf12edd32 rdf:first sg:person.0616047031.45
101 rdf:rest N7b2cd21752444ef9a6dc003c7fb4bfe9
102 Neeb8321da1c64d248204821c91fc70e2 schema:name doi
103 schema:value 10.1038/s41467-018-06113-4
104 rdf:type schema:PropertyValue
105 Nfd40d9cd0abf4015ac9c0606ab296c3b schema:name readcube_id
106 schema:value 6cd55d90fabccce445e2c187344ac85a9d0edea06444a2577903248a336a9114
107 rdf:type schema:PropertyValue
108 Nffc42f886ee246568f5a1eca9ee46bd0 schema:volumeNumber 9
109 rdf:type schema:PublicationVolume
110 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
111 schema:name Medical and Health Sciences
112 rdf:type schema:DefinedTerm
113 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
114 schema:name Immunology
115 rdf:type schema:DefinedTerm
116 sg:grant.6618971 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-06113-4
117 rdf:type schema:MonetaryGrant
118 sg:journal.1043282 schema:issn 2041-1723
119 schema:name Nature Communications
120 rdf:type schema:Periodical
121 sg:person.01123361413.74 schema:affiliation https://www.grid.ac/institutes/grid.440664.4
122 schema:familyName Zhao
123 schema:givenName Xuelian
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123361413.74
125 rdf:type schema:Person
126 sg:person.01131453372.26 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
127 schema:familyName Soto
128 schema:givenName Cinque
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131453372.26
130 rdf:type schema:Person
131 sg:person.013247615607.85 schema:affiliation https://www.grid.ac/institutes/grid.411024.2
132 schema:familyName Li
133 schema:givenName Yuxing
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013247615607.85
135 rdf:type schema:Person
136 sg:person.013734217351.67 schema:affiliation https://www.grid.ac/institutes/grid.164295.d
137 schema:familyName Fuerst
138 schema:givenName Thomas R.
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013734217351.67
140 rdf:type schema:Person
141 sg:person.0603046752.25 schema:affiliation https://www.grid.ac/institutes/grid.164295.d
142 schema:familyName Ofek
143 schema:givenName Gilad
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603046752.25
145 rdf:type schema:Person
146 sg:person.0616047031.45 schema:affiliation https://www.grid.ac/institutes/grid.440664.4
147 schema:familyName van Dyk
148 schema:givenName Nydia
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616047031.45
150 rdf:type schema:Person
151 sg:person.0713521477.98 schema:affiliation https://www.grid.ac/institutes/grid.420253.2
152 schema:familyName Howell
153 schema:givenName Katie A.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713521477.98
155 rdf:type schema:Person
156 sg:person.0715152765.37 schema:affiliation https://www.grid.ac/institutes/grid.420253.2
157 schema:familyName Aman
158 schema:givenName M. Javad
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715152765.37
160 rdf:type schema:Person
161 sg:pub.10.1038/nature07082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002525629
162 https://doi.org/10.1038/nature07082
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/nature18615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032182701
165 https://doi.org/10.1038/nature18615
166 rdf:type schema:CreativeWork
167 sg:pub.10.1038/nmicrobiol.2016.128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043365156
168 https://doi.org/10.1038/nmicrobiol.2016.128
169 rdf:type schema:CreativeWork
170 sg:pub.10.1038/nmicrobiol.2016.199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046144185
171 https://doi.org/10.1038/nmicrobiol.2016.199
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/nsmb.2150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027461829
174 https://doi.org/10.1038/nsmb.2150
175 rdf:type schema:CreativeWork
176 sg:pub.10.1186/s40249-015-0055-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1022737189
177 https://doi.org/10.1186/s40249-015-0055-z
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.antiviral.2016.11.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015319697
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.cell.2015.12.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019397797
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.cell.2016.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037242940
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.cell.2016.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035326707
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.cell.2016.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028033221
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.cell.2017.04.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085444291
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.cell.2017.04.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085441537
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.celrep.2016.04.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011055310
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.jmb.2007.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042204379
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.virol.2015.03.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008778114
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/s1097-2765(00)80159-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042793681
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1021/acs.jmedchem.7b01249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099903744
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1056/nejmsr1513109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012639471
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1063/1.3067010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057907404
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1073/pnas.1414164111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001076275
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1073/pnas.1708052114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091494524
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1093/nar/gkr898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024121568
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1093/nar/gkw1065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021631519
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1101/gr.849004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016890117
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1107/s0907444902016657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051282549
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1107/s0907444904019158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020281098
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1107/s0907444909047337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032162623
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1107/s0907444909052925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020777046
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1107/s0907444910045749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002186240
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1126/science.aad6117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023349511
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1126/science.aae0474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048767271
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1126/scitranslmed.3005471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062687842
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1128/jvi.00396-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000353096
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1128/jvi.00652-17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085918933
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1128/jvi.01956-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048535130
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1128/jvi.02151-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038864290
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1128/jvi.02172-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048233929
242 rdf:type schema:CreativeWork
243 https://www.grid.ac/institutes/grid.164295.d schema:alternateName University of Maryland, College Park
244 schema:name Department of Cell Biology and Molecular Genetics, University of Maryland, 20742, College Park, MD, USA
245 Institute for Bioscience and Biotechnology Research, University of Maryland, 20850, Rockville, MD, USA
246 rdf:type schema:Organization
247 https://www.grid.ac/institutes/grid.411024.2 schema:alternateName University of Maryland, Baltimore
248 schema:name Department of Microbiology and Immunology, University of Maryland School of Medicine, 21201, Baltimore, MD, USA
249 Institute for Bioscience and Biotechnology Research, University of Maryland, 20850, Rockville, MD, USA
250 rdf:type schema:Organization
251 https://www.grid.ac/institutes/grid.412807.8 schema:alternateName Vanderbilt University Medical Center
252 schema:name Department of Pediatrics, Vanderbilt University Medical Center, 37232, Nashville, TN, USA
253 The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, 37232, Nashville, TN, USA
254 rdf:type schema:Organization
255 https://www.grid.ac/institutes/grid.420253.2 schema:alternateName Integrated BioTherapeutics (United States)
256 schema:name Integrated BioTherapeutics, 20850, Rockville, MD, USA
257 rdf:type schema:Organization
258 https://www.grid.ac/institutes/grid.440664.4 schema:alternateName Universities at Shady Grove
259 schema:name Institute for Bioscience and Biotechnology Research, University of Maryland, 20850, Rockville, MD, USA
260 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...