A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Prashant K. Srivastava, Jonathan van Eyll, Patrice Godard, Manuela Mazzuferi, Andree Delahaye-Duriez, Juliette Van Steenwinckel, Pierre Gressens, Benedicte Danis, Catherine Vandenplas, Patrik Foerch, Karine Leclercq, Georges Mairet-Coello, Alvaro Cardenas, Frederic Vanclef, Liisi Laaniste, Isabelle Niespodziany, James Keaney, Julien Gasser, Gaelle Gillet, Kirill Shkura, Seon-Ah Chong, Jacques Behmoaras, Irena Kadiu, Enrico Petretto, Rafal M. Kaminski, Michael R. Johnson

ABSTRACT

The identification of drug targets is highly challenging, particularly for diseases of the brain. To address this problem, we developed and experimentally validated a general computational framework for drug target discovery that combines gene regulatory information with causal reasoning ("Causal Reasoning Analytical Framework for Target discovery"-CRAFT). Using a systems genetics approach and starting from gene expression data from the target tissue, CRAFT provides a predictive framework for identifying cell membrane receptors with a direction-specified influence over disease-related gene expression profiles. As proof of concept, we applied CRAFT to epilepsy and predicted the tyrosine kinase receptor Csf1R as a potential therapeutic target. The predicted effect of Csf1R blockade in attenuating epilepsy seizures was validated in three pre-clinical models of epilepsy. These results highlight CRAFT as a systems-level framework for target discovery and suggest Csf1R blockade as a novel therapeutic strategy in epilepsy. CRAFT is applicable to disease settings other than epilepsy. More... »

PAGES

3561

References to SciGraph publications

  • 2015-02. Orchestrating high-throughput genomic analysis with Bioconductor in NATURE METHODS
  • 2009-04. A network view of disease and compound screening in NATURE REVIEWS DRUG DISCOVERY
  • 2006-12. How many drug targets are there? in NATURE REVIEWS DRUG DISCOVERY
  • 2010-03. How to improve R&D productivity: the pharmaceutical industry's grand challenge in NATURE REVIEWS DRUG DISCOVERY
  • 2007-02. qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data in GENOME BIOLOGY
  • 2015-12. Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus in NATURE COMMUNICATIONS
  • 2013-04. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions in GENOME BIOLOGY
  • 2015-09. TRRUST: a reference database of human transcriptional regulatory interactions in SCIENTIFIC REPORTS
  • 2010-09. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk in NATURE
  • 2018-04. Intrinsic Inflammation Is a Potential Anti-Epileptogenic Target in the Organotypic Hippocampal Slice Model in NEUROTHERAPEUTICS
  • 2002-06. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes in GENOME BIOLOGY
  • 2002-06. CLUSFAVOR 5.0: hierarchical cluster and principal-component analysis of microarray-based transcriptional profiles in GENOME BIOLOGY
  • 2014-01. Systems genetics approaches to understand complex traits in NATURE REVIEWS GENETICS
  • 2016-12. Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery in GENOME BIOLOGY
  • 2004-08. Can the pharmaceutical industry reduce attrition rates? in NATURE REVIEWS DRUG DISCOVERY
  • 2009-09-10. Molecular networks as sensors and drivers of common human diseases in NATURE
  • 2013-10. New avenues for anti-epileptic drug discovery and development in NATURE REVIEWS DRUG DISCOVERY
  • 2015-08. Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders in NATURE REVIEWS GENETICS
  • 2016-02. Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease in NATURE NEUROSCIENCE
  • 2008-05. Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-06008-4

    DOI

    http://dx.doi.org/10.1038/s41467-018-06008-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106394364

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30177815


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anticonvulsants", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Computer Simulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Discovery", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epilepsy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epilepsy, Temporal Lobe", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Association Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "High-Throughput Nucleotide Sequencing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Targeted Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Muscarinic Agonists", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pilocarpine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Granulocyte-Macrophage Colony-Stimulating Factor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Analysis, RNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Systems Biology", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Imperial College London", 
              "id": "https://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Division of Brain Sciences, Imperial College London, W12 0NN, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Srivastava", 
            "givenName": "Prashant K.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Eyll", 
            "givenName": "Jonathan", 
            "id": "sg:person.0743453640.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743453640.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Clarivate Analytics (formerly the IP & Science Business of Thomson Reuters), 5901 Priestly Drive, #200, 92008, Carlsbad, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Godard", 
            "givenName": "Patrice", 
            "id": "sg:person.0777266367.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777266367.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mazzuferi", 
            "givenName": "Manuela", 
            "id": "sg:person.01312641136.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312641136.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Paris 13 University", 
              "id": "https://www.grid.ac/institutes/grid.11318.3a", 
              "name": [
                "Division of Brain Sciences, Imperial College London, W12 0NN, London, UK", 
                "UFR de Sant\u00e9, M\u00e9decine et Biologie Humaine, Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris 13, Bobigny, France", 
                "PROTECT, INSERM, Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris Diderot, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Delahaye-Duriez", 
            "givenName": "Andree", 
            "id": "sg:person.0645074651.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645074651.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "PROTECT, INSERM, Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris Diderot, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Van Steenwinckel", 
            "givenName": "Juliette", 
            "id": "sg:person.0726435613.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726435613.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "King's College London", 
              "id": "https://www.grid.ac/institutes/grid.13097.3c", 
              "name": [
                "PROTECT, INSERM, Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris Diderot, Paris, France", 
                "School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King\u2019s College London, St. Thomas\u2019 Hospital, SE1 7EH, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gressens", 
            "givenName": "Pierre", 
            "id": "sg:person.0643134421.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643134421.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Danis", 
            "givenName": "Benedicte", 
            "id": "sg:person.01113714132.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113714132.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vandenplas", 
            "givenName": "Catherine", 
            "id": "sg:person.01170203244.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170203244.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Foerch", 
            "givenName": "Patrik", 
            "id": "sg:person.01236316444.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236316444.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leclercq", 
            "givenName": "Karine", 
            "id": "sg:person.01173747010.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173747010.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mairet-Coello", 
            "givenName": "Georges", 
            "id": "sg:person.0665312373.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665312373.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cardenas", 
            "givenName": "Alvaro", 
            "id": "sg:person.01254455436.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254455436.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vanclef", 
            "givenName": "Frederic", 
            "id": "sg:person.016543250041.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016543250041.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Imperial College London", 
              "id": "https://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Division of Brain Sciences, Imperial College London, W12 0NN, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Laaniste", 
            "givenName": "Liisi", 
            "id": "sg:person.0635776424.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635776424.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Niespodziany", 
            "givenName": "Isabelle", 
            "id": "sg:person.01075037076.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075037076.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Keaney", 
            "givenName": "James", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gasser", 
            "givenName": "Julien", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gillet", 
            "givenName": "Gaelle", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Imperial College London", 
              "id": "https://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Division of Brain Sciences, Imperial College London, W12 0NN, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shkura", 
            "givenName": "Kirill", 
            "id": "sg:person.0611011560.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611011560.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chong", 
            "givenName": "Seon-Ah", 
            "id": "sg:person.016657522240.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016657522240.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Imperial College London", 
              "id": "https://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Centre for Complement and Inflammation Research, Imperial College London, W12 0NN, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Behmoaras", 
            "givenName": "Jacques", 
            "id": "sg:person.01020600421.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020600421.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kadiu", 
            "givenName": "Irena", 
            "id": "sg:person.0650427307.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650427307.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Imperial College London", 
              "id": "https://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Duke-NUS Medical School, Centre for Computational Biology, 8 College Road, 169857, Singapore, Republic of Singapore", 
                "Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, W12 0NN, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Petretto", 
            "givenName": "Enrico", 
            "id": "sg:person.01053327673.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053327673.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCB Pharma (Belgium)", 
              "id": "https://www.grid.ac/institutes/grid.421932.f", 
              "name": [
                "UCB Pharma, Avenue de l\u2019industrie, R9, B-1420, Braine-l\u2019Alleud, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kaminski", 
            "givenName": "Rafal M.", 
            "id": "sg:person.01233641526.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233641526.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Imperial College London", 
              "id": "https://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Division of Brain Sciences, Imperial College London, W12 0NN, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Johnson", 
            "givenName": "Michael R.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrd2826", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000699125", 
              "https://doi.org/10.1038/nrd2826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2826", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000699125", 
              "https://doi.org/10.1038/nrd2826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/wnp.0b013e3181fe0709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001447894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/wnp.0b013e3181fe0709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001447894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/wnp.0b013e3181fe0709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001447894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-1759(88)90310-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002255759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-1759(88)90310-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002255759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.23940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002397055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.23038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004835267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2007-8-2-r19", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007077528", 
              "https://doi.org/10.1186/gb-2007-8-2-r19"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0122912", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008550628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-016-1097-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008599753", 
              "https://doi.org/10.1186/s13059-016-1097-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-016-1097-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008599753", 
              "https://doi.org/10.1186/s13059-016-1097-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010695043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2002-3-7-software0002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011678864", 
              "https://doi.org/10.1186/gb-2002-3-7-software0002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep11432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012337694", 
              "https://doi.org/10.1038/srep11432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1132939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013321903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1528-1157.2002.26401.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013648797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0139446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015422988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2013-14-4-r36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015459845", 
              "https://doi.org/10.1186/gb-2013-14-4-r36"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.4205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016069245", 
              "https://doi.org/10.1038/nn.4205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkv007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016098431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016256401", 
              "https://doi.org/10.1038/nrd3078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016256401", 
              "https://doi.org/10.1038/nrd3078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016838186", 
              "https://doi.org/10.1038/nrd2199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016838186", 
              "https://doi.org/10.1038/nrd2199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awu206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017078667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awh267", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017597482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019220900", 
              "https://doi.org/10.1038/ng.134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd4126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019475641", 
              "https://doi.org/10.1038/nrd4126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/1467-9868.00293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021007117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btn224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021766380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1535-7511.2008.00272.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021935385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1535-7511.2008.00272.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021935385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cns.12523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022769797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1305814110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022915855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp616", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023247882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8274.cd-10-0028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023575473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq1039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026557089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2014.02.040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026943569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.09.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028058577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.09.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028058577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3575", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029459184", 
              "https://doi.org/10.1038/nrg3575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/14740338.2015.1010508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029527816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2796.2011.02431.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029795247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkv1351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031245559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5698/1535-7511-11.5.153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031733478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5698/1535-7511-11.5.153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031733478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms7031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033054936", 
              "https://doi.org/10.1038/ncomms7031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3934", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033820062", 
              "https://doi.org/10.1038/nrg3934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1528-1167.2009.02339.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034197523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1528-1167.2009.02339.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034197523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.expneurol.2007.06.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035398904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fgene.2011.00088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036399898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036670861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2012.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037968162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2002-3-7-research0034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039751959", 
              "https://doi.org/10.1186/gb-2002-3-7-research0034"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1470", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041019353", 
              "https://doi.org/10.1038/nrd1470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1470", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041019353", 
              "https://doi.org/10.1038/nrd1470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.seizure.2011.01.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042521712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.27941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044123911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-05-347393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044469905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2016.01.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045057537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1528-1167.2009.02089.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046035176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1528-1167.2009.02089.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046035176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.expneurol.2012.08.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046812770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047354122", 
              "https://doi.org/10.1038/nature08454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047354122", 
              "https://doi.org/10.1038/nature08454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0013-4694(72)90177-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047420585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0013-4694(72)90177-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047420585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2014.11.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049705138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050075164", 
              "https://doi.org/10.1038/nmeth.3252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aaa1934", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051709523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052043691", 
              "https://doi.org/10.1038/nature09386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052043691", 
              "https://doi.org/10.1038/nature09386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1000138107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053118853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/01621459.1963.10500845", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058299788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bib/bbw112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059413203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bib/bbw112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059413203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bib/bbx023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083930619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/077057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085111574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/077057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085111574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/077057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085111574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13311-018-0607-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101127821", 
              "https://doi.org/10.1007/s13311-018-0607-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13311-018-0607-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101127821", 
              "https://doi.org/10.1007/s13311-018-0607-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13311-018-0607-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101127821", 
              "https://doi.org/10.1007/s13311-018-0607-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13311-018-0607-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101127821", 
              "https://doi.org/10.1007/s13311-018-0607-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13311-018-0607-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101127821", 
              "https://doi.org/10.1007/s13311-018-0607-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13311-018-0607-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101127821", 
              "https://doi.org/10.1007/s13311-018-0607-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13311-018-0607-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101127821", 
              "https://doi.org/10.1007/s13311-018-0607-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13311-018-0607-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101127821", 
              "https://doi.org/10.1007/s13311-018-0607-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13311-018-0607-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101127821", 
              "https://doi.org/10.1007/s13311-018-0607-6"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "The identification of drug targets is highly challenging, particularly for diseases of the brain. To address this problem, we developed and experimentally validated a general computational framework for drug target discovery that combines gene regulatory information with causal reasoning (\"Causal Reasoning Analytical Framework for Target discovery\"-CRAFT). Using a systems genetics approach and starting from gene expression data from the target tissue, CRAFT provides a predictive framework for identifying cell membrane receptors with a direction-specified influence over disease-related gene expression profiles. As proof of concept, we applied CRAFT to epilepsy and predicted the tyrosine kinase receptor Csf1R as a potential therapeutic target. The predicted effect of Csf1R blockade in attenuating epilepsy seizures was validated in three pre-clinical models of epilepsy. These results highlight CRAFT as a systems-level framework for target discovery and suggest Csf1R blockade as a novel therapeutic strategy in epilepsy. CRAFT is applicable to disease settings other than epilepsy.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41467-018-06008-4", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3800125", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3957910", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target", 
        "pagination": "3561", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "5a3fc3b991f4f30032682229c168cf5a74c24ae58782c9cf7c42926bc5f4f70f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30177815"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101528555"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-018-06008-4"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1106394364"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-018-06008-4", 
          "https://app.dimensions.ai/details/publication/pub.1106394364"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T11:05", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000352_0000000352/records_60367_00000003.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41467-018-06008-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06008-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06008-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06008-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-06008-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    552 TRIPLES      21 PREDICATES      113 URIs      40 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-018-06008-4 schema:about N084578d28b414bef8d084555bfcfd54d
    2 N1494c7005e5f4ffb99268d2bf62ee3cc
    3 N2aadd4697ca04adcbd83a9c4b728200a
    4 N3a912cd8fb5347f5b469726646e677db
    5 N432c0aeb75cb4f1f9468c73275014b35
    6 N4ca753c0372c450a93bd0bcdc3dbcf05
    7 N6117173b359c41dfae7937798b37bb6b
    8 N6fb4543311934974a5e0acf08c670ebb
    9 N927837fb9bd947cea60a942827f076b2
    10 N9a50a9f51e4c4bcd80f505c27adf3705
    11 Na0e4ccc0fbc847de9cb62f4ebdd6652f
    12 Nb6424e2abe6948d8a46dc4fd80d585a7
    13 Nc0783dfc450d4414a91bea9636214b1d
    14 Nc113dddde49345f789e98aaf6bb29699
    15 Nc3bac44596144cdd96e95b5984464ba8
    16 Nc4f54540124e43fcb27f0a299dd4e825
    17 Nd79f668af7534b2396f5b085dcc438ca
    18 Nf3fe6662e5284b1ea4215bcfcf3285b8
    19 Nf42ac95e0544407da2c4eb4269b82bca
    20 anzsrc-for:11
    21 anzsrc-for:1109
    22 schema:author N6a7575f3803742778ac2df48062a8653
    23 schema:citation sg:pub.10.1007/s13311-018-0607-6
    24 sg:pub.10.1038/nature08454
    25 sg:pub.10.1038/nature09386
    26 sg:pub.10.1038/ncomms7031
    27 sg:pub.10.1038/ng.134
    28 sg:pub.10.1038/nmeth.3252
    29 sg:pub.10.1038/nn.4205
    30 sg:pub.10.1038/nrd1470
    31 sg:pub.10.1038/nrd2199
    32 sg:pub.10.1038/nrd2826
    33 sg:pub.10.1038/nrd3078
    34 sg:pub.10.1038/nrd4126
    35 sg:pub.10.1038/nrg3575
    36 sg:pub.10.1038/nrg3934
    37 sg:pub.10.1038/srep11432
    38 sg:pub.10.1186/gb-2002-3-7-research0034
    39 sg:pub.10.1186/gb-2002-3-7-software0002
    40 sg:pub.10.1186/gb-2007-8-2-r19
    41 sg:pub.10.1186/gb-2013-14-4-r36
    42 sg:pub.10.1186/s13059-016-1097-7
    43 https://doi.org/10.1002/ana.23940
    44 https://doi.org/10.1002/glia.23038
    45 https://doi.org/10.1002/ijc.27941
    46 https://doi.org/10.1016/0013-4694(72)90177-0
    47 https://doi.org/10.1016/0022-1759(88)90310-9
    48 https://doi.org/10.1016/j.cell.2014.09.021
    49 https://doi.org/10.1016/j.expneurol.2007.06.021
    50 https://doi.org/10.1016/j.expneurol.2012.08.022
    51 https://doi.org/10.1016/j.neuron.2014.02.040
    52 https://doi.org/10.1016/j.neuron.2016.01.034
    53 https://doi.org/10.1016/j.neuropharm.2012.04.004
    54 https://doi.org/10.1016/j.neuropharm.2014.11.008
    55 https://doi.org/10.1016/j.seizure.2011.01.003
    56 https://doi.org/10.1046/j.1528-1157.2002.26401.x
    57 https://doi.org/10.1073/pnas.1000138107
    58 https://doi.org/10.1073/pnas.1305814110
    59 https://doi.org/10.1080/01621459.1963.10500845
    60 https://doi.org/10.1093/bib/bbw112
    61 https://doi.org/10.1093/bib/bbx023
    62 https://doi.org/10.1093/bioinformatics/btn224
    63 https://doi.org/10.1093/bioinformatics/btp502
    64 https://doi.org/10.1093/bioinformatics/btp603
    65 https://doi.org/10.1093/bioinformatics/btp616
    66 https://doi.org/10.1093/brain/awh267
    67 https://doi.org/10.1093/brain/awu206
    68 https://doi.org/10.1093/nar/gkq1039
    69 https://doi.org/10.1093/nar/gkv007
    70 https://doi.org/10.1093/nar/gkv1351
    71 https://doi.org/10.1097/wnp.0b013e3181fe0709
    72 https://doi.org/10.1101/077057
    73 https://doi.org/10.1111/1467-9868.00293
    74 https://doi.org/10.1111/cns.12523
    75 https://doi.org/10.1111/j.1365-2796.2011.02431.x
    76 https://doi.org/10.1111/j.1528-1167.2009.02089.x
    77 https://doi.org/10.1111/j.1528-1167.2009.02339.x
    78 https://doi.org/10.1111/j.1535-7511.2008.00272.x
    79 https://doi.org/10.1126/science.1132939
    80 https://doi.org/10.1126/science.aaa1934
    81 https://doi.org/10.1158/2159-8274.cd-10-0028
    82 https://doi.org/10.1182/blood-2011-05-347393
    83 https://doi.org/10.1371/journal.pone.0122912
    84 https://doi.org/10.1371/journal.pone.0139446
    85 https://doi.org/10.1517/14740338.2015.1010508
    86 https://doi.org/10.3389/fgene.2011.00088
    87 https://doi.org/10.5698/1535-7511-11.5.153
    88 schema:datePublished 2018-12
    89 schema:datePublishedReg 2018-12-01
    90 schema:description The identification of drug targets is highly challenging, particularly for diseases of the brain. To address this problem, we developed and experimentally validated a general computational framework for drug target discovery that combines gene regulatory information with causal reasoning ("Causal Reasoning Analytical Framework for Target discovery"-CRAFT). Using a systems genetics approach and starting from gene expression data from the target tissue, CRAFT provides a predictive framework for identifying cell membrane receptors with a direction-specified influence over disease-related gene expression profiles. As proof of concept, we applied CRAFT to epilepsy and predicted the tyrosine kinase receptor Csf1R as a potential therapeutic target. The predicted effect of Csf1R blockade in attenuating epilepsy seizures was validated in three pre-clinical models of epilepsy. These results highlight CRAFT as a systems-level framework for target discovery and suggest Csf1R blockade as a novel therapeutic strategy in epilepsy. CRAFT is applicable to disease settings other than epilepsy.
    91 schema:genre research_article
    92 schema:inLanguage en
    93 schema:isAccessibleForFree true
    94 schema:isPartOf N442c0ee445f645e3be0b937d52025cb7
    95 Ne038beb1051a4fb2b3ebb054ae5ecf9f
    96 sg:journal.1043282
    97 schema:name A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target
    98 schema:pagination 3561
    99 schema:productId N3407bd2ed57a45c79c2cf8536524601a
    100 N6fb143b725bb4b11bf793196f2b1d21c
    101 N73a88c796fd24137b719c96392829ee8
    102 Na0bcf702dc984945a9bbddaffb21f7ab
    103 Nb459adcc098e43a898b1dfbe3a77f3bd
    104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106394364
    105 https://doi.org/10.1038/s41467-018-06008-4
    106 schema:sdDatePublished 2019-04-11T11:05
    107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    108 schema:sdPublisher N07e8619ccd08471692c1c086d2a923a3
    109 schema:url https://www.nature.com/articles/s41467-018-06008-4
    110 sgo:license sg:explorer/license/
    111 sgo:sdDataset articles
    112 rdf:type schema:ScholarlyArticle
    113 N07e8619ccd08471692c1c086d2a923a3 schema:name Springer Nature - SN SciGraph project
    114 rdf:type schema:Organization
    115 N084578d28b414bef8d084555bfcfd54d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Drug Discovery
    117 rdf:type schema:DefinedTerm
    118 N0a25f39f73354f83b39eabe51658e5ce rdf:first Na6276ac6206b4f819d5fcf93e4ab0916
    119 rdf:rest rdf:nil
    120 N0aa0dc2c605b4ae0a8d1d2b31df2df11 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    121 schema:familyName Keaney
    122 schema:givenName James
    123 rdf:type schema:Person
    124 N0abd9e94d6984b86addb3abca22a3457 rdf:first sg:person.016543250041.57
    125 rdf:rest Nadd6510a431e459cbfdb57bf22c3838f
    126 N1494c7005e5f4ffb99268d2bf62ee3cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
    128 rdf:type schema:DefinedTerm
    129 N2aadd4697ca04adcbd83a9c4b728200a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Animals
    131 rdf:type schema:DefinedTerm
    132 N31bdc200e35446a6b170e67c39efced2 schema:name PROTECT, INSERM, Sorbonne Paris Cité, Université Paris Diderot, Paris, France
    133 rdf:type schema:Organization
    134 N329b7ae16d8e4f319cccae293175b53b rdf:first sg:person.0777266367.22
    135 rdf:rest N7eb35e3f89174c7daf1f674fa7f6b892
    136 N3407bd2ed57a45c79c2cf8536524601a schema:name readcube_id
    137 schema:value 5a3fc3b991f4f30032682229c168cf5a74c24ae58782c9cf7c42926bc5f4f70f
    138 rdf:type schema:PropertyValue
    139 N390e1f97a46f441cbc8a52df14a4fdd2 rdf:first sg:person.01020600421.42
    140 rdf:rest Nce44741ee4a04f3fb7c78ae0ec8ed690
    141 N3a912cd8fb5347f5b469726646e677db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Systems Biology
    143 rdf:type schema:DefinedTerm
    144 N432c0aeb75cb4f1f9468c73275014b35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Muscarinic Agonists
    146 rdf:type schema:DefinedTerm
    147 N442c0ee445f645e3be0b937d52025cb7 schema:volumeNumber 9
    148 rdf:type schema:PublicationVolume
    149 N4ca753c0372c450a93bd0bcdc3dbcf05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Genetic Association Studies
    151 rdf:type schema:DefinedTerm
    152 N542f64942aff4a5c9408b7c91ac28738 rdf:first Nf70d57b774e84203b29ffe7d7875f878
    153 rdf:rest Nb7fde31a5fba40c886b5ccad622b4ecc
    154 N6117173b359c41dfae7937798b37bb6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Gene Expression Profiling
    156 rdf:type schema:DefinedTerm
    157 N6a7575f3803742778ac2df48062a8653 rdf:first N7e6f986235154f99b4ecc64686e0d8b3
    158 rdf:rest Ndcd109b4235c4399960806c5a3df3cee
    159 N6fb143b725bb4b11bf793196f2b1d21c schema:name nlm_unique_id
    160 schema:value 101528555
    161 rdf:type schema:PropertyValue
    162 N6fb4543311934974a5e0acf08c670ebb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name High-Throughput Nucleotide Sequencing
    164 rdf:type schema:DefinedTerm
    165 N73a88c796fd24137b719c96392829ee8 schema:name doi
    166 schema:value 10.1038/s41467-018-06008-4
    167 rdf:type schema:PropertyValue
    168 N763572aa5f3248cbb05d41bcdad4d970 rdf:first sg:person.01254455436.19
    169 rdf:rest N0abd9e94d6984b86addb3abca22a3457
    170 N7e6f986235154f99b4ecc64686e0d8b3 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
    171 schema:familyName Srivastava
    172 schema:givenName Prashant K.
    173 rdf:type schema:Person
    174 N7eb35e3f89174c7daf1f674fa7f6b892 rdf:first sg:person.01312641136.20
    175 rdf:rest Neefe9b224853439d8bdf959e3ee0d04b
    176 N90df4acfa05b4d7bad4b89a132745fb7 rdf:first sg:person.0643134421.39
    177 rdf:rest Na91c51b5352143368de2cc322f86df21
    178 N927837fb9bd947cea60a942827f076b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Disease Models, Animal
    180 rdf:type schema:DefinedTerm
    181 N96947b8448b74e6cb60b8203f4ac96c3 rdf:first sg:person.0665312373.17
    182 rdf:rest N763572aa5f3248cbb05d41bcdad4d970
    183 N9a50a9f51e4c4bcd80f505c27adf3705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Humans
    185 rdf:type schema:DefinedTerm
    186 N9bff8e7917834f319cec1db48f5b5ca4 rdf:first N0aa0dc2c605b4ae0a8d1d2b31df2df11
    187 rdf:rest N542f64942aff4a5c9408b7c91ac28738
    188 Na0bcf702dc984945a9bbddaffb21f7ab schema:name dimensions_id
    189 schema:value pub.1106394364
    190 rdf:type schema:PropertyValue
    191 Na0e4ccc0fbc847de9cb62f4ebdd6652f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Computer Simulation
    193 rdf:type schema:DefinedTerm
    194 Na6276ac6206b4f819d5fcf93e4ab0916 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
    195 schema:familyName Johnson
    196 schema:givenName Michael R.
    197 rdf:type schema:Person
    198 Na781aa75559641a7922480696d396327 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    199 schema:familyName Gillet
    200 schema:givenName Gaelle
    201 rdf:type schema:Person
    202 Na91c51b5352143368de2cc322f86df21 rdf:first sg:person.01113714132.03
    203 rdf:rest Nb963f8dbc6d74d9eadfbaddf3cd786da
    204 Nac8655784c8044648dff1a516788207c rdf:first sg:person.01233641526.79
    205 rdf:rest N0a25f39f73354f83b39eabe51658e5ce
    206 Nadd6510a431e459cbfdb57bf22c3838f rdf:first sg:person.0635776424.29
    207 rdf:rest Nfae3abe41e6244dbac593113ca067c87
    208 Nb459adcc098e43a898b1dfbe3a77f3bd schema:name pubmed_id
    209 schema:value 30177815
    210 rdf:type schema:PropertyValue
    211 Nb522b5cce7134aa7825410dc9e848f1c schema:name Clarivate Analytics (formerly the IP & Science Business of Thomson Reuters), 5901 Priestly Drive, #200, 92008, Carlsbad, CA, USA
    212 rdf:type schema:Organization
    213 Nb6424e2abe6948d8a46dc4fd80d585a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Anticonvulsants
    215 rdf:type schema:DefinedTerm
    216 Nb7fde31a5fba40c886b5ccad622b4ecc rdf:first Na781aa75559641a7922480696d396327
    217 rdf:rest Nf160f30d00854f38a38f4e8f2421021b
    218 Nb8261aa461014e4983223a49e6a9a927 rdf:first sg:person.01173747010.60
    219 rdf:rest N96947b8448b74e6cb60b8203f4ac96c3
    220 Nb963f8dbc6d74d9eadfbaddf3cd786da rdf:first sg:person.01170203244.12
    221 rdf:rest Nf3d9e8067b3b4c23b30012932c8538cb
    222 Nbadfcf2e216d48c4aea7e496c77de536 rdf:first sg:person.0726435613.27
    223 rdf:rest N90df4acfa05b4d7bad4b89a132745fb7
    224 Nc0783dfc450d4414a91bea9636214b1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Mice
    226 rdf:type schema:DefinedTerm
    227 Nc113dddde49345f789e98aaf6bb29699 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    228 schema:name Sequence Analysis, RNA
    229 rdf:type schema:DefinedTerm
    230 Nc3bac44596144cdd96e95b5984464ba8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    231 schema:name Epilepsy
    232 rdf:type schema:DefinedTerm
    233 Nc4f54540124e43fcb27f0a299dd4e825 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Molecular Targeted Therapy
    235 rdf:type schema:DefinedTerm
    236 Nce44741ee4a04f3fb7c78ae0ec8ed690 rdf:first sg:person.0650427307.04
    237 rdf:rest Nfb20dbdd36e243fbbef3c7f6daaa4a78
    238 Nd5bdbae1f98b4c1682e571a8d932665a rdf:first sg:person.016657522240.29
    239 rdf:rest N390e1f97a46f441cbc8a52df14a4fdd2
    240 Nd79f668af7534b2396f5b085dcc438ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    241 schema:name Epilepsy, Temporal Lobe
    242 rdf:type schema:DefinedTerm
    243 Ndcd109b4235c4399960806c5a3df3cee rdf:first sg:person.0743453640.65
    244 rdf:rest N329b7ae16d8e4f319cccae293175b53b
    245 Ne038beb1051a4fb2b3ebb054ae5ecf9f schema:issueNumber 1
    246 rdf:type schema:PublicationIssue
    247 Neefe9b224853439d8bdf959e3ee0d04b rdf:first sg:person.0645074651.46
    248 rdf:rest Nbadfcf2e216d48c4aea7e496c77de536
    249 Nf160f30d00854f38a38f4e8f2421021b rdf:first sg:person.0611011560.46
    250 rdf:rest Nd5bdbae1f98b4c1682e571a8d932665a
    251 Nf3d9e8067b3b4c23b30012932c8538cb rdf:first sg:person.01236316444.24
    252 rdf:rest Nb8261aa461014e4983223a49e6a9a927
    253 Nf3fe6662e5284b1ea4215bcfcf3285b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    254 schema:name Pilocarpine
    255 rdf:type schema:DefinedTerm
    256 Nf42ac95e0544407da2c4eb4269b82bca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    257 schema:name Gene Expression Regulation
    258 rdf:type schema:DefinedTerm
    259 Nf70d57b774e84203b29ffe7d7875f878 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    260 schema:familyName Gasser
    261 schema:givenName Julien
    262 rdf:type schema:Person
    263 Nfae3abe41e6244dbac593113ca067c87 rdf:first sg:person.01075037076.49
    264 rdf:rest N9bff8e7917834f319cec1db48f5b5ca4
    265 Nfb20dbdd36e243fbbef3c7f6daaa4a78 rdf:first sg:person.01053327673.48
    266 rdf:rest Nac8655784c8044648dff1a516788207c
    267 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    268 schema:name Medical and Health Sciences
    269 rdf:type schema:DefinedTerm
    270 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    271 schema:name Neurosciences
    272 rdf:type schema:DefinedTerm
    273 sg:grant.3800125 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-06008-4
    274 rdf:type schema:MonetaryGrant
    275 sg:grant.3957910 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-06008-4
    276 rdf:type schema:MonetaryGrant
    277 sg:journal.1043282 schema:issn 2041-1723
    278 schema:name Nature Communications
    279 rdf:type schema:Periodical
    280 sg:person.01020600421.42 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
    281 schema:familyName Behmoaras
    282 schema:givenName Jacques
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020600421.42
    284 rdf:type schema:Person
    285 sg:person.01053327673.48 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
    286 schema:familyName Petretto
    287 schema:givenName Enrico
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053327673.48
    289 rdf:type schema:Person
    290 sg:person.01075037076.49 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    291 schema:familyName Niespodziany
    292 schema:givenName Isabelle
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075037076.49
    294 rdf:type schema:Person
    295 sg:person.01113714132.03 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    296 schema:familyName Danis
    297 schema:givenName Benedicte
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113714132.03
    299 rdf:type schema:Person
    300 sg:person.01170203244.12 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    301 schema:familyName Vandenplas
    302 schema:givenName Catherine
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170203244.12
    304 rdf:type schema:Person
    305 sg:person.01173747010.60 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    306 schema:familyName Leclercq
    307 schema:givenName Karine
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173747010.60
    309 rdf:type schema:Person
    310 sg:person.01233641526.79 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    311 schema:familyName Kaminski
    312 schema:givenName Rafal M.
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233641526.79
    314 rdf:type schema:Person
    315 sg:person.01236316444.24 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    316 schema:familyName Foerch
    317 schema:givenName Patrik
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236316444.24
    319 rdf:type schema:Person
    320 sg:person.01254455436.19 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    321 schema:familyName Cardenas
    322 schema:givenName Alvaro
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254455436.19
    324 rdf:type schema:Person
    325 sg:person.01312641136.20 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    326 schema:familyName Mazzuferi
    327 schema:givenName Manuela
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312641136.20
    329 rdf:type schema:Person
    330 sg:person.016543250041.57 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    331 schema:familyName Vanclef
    332 schema:givenName Frederic
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016543250041.57
    334 rdf:type schema:Person
    335 sg:person.016657522240.29 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    336 schema:familyName Chong
    337 schema:givenName Seon-Ah
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016657522240.29
    339 rdf:type schema:Person
    340 sg:person.0611011560.46 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
    341 schema:familyName Shkura
    342 schema:givenName Kirill
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611011560.46
    344 rdf:type schema:Person
    345 sg:person.0635776424.29 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
    346 schema:familyName Laaniste
    347 schema:givenName Liisi
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635776424.29
    349 rdf:type schema:Person
    350 sg:person.0643134421.39 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
    351 schema:familyName Gressens
    352 schema:givenName Pierre
    353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643134421.39
    354 rdf:type schema:Person
    355 sg:person.0645074651.46 schema:affiliation https://www.grid.ac/institutes/grid.11318.3a
    356 schema:familyName Delahaye-Duriez
    357 schema:givenName Andree
    358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645074651.46
    359 rdf:type schema:Person
    360 sg:person.0650427307.04 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    361 schema:familyName Kadiu
    362 schema:givenName Irena
    363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650427307.04
    364 rdf:type schema:Person
    365 sg:person.0665312373.17 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    366 schema:familyName Mairet-Coello
    367 schema:givenName Georges
    368 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665312373.17
    369 rdf:type schema:Person
    370 sg:person.0726435613.27 schema:affiliation N31bdc200e35446a6b170e67c39efced2
    371 schema:familyName Van Steenwinckel
    372 schema:givenName Juliette
    373 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726435613.27
    374 rdf:type schema:Person
    375 sg:person.0743453640.65 schema:affiliation https://www.grid.ac/institutes/grid.421932.f
    376 schema:familyName van Eyll
    377 schema:givenName Jonathan
    378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743453640.65
    379 rdf:type schema:Person
    380 sg:person.0777266367.22 schema:affiliation Nb522b5cce7134aa7825410dc9e848f1c
    381 schema:familyName Godard
    382 schema:givenName Patrice
    383 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777266367.22
    384 rdf:type schema:Person
    385 sg:pub.10.1007/s13311-018-0607-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101127821
    386 https://doi.org/10.1007/s13311-018-0607-6
    387 rdf:type schema:CreativeWork
    388 sg:pub.10.1038/nature08454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047354122
    389 https://doi.org/10.1038/nature08454
    390 rdf:type schema:CreativeWork
    391 sg:pub.10.1038/nature09386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052043691
    392 https://doi.org/10.1038/nature09386
    393 rdf:type schema:CreativeWork
    394 sg:pub.10.1038/ncomms7031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033054936
    395 https://doi.org/10.1038/ncomms7031
    396 rdf:type schema:CreativeWork
    397 sg:pub.10.1038/ng.134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019220900
    398 https://doi.org/10.1038/ng.134
    399 rdf:type schema:CreativeWork
    400 sg:pub.10.1038/nmeth.3252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050075164
    401 https://doi.org/10.1038/nmeth.3252
    402 rdf:type schema:CreativeWork
    403 sg:pub.10.1038/nn.4205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016069245
    404 https://doi.org/10.1038/nn.4205
    405 rdf:type schema:CreativeWork
    406 sg:pub.10.1038/nrd1470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041019353
    407 https://doi.org/10.1038/nrd1470
    408 rdf:type schema:CreativeWork
    409 sg:pub.10.1038/nrd2199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016838186
    410 https://doi.org/10.1038/nrd2199
    411 rdf:type schema:CreativeWork
    412 sg:pub.10.1038/nrd2826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000699125
    413 https://doi.org/10.1038/nrd2826
    414 rdf:type schema:CreativeWork
    415 sg:pub.10.1038/nrd3078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016256401
    416 https://doi.org/10.1038/nrd3078
    417 rdf:type schema:CreativeWork
    418 sg:pub.10.1038/nrd4126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019475641
    419 https://doi.org/10.1038/nrd4126
    420 rdf:type schema:CreativeWork
    421 sg:pub.10.1038/nrg3575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029459184
    422 https://doi.org/10.1038/nrg3575
    423 rdf:type schema:CreativeWork
    424 sg:pub.10.1038/nrg3934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033820062
    425 https://doi.org/10.1038/nrg3934
    426 rdf:type schema:CreativeWork
    427 sg:pub.10.1038/srep11432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012337694
    428 https://doi.org/10.1038/srep11432
    429 rdf:type schema:CreativeWork
    430 sg:pub.10.1186/gb-2002-3-7-research0034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039751959
    431 https://doi.org/10.1186/gb-2002-3-7-research0034
    432 rdf:type schema:CreativeWork
    433 sg:pub.10.1186/gb-2002-3-7-software0002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011678864
    434 https://doi.org/10.1186/gb-2002-3-7-software0002
    435 rdf:type schema:CreativeWork
    436 sg:pub.10.1186/gb-2007-8-2-r19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007077528
    437 https://doi.org/10.1186/gb-2007-8-2-r19
    438 rdf:type schema:CreativeWork
    439 sg:pub.10.1186/gb-2013-14-4-r36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015459845
    440 https://doi.org/10.1186/gb-2013-14-4-r36
    441 rdf:type schema:CreativeWork
    442 sg:pub.10.1186/s13059-016-1097-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008599753
    443 https://doi.org/10.1186/s13059-016-1097-7
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1002/ana.23940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002397055
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1002/glia.23038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004835267
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1002/ijc.27941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044123911
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1016/0013-4694(72)90177-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047420585
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1016/0022-1759(88)90310-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002255759
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1016/j.cell.2014.09.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028058577
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1016/j.expneurol.2007.06.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035398904
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1016/j.expneurol.2012.08.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046812770
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1016/j.neuron.2014.02.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026943569
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1016/j.neuron.2016.01.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045057537
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1016/j.neuropharm.2012.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037968162
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1016/j.neuropharm.2014.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049705138
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1016/j.seizure.2011.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042521712
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1046/j.1528-1157.2002.26401.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013648797
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1073/pnas.1000138107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053118853
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1073/pnas.1305814110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022915855
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1080/01621459.1963.10500845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058299788
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1093/bib/bbw112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059413203
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1093/bib/bbx023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083930619
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1093/bioinformatics/btn224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021766380
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1093/bioinformatics/btp502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010695043
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1093/bioinformatics/btp603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036670861
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1093/bioinformatics/btp616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023247882
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1093/brain/awh267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017597482
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1093/brain/awu206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017078667
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1093/nar/gkq1039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026557089
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1093/nar/gkv007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016098431
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1093/nar/gkv1351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031245559
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1097/wnp.0b013e3181fe0709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001447894
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1101/077057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085111574
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1111/1467-9868.00293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021007117
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1111/cns.12523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022769797
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1111/j.1365-2796.2011.02431.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029795247
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1111/j.1528-1167.2009.02089.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046035176
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1111/j.1528-1167.2009.02339.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034197523
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1111/j.1535-7511.2008.00272.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021935385
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1126/science.1132939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013321903
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1126/science.aaa1934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051709523
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1158/2159-8274.cd-10-0028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023575473
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1182/blood-2011-05-347393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044469905
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1371/journal.pone.0122912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008550628
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1371/journal.pone.0139446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015422988
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1517/14740338.2015.1010508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029527816
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.3389/fgene.2011.00088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036399898
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.5698/1535-7511-11.5.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031733478
    534 rdf:type schema:CreativeWork
    535 https://www.grid.ac/institutes/grid.11318.3a schema:alternateName Paris 13 University
    536 schema:name Division of Brain Sciences, Imperial College London, W12 0NN, London, UK
    537 PROTECT, INSERM, Sorbonne Paris Cité, Université Paris Diderot, Paris, France
    538 UFR de Santé, Médecine et Biologie Humaine, Sorbonne Paris Cité, Université Paris 13, Bobigny, France
    539 rdf:type schema:Organization
    540 https://www.grid.ac/institutes/grid.13097.3c schema:alternateName King's College London
    541 schema:name PROTECT, INSERM, Sorbonne Paris Cité, Université Paris Diderot, Paris, France
    542 School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King’s College London, St. Thomas’ Hospital, SE1 7EH, London, UK
    543 rdf:type schema:Organization
    544 https://www.grid.ac/institutes/grid.421932.f schema:alternateName UCB Pharma (Belgium)
    545 schema:name UCB Pharma, Avenue de l’industrie, R9, B-1420, Braine-l’Alleud, Belgium
    546 rdf:type schema:Organization
    547 https://www.grid.ac/institutes/grid.7445.2 schema:alternateName Imperial College London
    548 schema:name Centre for Complement and Inflammation Research, Imperial College London, W12 0NN, London, UK
    549 Division of Brain Sciences, Imperial College London, W12 0NN, London, UK
    550 Duke-NUS Medical School, Centre for Computational Biology, 8 College Road, 169857, Singapore, Republic of Singapore
    551 Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, W12 0NN, London, UK
    552 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...