The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Alida Kindt, Gerhard Liebisch, Thomas Clavel, Dirk Haller, Gabriele Hörmannsperger, Hongsup Yoon, Daniela Kolmeder, Alexander Sigruener, Sabrina Krautbauer, Claudine Seeliger, Alexandra Ganzha, Sabine Schweizer, Rosalie Morisset, Till Strowig, Hannelore Daniel, Dominic Helm, Bernhard Küster, Jan Krumsiek, Josef Ecker

ABSTRACT

Interactions between the gut microbial ecosystem and host lipid homeostasis are highly relevant to host physiology and metabolic diseases. We present a comprehensive multi-omics view of the effect of intestinal microbial colonization on hepatic lipid metabolism, integrating transcriptomic, proteomic, phosphoproteomic, and lipidomic analyses of liver and plasma samples from germfree and specific pathogen-free mice. Microbes induce monounsaturated fatty acid generation by stearoyl-CoA desaturase 1 and polyunsaturated fatty acid elongation by fatty acid elongase 5, leading to significant alterations in glycerophospholipid acyl-chain profiles. A composite classification score calculated from the observed alterations in fatty acid profiles in germfree mice clearly differentiates antibiotic-treated mice from untreated controls with high sensitivity. Mechanistic investigations reveal that acetate originating from gut microbial degradation of dietary fiber serves as precursor for hepatic synthesis of C16 and C18 fatty acids and their related glycerophospholipid species that are also released into the circulation. More... »

PAGES

3760

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-05767-4

DOI

http://dx.doi.org/10.1038/s41467-018-05767-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106921227

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30218046


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442 schema:name German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany
443 Institute for Computational Biomedicine, Englander Institute for Precision Medicine, Department of Physiology and Biophysics, Weill Cornell Medicine, 10021, New York, USA
444 Institute of Computational Biology, Helmholtz Zentrum München, 85764, Neuherberg, Germany
445 rdf:type schema:Organization
446 https://www.grid.ac/institutes/grid.6936.a schema:alternateName Technical University Munich
447 schema:name Ernährung und Immunologie, Technische Universität München (TUM), 85354, Freising, Germany
448 Ernährungsphysiologie, Technische Universität München (TUM), 85354, Freising, Germany
449 Functional Microbiome Research Group, Institute of Medical Microbiology, Universitätsklinikum Aachen, 52074, Aachen, Germany
450 Proteomics and Bioanalytics, Technische Universität München (TUM), 85354, Freising, Germany
451 ZIEL Institute for Food and Health, Technische Universität München (TUM), 85354, Freising, Germany
452 rdf:type schema:Organization
 




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