PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-08-09

AUTHORS

Anne-Katrien Stark, Anita Chandra, Krishnendu Chakraborty, Rafeah Alam, Valentina Carbonaro, Jonathan Clark, Srividya Sriskantharajah, Glyn Bradley, Alex G. Richter, Edward Banham-Hall, Menna R. Clatworthy, Sergey Nejentsev, J. Nicole Hamblin, Edith M. Hessel, Alison M. Condliffe, Klaus Okkenhaug

ABSTRACT

Streptococcus pneumoniae is a major cause of pneumonia and a leading cause of death world-wide. Antibody-mediated immune responses can confer protection against repeated exposure to S. pneumoniae, yet vaccines offer only partial protection. Patients with Activated PI3Kδ Syndrome (APDS) are highly susceptible to S. pneumoniae. We generated a conditional knock-in mouse model of this disease and identify a CD19+B220- B cell subset that is induced by PI3Kδ signaling, resides in the lungs, and is correlated with increased susceptibility to S. pneumoniae during early phases of infection via an antibody-independent mechanism. We show that an inhaled PI3Kδ inhibitor improves survival rates following S. pneumoniae infection in wild-type mice and in mice with activated PI3Kδ. These results suggest that a subset of B cells in the lung can promote the severity of S. pneumoniae infection, representing a potential therapeutic target. More... »

PAGES

3174

Journal

TITLE

Nature Communications

ISSUE

1

VOLUME

9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-05674-8

DOI

http://dx.doi.org/10.1038/s41467-018-05674-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105993584

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30093657


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD19", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Class I Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Knock-In Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-10", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutrophils", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoinositide-3 Kinase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pneumococcal Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Species Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Streptococcus pneumoniae", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, CB2 1QP UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT UK", 
            "Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, CB2 1QP UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stark", 
        "givenName": "Anne-Katrien", 
        "id": "sg:person.0641617523.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641617523.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cambridge University Hospitals NHS Trust, Hills Road, Cambridge, CB2 0QQ UK", 
          "id": "http://www.grid.ac/institutes/grid.24029.3d", 
          "name": [
            "Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT UK", 
            "Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, CB2 1QP UK", 
            "Department of Medicine, University of Cambridge, Cambridge, CB2 OQQ UK", 
            "Cambridge University Hospitals NHS Trust, Hills Road, Cambridge, CB2 0QQ UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chandra", 
        "givenName": "Anita", 
        "id": "sg:person.01026403066.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026403066.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, University of Cambridge, Cambridge, CB2 OQQ UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT UK", 
            "Department of Medicine, University of Cambridge, Cambridge, CB2 OQQ UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chakraborty", 
        "givenName": "Krishnendu", 
        "id": "sg:person.013177047774.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013177047774.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT UK", 
          "id": "http://www.grid.ac/institutes/grid.418195.0", 
          "name": [
            "Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alam", 
        "givenName": "Rafeah", 
        "id": "sg:person.01062442203.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062442203.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT UK", 
          "id": "http://www.grid.ac/institutes/grid.418195.0", 
          "name": [
            "Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carbonaro", 
        "givenName": "Valentina", 
        "id": "sg:person.01024331521.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024331521.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biological Chemistry Laboratory, Babraham Institute, Cambridge, CB21 3AT UK", 
          "id": "http://www.grid.ac/institutes/grid.418195.0", 
          "name": [
            "Biological Chemistry Laboratory, Babraham Institute, Cambridge, CB21 3AT UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clark", 
        "givenName": "Jonathan", 
        "id": "sg:person.0720332755.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720332755.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Refractory Respiratory Inflammation Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, Stevenage, SG1 2NY UK", 
          "id": "http://www.grid.ac/institutes/grid.418236.a", 
          "name": [
            "Refractory Respiratory Inflammation Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, Stevenage, SG1 2NY UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sriskantharajah", 
        "givenName": "Srividya", 
        "id": "sg:person.01163523063.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163523063.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Computational Biology and Statistics, Target Sciences, GlaxoSmithKline, Stevenage, SG1 2NY UK", 
          "id": "http://www.grid.ac/institutes/grid.418236.a", 
          "name": [
            "Computational Biology and Statistics, Target Sciences, GlaxoSmithKline, Stevenage, SG1 2NY UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bradley", 
        "givenName": "Glyn", 
        "id": "sg:person.01302007607.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302007607.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT UK", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Department of Immunology, Queen Elizabeth Hospital, Birmingham, B15 2TH UK", 
            "Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Richter", 
        "givenName": "Alex G.", 
        "id": "sg:person.0603502337.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603502337.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cambridge University Hospitals NHS Trust, Hills Road, Cambridge, CB2 0QQ UK", 
          "id": "http://www.grid.ac/institutes/grid.24029.3d", 
          "name": [
            "Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT UK", 
            "Department of Medicine, University of Cambridge, Cambridge, CB2 OQQ UK", 
            "Cambridge University Hospitals NHS Trust, Hills Road, Cambridge, CB2 0QQ UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Banham-Hall", 
        "givenName": "Edward", 
        "id": "sg:person.0725563771.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725563771.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Immunity Unit, MRC Laboratory of Molecular Biology, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, CB2 OQQ UK", 
          "id": "http://www.grid.ac/institutes/grid.42475.30", 
          "name": [
            "Molecular Immunity Unit, MRC Laboratory of Molecular Biology, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, CB2 OQQ UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clatworthy", 
        "givenName": "Menna R.", 
        "id": "sg:person.0733226325.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733226325.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, University of Cambridge, Cambridge, CB2 OQQ UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Department of Medicine, University of Cambridge, Cambridge, CB2 OQQ UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nejentsev", 
        "givenName": "Sergey", 
        "id": "sg:person.01334150044.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334150044.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Refractory Respiratory Inflammation Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, Stevenage, SG1 2NY UK", 
          "id": "http://www.grid.ac/institutes/grid.418236.a", 
          "name": [
            "Refractory Respiratory Inflammation Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, Stevenage, SG1 2NY UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamblin", 
        "givenName": "J. Nicole", 
        "id": "sg:person.01156215433.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156215433.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Refractory Respiratory Inflammation Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, Stevenage, SG1 2NY UK", 
          "id": "http://www.grid.ac/institutes/grid.418236.a", 
          "name": [
            "Refractory Respiratory Inflammation Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, Stevenage, SG1 2NY UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hessel", 
        "givenName": "Edith M.", 
        "id": "sg:person.0740745307.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740745307.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Infection, Immunity and Cardiovascular Diseases, University of Sheffield, Sheffield, S10 2RX UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Department of Infection, Immunity and Cardiovascular Diseases, University of Sheffield, Sheffield, S10 2RX UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Condliffe", 
        "givenName": "Alison M.", 
        "id": "sg:person.01161633171.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161633171.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, CB2 1QP UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT UK", 
            "Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, CB2 1QP UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okkenhaug", 
        "givenName": "Klaus", 
        "id": "sg:person.01356616513.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356616513.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/350423a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018596250", 
          "https://doi.org/10.1038/350423a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.1564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032770146", 
          "https://doi.org/10.1038/nmeth.1564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mi.2017.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085421977", 
          "https://doi.org/10.1038/mi.2017.43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mi.2016.49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002757931", 
          "https://doi.org/10.1038/mi.2016.49"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri.2016.93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041797827", 
          "https://doi.org/10.1038/nri.2016.93"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035157346", 
          "https://doi.org/10.1038/nri3857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2004-5-10-r80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018457673", 
          "https://doi.org/10.1186/gb-2004-5-10-r80"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/361226a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012483561", 
          "https://doi.org/10.1038/361226a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.2771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012593761", 
          "https://doi.org/10.1038/ni.2771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1008942828960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011866095", 
          "https://doi.org/10.1023/a:1008942828960"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-08-09", 
    "datePublishedReg": "2018-08-09", 
    "description": "Streptococcus pneumoniae is a major cause of pneumonia and a leading cause of death world-wide. Antibody-mediated immune responses can confer protection against repeated exposure to S. pneumoniae, yet vaccines offer only partial protection. Patients with Activated PI3K\u03b4 Syndrome (APDS) are highly susceptible to S. pneumoniae. We generated a conditional knock-in mouse model of this disease and identify a CD19+B220- B cell subset that is induced by PI3K\u03b4 signaling, resides in the lungs, and is correlated with increased susceptibility to S. pneumoniae during early phases of infection via an antibody-independent mechanism. We show that an inhaled PI3K\u03b4 inhibitor improves survival rates following S. pneumoniae infection in wild-type mice and in mice with activated PI3K\u03b4. These results suggest that a subset of B cells in the lung can promote the severity of S. pneumoniae infection, representing a potential therapeutic target.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41467-018-05674-8", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8637539", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6446305", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2784635", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2777680", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2751473", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7159538", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3637833", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4106881", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4849827", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2756589", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3635849", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7748320", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3643234", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "keywords": [
      "pneumoniae infection", 
      "antibody-mediated immune responses", 
      "Activated PI3K\u03b4 Syndrome", 
      "antibody-independent mechanisms", 
      "Streptococcus pneumoniae infection", 
      "wild-type mice", 
      "potential therapeutic target", 
      "PI3K\u03b4 syndrome", 
      "cell subsets", 
      "immune response", 
      "antibody-independent manner", 
      "mouse model", 
      "therapeutic target", 
      "survival rate", 
      "death world", 
      "Streptococcus pneumoniae", 
      "infection", 
      "partial protection", 
      "major cause", 
      "PI3K\u03b4 inhibitors", 
      "Promotes Development", 
      "pneumoniae", 
      "lung", 
      "mice", 
      "early phase", 
      "cause", 
      "cells", 
      "pneumonia", 
      "patients", 
      "CD19", 
      "syndrome", 
      "vaccine", 
      "B220", 
      "disease", 
      "PI3K\u03b4", 
      "subset", 
      "severity", 
      "inhibitors", 
      "exposure", 
      "signaling", 
      "protection", 
      "susceptibility", 
      "response", 
      "target", 
      "rate", 
      "manner", 
      "mechanism", 
      "development", 
      "results", 
      "model", 
      "phase", 
      "world", 
      "PI3K\u03b4 signaling", 
      "hyper-activation promotes development"
    ], 
    "name": "PI3K\u03b4 hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner", 
    "pagination": "3174", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105993584"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-018-05674-8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30093657"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-018-05674-8", 
      "https://app.dimensions.ai/details/publication/pub.1105993584"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_763.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41467-018-05674-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-05674-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-05674-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-05674-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-05674-8'


 

This table displays all metadata directly associated to this object as RDF triples.

399 TRIPLES      22 PREDICATES      111 URIs      93 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-018-05674-8 schema:about N2348810d5fcc49418da9d123db0d7f07
2 N2d36adf9456d4f8fbdd75b536119b04a
3 N323459d836304ed0a9cc739e2536ec9b
4 N45b3d30a3cb64b10a29285a61d5409e6
5 N4f2c2bd9f1a048e8afcedc8474338816
6 N65c3e43141264e1985b99c2846e83079
7 N866ce2a11fbb4fa9a550584412195873
8 N8737ecaeadc14004999b8ec137b4a39b
9 N8d8598ae048646998e25da813f4aac60
10 N8e09405efa5b4a90b183b7bf0493a8e1
11 Naf8e0f41e40b4ceea70383438a582c15
12 Nafa755c758f849629ebff7bb9f404d0f
13 Nb32efc76b4df447e8227f6dc45bdd366
14 Nbc77b552a9034dfe950a7ba0a5e6666f
15 Nbd5a8f503aa34230b8c5cd9791b8d9a7
16 Nccda1ce4af954bd998e25120f864b62f
17 Ndc3637c6ec6f4898a87f822306934402
18 Ndea2353f67b44c3fb9e8d13ab8816798
19 Ne19a9d6d1d244656844a978ecbb43adb
20 Ne7ca6800a6e24d6ca6e8c42672c973fe
21 Nea5e2b0571a74881910606e87375a264
22 anzsrc-for:11
23 anzsrc-for:1107
24 schema:author N0da39aa641fc472d82aa6ad2821fec2c
25 schema:citation sg:pub.10.1023/a:1008942828960
26 sg:pub.10.1038/350423a0
27 sg:pub.10.1038/361226a0
28 sg:pub.10.1038/mi.2016.49
29 sg:pub.10.1038/mi.2017.43
30 sg:pub.10.1038/ni.2771
31 sg:pub.10.1038/nmeth.1564
32 sg:pub.10.1038/nri.2016.93
33 sg:pub.10.1038/nri3857
34 sg:pub.10.1186/gb-2004-5-10-r80
35 schema:datePublished 2018-08-09
36 schema:datePublishedReg 2018-08-09
37 schema:description Streptococcus pneumoniae is a major cause of pneumonia and a leading cause of death world-wide. Antibody-mediated immune responses can confer protection against repeated exposure to S. pneumoniae, yet vaccines offer only partial protection. Patients with Activated PI3Kδ Syndrome (APDS) are highly susceptible to S. pneumoniae. We generated a conditional knock-in mouse model of this disease and identify a CD19<sup>+</sup>B220<sup>-</sup> B cell subset that is induced by PI3Kδ signaling, resides in the lungs, and is correlated with increased susceptibility to S. pneumoniae during early phases of infection via an antibody-independent mechanism. We show that an inhaled PI3Kδ inhibitor improves survival rates following S. pneumoniae infection in wild-type mice and in mice with activated PI3Kδ. These results suggest that a subset of B cells in the lung can promote the severity of S. pneumoniae infection, representing a potential therapeutic target.
38 schema:genre article
39 schema:inLanguage en
40 schema:isAccessibleForFree true
41 schema:isPartOf N4170c2bfcdb44a5bbb18eab4cdceaf4f
42 N496e564566864339864667389b7be2af
43 sg:journal.1043282
44 schema:keywords Activated PI3Kδ Syndrome
45 B220
46 CD19
47 PI3Kδ
48 PI3Kδ inhibitors
49 PI3Kδ signaling
50 PI3Kδ syndrome
51 Promotes Development
52 Streptococcus pneumoniae
53 Streptococcus pneumoniae infection
54 antibody-independent manner
55 antibody-independent mechanisms
56 antibody-mediated immune responses
57 cause
58 cell subsets
59 cells
60 death world
61 development
62 disease
63 early phase
64 exposure
65 hyper-activation promotes development
66 immune response
67 infection
68 inhibitors
69 lung
70 major cause
71 manner
72 mechanism
73 mice
74 model
75 mouse model
76 partial protection
77 patients
78 phase
79 pneumonia
80 pneumoniae
81 pneumoniae infection
82 potential therapeutic target
83 protection
84 rate
85 response
86 results
87 severity
88 signaling
89 subset
90 survival rate
91 susceptibility
92 syndrome
93 target
94 therapeutic target
95 vaccine
96 wild-type mice
97 world
98 schema:name PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
99 schema:pagination 3174
100 schema:productId N1147e8b912b34904ba26b84a12498c30
101 N50cd3f7de59d46288adf341e05a20cd3
102 Ncdbdd35bd0a148cf9b5d7f035a777bb4
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105993584
104 https://doi.org/10.1038/s41467-018-05674-8
105 schema:sdDatePublished 2021-11-01T18:31
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher Nf0faa8d46faa4ad093c6b14304ea3e16
108 schema:url https://doi.org/10.1038/s41467-018-05674-8
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N0da39aa641fc472d82aa6ad2821fec2c rdf:first sg:person.0641617523.08
113 rdf:rest N156352ee736647ecb33792fb9baf03a8
114 N1147e8b912b34904ba26b84a12498c30 schema:name pubmed_id
115 schema:value 30093657
116 rdf:type schema:PropertyValue
117 N156352ee736647ecb33792fb9baf03a8 rdf:first sg:person.01026403066.64
118 rdf:rest Ne36b7a8123e94f95903db44d37bc936e
119 N2348810d5fcc49418da9d123db0d7f07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Phosphatidylinositol 3-Kinases
121 rdf:type schema:DefinedTerm
122 N2d36adf9456d4f8fbdd75b536119b04a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Neutrophils
124 rdf:type schema:DefinedTerm
125 N323459d836304ed0a9cc739e2536ec9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name B-Lymphocytes
127 rdf:type schema:DefinedTerm
128 N33f889b4c35742909b9be4ed59a33cac rdf:first sg:person.0725563771.28
129 rdf:rest Nabed918208ed428da0b708ce29e1def2
130 N4170c2bfcdb44a5bbb18eab4cdceaf4f schema:volumeNumber 9
131 rdf:type schema:PublicationVolume
132 N45b3d30a3cb64b10a29285a61d5409e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Interleukin-10
134 rdf:type schema:DefinedTerm
135 N496e564566864339864667389b7be2af schema:issueNumber 1
136 rdf:type schema:PublicationIssue
137 N4f2c2bd9f1a048e8afcedc8474338816 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Species Specificity
139 rdf:type schema:DefinedTerm
140 N50cd3f7de59d46288adf341e05a20cd3 schema:name dimensions_id
141 schema:value pub.1105993584
142 rdf:type schema:PropertyValue
143 N65c3e43141264e1985b99c2846e83079 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Streptococcus pneumoniae
145 rdf:type schema:DefinedTerm
146 N702d1ccbcc164812b508c846b82ec061 rdf:first sg:person.01024331521.64
147 rdf:rest Na8cd1d90700f4b76a72cee8b77d69ba3
148 N7941480ff40146d5aa8ffff9eed77a08 rdf:first sg:person.01161633171.28
149 rdf:rest Nca3769e3a03142a2baaca2ec8b071b08
150 N7947e2b11e974ae0ad947e858fc0c6fb rdf:first sg:person.01062442203.54
151 rdf:rest N702d1ccbcc164812b508c846b82ec061
152 N84e0b283e6c548b18b15636ae253b141 rdf:first sg:person.01163523063.88
153 rdf:rest Nb27b463bbe1f414aafcb51ebdd0c6d51
154 N866ce2a11fbb4fa9a550584412195873 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Animals
156 rdf:type schema:DefinedTerm
157 N8737ecaeadc14004999b8ec137b4a39b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Genotype
159 rdf:type schema:DefinedTerm
160 N8d8598ae048646998e25da813f4aac60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Humans
162 rdf:type schema:DefinedTerm
163 N8e09405efa5b4a90b183b7bf0493a8e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Phosphoinositide-3 Kinase Inhibitors
165 rdf:type schema:DefinedTerm
166 N9c53a769990e419692f2ee87c8157c68 rdf:first sg:person.01334150044.66
167 rdf:rest Ncc9a4ea16f984a4eac538b1bc03d7e1a
168 Na8cd1d90700f4b76a72cee8b77d69ba3 rdf:first sg:person.0720332755.51
169 rdf:rest N84e0b283e6c548b18b15636ae253b141
170 Nabed918208ed428da0b708ce29e1def2 rdf:first sg:person.0733226325.40
171 rdf:rest N9c53a769990e419692f2ee87c8157c68
172 Naf8e0f41e40b4ceea70383438a582c15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Antigens, CD19
174 rdf:type schema:DefinedTerm
175 Nafa755c758f849629ebff7bb9f404d0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Male
177 rdf:type schema:DefinedTerm
178 Nb27b463bbe1f414aafcb51ebdd0c6d51 rdf:first sg:person.01302007607.64
179 rdf:rest Nfb2a40943d0d4edf88deaaa0a189a5c8
180 Nb32efc76b4df447e8227f6dc45bdd366 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Signal Transduction
182 rdf:type schema:DefinedTerm
183 Nb70704058e074f83a54deb18f11649af rdf:first sg:person.0740745307.30
184 rdf:rest N7941480ff40146d5aa8ffff9eed77a08
185 Nbc77b552a9034dfe950a7ba0a5e6666f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Mice
187 rdf:type schema:DefinedTerm
188 Nbd5a8f503aa34230b8c5cd9791b8d9a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Enzyme Activation
190 rdf:type schema:DefinedTerm
191 Nca3769e3a03142a2baaca2ec8b071b08 rdf:first sg:person.01356616513.06
192 rdf:rest rdf:nil
193 Ncc9a4ea16f984a4eac538b1bc03d7e1a rdf:first sg:person.01156215433.37
194 rdf:rest Nb70704058e074f83a54deb18f11649af
195 Nccda1ce4af954bd998e25120f864b62f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Class I Phosphatidylinositol 3-Kinases
197 rdf:type schema:DefinedTerm
198 Ncdbdd35bd0a148cf9b5d7f035a777bb4 schema:name doi
199 schema:value 10.1038/s41467-018-05674-8
200 rdf:type schema:PropertyValue
201 Ndc3637c6ec6f4898a87f822306934402 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Pneumococcal Infections
203 rdf:type schema:DefinedTerm
204 Ndea2353f67b44c3fb9e8d13ab8816798 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Mice, Inbred C57BL
206 rdf:type schema:DefinedTerm
207 Ne19a9d6d1d244656844a978ecbb43adb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Gene Knock-In Techniques
209 rdf:type schema:DefinedTerm
210 Ne36b7a8123e94f95903db44d37bc936e rdf:first sg:person.013177047774.31
211 rdf:rest N7947e2b11e974ae0ad947e858fc0c6fb
212 Ne7ca6800a6e24d6ca6e8c42672c973fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Female
214 rdf:type schema:DefinedTerm
215 Nea5e2b0571a74881910606e87375a264 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Lung
217 rdf:type schema:DefinedTerm
218 Nf0faa8d46faa4ad093c6b14304ea3e16 schema:name Springer Nature - SN SciGraph project
219 rdf:type schema:Organization
220 Nfb2a40943d0d4edf88deaaa0a189a5c8 rdf:first sg:person.0603502337.80
221 rdf:rest N33f889b4c35742909b9be4ed59a33cac
222 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
223 schema:name Medical and Health Sciences
224 rdf:type schema:DefinedTerm
225 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
226 schema:name Immunology
227 rdf:type schema:DefinedTerm
228 sg:grant.2751473 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-05674-8
229 rdf:type schema:MonetaryGrant
230 sg:grant.2756589 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-05674-8
231 rdf:type schema:MonetaryGrant
232 sg:grant.2777680 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-05674-8
233 rdf:type schema:MonetaryGrant
234 sg:grant.2784635 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-05674-8
235 rdf:type schema:MonetaryGrant
236 sg:grant.3635849 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-05674-8
237 rdf:type schema:MonetaryGrant
238 sg:grant.3637833 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-05674-8
239 rdf:type schema:MonetaryGrant
240 sg:grant.3643234 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-05674-8
241 rdf:type schema:MonetaryGrant
242 sg:grant.4106881 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-05674-8
243 rdf:type schema:MonetaryGrant
244 sg:grant.4849827 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-05674-8
245 rdf:type schema:MonetaryGrant
246 sg:grant.6446305 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-05674-8
247 rdf:type schema:MonetaryGrant
248 sg:grant.7159538 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-05674-8
249 rdf:type schema:MonetaryGrant
250 sg:grant.7748320 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-05674-8
251 rdf:type schema:MonetaryGrant
252 sg:grant.8637539 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-05674-8
253 rdf:type schema:MonetaryGrant
254 sg:journal.1043282 schema:issn 2041-1723
255 schema:name Nature Communications
256 schema:publisher Springer Nature
257 rdf:type schema:Periodical
258 sg:person.01024331521.64 schema:affiliation grid-institutes:grid.418195.0
259 schema:familyName Carbonaro
260 schema:givenName Valentina
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024331521.64
262 rdf:type schema:Person
263 sg:person.01026403066.64 schema:affiliation grid-institutes:grid.24029.3d
264 schema:familyName Chandra
265 schema:givenName Anita
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026403066.64
267 rdf:type schema:Person
268 sg:person.01062442203.54 schema:affiliation grid-institutes:grid.418195.0
269 schema:familyName Alam
270 schema:givenName Rafeah
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062442203.54
272 rdf:type schema:Person
273 sg:person.01156215433.37 schema:affiliation grid-institutes:grid.418236.a
274 schema:familyName Hamblin
275 schema:givenName J. Nicole
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156215433.37
277 rdf:type schema:Person
278 sg:person.01161633171.28 schema:affiliation grid-institutes:grid.11835.3e
279 schema:familyName Condliffe
280 schema:givenName Alison M.
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161633171.28
282 rdf:type schema:Person
283 sg:person.01163523063.88 schema:affiliation grid-institutes:grid.418236.a
284 schema:familyName Sriskantharajah
285 schema:givenName Srividya
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163523063.88
287 rdf:type schema:Person
288 sg:person.01302007607.64 schema:affiliation grid-institutes:grid.418236.a
289 schema:familyName Bradley
290 schema:givenName Glyn
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302007607.64
292 rdf:type schema:Person
293 sg:person.013177047774.31 schema:affiliation grid-institutes:grid.5335.0
294 schema:familyName Chakraborty
295 schema:givenName Krishnendu
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013177047774.31
297 rdf:type schema:Person
298 sg:person.01334150044.66 schema:affiliation grid-institutes:grid.5335.0
299 schema:familyName Nejentsev
300 schema:givenName Sergey
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334150044.66
302 rdf:type schema:Person
303 sg:person.01356616513.06 schema:affiliation grid-institutes:grid.5335.0
304 schema:familyName Okkenhaug
305 schema:givenName Klaus
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356616513.06
307 rdf:type schema:Person
308 sg:person.0603502337.80 schema:affiliation grid-institutes:grid.6572.6
309 schema:familyName Richter
310 schema:givenName Alex G.
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603502337.80
312 rdf:type schema:Person
313 sg:person.0641617523.08 schema:affiliation grid-institutes:grid.5335.0
314 schema:familyName Stark
315 schema:givenName Anne-Katrien
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641617523.08
317 rdf:type schema:Person
318 sg:person.0720332755.51 schema:affiliation grid-institutes:grid.418195.0
319 schema:familyName Clark
320 schema:givenName Jonathan
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720332755.51
322 rdf:type schema:Person
323 sg:person.0725563771.28 schema:affiliation grid-institutes:grid.24029.3d
324 schema:familyName Banham-Hall
325 schema:givenName Edward
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725563771.28
327 rdf:type schema:Person
328 sg:person.0733226325.40 schema:affiliation grid-institutes:grid.42475.30
329 schema:familyName Clatworthy
330 schema:givenName Menna R.
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733226325.40
332 rdf:type schema:Person
333 sg:person.0740745307.30 schema:affiliation grid-institutes:grid.418236.a
334 schema:familyName Hessel
335 schema:givenName Edith M.
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740745307.30
337 rdf:type schema:Person
338 sg:pub.10.1023/a:1008942828960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011866095
339 https://doi.org/10.1023/a:1008942828960
340 rdf:type schema:CreativeWork
341 sg:pub.10.1038/350423a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018596250
342 https://doi.org/10.1038/350423a0
343 rdf:type schema:CreativeWork
344 sg:pub.10.1038/361226a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012483561
345 https://doi.org/10.1038/361226a0
346 rdf:type schema:CreativeWork
347 sg:pub.10.1038/mi.2016.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002757931
348 https://doi.org/10.1038/mi.2016.49
349 rdf:type schema:CreativeWork
350 sg:pub.10.1038/mi.2017.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085421977
351 https://doi.org/10.1038/mi.2017.43
352 rdf:type schema:CreativeWork
353 sg:pub.10.1038/ni.2771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012593761
354 https://doi.org/10.1038/ni.2771
355 rdf:type schema:CreativeWork
356 sg:pub.10.1038/nmeth.1564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032770146
357 https://doi.org/10.1038/nmeth.1564
358 rdf:type schema:CreativeWork
359 sg:pub.10.1038/nri.2016.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041797827
360 https://doi.org/10.1038/nri.2016.93
361 rdf:type schema:CreativeWork
362 sg:pub.10.1038/nri3857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035157346
363 https://doi.org/10.1038/nri3857
364 rdf:type schema:CreativeWork
365 sg:pub.10.1186/gb-2004-5-10-r80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018457673
366 https://doi.org/10.1186/gb-2004-5-10-r80
367 rdf:type schema:CreativeWork
368 grid-institutes:grid.11835.3e schema:alternateName Department of Infection, Immunity and Cardiovascular Diseases, University of Sheffield, Sheffield, S10 2RX UK
369 schema:name Department of Infection, Immunity and Cardiovascular Diseases, University of Sheffield, Sheffield, S10 2RX UK
370 rdf:type schema:Organization
371 grid-institutes:grid.24029.3d schema:alternateName Cambridge University Hospitals NHS Trust, Hills Road, Cambridge, CB2 0QQ UK
372 schema:name Cambridge University Hospitals NHS Trust, Hills Road, Cambridge, CB2 0QQ UK
373 Department of Medicine, University of Cambridge, Cambridge, CB2 OQQ UK
374 Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, CB2 1QP UK
375 Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT UK
376 rdf:type schema:Organization
377 grid-institutes:grid.418195.0 schema:alternateName Biological Chemistry Laboratory, Babraham Institute, Cambridge, CB21 3AT UK
378 Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT UK
379 schema:name Biological Chemistry Laboratory, Babraham Institute, Cambridge, CB21 3AT UK
380 Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT UK
381 rdf:type schema:Organization
382 grid-institutes:grid.418236.a schema:alternateName Computational Biology and Statistics, Target Sciences, GlaxoSmithKline, Stevenage, SG1 2NY UK
383 Refractory Respiratory Inflammation Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, Stevenage, SG1 2NY UK
384 schema:name Computational Biology and Statistics, Target Sciences, GlaxoSmithKline, Stevenage, SG1 2NY UK
385 Refractory Respiratory Inflammation Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, Stevenage, SG1 2NY UK
386 rdf:type schema:Organization
387 grid-institutes:grid.42475.30 schema:alternateName Molecular Immunity Unit, MRC Laboratory of Molecular Biology, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, CB2 OQQ UK
388 schema:name Molecular Immunity Unit, MRC Laboratory of Molecular Biology, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, CB2 OQQ UK
389 rdf:type schema:Organization
390 grid-institutes:grid.5335.0 schema:alternateName Department of Medicine, University of Cambridge, Cambridge, CB2 OQQ UK
391 Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, CB2 1QP UK
392 schema:name Department of Medicine, University of Cambridge, Cambridge, CB2 OQQ UK
393 Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, CB2 1QP UK
394 Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT UK
395 rdf:type schema:Organization
396 grid-institutes:grid.6572.6 schema:alternateName Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT UK
397 schema:name Department of Immunology, Queen Elizabeth Hospital, Birmingham, B15 2TH UK
398 Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT UK
399 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...