Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Thorunn Rafnar, Bjarni Gunnarsson, Olafur A. Stefansson, Patrick Sulem, Andres Ingason, Michael L. Frigge, Lilja Stefansdottir, Jon K. Sigurdsson, Vinicius Tragante, Valgerdur Steinthorsdottir, Unnur Styrkarsdottir, Simon N. Stacey, Julius Gudmundsson, Gudny A. Arnadottir, Asmundur Oddsson, Florian Zink, Gisli Halldorsson, Gardar Sveinbjornsson, Ragnar P. Kristjansson, Olafur B. Davidsson, Anna Salvarsdottir, Asgeir Thoroddsen, Elisabet A. Helgadottir, Katrin Kristjansdottir, Orri Ingthorsson, Valur Gudmundsson, Reynir T. Geirsson, Ragnheidur Arnadottir, Daniel F. Gudbjartsson, Gisli Masson, Folkert W. Asselbergs, Jon G. Jonasson, Karl Olafsson, Unnur Thorsteinsdottir, Bjarni V. Halldorsson, Gudmar Thorleifsson, Kari Stefansson

ABSTRACT

Uterine leiomyomas are common benign tumors of the myometrium. We performed a meta-analysis of two genome-wide association studies of leiomyoma in European women (16,595 cases and 523,330 controls), uncovering 21 variants at 16 loci that associate with the disease. Five variants were previously reported to confer risk of various malignant or benign tumors (rs78378222 in TP53, rs10069690 in TERT, rs1800057 and rs1801516 in ATM, and rs7907606 at OBFC1) and four signals are located at established risk loci for hormone-related traits (endometriosis and breast cancer) at 1q36.12 (CDC42/WNT4), 2p25.1 (GREB1), 20p12.3 (MCM8), and 6q26.2 (SYNE1/ESR1). Polygenic score for leiomyoma, computed using UKB data, is significantly correlated with risk of cancer in the Icelandic population. Functional annotation suggests that the non-coding risk variants affect multiple genes, including ESR1. Our results provide insights into the genetic background of leiomyoma that are shared by other benign and malignant tumors and highlight the role of hormones in leiomyoma growth. More... »

PAGES

3636

References to SciGraph publications

  • 2017-02-14. A genome-wide association study yields five novel thyroid cancer risk loci in NATURE COMMUNICATIONS
  • 2016-06. Five endometrial cancer risk loci identified through genome-wide association analysis in NATURE GENETICS
  • 2015-09. Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma in NATURE GENETICS
  • 2015-03. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies in NATURE GENETICS
  • 2009-07. Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array in BRITISH JOURNAL OF CANCER
  • 2009-11. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies in NATURE GENETICS
  • 2014-01. A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia in NATURE GENETICS
  • 2011-12. A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer in NATURE GENETICS
  • 2017-05. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer in NATURE GENETICS
  • 2016-03. Weighting sequence variants based on their annotation increases power of whole-genome association studies in NATURE GENETICS
  • 2013-05. Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222 in BRITISH JOURNAL OF CANCER
  • 2017-12. Comparison of DNA quantification methodology used in the DNA extraction protocol for the UK Biobank cohort in BMC GENOMICS
  • 2013-08. BET1L and TNRC6B associate with uterine fibroid risk among European Americans in HUMAN GENETICS
  • 2017-10. A multi-stage genome-wide association study of uterine fibroids in African Americans in HUMAN GENETICS
  • 2012-05. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture in NATURE GENETICS
  • 2016-12. Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma in NATURE COMMUNICATIONS
  • 2017-06-09. Genome-wide association study identifies multiple risk loci for renal cell carcinoma in NATURE COMMUNICATIONS
  • 2011-11. Genome-wide association study identifies three new melanoma susceptibility loci in NATURE GENETICS
  • 2017-05-24. Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism in NATURE COMMUNICATIONS
  • 2017-11. Association analysis identifies 65 new breast cancer risk loci in NATURE
  • 2009-06. Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche in NATURE GENETICS
  • 2015-05. Large-scale whole-genome sequencing of the Icelandic population in NATURE GENETICS
  • 2009-06. Genome-wide association studies identify loci associated with age at menarche and age at natural menopause in NATURE GENETICS
  • 2014-11. The contribution of genetic variants to disease depends on the ruler in NATURE REVIEWS GENETICS
  • 2015-08. Loss-of-function variants in ATM confer risk of gastric cancer in NATURE GENETICS
  • 2016-01-06. Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures in NATURE COMMUNICATIONS
  • 2004-08. ATM polymorphisms as risk factors for prostate cancer development in BRITISH JOURNAL OF CANCER
  • 2011-11. A germline variant in the TP53 polyadenylation signal confers cancer susceptibility in NATURE GENETICS
  • 2008-09. Detection of sharing by descent, long-range phasing and haplotype imputation in NATURE GENETICS
  • 2013-05. Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits in NATURE
  • 2016-04. Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 in NATURE GENETICS
  • 2012-04. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits in NATURE GENETICS
  • 2011-05. A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids in NATURE GENETICS
  • 2017-07. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes in NATURE GENETICS
  • 2015-02. Identification of six new susceptibility loci for invasive epithelial ovarian cancer in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-05428-6

    DOI

    http://dx.doi.org/10.1038/s41467-018-05428-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106545297

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30194396


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    574 Department of Obstetrics and Gynecology, Landspitali University Hospital, 101, Reykjavik, Iceland
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