Nonequilibrium self-assembly dynamics of icosahedral viral capsids packaging genome or polyelectrolyte View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Maelenn Chevreuil, Didier Law-Hine, Jingzhi Chen, Stéphane Bressanelli, Sophie Combet, Doru Constantin, Jéril Degrouard, Johannes Möller, Mehdi Zeghal, Guillaume Tresset

ABSTRACT

The survival of viruses partly relies on their ability to self-assemble inside host cells. Although coarse-grained simulations have identified different pathways leading to assembled virions from their components, experimental evidence is severely lacking. Here, we use time-resolved small-angle X-ray scattering to uncover the nonequilibrium self-assembly dynamics of icosahedral viral capsids packaging their full RNA genome. We reveal the formation of amorphous complexes via an en masse pathway and their relaxation into virions via a synchronous pathway. The binding energy of capsid subunits on the genome is moderate (~7kBT0, with kB the Boltzmann constant and T0 = 298 K, the room temperature), while the energy barrier separating the complexes and the virions is high (~ 20kBT0). A synthetic polyelectrolyte can lower this barrier so that filled capsids are formed in conditions where virions cannot build up. We propose a representation of the dynamics on a free energy landscape. More... »

PAGES

3071

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-05426-8

DOI

http://dx.doi.org/10.1038/s41467-018-05426-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105928848

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30082710


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