Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Janani Iyer, Mayanglambam Dhruba Singh, Matthew Jensen, Payal Patel, Lucilla Pizzo, Emily Huber, Haley Koerselman, Alexis T. Weiner, Paola Lepanto, Komal Vadodaria, Alexis Kubina, Qingyu Wang, Abigail Talbert, Sneha Yennawar, Jose Badano, J. Robert Manak, Melissa M. Rolls, Arjun Krishnan, Santhosh Girirajan

ABSTRACT

As opposed to syndromic CNVs caused by single genes, extensive phenotypic heterogeneity in variably-expressive CNVs complicates disease gene discovery and functional evaluation. Here, we propose a complex interaction model for pathogenicity of the autism-associated 16p11.2 deletion, where CNV genes interact with each other in conserved pathways to modulate expression of the phenotype. Using multiple quantitative methods in Drosophila RNAi lines, we identify a range of neurodevelopmental phenotypes for knockdown of individual 16p11.2 homologs in different tissues. We test 565 pairwise knockdowns in the developing eye, and identify 24 interactions between pairs of 16p11.2 homologs and 46 interactions between 16p11.2 homologs and neurodevelopmental genes that suppress or enhance cell proliferation phenotypes compared to one-hit knockdowns. These interactions within cell proliferation pathways are also enriched in a human brain-specific network, providing translational relevance in humans. Our study indicates a role for pervasive genetic interactions within CNVs towards cellular and developmental phenotypes. More... »

PAGES

2548

References to SciGraph publications

  • 2001-03. Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice in NATURE
  • 2017-06. Altered proliferation and networks in neural cells derived from idiopathic autistic individuals in MOLECULAR PSYCHIATRY
  • 2013-04. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions in GENOME BIOLOGY
  • 2015-06. Understanding multicellular function and disease with human tissue-specific networks in NATURE GENETICS
  • 2014-11. The contribution of de novo coding mutations to autism spectrum disorder in NATURE
  • 2010-12. Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication in MOLECULAR AUTISM
  • 2016-08. Analysis of protein-coding genetic variation in 60,706 humans in NATURE
  • 2009-12. Cell fate decisions are specified by the dynamic ERK interactome in NATURE CELL BIOLOGY
  • 2010-07. Functional impact of global rare copy number variation in autism spectrum disorders in NATURE
  • 2014-07. Genome sequencing identifies major causes of severe intellectual disability in NATURE
  • 2003-04. Mutations in RAI1 associated with Smith–Magenis syndrome in NATURE GENETICS
  • 2005-12. PAGE: Parametric Analysis of Gene Set Enrichment in BMC BIOINFORMATICS
  • 2014-01. Epistasis and quantitative traits: using model organisms to study gene–gene interactions in NATURE REVIEWS GENETICS
  • 2017-11. Kctd13 deletion reduces synaptic transmission via increased RhoA in NATURE
  • 2012-07. NIH Image to ImageJ: 25 years of image analysis in NATURE METHODS
  • 2016-11. Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling in NATURE NEUROSCIENCE
  • 2007-07. A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila in NATURE
  • 2017-06. Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes in MOLECULAR PSYCHIATRY
  • 2013-09. De novo mutations in epileptic encephalopathies in NATURE
  • 2016-11. Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder in NATURE NEUROSCIENCE
  • 2011-03. Dendritic spine pathology in neuropsychiatric disorders in NATURE NEUROSCIENCE
  • 2010-02. A new highly penetrant form of obesity due to deletions on chromosome 16p11.2 in NATURE
  • 2014-03. A Drosophila RNAi collection is subject to dominant phenotypic effects in NATURE METHODS
  • 2014-02. De novo mutations in schizophrenia implicate synaptic networks in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-04882-6

    DOI

    http://dx.doi.org/10.1038/s41467-018-04882-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105107298

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29959322


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Pennsylvania State University", 
              "id": "https://www.grid.ac/institutes/grid.29857.31", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 16802, University Park, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iyer", 
            "givenName": "Janani", 
            "id": "sg:person.01145533740.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145533740.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pennsylvania State University", 
              "id": "https://www.grid.ac/institutes/grid.29857.31", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 16802, University Park, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Singh", 
            "givenName": "Mayanglambam Dhruba", 
            "id": "sg:person.010242714740.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010242714740.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pennsylvania State University", 
              "id": "https://www.grid.ac/institutes/grid.29857.31", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 16802, University Park, PA, USA", 
                "Bioinformatics and Genomics Program, The Huck Institutes of the Life Sciences, The Pennsylvania State University, 16802, University Park, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jensen", 
            "givenName": "Matthew", 
            "id": "sg:person.016472405253.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016472405253.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pennsylvania State University", 
              "id": "https://www.grid.ac/institutes/grid.29857.31", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 16802, University Park, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Patel", 
            "givenName": "Payal", 
            "id": "sg:person.013230616740.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013230616740.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pennsylvania State University", 
              "id": "https://www.grid.ac/institutes/grid.29857.31", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 16802, University Park, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pizzo", 
            "givenName": "Lucilla", 
            "id": "sg:person.01161776022.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161776022.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pennsylvania State University", 
              "id": "https://www.grid.ac/institutes/grid.29857.31", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 16802, University Park, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huber", 
            "givenName": "Emily", 
            "id": "sg:person.016216520740.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016216520740.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Iowa", 
              "id": "https://www.grid.ac/institutes/grid.214572.7", 
              "name": [
                "Department of Biology, University of Iowa, 52242, Iowa City, IA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koerselman", 
            "givenName": "Haley", 
            "id": "sg:person.012131703301.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012131703301.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pennsylvania State University", 
              "id": "https://www.grid.ac/institutes/grid.29857.31", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 16802, University Park, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weiner", 
            "givenName": "Alexis T.", 
            "id": "sg:person.0607227026.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607227026.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur de Montevideo", 
              "id": "https://www.grid.ac/institutes/grid.418532.9", 
              "name": [
                "Human Molecular Genetics Laboratory, Institut Pasteur de Montevideo, CP11400, Montevideo, Uruguay"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lepanto", 
            "givenName": "Paola", 
            "id": "sg:person.01156262314.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156262314.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pennsylvania State University", 
              "id": "https://www.grid.ac/institutes/grid.29857.31", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 16802, University Park, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vadodaria", 
            "givenName": "Komal", 
            "id": "sg:person.014671673140.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014671673140.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pennsylvania State University", 
              "id": "https://www.grid.ac/institutes/grid.29857.31", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 16802, University Park, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kubina", 
            "givenName": "Alexis", 
            "id": "sg:person.016264634140.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016264634140.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pennsylvania State University", 
              "id": "https://www.grid.ac/institutes/grid.29857.31", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 16802, University Park, PA, USA", 
                "Bioinformatics and Genomics Program, The Huck Institutes of the Life Sciences, The Pennsylvania State University, 16802, University Park, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Qingyu", 
            "id": "sg:person.0712622647.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712622647.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pennsylvania State University", 
              "id": "https://www.grid.ac/institutes/grid.29857.31", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 16802, University Park, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Talbert", 
            "givenName": "Abigail", 
            "id": "sg:person.011154523740.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011154523740.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pennsylvania State University", 
              "id": "https://www.grid.ac/institutes/grid.29857.31", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 16802, University Park, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yennawar", 
            "givenName": "Sneha", 
            "id": "sg:person.012547464740.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012547464740.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur de Montevideo", 
              "id": "https://www.grid.ac/institutes/grid.418532.9", 
              "name": [
                "Human Molecular Genetics Laboratory, Institut Pasteur de Montevideo, CP11400, Montevideo, Uruguay"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Badano", 
            "givenName": "Jose", 
            "id": "sg:person.01317423656.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317423656.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Iowa", 
              "id": "https://www.grid.ac/institutes/grid.214572.7", 
              "name": [
                "Department of Biology, University of Iowa, 52242, Iowa City, IA, USA", 
                "Department of Pediatrics, University of Iowa, 52242, Iowa City, IA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Manak", 
            "givenName": "J. Robert", 
            "id": "sg:person.01201777730.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201777730.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pennsylvania State University", 
              "id": "https://www.grid.ac/institutes/grid.29857.31", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 16802, University Park, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rolls", 
            "givenName": "Melissa M.", 
            "id": "sg:person.0732043740.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732043740.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Michigan State University", 
              "id": "https://www.grid.ac/institutes/grid.17088.36", 
              "name": [
                "Department of Computational Mathematics, Science and Engineering, Michigan State University, 48824, East Lansing, MI, USA", 
                "Department of Biochemistry and Molecular Biology, Michigan State University, 48824, East Lansing, MI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Krishnan", 
            "givenName": "Arjun", 
            "id": "sg:person.01350742712.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350742712.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pennsylvania State University", 
              "id": "https://www.grid.ac/institutes/grid.29857.31", 
              "name": [
                "Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 16802, University Park, PA, USA", 
                "Bioinformatics and Genomics Program, The Huck Institutes of the Life Sciences, The Pennsylvania State University, 16802, University Park, PA, USA", 
                "Department of Anthropology, The Pennsylvania State University, 16802, University Park, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Girirajan", 
            "givenName": "Santhosh", 
            "id": "sg:person.0650527525.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650527525.97"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.1510104112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000652595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.0030177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002598657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1004998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003368585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003744287", 
              "https://doi.org/10.1038/nature12439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.5685-08.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003828658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009365689", 
              "https://doi.org/10.1038/nature05954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010093189", 
              "https://doi.org/10.1038/ng1126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010093189", 
              "https://doi.org/10.1038/ng1126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dmm.009944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010536644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010543892", 
              "https://doi.org/10.1038/ng.3259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddm376", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010834083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35065105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011836103", 
              "https://doi.org/10.1038/35065105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35065105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011836103", 
              "https://doi.org/10.1038/35065105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2016.84", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012485918", 
              "https://doi.org/10.1038/mp.2016.84"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012902412", 
              "https://doi.org/10.1038/nature09146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012902412", 
              "https://doi.org/10.1038/nature09146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1003709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013368129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.114.171785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014133886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.114.171785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014133886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.02370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014612979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2013-14-4-r36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015459845", 
              "https://doi.org/10.1186/gb-2013-14-4-r36"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2016.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015810739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2016.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015810739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2016.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015810739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmedgenet-2012-101203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017328389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.221452098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019940350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/gbb.12279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020984097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/g3.116.027060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021871973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/g3.116.027060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021871973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021971381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature19057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022281897", 
              "https://doi.org/10.1038/nature19057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022768937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp616", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023247882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-6-144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025271948", 
              "https://doi.org/10.1186/1471-2105-6-144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-6-144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025271948", 
              "https://doi.org/10.1186/1471-2105-6-144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra0903074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025383419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025596426", 
              "https://doi.org/10.1038/nrg3627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2040-2392-1-15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026591820", 
              "https://doi.org/10.1186/2040-2392-1-15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0888-7543(95)80010-j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027027849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0888-7543(95)80010-j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027027849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/acn3.334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027495214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.4864-13.2015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027782402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1120276109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028285083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pcbi.1004823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028428745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.conb.2011.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028441877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.184325.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028584362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.4400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031080832", 
              "https://doi.org/10.1038/nn.4400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2016.95", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031478945", 
              "https://doi.org/10.1038/mp.2016.95"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejmg.2009.03.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032488403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.06.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035386489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035817137", 
              "https://doi.org/10.1038/nmeth.2089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.01122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036672938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.4353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037071980", 
              "https://doi.org/10.1038/nn.4353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2016.03.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037185904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037440395", 
              "https://doi.org/10.1038/nn.2741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2009.04.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038993025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1200395", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039475746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039525547", 
              "https://doi.org/10.1038/nature08727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039525547", 
              "https://doi.org/10.1038/nature08727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1994", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041118720", 
              "https://doi.org/10.1038/ncb1994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btu170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042720804"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.conb.2010.07.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042789209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci72763", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043036836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci72763", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043036836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2014.05.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045028135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046951438", 
              "https://doi.org/10.1038/nature13908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047114804", 
              "https://doi.org/10.1038/nmeth.2856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-9525(99)01720-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049066663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddq366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049325913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddq366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049325913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049383355", 
              "https://doi.org/10.1038/nature12929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052525502", 
              "https://doi.org/10.1038/nature13394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2015.11.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053014970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btu638", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053282140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074547527", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075065712", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083215660", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/bio.024075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084256437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature24470", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092446312", 
              "https://doi.org/10.1038/nature24470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature24470", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092446312", 
              "https://doi.org/10.1038/nature24470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2017.11.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099603288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1716092115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101007434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2034-17.2018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101564673"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "As opposed to syndromic CNVs caused by single genes, extensive phenotypic heterogeneity in variably-expressive CNVs complicates disease gene discovery and functional evaluation. Here, we propose a complex interaction model for pathogenicity of the autism-associated 16p11.2 deletion, where CNV genes interact with each other in conserved pathways to modulate expression of the phenotype. Using multiple quantitative methods in Drosophila RNAi lines, we identify a range of neurodevelopmental phenotypes for knockdown of individual 16p11.2 homologs in different tissues. We test 565 pairwise knockdowns in the developing eye, and identify 24 interactions between pairs of 16p11.2 homologs and 46 interactions between 16p11.2 homologs and neurodevelopmental genes that suppress or enhance cell proliferation phenotypes compared to one-hit knockdowns. These interactions within cell proliferation pathways are also enriched in a human brain-specific network, providing translational relevance in humans. Our study indicates a role for pervasive genetic interactions within CNVs towards cellular and developmental phenotypes.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41467-018-04882-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2684183", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6617290", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster", 
        "pagination": "2548", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "9ec9093ee5a00068408f41276c1fef98cb2e353c8f2d32394b5e83171d12635e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29959322"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101528555"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-018-04882-6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1105107298"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-018-04882-6", 
          "https://app.dimensions.ai/details/publication/pub.1105107298"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T02:23", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000567.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41467-018-04882-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-04882-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-04882-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-04882-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-04882-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    442 TRIPLES      21 PREDICATES      99 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-018-04882-6 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N464b692ce7fc46feb0f733907c0e0a54
    4 schema:citation sg:pub.10.1038/35065105
    5 sg:pub.10.1038/mp.2016.84
    6 sg:pub.10.1038/mp.2016.95
    7 sg:pub.10.1038/nature05954
    8 sg:pub.10.1038/nature08727
    9 sg:pub.10.1038/nature09146
    10 sg:pub.10.1038/nature12439
    11 sg:pub.10.1038/nature12929
    12 sg:pub.10.1038/nature13394
    13 sg:pub.10.1038/nature13908
    14 sg:pub.10.1038/nature19057
    15 sg:pub.10.1038/nature24470
    16 sg:pub.10.1038/ncb1994
    17 sg:pub.10.1038/ng.3259
    18 sg:pub.10.1038/ng1126
    19 sg:pub.10.1038/nmeth.2089
    20 sg:pub.10.1038/nmeth.2856
    21 sg:pub.10.1038/nn.2741
    22 sg:pub.10.1038/nn.4353
    23 sg:pub.10.1038/nn.4400
    24 sg:pub.10.1038/nrg3627
    25 sg:pub.10.1186/1471-2105-6-144
    26 sg:pub.10.1186/2040-2392-1-15
    27 sg:pub.10.1186/gb-2013-14-4-r36
    28 https://app.dimensions.ai/details/publication/pub.1074547527
    29 https://app.dimensions.ai/details/publication/pub.1075065712
    30 https://app.dimensions.ai/details/publication/pub.1083215660
    31 https://doi.org/10.1002/acn3.334
    32 https://doi.org/10.1016/0888-7543(95)80010-j
    33 https://doi.org/10.1016/j.ajhg.2014.05.004
    34 https://doi.org/10.1016/j.ajhg.2015.11.024
    35 https://doi.org/10.1016/j.cell.2015.06.023
    36 https://doi.org/10.1016/j.celrep.2017.11.037
    37 https://doi.org/10.1016/j.conb.2010.07.012
    38 https://doi.org/10.1016/j.conb.2011.04.009
    39 https://doi.org/10.1016/j.ejmg.2009.03.006
    40 https://doi.org/10.1016/j.tig.2016.01.001
    41 https://doi.org/10.1016/j.tins.2009.04.003
    42 https://doi.org/10.1016/j.tins.2016.03.001
    43 https://doi.org/10.1016/s0168-9525(99)01720-5
    44 https://doi.org/10.1056/nejmoa1200395
    45 https://doi.org/10.1056/nejmra0903074
    46 https://doi.org/10.1073/pnas.1120276109
    47 https://doi.org/10.1073/pnas.1510104112
    48 https://doi.org/10.1073/pnas.1716092115
    49 https://doi.org/10.1073/pnas.221452098
    50 https://doi.org/10.1093/bioinformatics/btp616
    51 https://doi.org/10.1093/bioinformatics/btu170
    52 https://doi.org/10.1093/bioinformatics/btu638
    53 https://doi.org/10.1093/hmg/ddm376
    54 https://doi.org/10.1093/hmg/ddq366
    55 https://doi.org/10.1093/nar/gkq537
    56 https://doi.org/10.1101/gr.184325.114
    57 https://doi.org/10.1111/gbb.12279
    58 https://doi.org/10.1136/jmedgenet-2012-101203
    59 https://doi.org/10.1172/jci72763
    60 https://doi.org/10.1242/bio.024075
    61 https://doi.org/10.1242/dev.01122
    62 https://doi.org/10.1242/dev.02370
    63 https://doi.org/10.1242/dmm.009944
    64 https://doi.org/10.1371/journal.pcbi.1004823
    65 https://doi.org/10.1371/journal.pgen.0030177
    66 https://doi.org/10.1371/journal.pgen.1000962
    67 https://doi.org/10.1371/journal.pgen.1003709
    68 https://doi.org/10.1371/journal.pgen.1004998
    69 https://doi.org/10.1523/jneurosci.2034-17.2018
    70 https://doi.org/10.1523/jneurosci.4864-13.2015
    71 https://doi.org/10.1523/jneurosci.5685-08.2009
    72 https://doi.org/10.1534/g3.116.027060
    73 https://doi.org/10.1534/genetics.114.171785
    74 schema:datePublished 2018-12
    75 schema:datePublishedReg 2018-12-01
    76 schema:description As opposed to syndromic CNVs caused by single genes, extensive phenotypic heterogeneity in variably-expressive CNVs complicates disease gene discovery and functional evaluation. Here, we propose a complex interaction model for pathogenicity of the autism-associated 16p11.2 deletion, where CNV genes interact with each other in conserved pathways to modulate expression of the phenotype. Using multiple quantitative methods in Drosophila RNAi lines, we identify a range of neurodevelopmental phenotypes for knockdown of individual 16p11.2 homologs in different tissues. We test 565 pairwise knockdowns in the developing eye, and identify 24 interactions between pairs of 16p11.2 homologs and 46 interactions between 16p11.2 homologs and neurodevelopmental genes that suppress or enhance cell proliferation phenotypes compared to one-hit knockdowns. These interactions within cell proliferation pathways are also enriched in a human brain-specific network, providing translational relevance in humans. Our study indicates a role for pervasive genetic interactions within CNVs towards cellular and developmental phenotypes.
    77 schema:genre research_article
    78 schema:inLanguage en
    79 schema:isAccessibleForFree true
    80 schema:isPartOf N9fbaa9aafb0c4c6b885206dc06569153
    81 Nbc438acdd8ac4a59ae48614215ccaab3
    82 sg:journal.1043282
    83 schema:name Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster
    84 schema:pagination 2548
    85 schema:productId N24d9bd6747e44b91973fcd884b6fb88b
    86 N3c13693cdc09453da13813d95c7f06f0
    87 Naed38db296c141acbe696e6c00a22c33
    88 Nfa414480a0874075bbb0f05a18776f70
    89 Nff4bcf70ac044e27aba9a8d09b888bbb
    90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105107298
    91 https://doi.org/10.1038/s41467-018-04882-6
    92 schema:sdDatePublished 2019-04-11T02:23
    93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    94 schema:sdPublisher N880cb1f8d3c84ecc8e405d1dd688c678
    95 schema:url https://www.nature.com/articles/s41467-018-04882-6
    96 sgo:license sg:explorer/license/
    97 sgo:sdDataset articles
    98 rdf:type schema:ScholarlyArticle
    99 N064bca63dd3c48cab7cb69e341f26d80 rdf:first sg:person.0650527525.97
    100 rdf:rest rdf:nil
    101 N06a31883913f443a9176d5b8b0446455 rdf:first sg:person.01350742712.44
    102 rdf:rest N064bca63dd3c48cab7cb69e341f26d80
    103 N0b50404e662c4c64b8d3a4c87acb732d rdf:first sg:person.010242714740.30
    104 rdf:rest Nd3661ec024a844389cb41ceabecd6a21
    105 N0ccafe93da894e32a41df35a6619fb19 rdf:first sg:person.01317423656.41
    106 rdf:rest N9e71b26bcd104d598bc98459eefc7ab0
    107 N1fbbe734c5d64072aeac72d30d31a32c rdf:first sg:person.016264634140.27
    108 rdf:rest N4d4c1ed3efa64b37837b1e46ed7d5de7
    109 N24d9bd6747e44b91973fcd884b6fb88b schema:name dimensions_id
    110 schema:value pub.1105107298
    111 rdf:type schema:PropertyValue
    112 N264d7de8028c413d8437769dff7328f4 rdf:first sg:person.012547464740.97
    113 rdf:rest N0ccafe93da894e32a41df35a6619fb19
    114 N336ad1b47559475ebbe1fe211dd37a8e rdf:first sg:person.014671673140.83
    115 rdf:rest N1fbbe734c5d64072aeac72d30d31a32c
    116 N3c13693cdc09453da13813d95c7f06f0 schema:name doi
    117 schema:value 10.1038/s41467-018-04882-6
    118 rdf:type schema:PropertyValue
    119 N464b692ce7fc46feb0f733907c0e0a54 rdf:first sg:person.01145533740.96
    120 rdf:rest N0b50404e662c4c64b8d3a4c87acb732d
    121 N4d4c1ed3efa64b37837b1e46ed7d5de7 rdf:first sg:person.0712622647.11
    122 rdf:rest N6afafa4f7b1c4201a6581d3b31c80962
    123 N5e75824d85474672929868d9f59d2dd4 rdf:first sg:person.0607227026.10
    124 rdf:rest Nfe276fc0b0734c328bc474e693fc5188
    125 N6afafa4f7b1c4201a6581d3b31c80962 rdf:first sg:person.011154523740.37
    126 rdf:rest N264d7de8028c413d8437769dff7328f4
    127 N71d2ab29ec974ac29d907764101cfa17 rdf:first sg:person.016216520740.31
    128 rdf:rest N969adb16ce554d3a8fb80d2604cb8c15
    129 N82bcf0360b8a46aab82c16ed912351e2 rdf:first sg:person.0732043740.93
    130 rdf:rest N06a31883913f443a9176d5b8b0446455
    131 N880cb1f8d3c84ecc8e405d1dd688c678 schema:name Springer Nature - SN SciGraph project
    132 rdf:type schema:Organization
    133 N969adb16ce554d3a8fb80d2604cb8c15 rdf:first sg:person.012131703301.52
    134 rdf:rest N5e75824d85474672929868d9f59d2dd4
    135 N9e71b26bcd104d598bc98459eefc7ab0 rdf:first sg:person.01201777730.99
    136 rdf:rest N82bcf0360b8a46aab82c16ed912351e2
    137 N9fbaa9aafb0c4c6b885206dc06569153 schema:volumeNumber 9
    138 rdf:type schema:PublicationVolume
    139 Na2856465dc944bb0974b50384e216cd1 rdf:first sg:person.01161776022.22
    140 rdf:rest N71d2ab29ec974ac29d907764101cfa17
    141 Naed38db296c141acbe696e6c00a22c33 schema:name pubmed_id
    142 schema:value 29959322
    143 rdf:type schema:PropertyValue
    144 Nbc438acdd8ac4a59ae48614215ccaab3 schema:issueNumber 1
    145 rdf:type schema:PublicationIssue
    146 Nd3661ec024a844389cb41ceabecd6a21 rdf:first sg:person.016472405253.62
    147 rdf:rest Nf1d5ae4d3ec640f398ab1d639b0603d9
    148 Nf1d5ae4d3ec640f398ab1d639b0603d9 rdf:first sg:person.013230616740.35
    149 rdf:rest Na2856465dc944bb0974b50384e216cd1
    150 Nfa414480a0874075bbb0f05a18776f70 schema:name readcube_id
    151 schema:value 9ec9093ee5a00068408f41276c1fef98cb2e353c8f2d32394b5e83171d12635e
    152 rdf:type schema:PropertyValue
    153 Nfe276fc0b0734c328bc474e693fc5188 rdf:first sg:person.01156262314.13
    154 rdf:rest N336ad1b47559475ebbe1fe211dd37a8e
    155 Nff4bcf70ac044e27aba9a8d09b888bbb schema:name nlm_unique_id
    156 schema:value 101528555
    157 rdf:type schema:PropertyValue
    158 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    159 schema:name Biological Sciences
    160 rdf:type schema:DefinedTerm
    161 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    162 schema:name Genetics
    163 rdf:type schema:DefinedTerm
    164 sg:grant.2684183 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-04882-6
    165 rdf:type schema:MonetaryGrant
    166 sg:grant.6617290 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-04882-6
    167 rdf:type schema:MonetaryGrant
    168 sg:journal.1043282 schema:issn 2041-1723
    169 schema:name Nature Communications
    170 rdf:type schema:Periodical
    171 sg:person.010242714740.30 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
    172 schema:familyName Singh
    173 schema:givenName Mayanglambam Dhruba
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010242714740.30
    175 rdf:type schema:Person
    176 sg:person.011154523740.37 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
    177 schema:familyName Talbert
    178 schema:givenName Abigail
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011154523740.37
    180 rdf:type schema:Person
    181 sg:person.01145533740.96 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
    182 schema:familyName Iyer
    183 schema:givenName Janani
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145533740.96
    185 rdf:type schema:Person
    186 sg:person.01156262314.13 schema:affiliation https://www.grid.ac/institutes/grid.418532.9
    187 schema:familyName Lepanto
    188 schema:givenName Paola
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156262314.13
    190 rdf:type schema:Person
    191 sg:person.01161776022.22 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
    192 schema:familyName Pizzo
    193 schema:givenName Lucilla
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161776022.22
    195 rdf:type schema:Person
    196 sg:person.01201777730.99 schema:affiliation https://www.grid.ac/institutes/grid.214572.7
    197 schema:familyName Manak
    198 schema:givenName J. Robert
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201777730.99
    200 rdf:type schema:Person
    201 sg:person.012131703301.52 schema:affiliation https://www.grid.ac/institutes/grid.214572.7
    202 schema:familyName Koerselman
    203 schema:givenName Haley
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012131703301.52
    205 rdf:type schema:Person
    206 sg:person.012547464740.97 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
    207 schema:familyName Yennawar
    208 schema:givenName Sneha
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012547464740.97
    210 rdf:type schema:Person
    211 sg:person.01317423656.41 schema:affiliation https://www.grid.ac/institutes/grid.418532.9
    212 schema:familyName Badano
    213 schema:givenName Jose
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317423656.41
    215 rdf:type schema:Person
    216 sg:person.013230616740.35 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
    217 schema:familyName Patel
    218 schema:givenName Payal
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013230616740.35
    220 rdf:type schema:Person
    221 sg:person.01350742712.44 schema:affiliation https://www.grid.ac/institutes/grid.17088.36
    222 schema:familyName Krishnan
    223 schema:givenName Arjun
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350742712.44
    225 rdf:type schema:Person
    226 sg:person.014671673140.83 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
    227 schema:familyName Vadodaria
    228 schema:givenName Komal
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014671673140.83
    230 rdf:type schema:Person
    231 sg:person.016216520740.31 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
    232 schema:familyName Huber
    233 schema:givenName Emily
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016216520740.31
    235 rdf:type schema:Person
    236 sg:person.016264634140.27 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
    237 schema:familyName Kubina
    238 schema:givenName Alexis
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016264634140.27
    240 rdf:type schema:Person
    241 sg:person.016472405253.62 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
    242 schema:familyName Jensen
    243 schema:givenName Matthew
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016472405253.62
    245 rdf:type schema:Person
    246 sg:person.0607227026.10 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
    247 schema:familyName Weiner
    248 schema:givenName Alexis T.
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607227026.10
    250 rdf:type schema:Person
    251 sg:person.0650527525.97 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
    252 schema:familyName Girirajan
    253 schema:givenName Santhosh
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650527525.97
    255 rdf:type schema:Person
    256 sg:person.0712622647.11 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
    257 schema:familyName Wang
    258 schema:givenName Qingyu
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712622647.11
    260 rdf:type schema:Person
    261 sg:person.0732043740.93 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
    262 schema:familyName Rolls
    263 schema:givenName Melissa M.
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732043740.93
    265 rdf:type schema:Person
    266 sg:pub.10.1038/35065105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011836103
    267 https://doi.org/10.1038/35065105
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/mp.2016.84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012485918
    270 https://doi.org/10.1038/mp.2016.84
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/mp.2016.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031478945
    273 https://doi.org/10.1038/mp.2016.95
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nature05954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009365689
    276 https://doi.org/10.1038/nature05954
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/nature08727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039525547
    279 https://doi.org/10.1038/nature08727
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/nature09146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012902412
    282 https://doi.org/10.1038/nature09146
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/nature12439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003744287
    285 https://doi.org/10.1038/nature12439
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nature12929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049383355
    288 https://doi.org/10.1038/nature12929
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/nature13394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052525502
    291 https://doi.org/10.1038/nature13394
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/nature13908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046951438
    294 https://doi.org/10.1038/nature13908
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/nature19057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022281897
    297 https://doi.org/10.1038/nature19057
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/nature24470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092446312
    300 https://doi.org/10.1038/nature24470
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/ncb1994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041118720
    303 https://doi.org/10.1038/ncb1994
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/ng.3259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010543892
    306 https://doi.org/10.1038/ng.3259
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/ng1126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010093189
    309 https://doi.org/10.1038/ng1126
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/nmeth.2089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035817137
    312 https://doi.org/10.1038/nmeth.2089
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/nmeth.2856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047114804
    315 https://doi.org/10.1038/nmeth.2856
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/nn.2741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037440395
    318 https://doi.org/10.1038/nn.2741
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1038/nn.4353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037071980
    321 https://doi.org/10.1038/nn.4353
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1038/nn.4400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031080832
    324 https://doi.org/10.1038/nn.4400
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1038/nrg3627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025596426
    327 https://doi.org/10.1038/nrg3627
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1186/1471-2105-6-144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025271948
    330 https://doi.org/10.1186/1471-2105-6-144
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1186/2040-2392-1-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026591820
    333 https://doi.org/10.1186/2040-2392-1-15
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1186/gb-2013-14-4-r36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015459845
    336 https://doi.org/10.1186/gb-2013-14-4-r36
    337 rdf:type schema:CreativeWork
    338 https://app.dimensions.ai/details/publication/pub.1074547527 schema:CreativeWork
    339 https://app.dimensions.ai/details/publication/pub.1075065712 schema:CreativeWork
    340 https://app.dimensions.ai/details/publication/pub.1083215660 schema:CreativeWork
    341 https://doi.org/10.1002/acn3.334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027495214
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1016/0888-7543(95)80010-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1027027849
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1016/j.ajhg.2014.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045028135
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1016/j.ajhg.2015.11.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053014970
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1016/j.cell.2015.06.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035386489
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1016/j.celrep.2017.11.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099603288
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1016/j.conb.2010.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042789209
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1016/j.conb.2011.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028441877
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1016/j.ejmg.2009.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032488403
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1016/j.tig.2016.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015810739
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1016/j.tins.2009.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038993025
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1016/j.tins.2016.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037185904
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1016/s0168-9525(99)01720-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049066663
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1056/nejmoa1200395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039475746
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1056/nejmra0903074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025383419
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1073/pnas.1120276109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028285083
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1073/pnas.1510104112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000652595
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1073/pnas.1716092115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101007434
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1073/pnas.221452098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019940350
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1093/bioinformatics/btp616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023247882
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1093/bioinformatics/btu170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042720804
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1093/bioinformatics/btu638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053282140
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1093/hmg/ddm376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010834083
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1093/hmg/ddq366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049325913
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1093/nar/gkq537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021971381
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1101/gr.184325.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028584362
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1111/gbb.12279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020984097
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1136/jmedgenet-2012-101203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017328389
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1172/jci72763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043036836
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1242/bio.024075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084256437
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1242/dev.01122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036672938
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1242/dev.02370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014612979
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1242/dmm.009944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010536644
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1371/journal.pcbi.1004823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028428745
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1371/journal.pgen.0030177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002598657
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1371/journal.pgen.1000962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022768937
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1371/journal.pgen.1003709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013368129
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1371/journal.pgen.1004998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003368585
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1523/jneurosci.2034-17.2018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101564673
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1523/jneurosci.4864-13.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027782402
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1523/jneurosci.5685-08.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003828658
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1534/g3.116.027060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021871973
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1534/genetics.114.171785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014133886
    426 rdf:type schema:CreativeWork
    427 https://www.grid.ac/institutes/grid.17088.36 schema:alternateName Michigan State University
    428 schema:name Department of Biochemistry and Molecular Biology, Michigan State University, 48824, East Lansing, MI, USA
    429 Department of Computational Mathematics, Science and Engineering, Michigan State University, 48824, East Lansing, MI, USA
    430 rdf:type schema:Organization
    431 https://www.grid.ac/institutes/grid.214572.7 schema:alternateName University of Iowa
    432 schema:name Department of Biology, University of Iowa, 52242, Iowa City, IA, USA
    433 Department of Pediatrics, University of Iowa, 52242, Iowa City, IA, USA
    434 rdf:type schema:Organization
    435 https://www.grid.ac/institutes/grid.29857.31 schema:alternateName Pennsylvania State University
    436 schema:name Bioinformatics and Genomics Program, The Huck Institutes of the Life Sciences, The Pennsylvania State University, 16802, University Park, PA, USA
    437 Department of Anthropology, The Pennsylvania State University, 16802, University Park, PA, USA
    438 Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 16802, University Park, PA, USA
    439 rdf:type schema:Organization
    440 https://www.grid.ac/institutes/grid.418532.9 schema:alternateName Institut Pasteur de Montevideo
    441 schema:name Human Molecular Genetics Laboratory, Institut Pasteur de Montevideo, CP11400, Montevideo, Uruguay
    442 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...