Single cell analysis of kynurenine and System L amino acid transport in T cells View Full Text


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Article Info

DATE

2018-12

AUTHORS

Linda V. Sinclair, Damien Neyens, George Ramsay, Peter M. Taylor, Doreen A. Cantrell

ABSTRACT

The tryptophan metabolite kynurenine has critical immunomodulatory properties and can function as an aryl hydrocarbon receptor (AHR) ligand. Here we show that the ability of T cells to transport kynurenine is restricted to cells activated by the T-cell antigen receptor or proinflammatory cytokines. Kynurenine is transported across the T-cell membrane by the System L transporter SLC7A5. Accordingly, the ability of kynurenine to activate the AHR is restricted to T cells that express SLC7A5. We use the fluorescence spectral properties of kynurenine to develop a flow cytometry-based assay for rapid, sensitive and quantitative measurement of the kynurenine transport capacity in a single cell. Our findings provide a method to assess the susceptibility of T cells to kynurenine, and a sensitive single cell assay to monitor System L amino acid transport. More... »

PAGES

1981

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-04366-7

DOI

http://dx.doi.org/10.1038/s41467-018-04366-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103956842

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29773791


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