IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Yukihide Momozawa, Julia Dmitrieva, Emilie Théâtre, Valérie Deffontaine, Souad Rahmouni, Benoît Charloteaux, François Crins, Elisa Docampo, Mahmoud Elansary, Ann-Stephan Gori, Christelle Lecut, Rob Mariman, Myriam Mni, Cécile Oury, Ilya Altukhov, Dmitry Alexeev, Yuri Aulchenko, Leila Amininejad, Gerd Bouma, Frank Hoentjen, Mark Löwenberg, Bas Oldenburg, Marieke J. Pierik, Andrea E. vander Meulen-de Jong, C. Janneke van der Woude, Marijn C. Visschedijk, , Mark Lathrop, Jean-Pierre Hugot, Rinse K. Weersma, Martine De Vos, Denis Franchimont, Severine Vermeire, Michiaki Kubo, Edouard Louis, Michel Georges

ABSTRACT

GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and identify 23,650 cis-eQTL. We show that these are determined by ∼9720 regulatory modules, of which ∼3000 operate in multiple tissues and ∼970 on multiple genes. We identify regulatory modules that drive the disease association for 63 of the 200 risk loci, and show that these are enriched in multigenic modules. Based on these analyses, we resequence 45 of the corresponding 100 candidate genes in 6600 Crohn disease (CD) cases and 5500 controls, and show with burden tests that they include likely causative genes. Our analyses indicate that ≥10-fold larger sample sizes will be required to demonstrate the causality of individual genes using this approach. More... »

PAGES

2427

References to SciGraph publications

  • 2015-12. Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel in NATURE COMMUNICATIONS
  • 2016-08. Analysis of protein-coding genetic variation in 60,706 humans in NATURE
  • 2007-02. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 in NATURE GENETICS
  • 2012-11. Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease in NATURE
  • 2016-10. A reference panel of 64,976 haplotypes for genotype imputation in NATURE GENETICS
  • 2009-07. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm in NATURE PROTOCOLS
  • 2011-06. Genetics and pathogenesis of inflammatory bowel disease in NATURE
  • 2015-09. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations in NATURE GENETICS
  • 2001-01. Quantitative trait loci in Drosophila in NATURE REVIEWS GENETICS
  • 2002-03. Dissecting the architecture of a quantitative trait locus in yeast in NATURE
  • 2004-11. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice in NATURE GENETICS
  • 2011-01. Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease in NATURE GENETICS
  • 2017-07. Fine-mapping inflammatory bowel disease loci to single-variant resolution in NATURE
  • 2015-12. Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci in BMC GENOMICS
  • 2007-08. Morphological evolution through multiple cis-regulatory mutations at a single gene in NATURE
  • 2011-11. Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease in NATURE GENETICS
  • 2015-10. A global reference for human genetic variation in NATURE
  • 2016-05. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets in NATURE GENETICS
  • 2011-05. Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature in NATURE GENETICS
  • 2016-08. The genetic architecture of type 2 diabetes in NATURE
  • 2015-09. A gene-based association method for mapping traits using reference transcriptome data in NATURE GENETICS
  • 2017-01. A pathway-centric approach to rare variant association analysis in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2001-05. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease in NATURE
  • 2012-09. An integrated encyclopedia of DNA elements in the human genome in NATURE
  • 2017-04. Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types in NATURE GENETICS
  • 2010-04. A method and server for predicting damaging missense mutations in NATURE METHODS
  • 2009-12. Common variants at five new loci associated with early-onset inflammatory bowel disease in NATURE GENETICS
  • 2008-09. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease in NATURE GENETICS
  • 2013-12. A practical method to detect SNVs and indels from whole genome and exome sequencing data in SCIENTIFIC REPORTS
  • 2016-12. Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits in GENOME MEDICINE
  • 2017-10. Genetic effects on gene expression across human tissues in NATURE
  • 2017-02. Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease in NATURE GENETICS
  • 2004-05. Functional variants of OCTN cation transporter genes are associated with Crohn disease in NATURE GENETICS
  • 2011-05. A framework for variation discovery and genotyping using next-generation DNA sequencing data in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-04365-8

    DOI

    http://dx.doi.org/10.1038/s41467-018-04365-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104656541

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29930244


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Crohn Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Association Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Predisposition to Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inflammatory Bowel Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multifactorial Inheritance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Quantitative Trait Loci", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Analysis, DNA", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "RIKEN", 
              "id": "https://www.grid.ac/institutes/grid.7597.c", 
              "name": [
                "Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Li\u00e8ge (B34), 1 Avenue de l\u2019H\u00f4pital, Li\u00e8ge, 4000 Belgium", 
                "Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Science, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Momozawa", 
            "givenName": "Yukihide", 
            "id": "sg:person.01032327555.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032327555.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Li\u00e8ge (B34), 1 Avenue de l\u2019H\u00f4pital, Li\u00e8ge, 4000 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dmitrieva", 
            "givenName": "Julia", 
            "id": "sg:person.012424406363.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012424406363.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Li\u00e8ge (B34), 1 Avenue de l\u2019H\u00f4pital, Li\u00e8ge, 4000 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Th\u00e9\u00e2tre", 
            "givenName": "Emilie", 
            "id": "sg:person.01066520355.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066520355.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Li\u00e8ge (B34), 1 Avenue de l\u2019H\u00f4pital, Li\u00e8ge, 4000 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deffontaine", 
            "givenName": "Val\u00e9rie", 
            "id": "sg:person.01063602670.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063602670.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Li\u00e8ge (B34), 1 Avenue de l\u2019H\u00f4pital, Li\u00e8ge, 4000 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rahmouni", 
            "givenName": "Souad", 
            "id": "sg:person.0712331156.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712331156.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Li\u00e8ge (B34), 1 Avenue de l\u2019H\u00f4pital, Li\u00e8ge, 4000 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Charloteaux", 
            "givenName": "Beno\u00eet", 
            "id": "sg:person.01257135547.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257135547.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Li\u00e8ge (B34), 1 Avenue de l\u2019H\u00f4pital, Li\u00e8ge, 4000 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Crins", 
            "givenName": "Fran\u00e7ois", 
            "id": "sg:person.010234064763.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010234064763.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Li\u00e8ge (B34), 1 Avenue de l\u2019H\u00f4pital, Li\u00e8ge, 4000 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Docampo", 
            "givenName": "Elisa", 
            "id": "sg:person.01351611201.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351611201.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Li\u00e8ge (B34), 1 Avenue de l\u2019H\u00f4pital, Li\u00e8ge, 4000 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Elansary", 
            "givenName": "Mahmoud", 
            "id": "sg:person.01004774511.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004774511.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Li\u00e8ge (B34), 1 Avenue de l\u2019H\u00f4pital, Li\u00e8ge, 4000 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gori", 
            "givenName": "Ann-Stephan", 
            "id": "sg:person.016274650701.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016274650701.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Laboratory of Thrombosis and Hemostasis, GIGA-R, University of Li\u00e8ge (B34), 1 Avenue de l\u2019H\u00f4pital, 4000 Li\u00e8ge, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lecut", 
            "givenName": "Christelle", 
            "id": "sg:person.01317175355.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317175355.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Li\u00e8ge (B34), 1 Avenue de l\u2019H\u00f4pital, Li\u00e8ge, 4000 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mariman", 
            "givenName": "Rob", 
            "id": "sg:person.014663043163.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014663043163.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Li\u00e8ge (B34), 1 Avenue de l\u2019H\u00f4pital, Li\u00e8ge, 4000 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mni", 
            "givenName": "Myriam", 
            "id": "sg:person.0752141333.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752141333.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Laboratory of Thrombosis and Hemostasis, GIGA-R, University of Li\u00e8ge (B34), 1 Avenue de l\u2019H\u00f4pital, 4000 Li\u00e8ge, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oury", 
            "givenName": "C\u00e9cile", 
            "id": "sg:person.0710017655.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710017655.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Moscow Institute of Physics and Technology", 
              "id": "https://www.grid.ac/institutes/grid.18763.3b", 
              "name": [
                "Moscow Institute of Physics and Technology, Institutskiy Pereulok 9, Dolgoprudny, 141700 Russian Federation"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Altukhov", 
            "givenName": "Ilya", 
            "id": "sg:person.01055723435.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055723435.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novosibirsk State University", 
              "id": "https://www.grid.ac/institutes/grid.4605.7", 
              "name": [
                "Novosibirsk State University, Pirogova ave. 2, Novosibirsk, 630090 Russian Federation"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alexeev", 
            "givenName": "Dmitry", 
            "id": "sg:person.01261620632.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261620632.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Edinburgh", 
              "id": "https://www.grid.ac/institutes/grid.4305.2", 
              "name": [
                "PolyOmica, Het Vlaggeschip 61, \u2018s-Hertogenbosch, 5237 PA The Netherlands", 
                "Institute of Cytology and Genetics SD RAS, Lavrentyeva ave. 10, 630090 Novosibirsk, Russia", 
                "Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aulchenko", 
            "givenName": "Yuri", 
            "id": "sg:person.01231510236.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231510236.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Gastroent\u00e9rologie M\u00e9dicale, Facult\u00e9 de M\u00e9dicine, Universit\u00e9 Libre de Bruxelles, Route de Lennik 808, Anderlecht, 1070 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Amininejad", 
            "givenName": "Leila", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Gastroenterology and Hepatology, VU University Medical Centre, Amsterdam, 1081 HV The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bouma", 
            "givenName": "Gerd", 
            "id": "sg:person.01055745613.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055745613.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Radboud University Nijmegen Medical Centre", 
              "id": "https://www.grid.ac/institutes/grid.10417.33", 
              "name": [
                "Department of Gastroenterology and Hepatology, University Medical Centre St. Radboud, Nijmegen, 6525 GA The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hoentjen", 
            "givenName": "Frank", 
            "id": "sg:person.01306547701.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306547701.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Gastroenterology and Hepatology, Amsterdam Medical Centre, Amsterdam, 1105 AZ The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "L\u00f6wenberg", 
            "givenName": "Mark", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Medical Center Utrecht", 
              "id": "https://www.grid.ac/institutes/grid.7692.a", 
              "name": [
                "Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, 3584 cX, Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oldenburg", 
            "givenName": "Bas", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Maastricht University Medical Centre", 
              "id": "https://www.grid.ac/institutes/grid.412966.e", 
              "name": [
                "Department of Gastroenterology and Hepatology, University Medical Centre Maastricht, Maastricht, 6229 HX The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pierik", 
            "givenName": "Marieke J.", 
            "id": "sg:person.01136573140.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136573140.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leiden University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.10419.3d", 
              "name": [
                "Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, 2333 ZA The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "vander Meulen-de Jong", 
            "givenName": "Andrea E.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Erasmus University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.5645.2", 
              "name": [
                "Department of Gastroenterology and Hepatology, Erasmus Medical Centre, Rotterdam, 3015 CE The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Janneke van der Woude", 
            "givenName": "C.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Visschedijk", 
            "givenName": "Marijn C.", 
            "id": "sg:person.01335131244.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335131244.63"
            ], 
            "type": "Person"
          }, 
          {}, 
          {
            "affiliation": {
              "alternateName": "McGill University", 
              "id": "https://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "McGill University Centre for Molecular and Computational Genomics, 740 Dr. Penfield Avenue, Montreal, H3A 0G1 QC Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lathrop", 
            "givenName": "Mark", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Assistance Publique -Hopitaux De Paris", 
              "id": "https://www.grid.ac/institutes/grid.50550.35", 
              "name": [
                "UMR 1149 INSERM/Universit\u00e9 Paris-Diderot Sorbonne Paris-Cit\u00e9, Assistance Publique H\u00f4pitaux de Paris, 48 Bd S\u00e9rurier, Paris, 75019 France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hugot", 
            "givenName": "Jean-Pierre", 
            "id": "sg:person.0612031400.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612031400.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weersma", 
            "givenName": "Rinse K.", 
            "id": "sg:person.01346343347.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346343347.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ghent University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.410566.0", 
              "name": [
                "Department of Gastroenterology, University Hospital, De Pintelaan 185, Gent, 9000 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "De Vos", 
            "givenName": "Martine", 
            "id": "sg:person.01303044660.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303044660.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Gastroent\u00e9rologie M\u00e9dicale, Facult\u00e9 de M\u00e9dicine, Universit\u00e9 Libre de Bruxelles, Route de Lennik 808, Anderlecht, 1070 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Franchimont", 
            "givenName": "Denis", 
            "id": "sg:person.0765157545.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765157545.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "KU Leuven", 
              "id": "https://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Translational Research in Gastrointestinal Disorders, Department of Clinical and Experimental Medicine, KU Leuven, UZ Herestraat 49, Leuven, 3000 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vermeire", 
            "givenName": "Severine", 
            "id": "sg:person.015675316102.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015675316102.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "RIKEN", 
              "id": "https://www.grid.ac/institutes/grid.7597.c", 
              "name": [
                "Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Science, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kubo", 
            "givenName": "Michiaki", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "CHU-Li\u00e8ge and Unit of Gastroenterology, GIGA-R & Faculty of Medicine, University of Li\u00e8ge, 1 Avenue de l\u2019H\u00f4pital, Li\u00e8ge, 4000 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Louis", 
            "givenName": "Edouard", 
            "id": "sg:person.01231145754.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231145754.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Li\u00e8ge (B34), 1 Avenue de l\u2019H\u00f4pital, Li\u00e8ge, 4000 Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Georges", 
            "givenName": "Michel", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature05988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000863374", 
              "https://doi.org/10.1038/nature05988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000943115", 
              "https://doi.org/10.1038/ng.814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2011.05.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001583272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002345204", 
              "https://doi.org/10.1038/ng.733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005364973", 
              "https://doi.org/10.1038/ng.3367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005955498", 
              "https://doi.org/10.1038/ng1339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005955498", 
              "https://doi.org/10.1038/ng1339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0139516", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006567268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth0410-248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007489634", 
              "https://doi.org/10.1038/nmeth0410-248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth0410-248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007489634", 
              "https://doi.org/10.1038/nmeth0410-248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010244476", 
              "https://doi.org/10.1038/ng.806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011250403", 
              "https://doi.org/10.1038/nature10209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-genom-083115-022609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013540747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3538", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013588188", 
              "https://doi.org/10.1038/ng.3538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2009.86", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015642657", 
              "https://doi.org/10.1038/nprot.2009.86"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkt1059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015878102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkw1133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016126515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/biostatistics/kxj037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016217055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1246949", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016223437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/519795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019061180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019843926", 
              "https://doi.org/10.1038/ng.3359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1004383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020333172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2016.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020519281", 
              "https://doi.org/10.1038/ejhg.2016.113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020669934", 
              "https://doi.org/10.1038/ng1954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020669934", 
              "https://doi.org/10.1038/ng1954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-015-1292-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020957879", 
              "https://doi.org/10.1186/s12864-015-1292-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-015-1292-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020957879", 
              "https://doi.org/10.1186/s12864-015-1292-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep02161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021729466", 
              "https://doi.org/10.1038/srep02161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btn224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021766380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021812064", 
              "https://doi.org/10.1038/nature15393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature19057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022281897", 
              "https://doi.org/10.1038/nature19057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023014918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/11.20.2417", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026597848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029065430", 
              "https://doi.org/10.1038/nature11247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1262110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029707840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1450", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029813476", 
              "https://doi.org/10.1038/ng1450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1450", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029813476", 
              "https://doi.org/10.1038/ng1450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35079107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031360950", 
              "https://doi.org/10.1038/35079107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35079107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031360950", 
              "https://doi.org/10.1038/35079107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mrfmmm.2006.09.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033887004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.0030058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034397645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034479065", 
              "https://doi.org/10.1038/ng.215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature18642", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036558635", 
              "https://doi.org/10.1038/nature18642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3760", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038217442", 
              "https://doi.org/10.1038/ng.3760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038266369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/416326a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041884300", 
              "https://doi.org/10.1038/416326a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/416326a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041884300", 
              "https://doi.org/10.1038/416326a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.952", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043485621", 
              "https://doi.org/10.1038/ng.952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13073-016-0338-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044314445", 
              "https://doi.org/10.1186/s13073-016-0338-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13073-016-0338-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044314445", 
              "https://doi.org/10.1186/s13073-016-0338-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms9111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044833567", 
              "https://doi.org/10.1038/ncomms9111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35047544", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045027520", 
              "https://doi.org/10.1038/35047544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35047544", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045027520", 
              "https://doi.org/10.1038/35047544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1502214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046520303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11582", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046541188", 
              "https://doi.org/10.1038/nature11582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047391697", 
              "https://doi.org/10.1038/ng.489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047391697", 
              "https://doi.org/10.1038/ng.489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3643", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050700099", 
              "https://doi.org/10.1038/ng.3643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3643", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050700099", 
              "https://doi.org/10.1038/ng.3643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052929732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddw335", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083732410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083850743", 
              "https://doi.org/10.1038/ng.3795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2017.05.038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086036175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090278096", 
              "https://doi.org/10.1038/nature22969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090278096", 
              "https://doi.org/10.1038/nature22969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature24277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092152730", 
              "https://doi.org/10.1038/nature24277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature24277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092152730", 
              "https://doi.org/10.1038/nature24277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature24277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092152730", 
              "https://doi.org/10.1038/nature24277"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and identify 23,650 cis-eQTL. We show that these are determined by \u223c9720 regulatory modules, of which \u223c3000 operate in multiple tissues and \u223c970 on multiple genes. We identify regulatory modules that drive the disease association for 63 of the 200 risk loci, and show that these are enriched in multigenic modules. Based on these analyses, we resequence 45 of the corresponding 100 candidate genes in 6600 Crohn disease (CD) cases and 5500 controls, and show with burden tests that they include likely causative genes. Our analyses indicate that \u226510-fold larger sample sizes will be required to demonstrate the causality of individual genes using this approach.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41467-018-04365-8", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2439002", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6442766", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2439042", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2690023", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes", 
        "pagination": "2427", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "09d35c901a8732d9d887fd32b2a83e2844365293bea0b43c95cf45a6c6c70c3a"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29930244"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101528555"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-018-04365-8"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1104656541"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-018-04365-8", 
          "https://app.dimensions.ai/details/publication/pub.1104656541"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78965_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41467-018-04365-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-04365-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-04365-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-04365-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-04365-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    633 TRIPLES      21 PREDICATES      101 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-018-04365-8 schema:about N0663e2aea88e408e8ee94590ec5ec4a2
    2 N2bec47eccbba464fa3831cf3519a5dd8
    3 N31322eb903674fbfb630ab4050f70a0a
    4 N461911b742ca4cf5b3f5a968708375db
    5 N4de524ce7c5e41fa88a777ca9545c28a
    6 N657aef12cbf44465aeaa09378e7dd793
    7 N670099556ea74e609f974d9513f58042
    8 N7498ed537af3439ca321537f84626f3d
    9 N85e4f1f9fa834b5e886ce4f7f8d44a8f
    10 N8a0549a2fb0f4c998d108eeb376609b8
    11 N94c261ac6faf492099a4890672138724
    12 Na6be2ef741d64c7c9438728599431b22
    13 Nab8050912d55421a818a20c4c2885409
    14 Ne8c30795240e47469200e70ee48689cf
    15 Ne9cb16e11ef544258841929315df249e
    16 Neb5ca2984f6446049dd6fb2cefa7afed
    17 Nf2077ad51224467f8dfc6403b3e1351f
    18 Nfad6be080b0e4c1da27d633a38a07d63
    19 anzsrc-for:06
    20 anzsrc-for:0604
    21 schema:author N15d8a917690f43b484264440dd614665
    22 schema:citation sg:pub.10.1038/35047544
    23 sg:pub.10.1038/35079107
    24 sg:pub.10.1038/416326a
    25 sg:pub.10.1038/ejhg.2016.113
    26 sg:pub.10.1038/nature05988
    27 sg:pub.10.1038/nature10209
    28 sg:pub.10.1038/nature11247
    29 sg:pub.10.1038/nature11582
    30 sg:pub.10.1038/nature15393
    31 sg:pub.10.1038/nature18642
    32 sg:pub.10.1038/nature19057
    33 sg:pub.10.1038/nature22969
    34 sg:pub.10.1038/nature24277
    35 sg:pub.10.1038/ncomms9111
    36 sg:pub.10.1038/ng.215
    37 sg:pub.10.1038/ng.3359
    38 sg:pub.10.1038/ng.3367
    39 sg:pub.10.1038/ng.3538
    40 sg:pub.10.1038/ng.3643
    41 sg:pub.10.1038/ng.3760
    42 sg:pub.10.1038/ng.3795
    43 sg:pub.10.1038/ng.489
    44 sg:pub.10.1038/ng.733
    45 sg:pub.10.1038/ng.806
    46 sg:pub.10.1038/ng.814
    47 sg:pub.10.1038/ng.952
    48 sg:pub.10.1038/ng1339
    49 sg:pub.10.1038/ng1450
    50 sg:pub.10.1038/ng1954
    51 sg:pub.10.1038/nmeth0410-248
    52 sg:pub.10.1038/nprot.2009.86
    53 sg:pub.10.1038/srep02161
    54 sg:pub.10.1186/s12864-015-1292-z
    55 sg:pub.10.1186/s13073-016-0338-4
    56 https://doi.org/10.1016/j.ajhg.2011.05.029
    57 https://doi.org/10.1016/j.cell.2017.05.038
    58 https://doi.org/10.1016/j.mrfmmm.2006.09.003
    59 https://doi.org/10.1056/nejmoa1502214
    60 https://doi.org/10.1086/519795
    61 https://doi.org/10.1093/bioinformatics/btn224
    62 https://doi.org/10.1093/bioinformatics/btp324
    63 https://doi.org/10.1093/bioinformatics/btp352
    64 https://doi.org/10.1093/biostatistics/kxj037
    65 https://doi.org/10.1093/hmg/11.20.2417
    66 https://doi.org/10.1093/hmg/ddw335
    67 https://doi.org/10.1093/nar/gkt1059
    68 https://doi.org/10.1093/nar/gkw1133
    69 https://doi.org/10.1126/science.1246949
    70 https://doi.org/10.1126/science.1262110
    71 https://doi.org/10.1146/annurev-genom-083115-022609
    72 https://doi.org/10.1371/journal.pgen.0030058
    73 https://doi.org/10.1371/journal.pgen.1000895
    74 https://doi.org/10.1371/journal.pgen.1004383
    75 https://doi.org/10.1371/journal.pone.0139516
    76 schema:datePublished 2018-12
    77 schema:datePublishedReg 2018-12-01
    78 schema:description GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and identify 23,650 cis-eQTL. We show that these are determined by ∼9720 regulatory modules, of which ∼3000 operate in multiple tissues and ∼970 on multiple genes. We identify regulatory modules that drive the disease association for 63 of the 200 risk loci, and show that these are enriched in multigenic modules. Based on these analyses, we resequence 45 of the corresponding 100 candidate genes in 6600 Crohn disease (CD) cases and 5500 controls, and show with burden tests that they include likely causative genes. Our analyses indicate that ≥10-fold larger sample sizes will be required to demonstrate the causality of individual genes using this approach.
    79 schema:genre research_article
    80 schema:inLanguage en
    81 schema:isAccessibleForFree true
    82 schema:isPartOf N2a3a2165547f4a92a6873e175054526e
    83 N5210a60d78024c24b00a39f1ab3d15b7
    84 sg:journal.1043282
    85 schema:name IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes
    86 schema:pagination 2427
    87 schema:productId N0054008ac8cf4e00af3dc4ba60f47b4b
    88 N07249314d4c045c2b8c72f2a5a23ce22
    89 Nc0528d56419f4131baaa9d75d1d338a6
    90 Nd93649bff94846919bb9e2b5c792545d
    91 Nf192043c48364867937d08aa8091a449
    92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104656541
    93 https://doi.org/10.1038/s41467-018-04365-8
    94 schema:sdDatePublished 2019-04-11T13:20
    95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    96 schema:sdPublisher N4846a97bd2b54604aa15c2629f848cd6
    97 schema:url https://www.nature.com/articles/s41467-018-04365-8
    98 sgo:license sg:explorer/license/
    99 sgo:sdDataset articles
    100 rdf:type schema:ScholarlyArticle
    101 N0054008ac8cf4e00af3dc4ba60f47b4b schema:name dimensions_id
    102 schema:value pub.1104656541
    103 rdf:type schema:PropertyValue
    104 N02a51c3b94674c639a678fbcbf679504 rdf:first sg:person.014663043163.15
    105 rdf:rest Na10adaa7406d4ace8d8701704c55d799
    106 N0663e2aea88e408e8ee94590ec5ec4a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Adult
    108 rdf:type schema:DefinedTerm
    109 N06cf80b530ff4e1e83243c091f0dbada schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    110 schema:familyName Georges
    111 schema:givenName Michel
    112 rdf:type schema:Person
    113 N07249314d4c045c2b8c72f2a5a23ce22 schema:name pubmed_id
    114 schema:value 29930244
    115 rdf:type schema:PropertyValue
    116 N0d6d275a29b44a34aa9d39823e80cece rdf:first sg:person.01346343347.18
    117 rdf:rest Nc02ac021af6b42d9a825e18062ddca77
    118 N15d8a917690f43b484264440dd614665 rdf:first sg:person.01032327555.79
    119 rdf:rest N684aac275f534d649b41b4b61863249b
    120 N23a3241f205247a983ce73b40f7826ab rdf:first sg:person.01231145754.56
    121 rdf:rest Nc0badc99fb9947218ee6e276d024c870
    122 N2a3a2165547f4a92a6873e175054526e schema:issueNumber 1
    123 rdf:type schema:PublicationIssue
    124 N2bec47eccbba464fa3831cf3519a5dd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Sequence Analysis, DNA
    126 rdf:type schema:DefinedTerm
    127 N31322eb903674fbfb630ab4050f70a0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Middle Aged
    129 rdf:type schema:DefinedTerm
    130 N3c2a1e78348c4c81af4ea9184682cbe3 rdf:first N90b844c055f74938b26fa81698aec80b
    131 rdf:rest N5d2fa1acef8242a49db637eb3bc2e478
    132 N452a2ce47535473ab1c740c8ed3f3b1e rdf:first sg:person.01317175355.56
    133 rdf:rest N02a51c3b94674c639a678fbcbf679504
    134 N461911b742ca4cf5b3f5a968708375db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Multifactorial Inheritance
    136 rdf:type schema:DefinedTerm
    137 N4846a97bd2b54604aa15c2629f848cd6 schema:name Springer Nature - SN SciGraph project
    138 rdf:type schema:Organization
    139 N4a884a098d0740e28c56a3300b31ab51 rdf:first sg:person.01351611201.50
    140 rdf:rest Nb26855493a4e4cf28a94810fedcfa08f
    141 N4d3446843bbf4e9bbc2fb9a77a8ffc80 schema:affiliation Nd2ae514334bc42638af77cefd4b5ca5c
    142 schema:familyName Amininejad
    143 schema:givenName Leila
    144 rdf:type schema:Person
    145 N4de524ce7c5e41fa88a777ca9545c28a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Male
    147 rdf:type schema:DefinedTerm
    148 N5028d2d9ab584380be42b221b944a406 rdf:first sg:person.016274650701.15
    149 rdf:rest N452a2ce47535473ab1c740c8ed3f3b1e
    150 N5210a60d78024c24b00a39f1ab3d15b7 schema:volumeNumber 9
    151 rdf:type schema:PublicationVolume
    152 N5d2fa1acef8242a49db637eb3bc2e478 rdf:first N65f906e1dd6d47c19f49bd8584073cee
    153 rdf:rest Ncd51b4aab6cc40e384e2e82dad76bb9c
    154 N657aef12cbf44465aeaa09378e7dd793 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Genetic Association Studies
    156 rdf:type schema:DefinedTerm
    157 N65f906e1dd6d47c19f49bd8584073cee schema:affiliation https://www.grid.ac/institutes/grid.7692.a
    158 schema:familyName Oldenburg
    159 schema:givenName Bas
    160 rdf:type schema:Person
    161 N670099556ea74e609f974d9513f58042 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Quantitative Trait Loci
    163 rdf:type schema:DefinedTerm
    164 N67053b1199554ba8a8472b4818aca130 schema:name Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ The Netherlands
    165 rdf:type schema:Organization
    166 N684aac275f534d649b41b4b61863249b rdf:first sg:person.012424406363.37
    167 rdf:rest N815f37f1942442cea69c2cfe98355fd2
    168 N686c0fb9c16543d78a47e26a77dd6fff rdf:first sg:person.01261620632.22
    169 rdf:rest N7c84661acd0f4a618417146e900edfee
    170 N6902e4cd0e084cbaaada2a3cfa85b631 schema:name Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ The Netherlands
    171 rdf:type schema:Organization
    172 N7498ed537af3439ca321537f84626f3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Genetic Predisposition to Disease
    174 rdf:type schema:DefinedTerm
    175 N7c84661acd0f4a618417146e900edfee rdf:first sg:person.01231510236.78
    176 rdf:rest Nb0fb3c1d8b00447096d009d3fba3fb0e
    177 N80e0d008830b43fd8be268f3d7da31d2 rdf:first N6da453ad6eb9486f9cd4a3f8b32c2be9
    178 rdf:rest N8eb4849ad1504fe4bb6b266ddeffceda
    179 N815f37f1942442cea69c2cfe98355fd2 rdf:first sg:person.01066520355.14
    180 rdf:rest Na5ef7897322e412582bfbfe7e68076dd
    181 N85b7a4b185a742d5ae84e6a4114f751f rdf:first sg:person.010234064763.33
    182 rdf:rest N4a884a098d0740e28c56a3300b31ab51
    183 N85e4f1f9fa834b5e886ce4f7f8d44a8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Aged, 80 and over
    185 rdf:type schema:DefinedTerm
    186 N885e6721aa884a318f46b73761b19e85 rdf:first sg:person.01306547701.40
    187 rdf:rest N3c2a1e78348c4c81af4ea9184682cbe3
    188 N8a0549a2fb0f4c998d108eeb376609b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Aged
    190 rdf:type schema:DefinedTerm
    191 N8eb4849ad1504fe4bb6b266ddeffceda rdf:first Nf551feb976174c798758437db5925ac1
    192 rdf:rest Na23ce5296e5340319794df310c1b05a0
    193 N90b844c055f74938b26fa81698aec80b schema:affiliation Nb03466cf5c974ba48eb98dbe6ea10ccb
    194 schema:familyName Löwenberg
    195 schema:givenName Mark
    196 rdf:type schema:Person
    197 N94c261ac6faf492099a4890672138724 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Humans
    199 rdf:type schema:DefinedTerm
    200 Na0c3c5de773349a6ad043ee357c1e5da rdf:first sg:person.0710017655.07
    201 rdf:rest Nf0ea3d9249c94e129776d82b91058666
    202 Na10adaa7406d4ace8d8701704c55d799 rdf:first sg:person.0752141333.02
    203 rdf:rest Na0c3c5de773349a6ad043ee357c1e5da
    204 Na23ce5296e5340319794df310c1b05a0 rdf:first sg:person.0612031400.32
    205 rdf:rest N0d6d275a29b44a34aa9d39823e80cece
    206 Na5ef7897322e412582bfbfe7e68076dd rdf:first sg:person.01063602670.18
    207 rdf:rest Nf5570fa055824f03b079afcf1a54bb78
    208 Na6be2ef741d64c7c9438728599431b22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Gene Expression Profiling
    210 rdf:type schema:DefinedTerm
    211 Na95721729f874d05a687229cbd85903a rdf:first sg:person.01055745613.16
    212 rdf:rest N885e6721aa884a318f46b73761b19e85
    213 Na97dbdd1a64045dfafb4f6fffefe07bb schema:affiliation https://www.grid.ac/institutes/grid.7597.c
    214 schema:familyName Kubo
    215 schema:givenName Michiaki
    216 rdf:type schema:Person
    217 Naafab49cc5bd4dabaa32c71b7ecd799d rdf:first sg:person.01257135547.57
    218 rdf:rest N85b7a4b185a742d5ae84e6a4114f751f
    219 Nab8050912d55421a818a20c4c2885409 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Polymorphism, Single Nucleotide
    221 rdf:type schema:DefinedTerm
    222 Nb03466cf5c974ba48eb98dbe6ea10ccb schema:name Department of Gastroenterology and Hepatology, Amsterdam Medical Centre, Amsterdam, 1105 AZ The Netherlands
    223 rdf:type schema:Organization
    224 Nb0fb3c1d8b00447096d009d3fba3fb0e rdf:first N4d3446843bbf4e9bbc2fb9a77a8ffc80
    225 rdf:rest Na95721729f874d05a687229cbd85903a
    226 Nb26855493a4e4cf28a94810fedcfa08f rdf:first sg:person.01004774511.15
    227 rdf:rest N5028d2d9ab584380be42b221b944a406
    228 Nbf60e1d8064f4cd38565f8ac866128d0 schema:name Gastroentérologie Médicale, Faculté de Médicine, Université Libre de Bruxelles, Route de Lennik 808, Anderlecht, 1070 Belgium
    229 rdf:type schema:Organization
    230 Nc02ac021af6b42d9a825e18062ddca77 rdf:first sg:person.01303044660.24
    231 rdf:rest Ne73c51455329490497f48074e857599d
    232 Nc0528d56419f4131baaa9d75d1d338a6 schema:name nlm_unique_id
    233 schema:value 101528555
    234 rdf:type schema:PropertyValue
    235 Nc0badc99fb9947218ee6e276d024c870 rdf:first N06cf80b530ff4e1e83243c091f0dbada
    236 rdf:rest rdf:nil
    237 Nc134f660749a4b009152f0997febae01 rdf:first Na97dbdd1a64045dfafb4f6fffefe07bb
    238 rdf:rest N23a3241f205247a983ce73b40f7826ab
    239 Nc978e2cf86dd4afc9d327fb3d04f5063 rdf:first sg:person.015675316102.20
    240 rdf:rest Nc134f660749a4b009152f0997febae01
    241 Ncd51b4aab6cc40e384e2e82dad76bb9c rdf:first sg:person.01136573140.14
    242 rdf:rest Ne6f722762f9f4f2c91b362da1d36ac8d
    243 Ncfdacc45cfe3450f802e1a6d0691c05d rdf:first sg:person.01335131244.63
    244 rdf:rest N80e0d008830b43fd8be268f3d7da31d2
    245 Nd2ae514334bc42638af77cefd4b5ca5c schema:name Gastroentérologie Médicale, Faculté de Médicine, Université Libre de Bruxelles, Route de Lennik 808, Anderlecht, 1070 Belgium
    246 rdf:type schema:Organization
    247 Nd93649bff94846919bb9e2b5c792545d schema:name readcube_id
    248 schema:value 09d35c901a8732d9d887fd32b2a83e2844365293bea0b43c95cf45a6c6c70c3a
    249 rdf:type schema:PropertyValue
    250 Ndcd6dbcaf5b2464da7bcafe390b462e3 rdf:first Nf16a26471427485aaa81e5906e120e89
    251 rdf:rest Ncfdacc45cfe3450f802e1a6d0691c05d
    252 Ne6f722762f9f4f2c91b362da1d36ac8d rdf:first Nfd202f27c90e4876b19e879a892e62f9
    253 rdf:rest Ndcd6dbcaf5b2464da7bcafe390b462e3
    254 Ne73c51455329490497f48074e857599d rdf:first sg:person.0765157545.99
    255 rdf:rest Nc978e2cf86dd4afc9d327fb3d04f5063
    256 Ne8c30795240e47469200e70ee48689cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    257 schema:name Female
    258 rdf:type schema:DefinedTerm
    259 Ne9cb16e11ef544258841929315df249e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    260 schema:name Crohn Disease
    261 rdf:type schema:DefinedTerm
    262 Neb5ca2984f6446049dd6fb2cefa7afed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    263 schema:name Inflammatory Bowel Diseases
    264 rdf:type schema:DefinedTerm
    265 Nf0ea3d9249c94e129776d82b91058666 rdf:first sg:person.01055723435.53
    266 rdf:rest N686c0fb9c16543d78a47e26a77dd6fff
    267 Nf16a26471427485aaa81e5906e120e89 schema:affiliation https://www.grid.ac/institutes/grid.5645.2
    268 schema:familyName Janneke van der Woude
    269 schema:givenName C.
    270 rdf:type schema:Person
    271 Nf192043c48364867937d08aa8091a449 schema:name doi
    272 schema:value 10.1038/s41467-018-04365-8
    273 rdf:type schema:PropertyValue
    274 Nf2077ad51224467f8dfc6403b3e1351f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    275 schema:name Cohort Studies
    276 rdf:type schema:DefinedTerm
    277 Nf551feb976174c798758437db5925ac1 schema:affiliation https://www.grid.ac/institutes/grid.14709.3b
    278 schema:familyName Lathrop
    279 schema:givenName Mark
    280 rdf:type schema:Person
    281 Nf5570fa055824f03b079afcf1a54bb78 rdf:first sg:person.0712331156.40
    282 rdf:rest Naafab49cc5bd4dabaa32c71b7ecd799d
    283 Nfad6be080b0e4c1da27d633a38a07d63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    284 schema:name Genotype
    285 rdf:type schema:DefinedTerm
    286 Nfd202f27c90e4876b19e879a892e62f9 schema:affiliation https://www.grid.ac/institutes/grid.10419.3d
    287 schema:familyName vander Meulen-de Jong
    288 schema:givenName Andrea E.
    289 rdf:type schema:Person
    290 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    291 schema:name Biological Sciences
    292 rdf:type schema:DefinedTerm
    293 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    294 schema:name Genetics
    295 rdf:type schema:DefinedTerm
    296 sg:grant.2439002 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-04365-8
    297 rdf:type schema:MonetaryGrant
    298 sg:grant.2439042 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-04365-8
    299 rdf:type schema:MonetaryGrant
    300 sg:grant.2690023 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-04365-8
    301 rdf:type schema:MonetaryGrant
    302 sg:grant.6442766 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-04365-8
    303 rdf:type schema:MonetaryGrant
    304 sg:journal.1043282 schema:issn 2041-1723
    305 schema:name Nature Communications
    306 rdf:type schema:Periodical
    307 sg:person.01004774511.15 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    308 schema:familyName Elansary
    309 schema:givenName Mahmoud
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004774511.15
    311 rdf:type schema:Person
    312 sg:person.010234064763.33 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    313 schema:familyName Crins
    314 schema:givenName François
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010234064763.33
    316 rdf:type schema:Person
    317 sg:person.01032327555.79 schema:affiliation https://www.grid.ac/institutes/grid.7597.c
    318 schema:familyName Momozawa
    319 schema:givenName Yukihide
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032327555.79
    321 rdf:type schema:Person
    322 sg:person.01055723435.53 schema:affiliation https://www.grid.ac/institutes/grid.18763.3b
    323 schema:familyName Altukhov
    324 schema:givenName Ilya
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055723435.53
    326 rdf:type schema:Person
    327 sg:person.01055745613.16 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    328 schema:familyName Bouma
    329 schema:givenName Gerd
    330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055745613.16
    331 rdf:type schema:Person
    332 sg:person.01063602670.18 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    333 schema:familyName Deffontaine
    334 schema:givenName Valérie
    335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063602670.18
    336 rdf:type schema:Person
    337 sg:person.01066520355.14 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    338 schema:familyName Théâtre
    339 schema:givenName Emilie
    340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066520355.14
    341 rdf:type schema:Person
    342 sg:person.01136573140.14 schema:affiliation https://www.grid.ac/institutes/grid.412966.e
    343 schema:familyName Pierik
    344 schema:givenName Marieke J.
    345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136573140.14
    346 rdf:type schema:Person
    347 sg:person.01231145754.56 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    348 schema:familyName Louis
    349 schema:givenName Edouard
    350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231145754.56
    351 rdf:type schema:Person
    352 sg:person.01231510236.78 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
    353 schema:familyName Aulchenko
    354 schema:givenName Yuri
    355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231510236.78
    356 rdf:type schema:Person
    357 sg:person.012424406363.37 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    358 schema:familyName Dmitrieva
    359 schema:givenName Julia
    360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012424406363.37
    361 rdf:type schema:Person
    362 sg:person.01257135547.57 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    363 schema:familyName Charloteaux
    364 schema:givenName Benoît
    365 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257135547.57
    366 rdf:type schema:Person
    367 sg:person.01261620632.22 schema:affiliation https://www.grid.ac/institutes/grid.4605.7
    368 schema:familyName Alexeev
    369 schema:givenName Dmitry
    370 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261620632.22
    371 rdf:type schema:Person
    372 sg:person.01303044660.24 schema:affiliation https://www.grid.ac/institutes/grid.410566.0
    373 schema:familyName De Vos
    374 schema:givenName Martine
    375 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303044660.24
    376 rdf:type schema:Person
    377 sg:person.01306547701.40 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
    378 schema:familyName Hoentjen
    379 schema:givenName Frank
    380 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306547701.40
    381 rdf:type schema:Person
    382 sg:person.01317175355.56 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    383 schema:familyName Lecut
    384 schema:givenName Christelle
    385 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317175355.56
    386 rdf:type schema:Person
    387 sg:person.01335131244.63 schema:affiliation N6902e4cd0e084cbaaada2a3cfa85b631
    388 schema:familyName Visschedijk
    389 schema:givenName Marijn C.
    390 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335131244.63
    391 rdf:type schema:Person
    392 sg:person.01346343347.18 schema:affiliation N67053b1199554ba8a8472b4818aca130
    393 schema:familyName Weersma
    394 schema:givenName Rinse K.
    395 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346343347.18
    396 rdf:type schema:Person
    397 sg:person.01351611201.50 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    398 schema:familyName Docampo
    399 schema:givenName Elisa
    400 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351611201.50
    401 rdf:type schema:Person
    402 sg:person.014663043163.15 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    403 schema:familyName Mariman
    404 schema:givenName Rob
    405 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014663043163.15
    406 rdf:type schema:Person
    407 sg:person.015675316102.20 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
    408 schema:familyName Vermeire
    409 schema:givenName Severine
    410 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015675316102.20
    411 rdf:type schema:Person
    412 sg:person.016274650701.15 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    413 schema:familyName Gori
    414 schema:givenName Ann-Stephan
    415 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016274650701.15
    416 rdf:type schema:Person
    417 sg:person.0612031400.32 schema:affiliation https://www.grid.ac/institutes/grid.50550.35
    418 schema:familyName Hugot
    419 schema:givenName Jean-Pierre
    420 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612031400.32
    421 rdf:type schema:Person
    422 sg:person.0710017655.07 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    423 schema:familyName Oury
    424 schema:givenName Cécile
    425 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710017655.07
    426 rdf:type schema:Person
    427 sg:person.0712331156.40 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    428 schema:familyName Rahmouni
    429 schema:givenName Souad
    430 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712331156.40
    431 rdf:type schema:Person
    432 sg:person.0752141333.02 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    433 schema:familyName Mni
    434 schema:givenName Myriam
    435 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752141333.02
    436 rdf:type schema:Person
    437 sg:person.0765157545.99 schema:affiliation Nbf60e1d8064f4cd38565f8ac866128d0
    438 schema:familyName Franchimont
    439 schema:givenName Denis
    440 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765157545.99
    441 rdf:type schema:Person
    442 sg:pub.10.1038/35047544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045027520
    443 https://doi.org/10.1038/35047544
    444 rdf:type schema:CreativeWork
    445 sg:pub.10.1038/35079107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031360950
    446 https://doi.org/10.1038/35079107
    447 rdf:type schema:CreativeWork
    448 sg:pub.10.1038/416326a schema:sameAs https://app.dimensions.ai/details/publication/pub.1041884300
    449 https://doi.org/10.1038/416326a
    450 rdf:type schema:CreativeWork
    451 sg:pub.10.1038/ejhg.2016.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020519281
    452 https://doi.org/10.1038/ejhg.2016.113
    453 rdf:type schema:CreativeWork
    454 sg:pub.10.1038/nature05988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000863374
    455 https://doi.org/10.1038/nature05988
    456 rdf:type schema:CreativeWork
    457 sg:pub.10.1038/nature10209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011250403
    458 https://doi.org/10.1038/nature10209
    459 rdf:type schema:CreativeWork
    460 sg:pub.10.1038/nature11247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029065430
    461 https://doi.org/10.1038/nature11247
    462 rdf:type schema:CreativeWork
    463 sg:pub.10.1038/nature11582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046541188
    464 https://doi.org/10.1038/nature11582
    465 rdf:type schema:CreativeWork
    466 sg:pub.10.1038/nature15393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021812064
    467 https://doi.org/10.1038/nature15393
    468 rdf:type schema:CreativeWork
    469 sg:pub.10.1038/nature18642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036558635
    470 https://doi.org/10.1038/nature18642
    471 rdf:type schema:CreativeWork
    472 sg:pub.10.1038/nature19057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022281897
    473 https://doi.org/10.1038/nature19057
    474 rdf:type schema:CreativeWork
    475 sg:pub.10.1038/nature22969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090278096
    476 https://doi.org/10.1038/nature22969
    477 rdf:type schema:CreativeWork
    478 sg:pub.10.1038/nature24277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092152730
    479 https://doi.org/10.1038/nature24277
    480 rdf:type schema:CreativeWork
    481 sg:pub.10.1038/ncomms9111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044833567
    482 https://doi.org/10.1038/ncomms9111
    483 rdf:type schema:CreativeWork
    484 sg:pub.10.1038/ng.215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034479065
    485 https://doi.org/10.1038/ng.215
    486 rdf:type schema:CreativeWork
    487 sg:pub.10.1038/ng.3359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019843926
    488 https://doi.org/10.1038/ng.3359
    489 rdf:type schema:CreativeWork
    490 sg:pub.10.1038/ng.3367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005364973
    491 https://doi.org/10.1038/ng.3367
    492 rdf:type schema:CreativeWork
    493 sg:pub.10.1038/ng.3538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013588188
    494 https://doi.org/10.1038/ng.3538
    495 rdf:type schema:CreativeWork
    496 sg:pub.10.1038/ng.3643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050700099
    497 https://doi.org/10.1038/ng.3643
    498 rdf:type schema:CreativeWork
    499 sg:pub.10.1038/ng.3760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038217442
    500 https://doi.org/10.1038/ng.3760
    501 rdf:type schema:CreativeWork
    502 sg:pub.10.1038/ng.3795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083850743
    503 https://doi.org/10.1038/ng.3795
    504 rdf:type schema:CreativeWork
    505 sg:pub.10.1038/ng.489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047391697
    506 https://doi.org/10.1038/ng.489
    507 rdf:type schema:CreativeWork
    508 sg:pub.10.1038/ng.733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002345204
    509 https://doi.org/10.1038/ng.733
    510 rdf:type schema:CreativeWork
    511 sg:pub.10.1038/ng.806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010244476
    512 https://doi.org/10.1038/ng.806
    513 rdf:type schema:CreativeWork
    514 sg:pub.10.1038/ng.814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000943115
    515 https://doi.org/10.1038/ng.814
    516 rdf:type schema:CreativeWork
    517 sg:pub.10.1038/ng.952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043485621
    518 https://doi.org/10.1038/ng.952
    519 rdf:type schema:CreativeWork
    520 sg:pub.10.1038/ng1339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005955498
    521 https://doi.org/10.1038/ng1339
    522 rdf:type schema:CreativeWork
    523 sg:pub.10.1038/ng1450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029813476
    524 https://doi.org/10.1038/ng1450
    525 rdf:type schema:CreativeWork
    526 sg:pub.10.1038/ng1954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020669934
    527 https://doi.org/10.1038/ng1954
    528 rdf:type schema:CreativeWork
    529 sg:pub.10.1038/nmeth0410-248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007489634
    530 https://doi.org/10.1038/nmeth0410-248
    531 rdf:type schema:CreativeWork
    532 sg:pub.10.1038/nprot.2009.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015642657
    533 https://doi.org/10.1038/nprot.2009.86
    534 rdf:type schema:CreativeWork
    535 sg:pub.10.1038/srep02161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021729466
    536 https://doi.org/10.1038/srep02161
    537 rdf:type schema:CreativeWork
    538 sg:pub.10.1186/s12864-015-1292-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1020957879
    539 https://doi.org/10.1186/s12864-015-1292-z
    540 rdf:type schema:CreativeWork
    541 sg:pub.10.1186/s13073-016-0338-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044314445
    542 https://doi.org/10.1186/s13073-016-0338-4
    543 rdf:type schema:CreativeWork
    544 https://doi.org/10.1016/j.ajhg.2011.05.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001583272
    545 rdf:type schema:CreativeWork
    546 https://doi.org/10.1016/j.cell.2017.05.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086036175
    547 rdf:type schema:CreativeWork
    548 https://doi.org/10.1016/j.mrfmmm.2006.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033887004
    549 rdf:type schema:CreativeWork
    550 https://doi.org/10.1056/nejmoa1502214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046520303
    551 rdf:type schema:CreativeWork
    552 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
    553 rdf:type schema:CreativeWork
    554 https://doi.org/10.1093/bioinformatics/btn224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021766380
    555 rdf:type schema:CreativeWork
    556 https://doi.org/10.1093/bioinformatics/btp324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266369
    557 rdf:type schema:CreativeWork
    558 https://doi.org/10.1093/bioinformatics/btp352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023014918
    559 rdf:type schema:CreativeWork
    560 https://doi.org/10.1093/biostatistics/kxj037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016217055
    561 rdf:type schema:CreativeWork
    562 https://doi.org/10.1093/hmg/11.20.2417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026597848
    563 rdf:type schema:CreativeWork
    564 https://doi.org/10.1093/hmg/ddw335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083732410
    565 rdf:type schema:CreativeWork
    566 https://doi.org/10.1093/nar/gkt1059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015878102
    567 rdf:type schema:CreativeWork
    568 https://doi.org/10.1093/nar/gkw1133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016126515
    569 rdf:type schema:CreativeWork
    570 https://doi.org/10.1126/science.1246949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016223437
    571 rdf:type schema:CreativeWork
    572 https://doi.org/10.1126/science.1262110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029707840
    573 rdf:type schema:CreativeWork
    574 https://doi.org/10.1146/annurev-genom-083115-022609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013540747
    575 rdf:type schema:CreativeWork
    576 https://doi.org/10.1371/journal.pgen.0030058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034397645
    577 rdf:type schema:CreativeWork
    578 https://doi.org/10.1371/journal.pgen.1000895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052929732
    579 rdf:type schema:CreativeWork
    580 https://doi.org/10.1371/journal.pgen.1004383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020333172
    581 rdf:type schema:CreativeWork
    582 https://doi.org/10.1371/journal.pone.0139516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006567268
    583 rdf:type schema:CreativeWork
    584 https://www.grid.ac/institutes/grid.10417.33 schema:alternateName Radboud University Nijmegen Medical Centre
    585 schema:name Department of Gastroenterology and Hepatology, University Medical Centre St. Radboud, Nijmegen, 6525 GA The Netherlands
    586 rdf:type schema:Organization
    587 https://www.grid.ac/institutes/grid.10419.3d schema:alternateName Leiden University Medical Center
    588 schema:name Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, 2333 ZA The Netherlands
    589 rdf:type schema:Organization
    590 https://www.grid.ac/institutes/grid.14709.3b schema:alternateName McGill University
    591 schema:name McGill University Centre for Molecular and Computational Genomics, 740 Dr. Penfield Avenue, Montreal, H3A 0G1 QC Canada
    592 rdf:type schema:Organization
    593 https://www.grid.ac/institutes/grid.16872.3a schema:alternateName VU University Medical Center
    594 schema:name Department of Gastroenterology and Hepatology, VU University Medical Centre, Amsterdam, 1081 HV The Netherlands
    595 rdf:type schema:Organization
    596 https://www.grid.ac/institutes/grid.18763.3b schema:alternateName Moscow Institute of Physics and Technology
    597 schema:name Moscow Institute of Physics and Technology, Institutskiy Pereulok 9, Dolgoprudny, 141700 Russian Federation
    598 rdf:type schema:Organization
    599 https://www.grid.ac/institutes/grid.410566.0 schema:alternateName Ghent University Hospital
    600 schema:name Department of Gastroenterology, University Hospital, De Pintelaan 185, Gent, 9000 Belgium
    601 rdf:type schema:Organization
    602 https://www.grid.ac/institutes/grid.412966.e schema:alternateName Maastricht University Medical Centre
    603 schema:name Department of Gastroenterology and Hepatology, University Medical Centre Maastricht, Maastricht, 6229 HX The Netherlands
    604 rdf:type schema:Organization
    605 https://www.grid.ac/institutes/grid.4305.2 schema:alternateName University of Edinburgh
    606 schema:name Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG UK
    607 Institute of Cytology and Genetics SD RAS, Lavrentyeva ave. 10, 630090 Novosibirsk, Russia
    608 PolyOmica, Het Vlaggeschip 61, ‘s-Hertogenbosch, 5237 PA The Netherlands
    609 rdf:type schema:Organization
    610 https://www.grid.ac/institutes/grid.4605.7 schema:alternateName Novosibirsk State University
    611 schema:name Novosibirsk State University, Pirogova ave. 2, Novosibirsk, 630090 Russian Federation
    612 rdf:type schema:Organization
    613 https://www.grid.ac/institutes/grid.4861.b schema:alternateName University of Liège
    614 schema:name CHU-Liège and Unit of Gastroenterology, GIGA-R & Faculty of Medicine, University of Liège, 1 Avenue de l’Hôpital, Liège, 4000 Belgium
    615 Laboratory of Thrombosis and Hemostasis, GIGA-R, University of Liège (B34), 1 Avenue de l’Hôpital, 4000 Liège, Belgium
    616 Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34), 1 Avenue de l’Hôpital, Liège, 4000 Belgium
    617 rdf:type schema:Organization
    618 https://www.grid.ac/institutes/grid.50550.35 schema:alternateName Assistance Publique -Hopitaux De Paris
    619 schema:name UMR 1149 INSERM/Université Paris-Diderot Sorbonne Paris-Cité, Assistance Publique Hôpitaux de Paris, 48 Bd Sérurier, Paris, 75019 France
    620 rdf:type schema:Organization
    621 https://www.grid.ac/institutes/grid.5596.f schema:alternateName KU Leuven
    622 schema:name Translational Research in Gastrointestinal Disorders, Department of Clinical and Experimental Medicine, KU Leuven, UZ Herestraat 49, Leuven, 3000 Belgium
    623 rdf:type schema:Organization
    624 https://www.grid.ac/institutes/grid.5645.2 schema:alternateName Erasmus University Medical Center
    625 schema:name Department of Gastroenterology and Hepatology, Erasmus Medical Centre, Rotterdam, 3015 CE The Netherlands
    626 rdf:type schema:Organization
    627 https://www.grid.ac/institutes/grid.7597.c schema:alternateName RIKEN
    628 schema:name Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Science, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045 Japan
    629 Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34), 1 Avenue de l’Hôpital, Liège, 4000 Belgium
    630 rdf:type schema:Organization
    631 https://www.grid.ac/institutes/grid.7692.a schema:alternateName University Medical Center Utrecht
    632 schema:name Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, 3584 cX, Utrecht, The Netherlands
    633 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...