Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Teppei Ebina, Yoshito Masamizu, Yasuhiro R. Tanaka, Akiya Watakabe, Reiko Hirakawa, Yuka Hirayama, Riichiro Hira, Shin-Ichiro Terada, Daisuke Koketsu, Kazuo Hikosaka, Hiroaki Mizukami, Atsushi Nambu, Erika Sasaki, Tetsuo Yamamori, Masanori Matsuzaki

ABSTRACT

Two-photon imaging in behaving animals has revealed neuronal activities related to behavioral and cognitive function at single-cell resolution. However, marmosets have posed a challenge due to limited success in training on motor tasks. Here we report the development of protocols to train head-fixed common marmosets to perform upper-limb movement tasks and simultaneously perform two-photon imaging. After 2-5 months of training sessions, head-fixed marmosets can control a manipulandum to move a cursor to a target on a screen. We conduct two-photon calcium imaging of layer 2/3 neurons in the motor cortex during this motor task performance, and detect task-relevant activity from multiple neurons at cellular and subcellular resolutions. In a two-target reaching task, some neurons show direction-selective activity over the training days. In a short-term force-field adaptation task, some neurons change their activity when the force field is on. Two-photon calcium imaging in behaving marmosets may become a fundamental technique for determining the spatial organization of the cortical dynamics underlying action and cognition. More... »

PAGES

1879

References to SciGraph publications

  • 2017-12. Targeted Patching and Dendritic Ca2+ Imaging in Nonhuman Primate Brain in vivo in SCIENTIFIC REPORTS
  • 1996-03. Dissociation in prefrontal cortex of affective and attentional shifts in NATURE
  • 2012-11. Reorganization of cortical population activity imaged throughout long-term sensory deprivation in NATURE NEUROSCIENCE
  • 2014-07. Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task in NATURE NEUROSCIENCE
  • 1993-09. Inverse-dynamics model eye movement control by Purkinje cells in the cerebellum in NATURE
  • 2013-12. Visualizing hippocampal neurons with in vivo two-photon microscopy using a 1030 nm picosecond pulse laser in SCIENTIFIC REPORTS
  • 2014-02. Temporal structure of motor variability is dynamically regulated and predicts motor learning ability in NATURE NEUROSCIENCE
  • 2010-04. Dendritic organization of sensory input to cortical neurons in vivo in NATURE
  • 2017-04. In vivo three-photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain in NATURE METHODS
  • 2013-07. Ultrasensitive fluorescent proteins for imaging neuronal activity in NATURE
  • 2012-07. Neural population dynamics during reaching in NATURE
  • 2001-10. Conditional control of gene expression in the mouse in NATURE REVIEWS GENETICS
  • 2014-06. Emergence of reproducible spatiotemporal activity during motor learning in NATURE
  • 2013-02. Cortico-cortical projections in mouse visual cortex are functionally target specific in NATURE NEUROSCIENCE
  • 2017-12. The role of forelimb motor cortex areas in goal directed action in mice in SCIENTIFIC REPORTS
  • 2016-12. Generation of transgenic marmosets expressing genetically encoded calcium indicators in SCIENTIFIC REPORTS
  • 2004-01. Bayesian integration in sensorimotor learning in NATURE
  • 2012-04-25. Multiple dynamic representations in the motor cortex during sensorimotor learning in NATURE
  • 2016-12. Unstable neurons underlie a stable learned behavior in NATURE NEUROSCIENCE
  • 2008-06. Neural substrates of vocalization feedback monitoring in primate auditory cortex in NATURE
  • 2016-12. Chronic multiscale imaging of neuronal activity in the awake common marmoset in SCIENTIFIC REPORTS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-04286-6

    DOI

    http://dx.doi.org/10.1038/s41467-018-04286-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103889251

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29760466


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    433 https://www.grid.ac/institutes/grid.452212.2 schema:alternateName Central Institute for Experimental Animals
    434 schema:name Central Institute for Experimental Animals, 210-0821, Kanagawa, Japan
    435 Division of Brain Circuits, National Institute for Basic Biology, 444-8585, Aichi, Japan
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    437 https://www.grid.ac/institutes/grid.467811.d schema:alternateName National Institute for Physiological Sciences
    438 schema:name Division of System Neurophysiology, National Institute for Physiological Sciences, 444-8585, Aichi, Japan
    439 School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), 444-8585, Aichi, Japan
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    441 https://www.grid.ac/institutes/grid.474690.8 schema:alternateName RIKEN Center for Brain Science
    442 schema:name Laboratory for Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science, 351-0198, Saitama, Japan
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