High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Thomas Mager, David Lopez de la Morena, Verena Senn, Johannes Schlotte, Anna D´Errico, Katrin Feldbauer, Christian Wrobel, Sangyong Jung, Kai Bodensiek, Vladan Rankovic, Lorcan Browne, Antoine Huet, Josephine Jüttner, Phillip G. Wood, Johannes J. Letzkus, Tobias Moser, Ernst Bamberg

ABSTRACT

Optogenetics revolutionizes basic research in neuroscience and cell biology and bears potential for medical applications. We develop mutants leading to a unifying concept for the construction of various channelrhodopsins with fast closing kinetics. Due to different absorption maxima these channelrhodopsins allow fast neural photoactivation over the whole range of the visible spectrum. We focus our functional analysis on the fast-switching, red light-activated Chrimson variants, because red light has lower light scattering and marginal phototoxicity in tissues. We show paradigmatically for neurons of the cerebral cortex and the auditory nerve that the fast Chrimson mutants enable neural stimulation with firing frequencies of several hundred Hz. They drive spiking at high rates and temporal fidelity with low thresholds for stimulus intensity and duration. Optical cochlear implants restore auditory nerve activity in deaf mice. This demonstrates that the mutants facilitate neuroscience research and future medical applications such as hearing restoration. More... »

PAGES

1750

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-04146-3

DOI

http://dx.doi.org/10.1038/s41467-018-04146-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103640980

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29717130


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Biophysics", 
          "id": "https://www.grid.ac/institutes/grid.419494.5", 
          "name": [
            "Department of Biophysical Chemistry, Max Planck Institute of Biophysics, D-60438, Frankfurt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mager", 
        "givenName": "Thomas", 
        "id": "sg:person.01230615472.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230615472.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of G\u00f6ttingen", 
          "id": "https://www.grid.ac/institutes/grid.7450.6", 
          "name": [
            "Institute for Auditory Neuroscience and InnerEarLab, University Medical Center G\u00f6ttingen, D-37075, G\u00f6ttingen, Germany", 
            "G\u00f6ttingen Graduate School for Neuroscience and Molecular Biosciences, University of G\u00f6ttingen, D-37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de la Morena", 
        "givenName": "David Lopez", 
        "id": "sg:person.011426415240.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011426415240.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ernst Str\u00fcngmann Institute for Neuroscience", 
          "id": "https://www.grid.ac/institutes/grid.461715.0", 
          "name": [
            "Neocortical Circuits Lab, Max Planck Institute for Brain Research, D-60438, Frankfurt, Germany", 
            "Ernst-Str\u00fcngmann-Institute for Neuroscience, D-60528, Frankfurt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Senn", 
        "givenName": "Verena", 
        "id": "sg:person.0765530253.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765530253.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Basel", 
          "id": "https://www.grid.ac/institutes/grid.6612.3", 
          "name": [
            "Department of Biophysical Chemistry, Max Planck Institute of Biophysics, D-60438, Frankfurt, Germany", 
            "Biozentrum, University of Basel, CH-4056, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schlotte", 
        "givenName": "Johannes", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Department of Biophysical Chemistry, Max Planck Institute of Biophysics, D-60438, Frankfurt, Germany", 
            "Buchmann Institute of Molecular Life Sciences, Goethe Universit\u00e4t Frankfurt, D-60438, Frankfurt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "D\u00b4Errico", 
        "givenName": "Anna", 
        "id": "sg:person.0642303401.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642303401.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Heart and Lung Research", 
          "id": "https://www.grid.ac/institutes/grid.418032.c", 
          "name": [
            "Department of Biophysical Chemistry, Max Planck Institute of Biophysics, D-60438, Frankfurt, Germany", 
            "Max-Planck-Institut f\u00fcr Herz- und Lungenforschung, D-61231, Bad Nauheim, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Feldbauer", 
        "givenName": "Katrin", 
        "id": "sg:person.0660437501.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660437501.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin G\u00f6ttingen", 
          "id": "https://www.grid.ac/institutes/grid.411984.1", 
          "name": [
            "Institute for Auditory Neuroscience and InnerEarLab, University Medical Center G\u00f6ttingen, D-37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wrobel", 
        "givenName": "Christian", 
        "id": "sg:person.07707563016.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07707563016.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Singapore Bioimaging Consortium", 
          "id": "https://www.grid.ac/institutes/grid.452254.0", 
          "name": [
            "Institute for Auditory Neuroscience and InnerEarLab, University Medical Center G\u00f6ttingen, D-37075, G\u00f6ttingen, Germany", 
            "Neuro Modulation and Neuro Circuitry Group, Singapore Bioimaging Consortium (SBIC), Biomedical Sciences Institutes, A*STAR, 138667, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jung", 
        "givenName": "Sangyong", 
        "id": "sg:person.0776031027.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776031027.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin G\u00f6ttingen", 
          "id": "https://www.grid.ac/institutes/grid.411984.1", 
          "name": [
            "Institute for Auditory Neuroscience and InnerEarLab, University Medical Center G\u00f6ttingen, D-37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bodensiek", 
        "givenName": "Kai", 
        "id": "sg:person.0726473041.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726473041.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Primate Center", 
          "id": "https://www.grid.ac/institutes/grid.418215.b", 
          "name": [
            "Institute for Auditory Neuroscience and InnerEarLab, University Medical Center G\u00f6ttingen, D-37075, G\u00f6ttingen, Germany", 
            "Auditory Neuroscience and Optogenetics Group, German Primate Center, D-37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rankovic", 
        "givenName": "Vladan", 
        "id": "sg:person.0726164217.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726164217.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Institute for Auditory Neuroscience and InnerEarLab, University Medical Center G\u00f6ttingen, D-37075, G\u00f6ttingen, Germany", 
            "Auditory Neuroscience and Optogenetics Group, German Primate Center, D-37075, G\u00f6ttingen, Germany", 
            "UCL Ear Institute, University College London, WC1X 8EE, London, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Browne", 
        "givenName": "Lorcan", 
        "id": "sg:person.01341773304.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341773304.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Primate Center", 
          "id": "https://www.grid.ac/institutes/grid.418215.b", 
          "name": [
            "Institute for Auditory Neuroscience and InnerEarLab, University Medical Center G\u00f6ttingen, D-37075, G\u00f6ttingen, Germany", 
            "Auditory Neuroscience and Optogenetics Group, German Primate Center, D-37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huet", 
        "givenName": "Antoine", 
        "id": "sg:person.01321542450.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321542450.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Friedrich Miescher Institute", 
          "id": "https://www.grid.ac/institutes/grid.482245.d", 
          "name": [
            "Friedrich Miescher Institute for Biomedical Research, CH-4058, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "J\u00fcttner", 
        "givenName": "Josephine", 
        "id": "sg:person.0774473076.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774473076.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Biophysics", 
          "id": "https://www.grid.ac/institutes/grid.419494.5", 
          "name": [
            "Department of Biophysical Chemistry, Max Planck Institute of Biophysics, D-60438, Frankfurt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wood", 
        "givenName": "Phillip G.", 
        "id": "sg:person.01071220166.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071220166.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Brain Research", 
          "id": "https://www.grid.ac/institutes/grid.419505.c", 
          "name": [
            "Neocortical Circuits Lab, Max Planck Institute for Brain Research, D-60438, Frankfurt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Letzkus", 
        "givenName": "Johannes J.", 
        "id": "sg:person.0625673070.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625673070.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Primate Center", 
          "id": "https://www.grid.ac/institutes/grid.418215.b", 
          "name": [
            "Institute for Auditory Neuroscience and InnerEarLab, University Medical Center G\u00f6ttingen, D-37075, G\u00f6ttingen, Germany", 
            "G\u00f6ttingen Graduate School for Neuroscience and Molecular Biosciences, University of G\u00f6ttingen, D-37075, G\u00f6ttingen, Germany", 
            "Auditory Neuroscience and Optogenetics Group, German Primate Center, D-37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moser", 
        "givenName": "Tobias", 
        "id": "sg:person.01117732564.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117732564.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Biophysics", 
          "id": "https://www.grid.ac/institutes/grid.419494.5", 
          "name": [
            "Department of Biophysical Chemistry, Max Planck Institute of Biophysics, D-60438, Frankfurt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bamberg", 
        "givenName": "Ernst", 
        "id": "sg:person.01234642424.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234642424.75"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature05744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000034210", 
          "https://doi.org/10.1038/nature05744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000034210", 
          "https://doi.org/10.1038/nature05744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1936192100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001065397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/19.10.2152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005116918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2014.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006355659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-neuro-062012-170304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008460186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.conb.2015.01.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008981388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2012.05.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011084383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2012.12.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011581777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-3806(81)90059-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015039180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-3806(81)90059-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015039180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biophys.28.1.367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015502659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(95)01356-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015572404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10162-007-0108-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015822065", 
          "https://doi.org/10.1007/s10162-007-0108-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10162-007-0108-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015822065", 
          "https://doi.org/10.1007/s10162-007-0108-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hipo.22488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018020039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.2467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022194277", 
          "https://doi.org/10.1038/nn.2467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.2467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022194277", 
          "https://doi.org/10.1038/nn.2467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0030159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023311897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2008.11.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024323914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/rbme.2008.2008250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025539546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10870", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025722569", 
          "https://doi.org/10.1038/nature10870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0389-10.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026476257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201301698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027454741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0496-15.2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027568951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.heares.2015.01.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029676860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1255263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030359862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030668007", 
          "https://doi.org/10.1038/nmeth.2836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5955(87)90095-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032921024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5955(87)90095-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032921024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.3502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037754750", 
          "https://doi.org/10.1038/nn.3502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.2495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038906759", 
          "https://doi.org/10.1038/nn.2495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.2495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038906759", 
          "https://doi.org/10.1038/nn.2495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.23.13362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039245189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnsys.2016.00074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041908111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.2120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042891337", 
          "https://doi.org/10.1038/nn.2120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043162871", 
          "https://doi.org/10.1038/nn1525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043162871", 
          "https://doi.org/10.1038/nn1525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043162871", 
          "https://doi.org/10.1038/nn1525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1072068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047484856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.2776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047761855", 
          "https://doi.org/10.1038/nn.2776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00574.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048960410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci69050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049344178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2005.11.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050460105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/86.372900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061241163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1121/1.381736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062333031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1062977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062445277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3791/2968", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071422856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3791/52069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071424716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1969.32.4.613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081357105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082255115", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1993.tb05625.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082802958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082964371", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.17-09-03312.1997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083069444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-09600-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091344499", 
          "https://doi.org/10.1038/s41598-017-09600-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-09600-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091344499", 
          "https://doi.org/10.1038/s41598-017-09600-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-09600-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091344499", 
          "https://doi.org/10.1038/s41598-017-09600-8"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Optogenetics revolutionizes basic research in neuroscience and cell biology and bears potential for medical applications. We develop mutants leading to a unifying concept for the construction of various channelrhodopsins with fast closing kinetics. Due to different absorption maxima these channelrhodopsins allow fast neural photoactivation over the whole range of the visible spectrum. We focus our functional analysis on the fast-switching, red light-activated Chrimson variants, because red light has lower light scattering and marginal phototoxicity in tissues. We show paradigmatically for neurons of the cerebral cortex and the auditory nerve that the fast Chrimson mutants enable neural stimulation with firing frequencies of several hundred Hz. They drive spiking at high rates and temporal fidelity with low thresholds for stimulus intensity and duration. Optical cochlear implants restore auditory nerve activity in deaf mice. This demonstrates that the mutants facilitate neuroscience research and future medical applications such as hearing restoration.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-018-04146-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5051178", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3795975", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics", 
    "pagination": "1750", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "99cab1d36c7e589e88ba6df5ed1793e74a42bd30e6272601444695cb83dd771a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29717130"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-018-04146-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103640980"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-018-04146-3", 
      "https://app.dimensions.ai/details/publication/pub.1103640980"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000604.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-018-04146-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-04146-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-04146-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-04146-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-04146-3'


 

This table displays all metadata directly associated to this object as RDF triples.

376 TRIPLES      21 PREDICATES      76 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-018-04146-3 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author Ne90051ed180846d087477c7d2702c5e0
4 schema:citation sg:pub.10.1007/s10162-007-0108-5
5 sg:pub.10.1038/nature05744
6 sg:pub.10.1038/nature10870
7 sg:pub.10.1038/nmeth.2836
8 sg:pub.10.1038/nn.2120
9 sg:pub.10.1038/nn.2467
10 sg:pub.10.1038/nn.2495
11 sg:pub.10.1038/nn.2776
12 sg:pub.10.1038/nn.3502
13 sg:pub.10.1038/nn1525
14 sg:pub.10.1038/s41598-017-09600-8
15 https://app.dimensions.ai/details/publication/pub.1082255115
16 https://app.dimensions.ai/details/publication/pub.1082964371
17 https://doi.org/10.1002/anie.201301698
18 https://doi.org/10.1002/hipo.22488
19 https://doi.org/10.1002/j.1460-2075.1993.tb05625.x
20 https://doi.org/10.1016/0014-5793(95)01356-3
21 https://doi.org/10.1016/0165-3806(81)90059-6
22 https://doi.org/10.1016/0378-5955(87)90095-5
23 https://doi.org/10.1016/j.bpj.2008.11.034
24 https://doi.org/10.1016/j.bpj.2012.12.018
25 https://doi.org/10.1016/j.conb.2015.01.004
26 https://doi.org/10.1016/j.cub.2005.11.032
27 https://doi.org/10.1016/j.heares.2015.01.004
28 https://doi.org/10.1016/j.jmb.2014.11.004
29 https://doi.org/10.1016/j.neuron.2012.05.019
30 https://doi.org/10.1073/pnas.1936192100
31 https://doi.org/10.1073/pnas.93.23.13362
32 https://doi.org/10.1093/emboj/19.10.2152
33 https://doi.org/10.1109/86.372900
34 https://doi.org/10.1109/rbme.2008.2008250
35 https://doi.org/10.1121/1.381736
36 https://doi.org/10.1126/science.1062977
37 https://doi.org/10.1126/science.1072068
38 https://doi.org/10.1126/science.1255263
39 https://doi.org/10.1146/annurev-neuro-062012-170304
40 https://doi.org/10.1146/annurev.biophys.28.1.367
41 https://doi.org/10.1152/jn.00574.2004
42 https://doi.org/10.1152/jn.1969.32.4.613
43 https://doi.org/10.1172/jci69050
44 https://doi.org/10.1371/journal.pbio.0030159
45 https://doi.org/10.1523/jneurosci.0389-10.2010
46 https://doi.org/10.1523/jneurosci.0496-15.2015
47 https://doi.org/10.1523/jneurosci.17-09-03312.1997
48 https://doi.org/10.3389/fnsys.2016.00074
49 https://doi.org/10.3791/2968
50 https://doi.org/10.3791/52069
51 schema:datePublished 2018-12
52 schema:datePublishedReg 2018-12-01
53 schema:description Optogenetics revolutionizes basic research in neuroscience and cell biology and bears potential for medical applications. We develop mutants leading to a unifying concept for the construction of various channelrhodopsins with fast closing kinetics. Due to different absorption maxima these channelrhodopsins allow fast neural photoactivation over the whole range of the visible spectrum. We focus our functional analysis on the fast-switching, red light-activated Chrimson variants, because red light has lower light scattering and marginal phototoxicity in tissues. We show paradigmatically for neurons of the cerebral cortex and the auditory nerve that the fast Chrimson mutants enable neural stimulation with firing frequencies of several hundred Hz. They drive spiking at high rates and temporal fidelity with low thresholds for stimulus intensity and duration. Optical cochlear implants restore auditory nerve activity in deaf mice. This demonstrates that the mutants facilitate neuroscience research and future medical applications such as hearing restoration.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree true
57 schema:isPartOf N0fda99096ba040a7a87084b0ec59cd65
58 N89d9b8c5250745d6b8877ce405033302
59 sg:journal.1043282
60 schema:name High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics
61 schema:pagination 1750
62 schema:productId N0dd8137bbaf945abaca46873217591df
63 N199849f8f9d445d9b82b0f0977aa0d6b
64 N81750d5d5f694cada3f57015cb345ccf
65 N9a3234fff5db458499b5a6fff224f619
66 Ndd8b62365b844291a252b1ca8c825427
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103640980
68 https://doi.org/10.1038/s41467-018-04146-3
69 schema:sdDatePublished 2019-04-10T19:21
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N0d612552c94d49cdb7105d8ef67e972f
72 schema:url https://www.nature.com/articles/s41467-018-04146-3
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N0d612552c94d49cdb7105d8ef67e972f schema:name Springer Nature - SN SciGraph project
77 rdf:type schema:Organization
78 N0dd8137bbaf945abaca46873217591df schema:name doi
79 schema:value 10.1038/s41467-018-04146-3
80 rdf:type schema:PropertyValue
81 N0fda99096ba040a7a87084b0ec59cd65 schema:issueNumber 1
82 rdf:type schema:PublicationIssue
83 N119041cdeabd4321affad42bac7af9f5 rdf:first sg:person.0660437501.31
84 rdf:rest N2822fecac4af4b18895b8e802d5eb1d0
85 N199849f8f9d445d9b82b0f0977aa0d6b schema:name dimensions_id
86 schema:value pub.1103640980
87 rdf:type schema:PropertyValue
88 N264438041e8e44c599e4847de5cf8ae8 rdf:first sg:person.01071220166.62
89 rdf:rest N5812fb6d63f74f9ca0d5ec4761a0b234
90 N2822fecac4af4b18895b8e802d5eb1d0 rdf:first sg:person.07707563016.07
91 rdf:rest Naca1e32959824589b12b6d7b154b113b
92 N37f6cd27c8fa460fa0a4547ecab99e4c rdf:first sg:person.01117732564.89
93 rdf:rest Nc7ec3a78697942b6a3b2f26c6879a1e3
94 N5812fb6d63f74f9ca0d5ec4761a0b234 rdf:first sg:person.0625673070.83
95 rdf:rest N37f6cd27c8fa460fa0a4547ecab99e4c
96 N81750d5d5f694cada3f57015cb345ccf schema:name pubmed_id
97 schema:value 29717130
98 rdf:type schema:PropertyValue
99 N8942916e1b1c424cbcd3e147b9b1a3fd rdf:first sg:person.01341773304.85
100 rdf:rest Nfd1a3786dcb2443c87c2cf9a7ab274a9
101 N89d9b8c5250745d6b8877ce405033302 schema:volumeNumber 9
102 rdf:type schema:PublicationVolume
103 N8dbce8af5ace4a98af1069de0999312c rdf:first sg:person.0726473041.93
104 rdf:rest Nfafafd0310a840979bc17283865aa287
105 N98bb5d5b9c764672a6b4b35d782cf061 rdf:first sg:person.0642303401.32
106 rdf:rest N119041cdeabd4321affad42bac7af9f5
107 N9a3234fff5db458499b5a6fff224f619 schema:name readcube_id
108 schema:value 99cab1d36c7e589e88ba6df5ed1793e74a42bd30e6272601444695cb83dd771a
109 rdf:type schema:PropertyValue
110 Na1f1c7e58f434189b39a12d9b87a66e6 rdf:first sg:person.011426415240.42
111 rdf:rest Nb546d4c642b74f3b84c5996d8b1a6cca
112 Na62da1becb9d4c2499d7bfbbc9eb3295 schema:affiliation https://www.grid.ac/institutes/grid.6612.3
113 schema:familyName Schlotte
114 schema:givenName Johannes
115 rdf:type schema:Person
116 Naca1e32959824589b12b6d7b154b113b rdf:first sg:person.0776031027.70
117 rdf:rest N8dbce8af5ace4a98af1069de0999312c
118 Nb546d4c642b74f3b84c5996d8b1a6cca rdf:first sg:person.0765530253.97
119 rdf:rest Ne66cd2ab84b74722a61568009081fde2
120 Nc7ec3a78697942b6a3b2f26c6879a1e3 rdf:first sg:person.01234642424.75
121 rdf:rest rdf:nil
122 Ncc9c8146e2334515b29e6ec2fee3a2cb rdf:first sg:person.0774473076.24
123 rdf:rest N264438041e8e44c599e4847de5cf8ae8
124 Ndd8b62365b844291a252b1ca8c825427 schema:name nlm_unique_id
125 schema:value 101528555
126 rdf:type schema:PropertyValue
127 Ne66cd2ab84b74722a61568009081fde2 rdf:first Na62da1becb9d4c2499d7bfbbc9eb3295
128 rdf:rest N98bb5d5b9c764672a6b4b35d782cf061
129 Ne90051ed180846d087477c7d2702c5e0 rdf:first sg:person.01230615472.47
130 rdf:rest Na1f1c7e58f434189b39a12d9b87a66e6
131 Nfafafd0310a840979bc17283865aa287 rdf:first sg:person.0726164217.72
132 rdf:rest N8942916e1b1c424cbcd3e147b9b1a3fd
133 Nfd1a3786dcb2443c87c2cf9a7ab274a9 rdf:first sg:person.01321542450.71
134 rdf:rest Ncc9c8146e2334515b29e6ec2fee3a2cb
135 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
136 schema:name Medical and Health Sciences
137 rdf:type schema:DefinedTerm
138 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
139 schema:name Neurosciences
140 rdf:type schema:DefinedTerm
141 sg:grant.3795975 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-04146-3
142 rdf:type schema:MonetaryGrant
143 sg:grant.5051178 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-04146-3
144 rdf:type schema:MonetaryGrant
145 sg:journal.1043282 schema:issn 2041-1723
146 schema:name Nature Communications
147 rdf:type schema:Periodical
148 sg:person.01071220166.62 schema:affiliation https://www.grid.ac/institutes/grid.419494.5
149 schema:familyName Wood
150 schema:givenName Phillip G.
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071220166.62
152 rdf:type schema:Person
153 sg:person.01117732564.89 schema:affiliation https://www.grid.ac/institutes/grid.418215.b
154 schema:familyName Moser
155 schema:givenName Tobias
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117732564.89
157 rdf:type schema:Person
158 sg:person.011426415240.42 schema:affiliation https://www.grid.ac/institutes/grid.7450.6
159 schema:familyName de la Morena
160 schema:givenName David Lopez
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011426415240.42
162 rdf:type schema:Person
163 sg:person.01230615472.47 schema:affiliation https://www.grid.ac/institutes/grid.419494.5
164 schema:familyName Mager
165 schema:givenName Thomas
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230615472.47
167 rdf:type schema:Person
168 sg:person.01234642424.75 schema:affiliation https://www.grid.ac/institutes/grid.419494.5
169 schema:familyName Bamberg
170 schema:givenName Ernst
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234642424.75
172 rdf:type schema:Person
173 sg:person.01321542450.71 schema:affiliation https://www.grid.ac/institutes/grid.418215.b
174 schema:familyName Huet
175 schema:givenName Antoine
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321542450.71
177 rdf:type schema:Person
178 sg:person.01341773304.85 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
179 schema:familyName Browne
180 schema:givenName Lorcan
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341773304.85
182 rdf:type schema:Person
183 sg:person.0625673070.83 schema:affiliation https://www.grid.ac/institutes/grid.419505.c
184 schema:familyName Letzkus
185 schema:givenName Johannes J.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625673070.83
187 rdf:type schema:Person
188 sg:person.0642303401.32 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
189 schema:familyName D´Errico
190 schema:givenName Anna
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642303401.32
192 rdf:type schema:Person
193 sg:person.0660437501.31 schema:affiliation https://www.grid.ac/institutes/grid.418032.c
194 schema:familyName Feldbauer
195 schema:givenName Katrin
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660437501.31
197 rdf:type schema:Person
198 sg:person.0726164217.72 schema:affiliation https://www.grid.ac/institutes/grid.418215.b
199 schema:familyName Rankovic
200 schema:givenName Vladan
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726164217.72
202 rdf:type schema:Person
203 sg:person.0726473041.93 schema:affiliation https://www.grid.ac/institutes/grid.411984.1
204 schema:familyName Bodensiek
205 schema:givenName Kai
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726473041.93
207 rdf:type schema:Person
208 sg:person.0765530253.97 schema:affiliation https://www.grid.ac/institutes/grid.461715.0
209 schema:familyName Senn
210 schema:givenName Verena
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765530253.97
212 rdf:type schema:Person
213 sg:person.07707563016.07 schema:affiliation https://www.grid.ac/institutes/grid.411984.1
214 schema:familyName Wrobel
215 schema:givenName Christian
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07707563016.07
217 rdf:type schema:Person
218 sg:person.0774473076.24 schema:affiliation https://www.grid.ac/institutes/grid.482245.d
219 schema:familyName Jüttner
220 schema:givenName Josephine
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774473076.24
222 rdf:type schema:Person
223 sg:person.0776031027.70 schema:affiliation https://www.grid.ac/institutes/grid.452254.0
224 schema:familyName Jung
225 schema:givenName Sangyong
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776031027.70
227 rdf:type schema:Person
228 sg:pub.10.1007/s10162-007-0108-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015822065
229 https://doi.org/10.1007/s10162-007-0108-5
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/nature05744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000034210
232 https://doi.org/10.1038/nature05744
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nature10870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025722569
235 https://doi.org/10.1038/nature10870
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nmeth.2836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030668007
238 https://doi.org/10.1038/nmeth.2836
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nn.2120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042891337
241 https://doi.org/10.1038/nn.2120
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/nn.2467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022194277
244 https://doi.org/10.1038/nn.2467
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/nn.2495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038906759
247 https://doi.org/10.1038/nn.2495
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/nn.2776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047761855
250 https://doi.org/10.1038/nn.2776
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/nn.3502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037754750
253 https://doi.org/10.1038/nn.3502
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/nn1525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043162871
256 https://doi.org/10.1038/nn1525
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/s41598-017-09600-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091344499
259 https://doi.org/10.1038/s41598-017-09600-8
260 rdf:type schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1082255115 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1082964371 schema:CreativeWork
263 https://doi.org/10.1002/anie.201301698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027454741
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/hipo.22488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018020039
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/j.1460-2075.1993.tb05625.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082802958
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/0014-5793(95)01356-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015572404
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/0165-3806(81)90059-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015039180
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/0378-5955(87)90095-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032921024
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.bpj.2008.11.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024323914
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.bpj.2012.12.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011581777
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.conb.2015.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008981388
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.cub.2005.11.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050460105
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.heares.2015.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029676860
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.jmb.2014.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006355659
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.neuron.2012.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011084383
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1073/pnas.1936192100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001065397
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1073/pnas.93.23.13362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039245189
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1093/emboj/19.10.2152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005116918
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1109/86.372900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061241163
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1109/rbme.2008.2008250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025539546
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1121/1.381736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062333031
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1126/science.1062977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445277
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1126/science.1072068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047484856
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1126/science.1255263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030359862
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1146/annurev-neuro-062012-170304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008460186
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1146/annurev.biophys.28.1.367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015502659
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1152/jn.00574.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048960410
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1152/jn.1969.32.4.613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081357105
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1172/jci69050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049344178
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1371/journal.pbio.0030159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023311897
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1523/jneurosci.0389-10.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026476257
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1523/jneurosci.0496-15.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027568951
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1523/jneurosci.17-09-03312.1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083069444
324 rdf:type schema:CreativeWork
325 https://doi.org/10.3389/fnsys.2016.00074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041908111
326 rdf:type schema:CreativeWork
327 https://doi.org/10.3791/2968 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071422856
328 rdf:type schema:CreativeWork
329 https://doi.org/10.3791/52069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071424716
330 rdf:type schema:CreativeWork
331 https://www.grid.ac/institutes/grid.411984.1 schema:alternateName Universitätsmedizin Göttingen
332 schema:name Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, D-37075, Göttingen, Germany
333 rdf:type schema:Organization
334 https://www.grid.ac/institutes/grid.418032.c schema:alternateName Max Planck Institute for Heart and Lung Research
335 schema:name Department of Biophysical Chemistry, Max Planck Institute of Biophysics, D-60438, Frankfurt, Germany
336 Max-Planck-Institut für Herz- und Lungenforschung, D-61231, Bad Nauheim, Germany
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.418215.b schema:alternateName German Primate Center
339 schema:name Auditory Neuroscience and Optogenetics Group, German Primate Center, D-37075, Göttingen, Germany
340 Göttingen Graduate School for Neuroscience and Molecular Biosciences, University of Göttingen, D-37075, Göttingen, Germany
341 Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, D-37075, Göttingen, Germany
342 rdf:type schema:Organization
343 https://www.grid.ac/institutes/grid.419494.5 schema:alternateName Max Planck Institute of Biophysics
344 schema:name Department of Biophysical Chemistry, Max Planck Institute of Biophysics, D-60438, Frankfurt, Germany
345 rdf:type schema:Organization
346 https://www.grid.ac/institutes/grid.419505.c schema:alternateName Max Planck Institute for Brain Research
347 schema:name Neocortical Circuits Lab, Max Planck Institute for Brain Research, D-60438, Frankfurt, Germany
348 rdf:type schema:Organization
349 https://www.grid.ac/institutes/grid.452254.0 schema:alternateName Singapore Bioimaging Consortium
350 schema:name Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, D-37075, Göttingen, Germany
351 Neuro Modulation and Neuro Circuitry Group, Singapore Bioimaging Consortium (SBIC), Biomedical Sciences Institutes, A*STAR, 138667, Singapore, Singapore
352 rdf:type schema:Organization
353 https://www.grid.ac/institutes/grid.461715.0 schema:alternateName Ernst Strüngmann Institute for Neuroscience
354 schema:name Ernst-Strüngmann-Institute for Neuroscience, D-60528, Frankfurt, Germany
355 Neocortical Circuits Lab, Max Planck Institute for Brain Research, D-60438, Frankfurt, Germany
356 rdf:type schema:Organization
357 https://www.grid.ac/institutes/grid.482245.d schema:alternateName Friedrich Miescher Institute
358 schema:name Friedrich Miescher Institute for Biomedical Research, CH-4058, Basel, Switzerland
359 rdf:type schema:Organization
360 https://www.grid.ac/institutes/grid.6612.3 schema:alternateName University of Basel
361 schema:name Biozentrum, University of Basel, CH-4056, Basel, Switzerland
362 Department of Biophysical Chemistry, Max Planck Institute of Biophysics, D-60438, Frankfurt, Germany
363 rdf:type schema:Organization
364 https://www.grid.ac/institutes/grid.7450.6 schema:alternateName University of Göttingen
365 schema:name Göttingen Graduate School for Neuroscience and Molecular Biosciences, University of Göttingen, D-37075, Göttingen, Germany
366 Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, D-37075, Göttingen, Germany
367 rdf:type schema:Organization
368 https://www.grid.ac/institutes/grid.7839.5 schema:alternateName Goethe University Frankfurt
369 schema:name Buchmann Institute of Molecular Life Sciences, Goethe Universität Frankfurt, D-60438, Frankfurt, Germany
370 Department of Biophysical Chemistry, Max Planck Institute of Biophysics, D-60438, Frankfurt, Germany
371 rdf:type schema:Organization
372 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
373 schema:name Auditory Neuroscience and Optogenetics Group, German Primate Center, D-37075, Göttingen, Germany
374 Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, D-37075, Göttingen, Germany
375 UCL Ear Institute, University College London, WC1X 8EE, London, United Kingdom
376 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...