Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Srinath C. Sampath, Srihari C. Sampath, Andrew T. V. Ho, Stéphane Y. Corbel, Joshua D. Millstone, John Lamb, John Walker, Bernd Kinzel, Christian Schmedt, Helen M. Blau

ABSTRACT

The balance between stem cell quiescence and proliferation in skeletal muscle is tightly controlled, but perturbed in a variety of disease states. Despite progress in identifying activators of stem cell proliferation, the niche factor(s) responsible for quiescence induction remain unclear. Here we report an in vivo imaging-based screen which identifies Oncostatin M (OSM), a member of the interleukin-6 family of cytokines, as a potent inducer of muscle stem cell (MuSC, satellite cell) quiescence. OSM is produced by muscle fibers, induces reversible MuSC cell cycle exit, and maintains stem cell regenerative capacity as judged by serial transplantation. Conditional OSM receptor deletion in satellite cells leads to stem cell depletion and impaired regeneration following injury. These results identify Oncostatin M as a secreted niche factor responsible for quiescence induction, and for the first time establish a direct connection between induction of quiescence, stemness, and transplantation potential in solid organ stem cells. More... »

PAGES

1531

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-03876-8

DOI

http://dx.doi.org/10.1038/s41467-018-03876-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103361059

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29670077


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of California, San Diego", 
          "id": "https://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 94305, Stanford, CA, USA", 
            "Genomics Institute of the Novartis Research Foundation, 92121, San Diego, CA, USA", 
            "Division of Musculoskeletal Imaging, Department of Radiology, University of California San Diego School of Medicine, 92103, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sampath", 
        "givenName": "Srinath C.", 
        "id": "sg:person.0703516637.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703516637.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Diego", 
          "id": "https://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 94305, Stanford, CA, USA", 
            "Genomics Institute of the Novartis Research Foundation, 92121, San Diego, CA, USA", 
            "Division of Musculoskeletal Imaging, Department of Radiology, University of California San Diego School of Medicine, 92103, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sampath", 
        "givenName": "Srihari C.", 
        "id": "sg:person.01057767242.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057767242.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 94305, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ho", 
        "givenName": "Andrew T. V.", 
        "id": "sg:person.016130342772.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016130342772.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genomics Institute of the Novartis Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418185.1", 
          "name": [
            "Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 94305, Stanford, CA, USA", 
            "Genomics Institute of the Novartis Research Foundation, 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corbel", 
        "givenName": "St\u00e9phane Y.", 
        "id": "sg:person.01063502127.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063502127.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genomics Institute of the Novartis Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418185.1", 
          "name": [
            "Genomics Institute of the Novartis Research Foundation, 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Millstone", 
        "givenName": "Joshua D.", 
        "id": "sg:person.012517043052.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012517043052.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genomics Institute of the Novartis Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418185.1", 
          "name": [
            "Genomics Institute of the Novartis Research Foundation, 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lamb", 
        "givenName": "John", 
        "id": "sg:person.013314423452.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013314423452.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genomics Institute of the Novartis Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418185.1", 
          "name": [
            "Genomics Institute of the Novartis Research Foundation, 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walker", 
        "givenName": "John", 
        "id": "sg:person.012634441207.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012634441207.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "Novartis Institutes for BioMedical Research, 4056, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kinzel", 
        "givenName": "Bernd", 
        "id": "sg:person.01316751363.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316751363.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genomics Institute of the Novartis Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418185.1", 
          "name": [
            "Genomics Institute of the Novartis Research Foundation, 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmedt", 
        "givenName": "Christian", 
        "id": "sg:person.01142403736.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142403736.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 94305, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blau", 
        "givenName": "Helen M.", 
        "id": "sg:person.01307671071.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307671071.44"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.stem.2009.12.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000357192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(92)90149-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000454760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(92)90149-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000454760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002058788", 
          "https://doi.org/10.1038/nm.3465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.2637010100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004201622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2010.144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005826115", 
          "https://doi.org/10.1038/cr.2010.144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.03.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006649264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1243904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006847477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007059619", 
          "https://doi.org/10.1038/nature11438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00574.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008875119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1307680110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011129569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.100842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012160918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.scr.2009.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012179705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3464", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012855627", 
          "https://doi.org/10.1038/nm.3464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0914019107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014260752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2007.00622.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014693955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015391294", 
          "https://doi.org/10.1038/nm.3655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1087573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015440760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015978154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1144090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017696289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.03-1259fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017975983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2010.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018514185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2015.04.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018626144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.83.24.9739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018860827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00043.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019264864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2016.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019920223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020257884", 
          "https://doi.org/10.1038/nm.3656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2011.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020527492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021560614", 
          "https://doi.org/10.1038/nm.3918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.11.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021948593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.11.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021948593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2011.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022242250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2014.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023542038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biocel.2006.07.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023608072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024625107", 
          "https://doi.org/10.1038/nature13255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2006.00523.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025144335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025614007", 
          "https://doi.org/10.1038/nature13013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.064162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027006938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1995.1329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027750800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1191035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029250420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1191035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029250420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1191035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029250420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.11.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035527066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.11.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035527066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.3153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035887518", 
          "https://doi.org/10.1038/ni.3153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.3153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035887518", 
          "https://doi.org/10.1038/ni.3153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2007.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036840815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci68523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040369128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3340297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041277059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3340297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041277059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2007-0019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043525659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2014.06.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044502124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044574283", 
          "https://doi.org/10.1038/nature07384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2007.11.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046444846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/002215549904700104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063643124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/002215549904700104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063643124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2012.1568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071512869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stemcr.2017.10.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093092242"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "The balance between stem cell quiescence and proliferation in skeletal muscle is tightly controlled, but perturbed in a variety of disease states. Despite progress in identifying activators of stem cell proliferation, the niche factor(s) responsible for quiescence induction remain unclear. Here we report an in vivo imaging-based screen which identifies Oncostatin M (OSM), a member of the interleukin-6 family of cytokines, as a potent inducer of muscle stem cell (MuSC, satellite cell) quiescence. OSM is produced by muscle fibers, induces reversible MuSC cell cycle exit, and maintains stem cell regenerative capacity as judged by serial transplantation. Conditional OSM receptor deletion in satellite cells leads to stem cell depletion and impaired regeneration following injury. These results identify Oncostatin M as a secreted niche factor responsible for quiescence induction, and for the first time establish a direct connection between induction of quiescence, stemness, and transplantation potential in solid organ stem cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-018-03876-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2447350", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3859273", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M", 
    "pagination": "1531", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7f682ea00d248171836ad58ac2997d1f2737923f10aca20ab869f7ff345c5e85"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29670077"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-018-03876-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103361059"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-018-03876-8", 
      "https://app.dimensions.ai/details/publication/pub.1103361059"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000552.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-018-03876-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-03876-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-03876-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-03876-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-03876-8'


 

This table displays all metadata directly associated to this object as RDF triples.

308 TRIPLES      21 PREDICATES      79 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-018-03876-8 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author Ndb320884a0214d969faabc0ab837138f
4 schema:citation sg:pub.10.1038/cr.2010.144
5 sg:pub.10.1038/nature07384
6 sg:pub.10.1038/nature11438
7 sg:pub.10.1038/nature13013
8 sg:pub.10.1038/nature13255
9 sg:pub.10.1038/ni.3153
10 sg:pub.10.1038/nm.3464
11 sg:pub.10.1038/nm.3465
12 sg:pub.10.1038/nm.3655
13 sg:pub.10.1038/nm.3656
14 sg:pub.10.1038/nm.3918
15 https://doi.org/10.1002/stem.773
16 https://doi.org/10.1006/excr.1995.1329
17 https://doi.org/10.1016/0022-510x(92)90149-f
18 https://doi.org/10.1016/j.biocel.2006.07.014
19 https://doi.org/10.1016/j.cell.2007.03.044
20 https://doi.org/10.1016/j.cell.2010.11.039
21 https://doi.org/10.1016/j.cell.2011.11.049
22 https://doi.org/10.1016/j.cellsig.2007.09.004
23 https://doi.org/10.1016/j.cmet.2007.11.011
24 https://doi.org/10.1016/j.immuni.2015.04.014
25 https://doi.org/10.1016/j.neuron.2014.06.015
26 https://doi.org/10.1016/j.scr.2009.10.003
27 https://doi.org/10.1016/j.stem.2009.12.015
28 https://doi.org/10.1016/j.stem.2010.08.013
29 https://doi.org/10.1016/j.stem.2011.07.003
30 https://doi.org/10.1016/j.stem.2011.08.013
31 https://doi.org/10.1016/j.stem.2014.06.009
32 https://doi.org/10.1016/j.stemcr.2017.10.027
33 https://doi.org/10.1016/j.tcb.2016.02.004
34 https://doi.org/10.1042/bj3340297
35 https://doi.org/10.1073/pnas.0914019107
36 https://doi.org/10.1073/pnas.1307680110
37 https://doi.org/10.1073/pnas.2637010100
38 https://doi.org/10.1073/pnas.83.24.9739
39 https://doi.org/10.1096/fj.03-1259fje
40 https://doi.org/10.1101/gad.1243904
41 https://doi.org/10.1111/j.1600-0854.2006.00523.x
42 https://doi.org/10.1111/j.1600-0854.2007.00622.x
43 https://doi.org/10.1126/science.1087573
44 https://doi.org/10.1126/science.1144090
45 https://doi.org/10.1126/science.1191035
46 https://doi.org/10.1152/ajpcell.00574.2001
47 https://doi.org/10.1152/physrev.00043.2011
48 https://doi.org/10.1172/jci68523
49 https://doi.org/10.1177/002215549904700104
50 https://doi.org/10.1242/dev.064162
51 https://doi.org/10.1242/dev.100842
52 https://doi.org/10.1634/stemcells.2007-0019
53 https://doi.org/10.3892/ijo.2012.1568
54 schema:datePublished 2018-12
55 schema:datePublishedReg 2018-12-01
56 schema:description The balance between stem cell quiescence and proliferation in skeletal muscle is tightly controlled, but perturbed in a variety of disease states. Despite progress in identifying activators of stem cell proliferation, the niche factor(s) responsible for quiescence induction remain unclear. Here we report an in vivo imaging-based screen which identifies Oncostatin M (OSM), a member of the interleukin-6 family of cytokines, as a potent inducer of muscle stem cell (MuSC, satellite cell) quiescence. OSM is produced by muscle fibers, induces reversible MuSC cell cycle exit, and maintains stem cell regenerative capacity as judged by serial transplantation. Conditional OSM receptor deletion in satellite cells leads to stem cell depletion and impaired regeneration following injury. These results identify Oncostatin M as a secreted niche factor responsible for quiescence induction, and for the first time establish a direct connection between induction of quiescence, stemness, and transplantation potential in solid organ stem cells.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N6c649adbe8b14939ba828f60dc4e7bed
61 Nbda6ff5dc84342bf840f38c5220a97d3
62 sg:journal.1043282
63 schema:name Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M
64 schema:pagination 1531
65 schema:productId N30cb2eafd2eb410fa88b0ffe781fe2a6
66 N4a18caadca834b12a55d531b2a562726
67 N5f9a25e0c3f349529bd2696878d33edb
68 N6d981a1b472a48beb59b6a8aeab04cf7
69 Nba1913ba38f84ca987f5e8d95bdc8ba9
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103361059
71 https://doi.org/10.1038/s41467-018-03876-8
72 schema:sdDatePublished 2019-04-10T20:53
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N8c81a31e04e248a1bde6f3fae4017191
75 schema:url https://www.nature.com/articles/s41467-018-03876-8
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N17306381a5834d679be0875be0106485 rdf:first sg:person.01316751363.23
80 rdf:rest Nf0cabf3d1db54ddcb3339cffcfd6e2a9
81 N30cb2eafd2eb410fa88b0ffe781fe2a6 schema:name readcube_id
82 schema:value 7f682ea00d248171836ad58ac2997d1f2737923f10aca20ab869f7ff345c5e85
83 rdf:type schema:PropertyValue
84 N4a18caadca834b12a55d531b2a562726 schema:name doi
85 schema:value 10.1038/s41467-018-03876-8
86 rdf:type schema:PropertyValue
87 N4fc6e061720642edbdbfeb6b60b593df rdf:first sg:person.01307671071.44
88 rdf:rest rdf:nil
89 N5f9a25e0c3f349529bd2696878d33edb schema:name pubmed_id
90 schema:value 29670077
91 rdf:type schema:PropertyValue
92 N6c649adbe8b14939ba828f60dc4e7bed schema:volumeNumber 9
93 rdf:type schema:PublicationVolume
94 N6d981a1b472a48beb59b6a8aeab04cf7 schema:name nlm_unique_id
95 schema:value 101528555
96 rdf:type schema:PropertyValue
97 N8c81a31e04e248a1bde6f3fae4017191 schema:name Springer Nature - SN SciGraph project
98 rdf:type schema:Organization
99 Na37496c72cba4413a19a2421db6bea7b rdf:first sg:person.013314423452.35
100 rdf:rest Ne1479c4291c84150b84d4a844c49773c
101 Nba1913ba38f84ca987f5e8d95bdc8ba9 schema:name dimensions_id
102 schema:value pub.1103361059
103 rdf:type schema:PropertyValue
104 Nbd2ea3e5f6964d049accf6ed5bbdff6d rdf:first sg:person.012517043052.91
105 rdf:rest Na37496c72cba4413a19a2421db6bea7b
106 Nbda6ff5dc84342bf840f38c5220a97d3 schema:issueNumber 1
107 rdf:type schema:PublicationIssue
108 Nc09aaf5b4ba240d6ad63667a2bc749b1 rdf:first sg:person.01057767242.79
109 rdf:rest Nc34f5aa834d049a99b53b45a9869f7d8
110 Nc34f5aa834d049a99b53b45a9869f7d8 rdf:first sg:person.016130342772.05
111 rdf:rest Nd217a24ddf274ae8957d8a7ea1bdb394
112 Nd217a24ddf274ae8957d8a7ea1bdb394 rdf:first sg:person.01063502127.60
113 rdf:rest Nbd2ea3e5f6964d049accf6ed5bbdff6d
114 Ndb320884a0214d969faabc0ab837138f rdf:first sg:person.0703516637.08
115 rdf:rest Nc09aaf5b4ba240d6ad63667a2bc749b1
116 Ne1479c4291c84150b84d4a844c49773c rdf:first sg:person.012634441207.67
117 rdf:rest N17306381a5834d679be0875be0106485
118 Nf0cabf3d1db54ddcb3339cffcfd6e2a9 rdf:first sg:person.01142403736.66
119 rdf:rest N4fc6e061720642edbdbfeb6b60b593df
120 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
121 schema:name Biological Sciences
122 rdf:type schema:DefinedTerm
123 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
124 schema:name Biochemistry and Cell Biology
125 rdf:type schema:DefinedTerm
126 sg:grant.2447350 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-03876-8
127 rdf:type schema:MonetaryGrant
128 sg:grant.3859273 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-03876-8
129 rdf:type schema:MonetaryGrant
130 sg:journal.1043282 schema:issn 2041-1723
131 schema:name Nature Communications
132 rdf:type schema:Periodical
133 sg:person.01057767242.79 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
134 schema:familyName Sampath
135 schema:givenName Srihari C.
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057767242.79
137 rdf:type schema:Person
138 sg:person.01063502127.60 schema:affiliation https://www.grid.ac/institutes/grid.418185.1
139 schema:familyName Corbel
140 schema:givenName Stéphane Y.
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063502127.60
142 rdf:type schema:Person
143 sg:person.01142403736.66 schema:affiliation https://www.grid.ac/institutes/grid.418185.1
144 schema:familyName Schmedt
145 schema:givenName Christian
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142403736.66
147 rdf:type schema:Person
148 sg:person.012517043052.91 schema:affiliation https://www.grid.ac/institutes/grid.418185.1
149 schema:familyName Millstone
150 schema:givenName Joshua D.
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012517043052.91
152 rdf:type schema:Person
153 sg:person.012634441207.67 schema:affiliation https://www.grid.ac/institutes/grid.418185.1
154 schema:familyName Walker
155 schema:givenName John
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012634441207.67
157 rdf:type schema:Person
158 sg:person.01307671071.44 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
159 schema:familyName Blau
160 schema:givenName Helen M.
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307671071.44
162 rdf:type schema:Person
163 sg:person.01316751363.23 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
164 schema:familyName Kinzel
165 schema:givenName Bernd
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316751363.23
167 rdf:type schema:Person
168 sg:person.013314423452.35 schema:affiliation https://www.grid.ac/institutes/grid.418185.1
169 schema:familyName Lamb
170 schema:givenName John
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013314423452.35
172 rdf:type schema:Person
173 sg:person.016130342772.05 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
174 schema:familyName Ho
175 schema:givenName Andrew T. V.
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016130342772.05
177 rdf:type schema:Person
178 sg:person.0703516637.08 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
179 schema:familyName Sampath
180 schema:givenName Srinath C.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703516637.08
182 rdf:type schema:Person
183 sg:pub.10.1038/cr.2010.144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005826115
184 https://doi.org/10.1038/cr.2010.144
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/nature07384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044574283
187 https://doi.org/10.1038/nature07384
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/nature11438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007059619
190 https://doi.org/10.1038/nature11438
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/nature13013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025614007
193 https://doi.org/10.1038/nature13013
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/nature13255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024625107
196 https://doi.org/10.1038/nature13255
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/ni.3153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035887518
199 https://doi.org/10.1038/ni.3153
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/nm.3464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012855627
202 https://doi.org/10.1038/nm.3464
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/nm.3465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002058788
205 https://doi.org/10.1038/nm.3465
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/nm.3655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015391294
208 https://doi.org/10.1038/nm.3655
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/nm.3656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020257884
211 https://doi.org/10.1038/nm.3656
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/nm.3918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021560614
214 https://doi.org/10.1038/nm.3918
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1002/stem.773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015978154
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1006/excr.1995.1329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027750800
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/0022-510x(92)90149-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1000454760
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.biocel.2006.07.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023608072
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.cell.2007.03.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006649264
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.cell.2010.11.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035527066
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.cell.2011.11.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021948593
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.cellsig.2007.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036840815
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.cmet.2007.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046444846
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.immuni.2015.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018626144
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.neuron.2014.06.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044502124
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.scr.2009.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012179705
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.stem.2009.12.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000357192
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.stem.2010.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018514185
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.stem.2011.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022242250
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.stem.2011.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020527492
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.stem.2014.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023542038
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.stemcr.2017.10.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093092242
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.tcb.2016.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019920223
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1042/bj3340297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041277059
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1073/pnas.0914019107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014260752
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1073/pnas.1307680110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011129569
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1073/pnas.2637010100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004201622
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1073/pnas.83.24.9739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018860827
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1096/fj.03-1259fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1017975983
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1101/gad.1243904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006847477
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1111/j.1600-0854.2006.00523.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025144335
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1111/j.1600-0854.2007.00622.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014693955
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1126/science.1087573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015440760
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1126/science.1144090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017696289
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1126/science.1191035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029250420
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1152/ajpcell.00574.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008875119
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1152/physrev.00043.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019264864
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1172/jci68523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040369128
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1177/002215549904700104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063643124
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1242/dev.064162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027006938
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1242/dev.100842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012160918
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1634/stemcells.2007-0019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043525659
291 rdf:type schema:CreativeWork
292 https://doi.org/10.3892/ijo.2012.1568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071512869
293 rdf:type schema:CreativeWork
294 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
295 schema:name Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 94305, Stanford, CA, USA
296 rdf:type schema:Organization
297 https://www.grid.ac/institutes/grid.266100.3 schema:alternateName University of California, San Diego
298 schema:name Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 94305, Stanford, CA, USA
299 Division of Musculoskeletal Imaging, Department of Radiology, University of California San Diego School of Medicine, 92103, San Diego, CA, USA
300 Genomics Institute of the Novartis Research Foundation, 92121, San Diego, CA, USA
301 rdf:type schema:Organization
302 https://www.grid.ac/institutes/grid.418185.1 schema:alternateName Genomics Institute of the Novartis Research Foundation
303 schema:name Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 94305, Stanford, CA, USA
304 Genomics Institute of the Novartis Research Foundation, 92121, San Diego, CA, USA
305 rdf:type schema:Organization
306 https://www.grid.ac/institutes/grid.419481.1 schema:alternateName Novartis (Switzerland)
307 schema:name Novartis Institutes for BioMedical Research, 4056, Basel, Switzerland
308 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...