Recurrent acquisition of cytosine methyltransferases into eukaryotic retrotransposons View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Alex de Mendoza, Amandine Bonnet, Dulce B. Vargas-Landin, Nanjing Ji, Hongfei Li, Feng Yang, Ling Li, Koichi Hori, Jahnvi Pflueger, Sam Buckberry, Hiroyuki Ohta, Nedeljka Rosic, Pascale Lesage, Senjie Lin, Ryan Lister

ABSTRACT

Transposable elements are in a constant arms race with the silencing mechanisms of their host genomes. One silencing mechanism commonly used by many eukaryotes is dependent on cytosine methylation, a covalent modification of DNA deposited by C5 cytosine methyltransferases (DNMTs). Here, we report how two distantly related eukaryotic lineages, dinoflagellates and charophytes, have independently incorporated DNMTs into the coding regions of distinct retrotransposon classes. Concomitantly, we show that dinoflagellates of the genus Symbiodinium have evolved cytosine methylation patterns unlike any other eukaryote, with most of the genome methylated at CG dinucleotides. Finally, we demonstrate the ability of retrotransposon DNMTs to methylate CGs de novo, suggesting that retrotransposons could self-methylate retrotranscribed DNA. Together, this is an example of how retrotransposons incorporate host-derived genes involved in DNA methylation. In some cases, this event could have implications for the composition and regulation of the host epigenomic environment. More... »

PAGES

1341

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-03724-9

    DOI

    http://dx.doi.org/10.1038/s41467-018-03724-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103148770

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29632298


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