Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Adriana I. Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N. Cooke Bailey, Colin E. Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P. Khawaja, Ozren Polašek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L. Haines, Lisa S. Kearns, Caroline Hayward, Yuan Shi, Elisabeth M. van Leeuwen, Kent D. Taylor, , Pieter Bonnemaijer, Jerome I. Rotter, Nicholas G. Martin, Tanja Zeller, Richard A. Mills, Sandra E. Staffieri, Jost B. Jonas, Irene Schmidtmann, Thibaud Boutin, Jae H. Kang, Sionne E. M. Lucas, Tien Yin Wong, Manfred E. Beutel, James F. Wilson, , , André G. Uitterlinden, Eranga N. Vithana, Paul J. Foster, Pirro G. Hysi, Alex W. Hewitt, Chiea Chuen Khor, Louis R. Pasquale, Grant W. Montgomery, Caroline C. W. Klaver, Tin Aung, Norbert Pfeiffer, David A. Mackey, Christopher J. Hammond, Ching-Yu Cheng, Jamie E. Craig, Yaron S. Rabinowitz, Janey L. Wiggs, Kathryn P. Burdon, Cornelia M. van Duijn, Stuart MacGregor

ABSTRACT

Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r = -0.62, P = 5.30 × 10-5) but not between CCT and primary open-angle glaucoma (r = -0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation. More... »

PAGES

1864

References to SciGraph publications

  • 2000-05. Mutations in KERA, encoding keratocan, cause cornea plana in NATURE GENETICS
  • 2010-01. Novel quantitative trait loci for central corneal thickness identified by candidate gene analysis of osteogenesis imperfecta genes in HUMAN GENETICS
  • 2011-12. Human cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivo in BMC CANCER
  • 2002-01. Merlin—rapid analysis of dense genetic maps using sparse gene flow trees in NATURE GENETICS
  • 2015-12. Biological interpretation of genome-wide association studies using predicted gene functions in NATURE COMMUNICATIONS
  • 2013-02. Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus in NATURE GENETICS
  • 2016-03-29. Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error in NATURE COMMUNICATIONS
  • 2012-11. Population-based meta-analysis in Caucasians confirms association with COL5A1 and ZNF469 but not COL8A2 with central corneal thickness in HUMAN GENETICS
  • 2004-10. Novel Types of Mutation Responsible for the Dermatosparactic Type of Ehlers–Danlos Syndrome (Type VIIC) and Common Polymorphisms in the ADAMTS2 Gene in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2013-06. The Genotype-Tissue Expression (GTEx) project in NATURE GENETICS
  • 2012-04. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits in NATURE GENETICS
  • 2012-01. Full spectrum genetics in NATURE GENETICS
  • 2003-03. Fibrillin controls TGF-β activation in NATURE GENETICS
  • 2000-07. Does ethnic origin influence the incidence or severity of keratoconus? in EYE
  • 2010-06. The association between lumican gene polymorphisms and high myopia in EYE
  • Journal

    TITLE

    Nature Communications

    ISSUE

    1

    VOLUME

    9

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-03646-6

    DOI

    http://dx.doi.org/10.1038/s41467-018-03646-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103889231

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29760442


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