Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Gaëlle Marteil, Adan Guerrero, André F. Vieira, Bernardo P. de Almeida, Pedro Machado, Susana Mendonça, Marta Mesquita, Beth Villarreal, Irina Fonseca, Maria E. Francia, Katharina Dores, Nuno P. Martins, Swadhin C. Jana, Erin M. Tranfield, Nuno L. Barbosa-Morais, Joana Paredes, David Pellman, Susana A. Godinho, Mónica Bettencourt-Dias

ABSTRACT

Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of human cancer cell lines to systematically analyse centriole number and structure. Our screen shows that centriole amplification is widespread in cancer cell lines and highly prevalent in aggressive breast carcinomas. Moreover, we identify another recurrent feature of cancer cells: centriole size deregulation. Further experiments demonstrate that severe centriole over-elongation can promote amplification through both centriole fragmentation and ectopic procentriole formation. Furthermore, we show that overly long centrioles form over-active centrosomes that nucleate more microtubules, a known cause of invasiveness, and perturb chromosome segregation. Our screen establishes centriole amplification and size deregulation as recurrent features of cancer cells and identifies novel causes and consequences of those abnormalities. More... »

PAGES

1258

References to SciGraph publications

  • 2000-03. A gene expression database for the molecular pharmacology of cancer in NATURE GENETICS
  • 2015-06. Chromothripsis from DNA damage in micronuclei in NATURE
  • 2009-07. A mechanism linking extra centrosomes to chromosomal instability in NATURE
  • 2016-12. Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer in BMC CANCER
  • 2007-12. Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype in BMC CANCER
  • 2002-09. Loss of p53 and centrosome hyperamplification in ONCOGENE
  • 2000-08. Molecular portraits of human breast tumours in NATURE
  • 2004-11. Aneuploidy and cancer in NATURE
  • 2009-10. Asymmetric centrosome inheritance maintains neural progenitors in the neocortex in NATURE
  • 2006-12. Comparative analysis and integrative classification of NCI60 cell lines and primary tumors using gene expression profiling data in BMC GENOMICS
  • 2012-07. Fiji: an open-source platform for biological-image analysis in NATURE METHODS
  • 2013-10. Centrosome aberrations in bone marrow cells from patients with myelodysplastic syndromes correlate with chromosomal instability in ANNALS OF HEMATOLOGY
  • 2016-03. Genomic analyses identify molecular subtypes of pancreatic cancer in NATURE
  • 2006-10. The NCI60 human tumour cell line anticancer drug screen in NATURE REVIEWS CANCER
  • 2013-07. Centrosome amplification causes microcephaly in NATURE CELL BIOLOGY
  • 2008-03. Control of daughter centriole formation by the pericentriolar material in NATURE CELL BIOLOGY
  • 2014-06. Oncogene-like induction of cellular invasion from centrosome amplification in NATURE
  • 2007-06. Centrosome biogenesis and function: centrosomics brings new understanding in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2012-04. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2009-07. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-03641-x

    DOI

    http://dx.doi.org/10.1038/s41467-018-03641-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101817450

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29593297


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