Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Delia Bucher, Felix Frey, Kem A. Sochacki, Susann Kummer, Jan-Philip Bergeest, William J. Godinez, Hans-Georg Kräusslich, Karl Rohr, Justin W. Taraska, Ulrich S. Schwarz, Steeve Boulant

ABSTRACT

Although essential for many cellular processes, the sequence of structural and molecular events during clathrin-mediated endocytosis remains elusive. While it was long believed that clathrin-coated pits grow with a constant curvature, it was recently suggested that clathrin first assembles to form flat structures that then bend while maintaining a constant surface area. Here, we combine correlative electron and light microscopy and mathematical growth laws to study the ultrastructural rearrangements of the clathrin coat during endocytosis in BSC-1 mammalian cells. We confirm that clathrin coats initially grow flat and demonstrate that curvature begins when around 70% of the final clathrin content is acquired. We find that this transition is marked by a change in the clathrin to clathrin-adaptor protein AP2 ratio and that membrane tension suppresses this transition. Our results support the notion that BSC-1 mammalian cells dynamically regulate the flat-to-curved transition in clathrin-mediated endocytosis by both biochemical and mechanical factors. More... »

PAGES

1109

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-018-03533-0

DOI

http://dx.doi.org/10.1038/s41467-018-03533-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101554671

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29549258


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cercopithecus aethiops", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clathrin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coated Pits, Cell-Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endocytosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acid-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Electron, Transmission", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osmotic Pressure", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Department of Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany", 
            "German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bucher", 
        "givenName": "Delia", 
        "id": "sg:person.013366173301.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013366173301.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "BioQuant Center, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany", 
            "Institute for Theoretical Physics, Heidelberg University, Philosophenweg 19, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frey", 
        "givenName": "Felix", 
        "id": "sg:person.011334154731.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011334154731.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "National Heart Lung and Blood Institute, National Institutes of Health, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sochacki", 
        "givenName": "Kem A.", 
        "id": "sg:person.01204617105.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204617105.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kummer", 
        "givenName": "Susann", 
        "id": "sg:person.01272115724.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272115724.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany", 
            "BioQuant Center, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany", 
            "Institute of Pharmacy and Molecular Biotechnology (IPMB), Department of Bioinformatics and Functional Genomics, Heidelberg University, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bergeest", 
        "givenName": "Jan-Philip", 
        "id": "sg:person.01336253175.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336253175.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany", 
            "BioQuant Center, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany", 
            "Institute of Pharmacy and Molecular Biotechnology (IPMB), Department of Bioinformatics and Functional Genomics, Heidelberg University, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Godinez", 
        "givenName": "William J.", 
        "id": "sg:person.01164774543.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164774543.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kr\u00e4usslich", 
        "givenName": "Hans-Georg", 
        "id": "sg:person.0731120455.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731120455.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany", 
            "BioQuant Center, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany", 
            "Institute of Pharmacy and Molecular Biotechnology (IPMB), Department of Bioinformatics and Functional Genomics, Heidelberg University, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rohr", 
        "givenName": "Karl", 
        "id": "sg:person.01214674260.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214674260.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "National Heart Lung and Blood Institute, National Institutes of Health, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taraska", 
        "givenName": "Justin W.", 
        "id": "sg:person.01013741744.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013741744.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "BioQuant Center, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany", 
            "Institute for Theoretical Physics, Heidelberg University, Philosophenweg 19, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwarz", 
        "givenName": "Ulrich S.", 
        "id": "sg:person.0710447535.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710447535.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Department of Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany", 
            "German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boulant", 
        "givenName": "Steeve", 
        "id": "sg:person.01132565671.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132565671.14"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00018-011-0768-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004487398", 
          "https://doi.org/10.1007/s00018-011-0768-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201604128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005853472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2011.01197.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006390824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.105.5.1999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008373797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009695629", 
          "https://doi.org/10.1038/nrm3266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2006.09.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009989321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-440x(05)80150-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011469268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(02)02089-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013525450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014109210", 
          "https://doi.org/10.1038/ncb2561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2009.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014473408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.108.2.389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014749020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2012.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015157526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms7249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016803865", 
          "https://doi.org/10.1038/ncomms7249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200104085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020241597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1529/biophysj.107.117234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021431298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.103.6.2619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021683281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.96.1.51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023603013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.1000191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023755227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e02-06-0353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025419866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(81)90439-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025491785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025861135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.1001670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028478724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aaa9555", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029626378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2016.07.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031534894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2016.07.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031534894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2016.07.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031534894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e14-06-1154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032154360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2004.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036315073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2015.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037083526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038900325", 
          "https://doi.org/10.1038/nrm3151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.1000604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045103336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201309096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045678671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046485018", 
          "https://doi.org/10.1038/ncb2307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048345698", 
          "https://doi.org/10.1038/nmeth.2816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000394", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049063891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.84.3.560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049400101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/tra.12335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049917767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2011.01241.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050016184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aab3500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051440627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.04137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052189515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physreve.94.062404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060751051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physreve.94.062404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060751051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/tmi.2014.2359541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061696393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1617705114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074240385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1984.tb02075.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081589969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb3498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084128698", 
          "https://doi.org/10.1038/ncb3498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e16-04-0213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084177624"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Although essential for many cellular processes, the sequence of structural and molecular events during clathrin-mediated endocytosis remains elusive. While it was long believed that clathrin-coated pits grow with a constant curvature, it was recently suggested that clathrin first assembles to form flat structures that then bend while maintaining a constant surface area. Here, we combine correlative electron and light microscopy and mathematical growth laws to study the ultrastructural rearrangements of the clathrin coat during endocytosis in BSC-1 mammalian cells. We confirm that clathrin coats initially grow flat and demonstrate that curvature begins when around 70% of the final clathrin content is acquired. We find that this transition is marked by a change in the clathrin to clathrin-adaptor protein AP2 ratio and that membrane tension suppresses this transition. Our results support the notion that BSC-1 mammalian cells dynamically regulate the flat-to-curved transition in clathrin-mediated endocytosis by both biochemical and mechanical factors.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-018-03533-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2725953", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis", 
    "pagination": "1109", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cb56daad14fa03f71f767f734934039149bdeb62b7d8b3195d64494b2311c9fc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29549258"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-018-03533-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101554671"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-018-03533-0", 
      "https://app.dimensions.ai/details/publication/pub.1101554671"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87097_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-018-03533-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-03533-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-03533-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-03533-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-03533-0'


 

This table displays all metadata directly associated to this object as RDF triples.

329 TRIPLES      21 PREDICATES      82 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-018-03533-0 schema:about N183df5e12048477395e6b6e5c023a82c
2 N2d3620fff53f466689495a6122f40094
3 N36891e0296d94184862dbbadb33be1ef
4 N4c5eb5ad06b54882aedd1f275a185520
5 N8e2506017abe4a8ab33e04c8bdaa5d5b
6 Nbe910f6c1bc94db793344ba84fef561e
7 Nc0d072b5c7224d99954ad8cf0999bb27
8 Ncb239b2ad3d2400f87d03822d5ac846d
9 Nf1dfa55493904eb9bebfd20cfdd41aaf
10 anzsrc-for:06
11 anzsrc-for:0601
12 schema:author N8f915db3d2624af1bd9749eeeca24b0b
13 schema:citation sg:pub.10.1007/s00018-011-0768-5
14 sg:pub.10.1038/ncb2307
15 sg:pub.10.1038/ncb2561
16 sg:pub.10.1038/ncb3498
17 sg:pub.10.1038/ncomms7249
18 sg:pub.10.1038/nmeth.2816
19 sg:pub.10.1038/nrm3151
20 sg:pub.10.1038/nrm3266
21 https://doi.org/10.1002/j.1460-2075.1984.tb02075.x
22 https://doi.org/10.1016/0092-8674(81)90439-6
23 https://doi.org/10.1016/j.cell.2004.08.017
24 https://doi.org/10.1016/j.cell.2005.03.015
25 https://doi.org/10.1016/j.devcel.2015.03.002
26 https://doi.org/10.1016/j.jsb.2016.07.009
27 https://doi.org/10.1016/j.tcb.2009.09.002
28 https://doi.org/10.1016/j.tibs.2012.09.001
29 https://doi.org/10.1016/j.yexcr.2006.09.025
30 https://doi.org/10.1016/s0959-440x(05)80150-2
31 https://doi.org/10.1016/s0968-0004(02)02089-3
32 https://doi.org/10.1073/pnas.1617705114
33 https://doi.org/10.1083/jcb.103.6.2619
34 https://doi.org/10.1083/jcb.105.5.1999
35 https://doi.org/10.1083/jcb.108.2.389
36 https://doi.org/10.1083/jcb.200104085
37 https://doi.org/10.1083/jcb.201309096
38 https://doi.org/10.1083/jcb.201604128
39 https://doi.org/10.1083/jcb.84.3.560
40 https://doi.org/10.1083/jcb.96.1.51
41 https://doi.org/10.1091/mbc.e02-06-0353
42 https://doi.org/10.1091/mbc.e14-06-1154
43 https://doi.org/10.1091/mbc.e16-04-0213
44 https://doi.org/10.1103/physreve.94.062404
45 https://doi.org/10.1109/tmi.2014.2359541
46 https://doi.org/10.1111/j.1600-0854.2011.01197.x
47 https://doi.org/10.1111/j.1600-0854.2011.01241.x
48 https://doi.org/10.1111/tra.12335
49 https://doi.org/10.1126/science.aaa9555
50 https://doi.org/10.1126/science.aab3500
51 https://doi.org/10.1371/journal.pbio.1000191
52 https://doi.org/10.1371/journal.pbio.1000604
53 https://doi.org/10.1371/journal.pbio.1001670
54 https://doi.org/10.1371/journal.ppat.1000394
55 https://doi.org/10.1529/biophysj.107.117234
56 https://doi.org/10.7554/elife.04137
57 schema:datePublished 2018-12
58 schema:datePublishedReg 2018-12-01
59 schema:description Although essential for many cellular processes, the sequence of structural and molecular events during clathrin-mediated endocytosis remains elusive. While it was long believed that clathrin-coated pits grow with a constant curvature, it was recently suggested that clathrin first assembles to form flat structures that then bend while maintaining a constant surface area. Here, we combine correlative electron and light microscopy and mathematical growth laws to study the ultrastructural rearrangements of the clathrin coat during endocytosis in BSC-1 mammalian cells. We confirm that clathrin coats initially grow flat and demonstrate that curvature begins when around 70% of the final clathrin content is acquired. We find that this transition is marked by a change in the clathrin to clathrin-adaptor protein AP2 ratio and that membrane tension suppresses this transition. Our results support the notion that BSC-1 mammalian cells dynamically regulate the flat-to-curved transition in clathrin-mediated endocytosis by both biochemical and mechanical factors.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree true
63 schema:isPartOf N92848bb2e85c49099cdcec7dc48c28ac
64 Neafbf9dafd344b1aa9a909fa81ef69a2
65 sg:journal.1043282
66 schema:name Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis
67 schema:pagination 1109
68 schema:productId N594c276f9178405d8e07cb412f793654
69 Na15bcd79795b4dd7853ce9a48d06035c
70 Nd774a9f8e26a4b0092467b5a07252e8a
71 Ndd3e9932c3d34ba8a385fd8d75fa6aa0
72 Ne8e4f9ec58024695ac77ca0e5c89d8eb
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101554671
74 https://doi.org/10.1038/s41467-018-03533-0
75 schema:sdDatePublished 2019-04-11T12:24
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N9b254c6f05624ca2942987c23489aca9
78 schema:url https://www.nature.com/articles/s41467-018-03533-0
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N183df5e12048477395e6b6e5c023a82c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Coated Pits, Cell-Membrane
84 rdf:type schema:DefinedTerm
85 N21af0fa7af894690b0a4b7819a8b57ec rdf:first sg:person.01013741744.01
86 rdf:rest Ne6d5aa59d493438e8a352be50ffa4313
87 N23d0ca5f89ec4a79bed93ffc983f9038 rdf:first sg:person.011334154731.70
88 rdf:rest N5131320a02d14e1fa4a7ddb58f2b1d8d
89 N28b5b2ba7d1e460abf30574a087fbb8f rdf:first sg:person.01272115724.55
90 rdf:rest Ne6743963afe74d47ab75246e57aa85d3
91 N2d3620fff53f466689495a6122f40094 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Cercopithecus aethiops
93 rdf:type schema:DefinedTerm
94 N36891e0296d94184862dbbadb33be1ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Osmotic Pressure
96 rdf:type schema:DefinedTerm
97 N4c5eb5ad06b54882aedd1f275a185520 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Cell Line
99 rdf:type schema:DefinedTerm
100 N5131320a02d14e1fa4a7ddb58f2b1d8d rdf:first sg:person.01204617105.52
101 rdf:rest N28b5b2ba7d1e460abf30574a087fbb8f
102 N594c276f9178405d8e07cb412f793654 schema:name dimensions_id
103 schema:value pub.1101554671
104 rdf:type schema:PropertyValue
105 N84fbc85b161e49c79ec37bd750c87837 rdf:first sg:person.0731120455.54
106 rdf:rest Na073c23bac9f414eb88fd867dde7d490
107 N8e2506017abe4a8ab33e04c8bdaa5d5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Microscopy, Electron, Transmission
109 rdf:type schema:DefinedTerm
110 N8f915db3d2624af1bd9749eeeca24b0b rdf:first sg:person.013366173301.25
111 rdf:rest N23d0ca5f89ec4a79bed93ffc983f9038
112 N91bc2f9af17f45d484308e4fa0f7d269 rdf:first sg:person.01132565671.14
113 rdf:rest rdf:nil
114 N92848bb2e85c49099cdcec7dc48c28ac schema:volumeNumber 9
115 rdf:type schema:PublicationVolume
116 N9b254c6f05624ca2942987c23489aca9 schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 Na073c23bac9f414eb88fd867dde7d490 rdf:first sg:person.01214674260.82
119 rdf:rest N21af0fa7af894690b0a4b7819a8b57ec
120 Na15bcd79795b4dd7853ce9a48d06035c schema:name pubmed_id
121 schema:value 29549258
122 rdf:type schema:PropertyValue
123 Na894cdc4ea774fe388f8b4c2e5f2dcf3 rdf:first sg:person.01164774543.09
124 rdf:rest N84fbc85b161e49c79ec37bd750c87837
125 Nbe910f6c1bc94db793344ba84fef561e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Endocytosis
127 rdf:type schema:DefinedTerm
128 Nc0d072b5c7224d99954ad8cf0999bb27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Clathrin
130 rdf:type schema:DefinedTerm
131 Ncb239b2ad3d2400f87d03822d5ac846d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Animals
133 rdf:type schema:DefinedTerm
134 Nd774a9f8e26a4b0092467b5a07252e8a schema:name doi
135 schema:value 10.1038/s41467-018-03533-0
136 rdf:type schema:PropertyValue
137 Ndd3e9932c3d34ba8a385fd8d75fa6aa0 schema:name readcube_id
138 schema:value cb56daad14fa03f71f767f734934039149bdeb62b7d8b3195d64494b2311c9fc
139 rdf:type schema:PropertyValue
140 Ne6743963afe74d47ab75246e57aa85d3 rdf:first sg:person.01336253175.23
141 rdf:rest Na894cdc4ea774fe388f8b4c2e5f2dcf3
142 Ne6d5aa59d493438e8a352be50ffa4313 rdf:first sg:person.0710447535.35
143 rdf:rest N91bc2f9af17f45d484308e4fa0f7d269
144 Ne8e4f9ec58024695ac77ca0e5c89d8eb schema:name nlm_unique_id
145 schema:value 101528555
146 rdf:type schema:PropertyValue
147 Neafbf9dafd344b1aa9a909fa81ef69a2 schema:issueNumber 1
148 rdf:type schema:PublicationIssue
149 Nf1dfa55493904eb9bebfd20cfdd41aaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Fatty Acid-Binding Proteins
151 rdf:type schema:DefinedTerm
152 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
153 schema:name Biological Sciences
154 rdf:type schema:DefinedTerm
155 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
156 schema:name Biochemistry and Cell Biology
157 rdf:type schema:DefinedTerm
158 sg:grant.2725953 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-03533-0
159 rdf:type schema:MonetaryGrant
160 sg:journal.1043282 schema:issn 2041-1723
161 schema:name Nature Communications
162 rdf:type schema:Periodical
163 sg:person.01013741744.01 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
164 schema:familyName Taraska
165 schema:givenName Justin W.
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013741744.01
167 rdf:type schema:Person
168 sg:person.01132565671.14 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
169 schema:familyName Boulant
170 schema:givenName Steeve
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132565671.14
172 rdf:type schema:Person
173 sg:person.011334154731.70 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
174 schema:familyName Frey
175 schema:givenName Felix
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011334154731.70
177 rdf:type schema:Person
178 sg:person.01164774543.09 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
179 schema:familyName Godinez
180 schema:givenName William J.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164774543.09
182 rdf:type schema:Person
183 sg:person.01204617105.52 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
184 schema:familyName Sochacki
185 schema:givenName Kem A.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204617105.52
187 rdf:type schema:Person
188 sg:person.01214674260.82 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
189 schema:familyName Rohr
190 schema:givenName Karl
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214674260.82
192 rdf:type schema:Person
193 sg:person.01272115724.55 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
194 schema:familyName Kummer
195 schema:givenName Susann
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272115724.55
197 rdf:type schema:Person
198 sg:person.01336253175.23 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
199 schema:familyName Bergeest
200 schema:givenName Jan-Philip
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336253175.23
202 rdf:type schema:Person
203 sg:person.013366173301.25 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
204 schema:familyName Bucher
205 schema:givenName Delia
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013366173301.25
207 rdf:type schema:Person
208 sg:person.0710447535.35 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
209 schema:familyName Schwarz
210 schema:givenName Ulrich S.
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710447535.35
212 rdf:type schema:Person
213 sg:person.0731120455.54 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
214 schema:familyName Kräusslich
215 schema:givenName Hans-Georg
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731120455.54
217 rdf:type schema:Person
218 sg:pub.10.1007/s00018-011-0768-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004487398
219 https://doi.org/10.1007/s00018-011-0768-5
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/ncb2307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046485018
222 https://doi.org/10.1038/ncb2307
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/ncb2561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014109210
225 https://doi.org/10.1038/ncb2561
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/ncb3498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128698
228 https://doi.org/10.1038/ncb3498
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/ncomms7249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016803865
231 https://doi.org/10.1038/ncomms7249
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/nmeth.2816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048345698
234 https://doi.org/10.1038/nmeth.2816
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/nrm3151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038900325
237 https://doi.org/10.1038/nrm3151
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/nrm3266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009695629
240 https://doi.org/10.1038/nrm3266
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1002/j.1460-2075.1984.tb02075.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1081589969
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/0092-8674(81)90439-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025491785
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.cell.2004.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036315073
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.cell.2005.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025861135
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.devcel.2015.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037083526
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.jsb.2016.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031534894
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.tcb.2009.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014473408
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.tibs.2012.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015157526
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.yexcr.2006.09.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009989321
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/s0959-440x(05)80150-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011469268
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/s0968-0004(02)02089-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013525450
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1073/pnas.1617705114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074240385
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1083/jcb.103.6.2619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021683281
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1083/jcb.105.5.1999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008373797
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1083/jcb.108.2.389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014749020
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1083/jcb.200104085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020241597
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1083/jcb.201309096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045678671
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1083/jcb.201604128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005853472
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1083/jcb.84.3.560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049400101
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1083/jcb.96.1.51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023603013
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1091/mbc.e02-06-0353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025419866
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1091/mbc.e14-06-1154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032154360
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1091/mbc.e16-04-0213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084177624
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1103/physreve.94.062404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060751051
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1109/tmi.2014.2359541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061696393
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1111/j.1600-0854.2011.01197.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006390824
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1111/j.1600-0854.2011.01241.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050016184
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1111/tra.12335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049917767
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1126/science.aaa9555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029626378
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1126/science.aab3500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051440627
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1371/journal.pbio.1000191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023755227
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1371/journal.pbio.1000604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045103336
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1371/journal.pbio.1001670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028478724
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1371/journal.ppat.1000394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049063891
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1529/biophysj.107.117234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021431298
311 rdf:type schema:CreativeWork
312 https://doi.org/10.7554/elife.04137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052189515
313 rdf:type schema:CreativeWork
314 https://www.grid.ac/institutes/grid.279885.9 schema:alternateName National Heart Lung and Blood Institute
315 schema:name National Heart Lung and Blood Institute, National Institutes of Health, 20892, Bethesda, MD, USA
316 rdf:type schema:Organization
317 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
318 schema:name Department of Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany
319 rdf:type schema:Organization
320 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
321 schema:name Department of Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany
322 German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.7700.0 schema:alternateName Heidelberg University
325 schema:name BioQuant Center, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany
326 German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
327 Institute for Theoretical Physics, Heidelberg University, Philosophenweg 19, 69120, Heidelberg, Germany
328 Institute of Pharmacy and Molecular Biotechnology (IPMB), Department of Bioinformatics and Functional Genomics, Heidelberg University, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany
329 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...