Genetic study links components of the autonomous nervous system to heart-rate profile during exercise View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Niek Verweij, Yordi J. van de Vegte, Pim van der Harst

ABSTRACT

Heart rate (HR) responds to exercise by increasing during exercise and recovering after exercise. As such, HR is an important predictor of mortality that researchers believe is modulated by the autonomic nervous system. However, the mechanistic basis underlying inter-individual differences has yet to be explained. Here, we perform a large-scale genome-wide analysis of HR increase and HR recovery in 58,818 UK Biobank individuals. Twenty-five independent SNPs in 23 loci are identified to be associated (p < 8.3 × 10-9) with HR increase or HR recovery. A total of 36 candidate causal genes are prioritized that are enriched for pathways related to neuron biology. No evidence is found of a causal relationship with mortality or cardiovascular diseases. However, a nominal association with parental lifespan requires further study. In conclusion, the findings provide new biological and clinical insight into the mechanistic underpinnings of HR response to exercise. The results also underscore the role of the autonomous nervous system in HR recovery. More... »

PAGES

898

References to SciGraph publications

  • 2011-10. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk in NATURE
  • 2012-12. Seventy-five genetic loci influencing the human red blood cell in NATURE
  • 2017-01. Disease variants alter transcription factor levels and methylation of their binding sites in NATURE GENETICS
  • 2011-12. Linking neurodevelopmental and synaptic theories of mental illness through DISC1 in NATURE REVIEWS NEUROSCIENCE
  • 2015-02. Gene expression analysis identifies global gene dosage sensitivity in cancer in NATURE GENETICS
  • 2015-03. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies in NATURE GENETICS
  • 2016-12. Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality in NATURE GENETICS
  • 2015-12. Biological interpretation of genome-wide association studies using predicted gene functions in NATURE COMMUNICATIONS
  • 2016-12. Heritability of heart rate recovery and vagal rebound after exercise in EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
  • 2013-06. Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders in NATURE GENETICS
  • 2017-12. Identification of 15 novel risk loci for coronary artery disease and genetic risk of recurrent events, atrial fibrillation and heart failure in SCIENTIFIC REPORTS
  • 2013-10. Systematic identification of trans eQTLs as putative drivers of known disease associations in NATURE GENETICS
  • 2013-06. The Genotype-Tissue Expression (GTEx) project in NATURE GENETICS
  • 2015-12. Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis in NATURE GENETICS
  • 2015-03. Efficient Bayesian mixed-model analysis increases association power in large cohorts in NATURE GENETICS
  • 2012-03. Genome-wide association study identifies multiple loci influencing human serum metabolite levels in NATURE GENETICS
  • 2013-12. Altered cardiac autonomic nervous function in depression in BMC PSYCHIATRY
  • 2017-06-14. Genetic loci associated with heart rate variability and their effects on cardiac disease risk in NATURE COMMUNICATIONS
  • 2017-01. Identification of context-dependent expression quantitative trait loci in whole blood in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-03395-6

    DOI

    http://dx.doi.org/10.1038/s41467-018-03395-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101201643

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29497042


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Autonomic Nervous System", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "European Continental Ancestry Group", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Exercise", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetics, Population", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome-Wide Association Study", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "United Kingdom", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University Medical Center Groningen", 
              "id": "https://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "University of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Verweij", 
            "givenName": "Niek", 
            "id": "sg:person.01302157177.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302157177.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Medical Center Groningen", 
              "id": "https://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "University of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van de Vegte", 
            "givenName": "Yordi J.", 
            "id": "sg:person.011565233274.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011565233274.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Netherlands Heart Institute", 
              "id": "https://www.grid.ac/institutes/grid.411737.7", 
              "name": [
                "University of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB, Groningen, The Netherlands", 
                "University of Groningen, University Medical Center Groningen, Department of Genetics, 9700 RB, Groningen, The Netherlands", 
                "Durrer Center for Cardiogenetic Research, ICIN - Netherlands Heart Institute, 3511GC, Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van der Harst", 
            "givenName": "Pim", 
            "id": "sg:person.0742714555.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742714555.32"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature10405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000059117", 
              "https://doi.org/10.1038/nature10405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11677", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001826873", 
              "https://doi.org/10.1038/nature11677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006502664", 
              "https://doi.org/10.1038/ng.2610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006502664", 
              "https://doi.org/10.1038/ng.2610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mayocp.2016.08.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006771811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3737", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007293699", 
              "https://doi.org/10.1038/ng.3737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199910283411804", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008202023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2010.12.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012365897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2756", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014945864", 
              "https://doi.org/10.1038/ng.2756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015010011", 
              "https://doi.org/10.1038/ng.3708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00421-016-3459-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015738335", 
              "https://doi.org/10.1007/s00421-016-3459-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00421-016-3459-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015738335", 
              "https://doi.org/10.1007/s00421-016-3459-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.10.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016584396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa043012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016624718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa043012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016624718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2016.07.729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018686465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/expphysiol.2009.047548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019842463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms6890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022399023", 
              "https://doi.org/10.1038/ncomms6890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/humu.22636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023111650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.114.302589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023237276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.114.302589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023237276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ahj.2005.09.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023674795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0021310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025191038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3721", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025378212", 
              "https://doi.org/10.1038/ng.3721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m116.742163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026950364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.1073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027410569", 
              "https://doi.org/10.1038/ng.1073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/aging.100930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029129417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-244x-13-187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029635855", 
              "https://doi.org/10.1186/1471-244x-13-187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-244x-13-187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029635855", 
              "https://doi.org/10.1186/1471-244x-13-187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.110.940577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029917078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/mcp.m113.031716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030103555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/hrt.2004.058073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030305922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031787995", 
              "https://doi.org/10.1038/ng.3431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032112039", 
              "https://doi.org/10.1038/ng.3173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032444369", 
              "https://doi.org/10.1038/ng.2653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.51.2.363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033619578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.1001779", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033632930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.00179.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034896388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddw058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036290545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddw058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036290545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(97)11144-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037817965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejheart.2007.11.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038104967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0735-1097(94)90150-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038300404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijcard.2016.06.149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041447145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041665159", 
              "https://doi.org/10.1038/ng.3190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn3120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041723266", 
              "https://doi.org/10.1038/nrn3120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044444076", 
              "https://doi.org/10.1038/ng.3211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(02)08525-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045092272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyt179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045144996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopsycho.2015.03.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047779384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.116.308577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048512048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.116.308577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048512048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jeb.110080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049232223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btw373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050018081"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2027-15.2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051035981"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/01621459.1993.10594321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058304562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/jbhi.2016.2631247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061277329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aad6970", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062667062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.93.5.1043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063337007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2307/2290724", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069863841"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074556911", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077369438", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.116.025312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083524039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.116.025312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083524039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddx043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083685852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.parkreldis.2017.03.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084100891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.26355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085061166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/jaha.117.005505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085376913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-03062-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085774697", 
              "https://doi.org/10.1038/s41598-017-03062-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btx359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085795396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms15805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086029538", 
              "https://doi.org/10.1038/ncomms15805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejmg.2017.06.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086116340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/166298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091921134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/166298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091921134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/166298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091921134"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "Heart rate (HR) responds to exercise by increasing during exercise and recovering after exercise. As such, HR is an important predictor of mortality that researchers believe is modulated by the autonomic nervous system. However, the mechanistic basis underlying inter-individual differences has yet to be explained. Here, we perform a large-scale genome-wide analysis of HR increase and HR recovery in 58,818 UK Biobank individuals. Twenty-five independent SNPs in 23 loci are identified to be associated (p\u2009<\u20098.3\u2009\u00d7\u200910-9) with HR increase or HR recovery. A total of 36 candidate causal genes are prioritized that are enriched for pathways related to neuron biology. No evidence is found of a causal relationship with mortality or cardiovascular diseases. However, a nominal association with parental lifespan requires further study. In conclusion, the findings provide new biological and clinical insight into the mechanistic underpinnings of HR response to exercise. The results also underscore the role of the autonomous nervous system in HR recovery.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41467-018-03395-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2786773", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Genetic study links components of the autonomous nervous system to heart-rate profile during exercise", 
        "pagination": "898", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d5894184175132198fe0df2f00fd6bc0916c60d0b03709d02c31ad71074361d3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29497042"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101528555"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-018-03395-6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1101201643"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-018-03395-6", 
          "https://app.dimensions.ai/details/publication/pub.1101201643"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:18", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78950_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41467-018-03395-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-03395-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-03395-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-03395-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-018-03395-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    361 TRIPLES      21 PREDICATES      109 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-018-03395-6 schema:about N10a440f2aa864a3b809b3219c193baa8
    2 N20970e7570954964a9a4030cc1e19614
    3 N306f86efc0a1474fae44a1c6bb754b01
    4 N4eb1e16989d848bf9a3d8d768705d1e1
    5 N6b1abc632098451293428d709fa8fe51
    6 N7c2e3e29b2cf4149a2cd1b3c12c2c31f
    7 N8eb709df53564abcad160c13224f58af
    8 Na4543cbdee924c40a0c88409359978d2
    9 Nbf1ab35edebc4d089954bec4bcd90fcc
    10 Nd3d29b2e0c3e4fc4935784e8b661df42
    11 Ne1a6f3a954c54988a5ec52e1b4918838
    12 Ne77ecec8e4914c24ba5795c96fccf0ef
    13 Ne8a4084662444226ad6b052fb27e2cc7
    14 Nfbe282079e42479aa3d074cdb332b919
    15 Nfcb1c69a85e94f11bf883247ad2bee39
    16 anzsrc-for:06
    17 anzsrc-for:0604
    18 schema:author N01a4a3d88a52405e9a8daabf2986e372
    19 schema:citation sg:pub.10.1007/s00421-016-3459-y
    20 sg:pub.10.1038/nature10405
    21 sg:pub.10.1038/nature11677
    22 sg:pub.10.1038/ncomms15805
    23 sg:pub.10.1038/ncomms6890
    24 sg:pub.10.1038/ng.1073
    25 sg:pub.10.1038/ng.2610
    26 sg:pub.10.1038/ng.2653
    27 sg:pub.10.1038/ng.2756
    28 sg:pub.10.1038/ng.3173
    29 sg:pub.10.1038/ng.3190
    30 sg:pub.10.1038/ng.3211
    31 sg:pub.10.1038/ng.3431
    32 sg:pub.10.1038/ng.3708
    33 sg:pub.10.1038/ng.3721
    34 sg:pub.10.1038/ng.3737
    35 sg:pub.10.1038/nrn3120
    36 sg:pub.10.1038/s41598-017-03062-8
    37 sg:pub.10.1186/1471-244x-13-187
    38 https://app.dimensions.ai/details/publication/pub.1074556911
    39 https://app.dimensions.ai/details/publication/pub.1077369438
    40 https://doi.org/10.1002/humu.22636
    41 https://doi.org/10.1016/0735-1097(94)90150-3
    42 https://doi.org/10.1016/j.ahj.2005.09.012
    43 https://doi.org/10.1016/j.biopsycho.2015.03.006
    44 https://doi.org/10.1016/j.cell.2008.10.015
    45 https://doi.org/10.1016/j.ejheart.2007.11.006
    46 https://doi.org/10.1016/j.ejmg.2017.06.004
    47 https://doi.org/10.1016/j.ijcard.2016.06.149
    48 https://doi.org/10.1016/j.jacc.2016.07.729
    49 https://doi.org/10.1016/j.mayocp.2016.08.012
    50 https://doi.org/10.1016/j.parkreldis.2017.03.014
    51 https://doi.org/10.1016/j.tins.2010.12.002
    52 https://doi.org/10.1016/s0140-6736(02)08525-2
    53 https://doi.org/10.1016/s0140-6736(97)11144-8
    54 https://doi.org/10.1056/nejm199910283411804
    55 https://doi.org/10.1056/nejmoa043012
    56 https://doi.org/10.1074/jbc.m116.742163
    57 https://doi.org/10.1074/mcp.m113.031716
    58 https://doi.org/10.1080/01621459.1993.10594321
    59 https://doi.org/10.1093/bioinformatics/btw373
    60 https://doi.org/10.1093/bioinformatics/btx359
    61 https://doi.org/10.1093/hmg/ddw058
    62 https://doi.org/10.1093/hmg/ddx043
    63 https://doi.org/10.1093/ije/dyt179
    64 https://doi.org/10.1101/166298
    65 https://doi.org/10.1109/jbhi.2016.2631247
    66 https://doi.org/10.1113/expphysiol.2009.047548
    67 https://doi.org/10.1126/science.aad6970
    68 https://doi.org/10.1136/hrt.2004.058073
    69 https://doi.org/10.1152/ajpcell.00179.2003
    70 https://doi.org/10.1161/01.cir.51.2.363
    71 https://doi.org/10.1161/01.cir.93.5.1043
    72 https://doi.org/10.1161/circresaha.114.302589
    73 https://doi.org/10.1161/circresaha.116.308577
    74 https://doi.org/10.1161/circulationaha.110.940577
    75 https://doi.org/10.1161/circulationaha.116.025312
    76 https://doi.org/10.1161/jaha.117.005505
    77 https://doi.org/10.1242/jeb.110080
    78 https://doi.org/10.1371/journal.pmed.1001779
    79 https://doi.org/10.1371/journal.pone.0021310
    80 https://doi.org/10.1523/jneurosci.2027-15.2016
    81 https://doi.org/10.18632/aging.100930
    82 https://doi.org/10.2307/2290724
    83 https://doi.org/10.7554/elife.26355
    84 schema:datePublished 2018-12
    85 schema:datePublishedReg 2018-12-01
    86 schema:description Heart rate (HR) responds to exercise by increasing during exercise and recovering after exercise. As such, HR is an important predictor of mortality that researchers believe is modulated by the autonomic nervous system. However, the mechanistic basis underlying inter-individual differences has yet to be explained. Here, we perform a large-scale genome-wide analysis of HR increase and HR recovery in 58,818 UK Biobank individuals. Twenty-five independent SNPs in 23 loci are identified to be associated (p &lt; 8.3 × 10<sup>-9</sup>) with HR increase or HR recovery. A total of 36 candidate causal genes are prioritized that are enriched for pathways related to neuron biology. No evidence is found of a causal relationship with mortality or cardiovascular diseases. However, a nominal association with parental lifespan requires further study. In conclusion, the findings provide new biological and clinical insight into the mechanistic underpinnings of HR response to exercise. The results also underscore the role of the autonomous nervous system in HR recovery.
    87 schema:genre research_article
    88 schema:inLanguage en
    89 schema:isAccessibleForFree true
    90 schema:isPartOf N82307e8b2d7f4a3fb95e96bbf9e03c1b
    91 N86991145e1c946739d5b606b15044c1c
    92 sg:journal.1043282
    93 schema:name Genetic study links components of the autonomous nervous system to heart-rate profile during exercise
    94 schema:pagination 898
    95 schema:productId N2361e0710b524632a903abf4e32e13fa
    96 N3e46d505dcd641e095ca153399203654
    97 N88196db4c35a463fa3c2f2c97906906d
    98 N9f94e5a902514bf0abb77d78caf43797
    99 Ne9f4cf97236949e88a6c06c64c6be5a5
    100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101201643
    101 https://doi.org/10.1038/s41467-018-03395-6
    102 schema:sdDatePublished 2019-04-11T13:18
    103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    104 schema:sdPublisher N1715e00ae791461691c1842489fca2b3
    105 schema:url https://www.nature.com/articles/s41467-018-03395-6
    106 sgo:license sg:explorer/license/
    107 sgo:sdDataset articles
    108 rdf:type schema:ScholarlyArticle
    109 N01a4a3d88a52405e9a8daabf2986e372 rdf:first sg:person.01302157177.43
    110 rdf:rest N7c5f4384ee434a3aa6f9941045e53f34
    111 N10a440f2aa864a3b809b3219c193baa8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Adult
    113 rdf:type schema:DefinedTerm
    114 N1715e00ae791461691c1842489fca2b3 schema:name Springer Nature - SN SciGraph project
    115 rdf:type schema:Organization
    116 N20970e7570954964a9a4030cc1e19614 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Exercise
    118 rdf:type schema:DefinedTerm
    119 N2361e0710b524632a903abf4e32e13fa schema:name dimensions_id
    120 schema:value pub.1101201643
    121 rdf:type schema:PropertyValue
    122 N306f86efc0a1474fae44a1c6bb754b01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Humans
    124 rdf:type schema:DefinedTerm
    125 N3e46d505dcd641e095ca153399203654 schema:name readcube_id
    126 schema:value d5894184175132198fe0df2f00fd6bc0916c60d0b03709d02c31ad71074361d3
    127 rdf:type schema:PropertyValue
    128 N4eb1e16989d848bf9a3d8d768705d1e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Heart Diseases
    130 rdf:type schema:DefinedTerm
    131 N653bbd0dc2f241e78d1ec80d8c60b9c8 rdf:first sg:person.0742714555.32
    132 rdf:rest rdf:nil
    133 N6b1abc632098451293428d709fa8fe51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name United Kingdom
    135 rdf:type schema:DefinedTerm
    136 N7c2e3e29b2cf4149a2cd1b3c12c2c31f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name European Continental Ancestry Group
    138 rdf:type schema:DefinedTerm
    139 N7c5f4384ee434a3aa6f9941045e53f34 rdf:first sg:person.011565233274.45
    140 rdf:rest N653bbd0dc2f241e78d1ec80d8c60b9c8
    141 N82307e8b2d7f4a3fb95e96bbf9e03c1b schema:volumeNumber 9
    142 rdf:type schema:PublicationVolume
    143 N86991145e1c946739d5b606b15044c1c schema:issueNumber 1
    144 rdf:type schema:PublicationIssue
    145 N88196db4c35a463fa3c2f2c97906906d schema:name pubmed_id
    146 schema:value 29497042
    147 rdf:type schema:PropertyValue
    148 N8eb709df53564abcad160c13224f58af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Aged
    150 rdf:type schema:DefinedTerm
    151 N9f94e5a902514bf0abb77d78caf43797 schema:name doi
    152 schema:value 10.1038/s41467-018-03395-6
    153 rdf:type schema:PropertyValue
    154 Na4543cbdee924c40a0c88409359978d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Male
    156 rdf:type schema:DefinedTerm
    157 Nbf1ab35edebc4d089954bec4bcd90fcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Heart Rate
    159 rdf:type schema:DefinedTerm
    160 Nd3d29b2e0c3e4fc4935784e8b661df42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Autonomic Nervous System
    162 rdf:type schema:DefinedTerm
    163 Ne1a6f3a954c54988a5ec52e1b4918838 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Genetics, Population
    165 rdf:type schema:DefinedTerm
    166 Ne77ecec8e4914c24ba5795c96fccf0ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Genome-Wide Association Study
    168 rdf:type schema:DefinedTerm
    169 Ne8a4084662444226ad6b052fb27e2cc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Cohort Studies
    171 rdf:type schema:DefinedTerm
    172 Ne9f4cf97236949e88a6c06c64c6be5a5 schema:name nlm_unique_id
    173 schema:value 101528555
    174 rdf:type schema:PropertyValue
    175 Nfbe282079e42479aa3d074cdb332b919 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Female
    177 rdf:type schema:DefinedTerm
    178 Nfcb1c69a85e94f11bf883247ad2bee39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Middle Aged
    180 rdf:type schema:DefinedTerm
    181 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    182 schema:name Biological Sciences
    183 rdf:type schema:DefinedTerm
    184 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    185 schema:name Genetics
    186 rdf:type schema:DefinedTerm
    187 sg:grant.2786773 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-018-03395-6
    188 rdf:type schema:MonetaryGrant
    189 sg:journal.1043282 schema:issn 2041-1723
    190 schema:name Nature Communications
    191 rdf:type schema:Periodical
    192 sg:person.011565233274.45 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
    193 schema:familyName van de Vegte
    194 schema:givenName Yordi J.
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011565233274.45
    196 rdf:type schema:Person
    197 sg:person.01302157177.43 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
    198 schema:familyName Verweij
    199 schema:givenName Niek
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302157177.43
    201 rdf:type schema:Person
    202 sg:person.0742714555.32 schema:affiliation https://www.grid.ac/institutes/grid.411737.7
    203 schema:familyName van der Harst
    204 schema:givenName Pim
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742714555.32
    206 rdf:type schema:Person
    207 sg:pub.10.1007/s00421-016-3459-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1015738335
    208 https://doi.org/10.1007/s00421-016-3459-y
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/nature10405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000059117
    211 https://doi.org/10.1038/nature10405
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/nature11677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001826873
    214 https://doi.org/10.1038/nature11677
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/ncomms15805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086029538
    217 https://doi.org/10.1038/ncomms15805
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/ncomms6890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022399023
    220 https://doi.org/10.1038/ncomms6890
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/ng.1073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027410569
    223 https://doi.org/10.1038/ng.1073
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/ng.2610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006502664
    226 https://doi.org/10.1038/ng.2610
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/ng.2653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032444369
    229 https://doi.org/10.1038/ng.2653
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/ng.2756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014945864
    232 https://doi.org/10.1038/ng.2756
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/ng.3173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032112039
    235 https://doi.org/10.1038/ng.3173
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/ng.3190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041665159
    238 https://doi.org/10.1038/ng.3190
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/ng.3211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044444076
    241 https://doi.org/10.1038/ng.3211
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/ng.3431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031787995
    244 https://doi.org/10.1038/ng.3431
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/ng.3708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015010011
    247 https://doi.org/10.1038/ng.3708
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/ng.3721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025378212
    250 https://doi.org/10.1038/ng.3721
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/ng.3737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007293699
    253 https://doi.org/10.1038/ng.3737
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/nrn3120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041723266
    256 https://doi.org/10.1038/nrn3120
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/s41598-017-03062-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085774697
    259 https://doi.org/10.1038/s41598-017-03062-8
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1186/1471-244x-13-187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029635855
    262 https://doi.org/10.1186/1471-244x-13-187
    263 rdf:type schema:CreativeWork
    264 https://app.dimensions.ai/details/publication/pub.1074556911 schema:CreativeWork
    265 https://app.dimensions.ai/details/publication/pub.1077369438 schema:CreativeWork
    266 https://doi.org/10.1002/humu.22636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023111650
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/0735-1097(94)90150-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038300404
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/j.ahj.2005.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023674795
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.biopsycho.2015.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047779384
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.cell.2008.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016584396
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.ejheart.2007.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038104967
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.ejmg.2017.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086116340
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.ijcard.2016.06.149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041447145
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.jacc.2016.07.729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018686465
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.mayocp.2016.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006771811
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.parkreldis.2017.03.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084100891
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.tins.2010.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012365897
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/s0140-6736(02)08525-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045092272
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/s0140-6736(97)11144-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037817965
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1056/nejm199910283411804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008202023
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1056/nejmoa043012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016624718
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1074/jbc.m116.742163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026950364
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1074/mcp.m113.031716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030103555
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1080/01621459.1993.10594321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058304562
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1093/bioinformatics/btw373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050018081
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1093/bioinformatics/btx359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085795396
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1093/hmg/ddw058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036290545
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1093/hmg/ddx043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083685852
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1093/ije/dyt179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045144996
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1101/166298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091921134
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1109/jbhi.2016.2631247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061277329
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1113/expphysiol.2009.047548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019842463
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1126/science.aad6970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062667062
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1136/hrt.2004.058073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030305922
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1152/ajpcell.00179.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034896388
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1161/01.cir.51.2.363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033619578
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1161/01.cir.93.5.1043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063337007
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1161/circresaha.114.302589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023237276
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1161/circresaha.116.308577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048512048
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1161/circulationaha.110.940577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029917078
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1161/circulationaha.116.025312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083524039
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1161/jaha.117.005505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085376913
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1242/jeb.110080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049232223
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1371/journal.pmed.1001779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033632930
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1371/journal.pone.0021310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025191038
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1523/jneurosci.2027-15.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051035981
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.18632/aging.100930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029129417
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.2307/2290724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069863841
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.7554/elife.26355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085061166
    353 rdf:type schema:CreativeWork
    354 https://www.grid.ac/institutes/grid.411737.7 schema:alternateName Netherlands Heart Institute
    355 schema:name Durrer Center for Cardiogenetic Research, ICIN - Netherlands Heart Institute, 3511GC, Utrecht, The Netherlands
    356 University of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB, Groningen, The Netherlands
    357 University of Groningen, University Medical Center Groningen, Department of Genetics, 9700 RB, Groningen, The Netherlands
    358 rdf:type schema:Organization
    359 https://www.grid.ac/institutes/grid.4494.d schema:alternateName University Medical Center Groningen
    360 schema:name University of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB, Groningen, The Netherlands
    361 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...