A regulatory circuit of two lncRNAs and a master regulator directs cell fate in yeast View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Fabien Moretto, N. Ezgi Wood, Gavin Kelly, Andreas Doncic, Folkert J. van Werven

ABSTRACT

Transcription of long noncoding RNAs (lncRNAs) regulates local gene expression in eukaryotes. Many examples of how a single lncRNA controls the expression of an adjacent or nearby protein-coding gene have been described. Here we examine the regulation of a locus consisting of two contiguous lncRNAs and the master regulator for entry into yeast meiosis, IME1. We find that the cluster of two lncRNAs together with several transcription factors form a regulatory circuit by which IME1 controls its own promoter and thereby promotes its own expression. Inhibition or stimulation of this unusual feedback circuit affects timing and rate of IME1 accumulation, and hence the ability for cells to enter meiosis. Our data demonstrate that orchestrated transcription through two contiguous lncRNAs promotes local gene expression and determines a critical cell fate decision. More... »

PAGES

780

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-03213-z

    DOI

    http://dx.doi.org/10.1038/s41467-018-03213-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101086631

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29472539


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