An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-02-22

AUTHORS

Federico Sabbadin, Glyn R. Hemsworth, Luisa Ciano, Bernard Henrissat, Paul Dupree, Theodora Tryfona, Rita D. S. Marques, Sean T. Sweeney, Katrin Besser, Luisa Elias, Giovanna Pesante, Yi Li, Adam A. Dowle, Rachel Bates, Leonardo D. Gomez, Rachael Simister, Gideon J. Davies, Paul H. Walton, Neil C. Bruce, Simon J. McQueen-Mason

ABSTRACT

Thermobia domestica belongs to an ancient group of insects and has a remarkable ability to digest crystalline cellulose without microbial assistance. By investigating the digestive proteome of Thermobia, we have identified over 20 members of an uncharacterized family of lytic polysaccharide monooxygenases (LPMOs). We show that this LPMO family spans across several clades of the Tree of Life, is of ancient origin, and was recruited by early arthropods with possible roles in remodeling endogenous chitin scaffolds during development and metamorphosis. Based on our in-depth characterization of Thermobia's LPMOs, we propose that diversification of these enzymes toward cellulose digestion might have endowed ancestral insects with an effective biochemical apparatus for biomass degradation, allowing the early colonization of land during the Paleozoic Era. The vital role of LPMOs in modern agricultural pests and disease vectors offers new opportunities to help tackle global challenges in food security and the control of infectious diseases. More... »

PAGES

756

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-018-03142-x

    DOI

    http://dx.doi.org/10.1038/s41467-018-03142-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101086623

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29472725


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