Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Rachel Fellows, Jérémy Denizot, Claudia Stellato, Alessandro Cuomo, Payal Jain, Elena Stoyanova, Szabina Balázsi, Zoltán Hajnády, Anke Liebert, Juri Kazakevych, Hector Blackburn, Renan Oliveira Corrêa, José Luís Fachi, Fabio Takeo Sato, Willian R. Ribeiro, Caroline Marcantonio Ferreira, Hélène Perée, Mariangela Spagnuolo, Raphaël Mattiuz, Csaba Matolcsi, Joana Guedes, Jonathan Clark, Marc Veldhoen, Tiziana Bonaldi, Marco Aurélio Ramirez Vinolo, Patrick Varga-Weisz

ABSTRACT

The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood. We characterize histone crotonylation in intestinal epithelia and find that histone H3 crotonylation at lysine 18 is a surprisingly abundant modification in the small intestine crypt and colon, and is linked to gene regulation. We show that this modification is highly dynamic and regulated during the cell cycle. We identify class I histone deacetylases, HDAC1, HDAC2, and HDAC3, as major executors of histone decrotonylation. We show that known HDAC inhibitors, including the gut microbiota-derived butyrate, affect histone decrotonylation. Consistent with this, we find that depletion of the gut microbiota leads to a global change in histone crotonylation in the colon. Our results suggest that histone crotonylation connects chromatin to the gut microbiota, at least in part, via short-chain fatty acids and HDACs. More... »

PAGES

105

References to SciGraph publications

  • 2017-07. Global profiling of crotonylation on non-histone proteins in CELL RESEARCH
  • 2009-10. Global Histone H4 Acetylation and HDAC2 Expression in Colon Adenoma and Carcinoma in DIGESTIVE DISEASES AND SCIENCES
  • 2011-07. SILAC-based proteomic analysis to dissect the “histone modification signature” of human breast cancer cells in AMINO ACIDS
  • 2001-02. Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases in NATURE CELL BIOLOGY
  • 2017-07. Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription in CELL RESEARCH
  • 2013-12. Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression in EPIGENETICS & CHROMATIN
  • 2016-10-27. The MaxQuant computational platform for mass spectrometry-based shotgun proteomics in NATURE PROTOCOLS
  • 2016-06. The Taf14 YEATS domain is a reader of histone crotonylation in NATURE CHEMICAL BIOLOGY
  • 2016-09. The Perseus computational platform for comprehensive analysis of (prote)omics data in NATURE METHODS
  • 2017. SILAC-Based Quantitative Strategies for Accurate Histone Posttranslational Modification Profiling Across Multiple Biological Samples in HISTONES
  • 2016-03. Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia in BRITISH JOURNAL OF CANCER
  • 2017-02. Metabolic regulation of gene expression through histone acylations in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2016-12. Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2 in NATURE CHEMICAL BIOLOGY
  • 2016-05. YEATS2 is a selective histone crotonylation reader in CELL RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-017-02651-5

    DOI

    http://dx.doi.org/10.1038/s41467-017-02651-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100179029

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29317660


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Acylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Cycle", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colon", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Crotonates", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fatty Acids, Volatile", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gastrointestinal Microbiome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HCT116 Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histone Deacetylase Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histone Deacetylases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histones", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intestinal Mucosa", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Processing, Post-Translational", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fellows", 
            "givenName": "Rachel", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Clermont Auvergne", 
              "id": "https://www.grid.ac/institutes/grid.494717.8", 
              "name": [
                "Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK", 
                "Universit\u00e9 Clermont Auvergne, Inserm U1071, INRA USC2018, M2iSH, F-63000, Clermont\u2013Ferrand, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Denizot", 
            "givenName": "J\u00e9r\u00e9my", 
            "id": "sg:person.014576132211.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014576132211.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stellato", 
            "givenName": "Claudia", 
            "id": "sg:person.0730314033.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730314033.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Institute of Oncology", 
              "id": "https://www.grid.ac/institutes/grid.15667.33", 
              "name": [
                "Department of Experimental Oncology, Istituto Europeo di Oncologia, 20139, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cuomo", 
            "givenName": "Alessandro", 
            "id": "sg:person.01322676206.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322676206.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jain", 
            "givenName": "Payal", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stoyanova", 
            "givenName": "Elena", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bal\u00e1zsi", 
            "givenName": "Szabina", 
            "id": "sg:person.016230733076.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016230733076.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hajn\u00e1dy", 
            "givenName": "Zolt\u00e1n", 
            "id": "sg:person.014063362571.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014063362571.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liebert", 
            "givenName": "Anke", 
            "id": "sg:person.01035515325.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035515325.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kazakevych", 
            "givenName": "Juri", 
            "id": "sg:person.016226144333.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016226144333.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blackburn", 
            "givenName": "Hector", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State University of Campinas", 
              "id": "https://www.grid.ac/institutes/grid.411087.b", 
              "name": [
                "Laboratory of Immunoinflammation, Institute of Biology, UNICAMP, 13083-862, Campinas, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Corr\u00eaa", 
            "givenName": "Renan Oliveira", 
            "id": "sg:person.014104377270.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014104377270.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State University of Campinas", 
              "id": "https://www.grid.ac/institutes/grid.411087.b", 
              "name": [
                "Laboratory of Immunoinflammation, Institute of Biology, UNICAMP, 13083-862, Campinas, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fachi", 
            "givenName": "Jos\u00e9 Lu\u00eds", 
            "id": "sg:person.0610771443.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610771443.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State University of Campinas", 
              "id": "https://www.grid.ac/institutes/grid.411087.b", 
              "name": [
                "Laboratory of Immunoinflammation, Institute of Biology, UNICAMP, 13083-862, Campinas, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sato", 
            "givenName": "Fabio Takeo", 
            "id": "sg:person.0654337411.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654337411.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Federal University of Sao Paulo", 
              "id": "https://www.grid.ac/institutes/grid.411249.b", 
              "name": [
                "Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de S\u00e3o Paulo, 09913-03, Diadema, SP, Brazil", 
                "Chemical Biology Graduate Program, Universidade Federal de S\u00e3o Paulo, 09913-03, Diadema, SP, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ribeiro", 
            "givenName": "Willian R.", 
            "id": "sg:person.01131725235.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131725235.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Federal University of Sao Paulo", 
              "id": "https://www.grid.ac/institutes/grid.411249.b", 
              "name": [
                "Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de S\u00e3o Paulo, 09913-03, Diadema, SP, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferreira", 
            "givenName": "Caroline Marcantonio", 
            "id": "sg:person.01351273542.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351273542.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Per\u00e9e", 
            "givenName": "H\u00e9l\u00e8ne", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Spagnuolo", 
            "givenName": "Mariangela", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mattiuz", 
            "givenName": "Rapha\u00ebl", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matolcsi", 
            "givenName": "Csaba", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Lymphocyte Signalling and Development, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guedes", 
            "givenName": "Joana", 
            "id": "sg:person.011347152270.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011347152270.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Babraham Institute", 
              "id": "https://www.grid.ac/institutes/grid.418195.0", 
              "name": [
                "Biological Chemistry, Babraham Institute, CB22 3AT, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Clark", 
            "givenName": "Jonathan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Lisbon", 
              "id": "https://www.grid.ac/institutes/grid.9983.b", 
              "name": [
                "Lymphocyte Signalling and Development, Babraham Institute, CB22 3AT, Cambridge, UK", 
                "Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649-028, Lisbon, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Veldhoen", 
            "givenName": "Marc", 
            "id": "sg:person.01142557251.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142557251.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Institute of Oncology", 
              "id": "https://www.grid.ac/institutes/grid.15667.33", 
              "name": [
                "Department of Experimental Oncology, Istituto Europeo di Oncologia, 20139, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bonaldi", 
            "givenName": "Tiziana", 
            "id": "sg:person.01225454106.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225454106.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State University of Campinas", 
              "id": "https://www.grid.ac/institutes/grid.411087.b", 
              "name": [
                "Laboratory of Immunoinflammation, Institute of Biology, UNICAMP, 13083-862, Campinas, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vinolo", 
            "givenName": "Marco Aur\u00e9lio Ramirez", 
            "id": "sg:person.012557172167.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012557172167.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Essex", 
              "id": "https://www.grid.ac/institutes/grid.8356.8", 
              "name": [
                "Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK", 
                "School of Biological Sciences, University of Essex, CO4 3SQ, Colchester, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Varga-Weisz", 
            "givenName": "Patrick", 
            "id": "sg:person.01070226471.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070226471.91"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1021/ac026117i", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000183287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac026117i", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000183287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.116.303936", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000286335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.116.303936", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000286335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.116.303936", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000286335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmc.2011.11.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000921953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.2065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001204414", 
              "https://doi.org/10.1038/nchembio.2065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2015.02.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002362071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2016.36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003603071", 
              "https://doi.org/10.1038/bjc.2016.36"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/nu7042839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007900393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.08.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009492522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm.2016.140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009727188", 
              "https://doi.org/10.1038/nrm.2016.140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(78)90305-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010035463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1234852", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010986971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2009.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013983423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.4.1237", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015308836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/27.9.2057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016307126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pmic.201400075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019717666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cb3001793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021289198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pmic.201400449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022979605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2016.05.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023287756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/mcp.m900489-mcp200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023704683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4939-6630-1_7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025224026", 
              "https://doi.org/10.1007/978-1-4939-6630-1_7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-010-0668-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025365710", 
              "https://doi.org/10.1007/s00726-010-0668-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-010-0668-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025365710", 
              "https://doi.org/10.1007/s00726-010-0668-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2016.03.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025835977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2016.03.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027761001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-5521(02)00305-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028266129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-5521(02)00305-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028266129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2011.02.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028381301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-8935-6-27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032233933", 
              "https://doi.org/10.1186/1756-8935-6-27"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032398342", 
              "https://doi.org/10.1038/nmeth.3901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/iai.01432-07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036060202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.24.8.3132-3139.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037028734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10620-008-0601-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037162226", 
              "https://doi.org/10.1007/s10620-008-0601-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2016.49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039060709", 
              "https://doi.org/10.1038/cr.2016.49"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.10.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042891274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2016.03.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043128799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/cdg315", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044213586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057111416004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044659057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057111416004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044659057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35055010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045406065", 
              "https://doi.org/10.1038/35055010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35055010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045406065", 
              "https://doi.org/10.1038/35055010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.01.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045543158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/mcp.m700021-mcp200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045553870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.147.6.1153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046825866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201203754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048786051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuint.2016.06.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049441059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2016.136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049695744", 
              "https://doi.org/10.1038/nprot.2016.136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbagrm.2011.07.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050048915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2016.10.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050660117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2016.10.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050660117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1535-6108(04)00114-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051297122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.2218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052104192", 
              "https://doi.org/10.1038/nchembio.2218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi0494471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055199751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi0494471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055199751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/cshperspect.a026831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060407218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2017.60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085001187", 
              "https://doi.org/10.1038/cr.2017.60"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2017.60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085001187", 
              "https://doi.org/10.1038/cr.2017.60"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2017.68", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085392521", 
              "https://doi.org/10.1038/cr.2017.68"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fmicb.2017.01732", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091537031"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood. We characterize histone crotonylation in intestinal epithelia and find that histone H3 crotonylation at lysine 18 is a surprisingly abundant modification in the small intestine crypt and colon, and is linked to gene regulation. We show that this modification is highly dynamic and regulated during the cell cycle. We identify class I histone deacetylases, HDAC1, HDAC2, and HDAC3, as major executors of histone decrotonylation. We show that known HDAC inhibitors, including the gut microbiota-derived butyrate, affect histone decrotonylation. Consistent with this, we find that depletion of the gut microbiota leads to a global change in histone crotonylation in the colon. Our results suggest that histone crotonylation connects chromatin to the gut microbiota, at least in part, via short-chain fatty acids and HDACs.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41467-017-02651-5", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2784635", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4604038", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2757947", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2768223", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4575830", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2753065", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4473475", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2765880", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7574453", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2756559", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5071453", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3864880", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases", 
        "pagination": "105", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "7adb7178efc4b99601a61655c2234d339fe12d88e5735d08ac376ef490515ace"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29317660"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101528555"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41467-017-02651-5"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1100179029"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41467-017-02651-5", 
          "https://app.dimensions.ai/details/publication/pub.1100179029"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78965_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41467-017-02651-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-02651-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-02651-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-02651-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-02651-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    513 TRIPLES      21 PREDICATES      96 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41467-017-02651-5 schema:about N0448f84d5b4d4373b6c05c0726f02249
    2 N07b41a86ddfa4572b49d9f0b93f71593
    3 N11438856484f4adfb36d5ff3bdcb3a12
    4 N2384cff0e61741fa87789ba6dac1cd83
    5 N2c3c9263ec2e438d8bae6399d9be7e89
    6 N415583c40db041a0a0516503ae1bc39f
    7 N41737ae426cf49c698862616a2bcae64
    8 N614ace47a2d743e2ac2649b2b788863c
    9 N65812151b0fe4b2b8a3ecc591920b913
    10 N67648a13c3b94ace9e76b7a57b7b8e57
    11 N6a305ece971b411f91424b6856ff2999
    12 N77475a474922466aa4b2b3383263f4d0
    13 N7f97eb5e4a724adaa3865925db7e049c
    14 N9ceb302a2a80499da3416c576467a1b1
    15 Nadc0dfc47d8842478d826df88998d632
    16 Nb11c9ea131794d1d98c577afce6d70fa
    17 anzsrc-for:06
    18 anzsrc-for:0601
    19 schema:author Ne43ca8889f314484b1d3a4a7d9e531bf
    20 schema:citation sg:pub.10.1007/978-1-4939-6630-1_7
    21 sg:pub.10.1007/s00726-010-0668-2
    22 sg:pub.10.1007/s10620-008-0601-7
    23 sg:pub.10.1038/35055010
    24 sg:pub.10.1038/bjc.2016.36
    25 sg:pub.10.1038/cr.2016.49
    26 sg:pub.10.1038/cr.2017.60
    27 sg:pub.10.1038/cr.2017.68
    28 sg:pub.10.1038/nchembio.2065
    29 sg:pub.10.1038/nchembio.2218
    30 sg:pub.10.1038/nmeth.3901
    31 sg:pub.10.1038/nprot.2016.136
    32 sg:pub.10.1038/nrm.2016.140
    33 sg:pub.10.1186/1756-8935-6-27
    34 https://doi.org/10.1002/anie.201203754
    35 https://doi.org/10.1002/pmic.201400075
    36 https://doi.org/10.1002/pmic.201400449
    37 https://doi.org/10.1016/0092-8674(78)90305-7
    38 https://doi.org/10.1016/j.bbagrm.2011.07.005
    39 https://doi.org/10.1016/j.bmc.2011.11.041
    40 https://doi.org/10.1016/j.canlet.2009.02.013
    41 https://doi.org/10.1016/j.ccr.2010.10.022
    42 https://doi.org/10.1016/j.cell.2011.08.008
    43 https://doi.org/10.1016/j.cell.2016.05.041
    44 https://doi.org/10.1016/j.cmet.2011.02.018
    45 https://doi.org/10.1016/j.molcel.2010.01.033
    46 https://doi.org/10.1016/j.molcel.2015.02.029
    47 https://doi.org/10.1016/j.molcel.2016.03.014
    48 https://doi.org/10.1016/j.molcel.2016.03.028
    49 https://doi.org/10.1016/j.molcel.2016.03.036
    50 https://doi.org/10.1016/j.molcel.2016.10.025
    51 https://doi.org/10.1016/j.neuint.2016.06.011
    52 https://doi.org/10.1016/s1074-5521(02)00305-8
    53 https://doi.org/10.1016/s1535-6108(04)00114-x
    54 https://doi.org/10.1021/ac026117i
    55 https://doi.org/10.1021/bi0494471
    56 https://doi.org/10.1021/cb3001793
    57 https://doi.org/10.1073/pnas.92.4.1237
    58 https://doi.org/10.1074/mcp.m700021-mcp200
    59 https://doi.org/10.1074/mcp.m900489-mcp200
    60 https://doi.org/10.1083/jcb.147.6.1153
    61 https://doi.org/10.1093/emboj/cdg315
    62 https://doi.org/10.1093/nar/27.9.2057
    63 https://doi.org/10.1101/cshperspect.a026831
    64 https://doi.org/10.1126/science.1234852
    65 https://doi.org/10.1128/iai.01432-07
    66 https://doi.org/10.1128/mcb.24.8.3132-3139.2004
    67 https://doi.org/10.1161/circresaha.116.303936
    68 https://doi.org/10.1177/1087057111416004
    69 https://doi.org/10.3389/fmicb.2017.01732
    70 https://doi.org/10.3390/nu7042839
    71 schema:datePublished 2018-12
    72 schema:datePublishedReg 2018-12-01
    73 schema:description The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood. We characterize histone crotonylation in intestinal epithelia and find that histone H3 crotonylation at lysine 18 is a surprisingly abundant modification in the small intestine crypt and colon, and is linked to gene regulation. We show that this modification is highly dynamic and regulated during the cell cycle. We identify class I histone deacetylases, HDAC1, HDAC2, and HDAC3, as major executors of histone decrotonylation. We show that known HDAC inhibitors, including the gut microbiota-derived butyrate, affect histone decrotonylation. Consistent with this, we find that depletion of the gut microbiota leads to a global change in histone crotonylation in the colon. Our results suggest that histone crotonylation connects chromatin to the gut microbiota, at least in part, via short-chain fatty acids and HDACs.
    74 schema:genre research_article
    75 schema:inLanguage en
    76 schema:isAccessibleForFree true
    77 schema:isPartOf N0fea37bb38a04ada82488fd090b0da53
    78 N492e00d0f7214df18fbd7b382cf78835
    79 sg:journal.1043282
    80 schema:name Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
    81 schema:pagination 105
    82 schema:productId N1c1c02df5b464c53be7bde2f3d83c70e
    83 Nb2e6232a86d84401984f5b85162fae0e
    84 Nb95e8a77333243748e25e48c4156f9fa
    85 Nc52be689ec3840598a6b048c0e4b8071
    86 Nf3cc86ad62a34e24b80d2d62b63e8ff1
    87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100179029
    88 https://doi.org/10.1038/s41467-017-02651-5
    89 schema:sdDatePublished 2019-04-11T13:20
    90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    91 schema:sdPublisher Ncdd9b33594cb41f987fea8ac4b936917
    92 schema:url https://www.nature.com/articles/s41467-017-02651-5
    93 sgo:license sg:explorer/license/
    94 sgo:sdDataset articles
    95 rdf:type schema:ScholarlyArticle
    96 N01c595802709485687c7ed194ac3cbe4 rdf:first sg:person.014063362571.01
    97 rdf:rest N68bce503847b4b049ca301bba2ae3f08
    98 N01ecd57d8a544facafada45b0f0b81ef rdf:first N776b348020994e03b2c176dad5a6e735
    99 rdf:rest N860cf703f9be4184bd38d987cf7a73ea
    100 N02b1095ced5e434ea39b286bbdcb0367 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    101 schema:familyName Matolcsi
    102 schema:givenName Csaba
    103 rdf:type schema:Person
    104 N0448f84d5b4d4373b6c05c0726f02249 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Histone Deacetylase Inhibitors
    106 rdf:type schema:DefinedTerm
    107 N07b41a86ddfa4572b49d9f0b93f71593 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Gastrointestinal Microbiome
    109 rdf:type schema:DefinedTerm
    110 N0fea37bb38a04ada82488fd090b0da53 schema:volumeNumber 9
    111 rdf:type schema:PublicationVolume
    112 N11438856484f4adfb36d5ff3bdcb3a12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Fatty Acids, Volatile
    114 rdf:type schema:DefinedTerm
    115 N14464a55e98c43e29afac4ab73b0ea16 rdf:first N542f42e4ef274e42886003a385c01d61
    116 rdf:rest Nad91fd4e97a04c24968d858979043214
    117 N1c1c02df5b464c53be7bde2f3d83c70e schema:name dimensions_id
    118 schema:value pub.1100179029
    119 rdf:type schema:PropertyValue
    120 N2384cff0e61741fa87789ba6dac1cd83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Humans
    122 rdf:type schema:DefinedTerm
    123 N2c3c9263ec2e438d8bae6399d9be7e89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name HCT116 Cells
    125 rdf:type schema:DefinedTerm
    126 N331680ea3f9747fb8fe430d6522e099e rdf:first sg:person.01322676206.52
    127 rdf:rest N621d50d244df4d3d836d9a36cb8f666a
    128 N33a63b583f2145ff803f2f4b7cf02ccb rdf:first N9f4b4dc6e5d54c38a038ae9ef60df525
    129 rdf:rest Nffca1ad884b2464392347b159614da27
    130 N415583c40db041a0a0516503ae1bc39f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Mice, Inbred C57BL
    132 rdf:type schema:DefinedTerm
    133 N4164c80a9dd245c38beafcd1cbb84aa4 rdf:first sg:person.014104377270.70
    134 rdf:rest Na77ce3dfa6734d6089aaa1087a30ecd6
    135 N41737ae426cf49c698862616a2bcae64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Protein Processing, Post-Translational
    137 rdf:type schema:DefinedTerm
    138 N419be5a087ac49279b48a2b764788a45 rdf:first sg:person.0654337411.46
    139 rdf:rest N7892bcb188664a6190ef3e1a6cbbd402
    140 N492e00d0f7214df18fbd7b382cf78835 schema:issueNumber 1
    141 rdf:type schema:PublicationIssue
    142 N4a6f94ae814c4b4fbc76aacc435b13e8 rdf:first sg:person.011347152270.13
    143 rdf:rest N01ecd57d8a544facafada45b0f0b81ef
    144 N542f42e4ef274e42886003a385c01d61 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    145 schema:familyName Mattiuz
    146 schema:givenName Raphaël
    147 rdf:type schema:Person
    148 N5576bd01bf1d46daa3cb6b39372a2aa9 rdf:first sg:person.014576132211.00
    149 rdf:rest Nc0eedbebbd6f4e3287fc2e69ab513b56
    150 N614ace47a2d743e2ac2649b2b788863c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Histone Deacetylases
    152 rdf:type schema:DefinedTerm
    153 N621d50d244df4d3d836d9a36cb8f666a rdf:first Nb11cfd01f28442958c77bdc4ebd3e862
    154 rdf:rest Na9cf1e89d86a4f54a4b208a368b156a1
    155 N65812151b0fe4b2b8a3ecc591920b913 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Acylation
    157 rdf:type schema:DefinedTerm
    158 N669034a1e25649babdf9c8f37b335015 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    159 schema:familyName Blackburn
    160 schema:givenName Hector
    161 rdf:type schema:Person
    162 N67648a13c3b94ace9e76b7a57b7b8e57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Intestinal Mucosa
    164 rdf:type schema:DefinedTerm
    165 N68bce503847b4b049ca301bba2ae3f08 rdf:first sg:person.01035515325.64
    166 rdf:rest N73a39379f84a435593fb335cf4665486
    167 N6a305ece971b411f91424b6856ff2999 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Histones
    169 rdf:type schema:DefinedTerm
    170 N73a39379f84a435593fb335cf4665486 rdf:first sg:person.016226144333.02
    171 rdf:rest N99884a44bc2349e785ae56644046f199
    172 N77475a474922466aa4b2b3383263f4d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Cell Cycle
    174 rdf:type schema:DefinedTerm
    175 N776b348020994e03b2c176dad5a6e735 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    176 schema:familyName Clark
    177 schema:givenName Jonathan
    178 rdf:type schema:Person
    179 N7892bcb188664a6190ef3e1a6cbbd402 rdf:first sg:person.01131725235.39
    180 rdf:rest Ne402d99c7c1443c5b49e906d08edc4e3
    181 N7965e40c63d94fec89e0bc9f4feb961d rdf:first sg:person.016230733076.57
    182 rdf:rest N01c595802709485687c7ed194ac3cbe4
    183 N7f97eb5e4a724adaa3865925db7e049c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Colon
    185 rdf:type schema:DefinedTerm
    186 N860cf703f9be4184bd38d987cf7a73ea rdf:first sg:person.01142557251.25
    187 rdf:rest Nac60eceea92040e0a584115ac67f5730
    188 N99884a44bc2349e785ae56644046f199 rdf:first N669034a1e25649babdf9c8f37b335015
    189 rdf:rest N4164c80a9dd245c38beafcd1cbb84aa4
    190 N9ceb302a2a80499da3416c576467a1b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Male
    192 rdf:type schema:DefinedTerm
    193 N9f4b4dc6e5d54c38a038ae9ef60df525 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    194 schema:familyName Perée
    195 schema:givenName Hélène
    196 rdf:type schema:Person
    197 Na059cbeb534a48b583e1233152af0501 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    198 schema:familyName Spagnuolo
    199 schema:givenName Mariangela
    200 rdf:type schema:Person
    201 Na77ce3dfa6734d6089aaa1087a30ecd6 rdf:first sg:person.0610771443.21
    202 rdf:rest N419be5a087ac49279b48a2b764788a45
    203 Na9cf1e89d86a4f54a4b208a368b156a1 rdf:first Nc720716085bf48b8bcee51102711ed97
    204 rdf:rest N7965e40c63d94fec89e0bc9f4feb961d
    205 Nac60eceea92040e0a584115ac67f5730 rdf:first sg:person.01225454106.40
    206 rdf:rest Ndbb815acd50a4dbe9a12ab312f7d89cc
    207 Nad91fd4e97a04c24968d858979043214 rdf:first N02b1095ced5e434ea39b286bbdcb0367
    208 rdf:rest N4a6f94ae814c4b4fbc76aacc435b13e8
    209 Nadc0dfc47d8842478d826df88998d632 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Animals
    211 rdf:type schema:DefinedTerm
    212 Nb11c9ea131794d1d98c577afce6d70fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Crotonates
    214 rdf:type schema:DefinedTerm
    215 Nb11cfd01f28442958c77bdc4ebd3e862 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    216 schema:familyName Jain
    217 schema:givenName Payal
    218 rdf:type schema:Person
    219 Nb2e6232a86d84401984f5b85162fae0e schema:name pubmed_id
    220 schema:value 29317660
    221 rdf:type schema:PropertyValue
    222 Nb95e8a77333243748e25e48c4156f9fa schema:name nlm_unique_id
    223 schema:value 101528555
    224 rdf:type schema:PropertyValue
    225 Nbeb3c9fefbfa40a5b99e396ef8011e6c schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    226 schema:familyName Fellows
    227 schema:givenName Rachel
    228 rdf:type schema:Person
    229 Nc0eedbebbd6f4e3287fc2e69ab513b56 rdf:first sg:person.0730314033.10
    230 rdf:rest N331680ea3f9747fb8fe430d6522e099e
    231 Nc52be689ec3840598a6b048c0e4b8071 schema:name doi
    232 schema:value 10.1038/s41467-017-02651-5
    233 rdf:type schema:PropertyValue
    234 Nc720716085bf48b8bcee51102711ed97 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    235 schema:familyName Stoyanova
    236 schema:givenName Elena
    237 rdf:type schema:Person
    238 Ncdd9b33594cb41f987fea8ac4b936917 schema:name Springer Nature - SN SciGraph project
    239 rdf:type schema:Organization
    240 Ndbb815acd50a4dbe9a12ab312f7d89cc rdf:first sg:person.012557172167.30
    241 rdf:rest Ne9df99939ecd4030b41dd0ad6d0a4f67
    242 Ne402d99c7c1443c5b49e906d08edc4e3 rdf:first sg:person.01351273542.97
    243 rdf:rest N33a63b583f2145ff803f2f4b7cf02ccb
    244 Ne43ca8889f314484b1d3a4a7d9e531bf rdf:first Nbeb3c9fefbfa40a5b99e396ef8011e6c
    245 rdf:rest N5576bd01bf1d46daa3cb6b39372a2aa9
    246 Ne9df99939ecd4030b41dd0ad6d0a4f67 rdf:first sg:person.01070226471.91
    247 rdf:rest rdf:nil
    248 Nf3cc86ad62a34e24b80d2d62b63e8ff1 schema:name readcube_id
    249 schema:value 7adb7178efc4b99601a61655c2234d339fe12d88e5735d08ac376ef490515ace
    250 rdf:type schema:PropertyValue
    251 Nffca1ad884b2464392347b159614da27 rdf:first Na059cbeb534a48b583e1233152af0501
    252 rdf:rest N14464a55e98c43e29afac4ab73b0ea16
    253 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    254 schema:name Biological Sciences
    255 rdf:type schema:DefinedTerm
    256 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    257 schema:name Biochemistry and Cell Biology
    258 rdf:type schema:DefinedTerm
    259 sg:grant.2753065 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-017-02651-5
    260 rdf:type schema:MonetaryGrant
    261 sg:grant.2756559 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-017-02651-5
    262 rdf:type schema:MonetaryGrant
    263 sg:grant.2757947 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-017-02651-5
    264 rdf:type schema:MonetaryGrant
    265 sg:grant.2765880 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-017-02651-5
    266 rdf:type schema:MonetaryGrant
    267 sg:grant.2768223 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-017-02651-5
    268 rdf:type schema:MonetaryGrant
    269 sg:grant.2784635 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-017-02651-5
    270 rdf:type schema:MonetaryGrant
    271 sg:grant.3864880 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-017-02651-5
    272 rdf:type schema:MonetaryGrant
    273 sg:grant.4473475 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-017-02651-5
    274 rdf:type schema:MonetaryGrant
    275 sg:grant.4575830 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-017-02651-5
    276 rdf:type schema:MonetaryGrant
    277 sg:grant.4604038 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-017-02651-5
    278 rdf:type schema:MonetaryGrant
    279 sg:grant.5071453 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-017-02651-5
    280 rdf:type schema:MonetaryGrant
    281 sg:grant.7574453 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-017-02651-5
    282 rdf:type schema:MonetaryGrant
    283 sg:journal.1043282 schema:issn 2041-1723
    284 schema:name Nature Communications
    285 rdf:type schema:Periodical
    286 sg:person.01035515325.64 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    287 schema:familyName Liebert
    288 schema:givenName Anke
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035515325.64
    290 rdf:type schema:Person
    291 sg:person.01070226471.91 schema:affiliation https://www.grid.ac/institutes/grid.8356.8
    292 schema:familyName Varga-Weisz
    293 schema:givenName Patrick
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070226471.91
    295 rdf:type schema:Person
    296 sg:person.01131725235.39 schema:affiliation https://www.grid.ac/institutes/grid.411249.b
    297 schema:familyName Ribeiro
    298 schema:givenName Willian R.
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131725235.39
    300 rdf:type schema:Person
    301 sg:person.011347152270.13 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    302 schema:familyName Guedes
    303 schema:givenName Joana
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011347152270.13
    305 rdf:type schema:Person
    306 sg:person.01142557251.25 schema:affiliation https://www.grid.ac/institutes/grid.9983.b
    307 schema:familyName Veldhoen
    308 schema:givenName Marc
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142557251.25
    310 rdf:type schema:Person
    311 sg:person.01225454106.40 schema:affiliation https://www.grid.ac/institutes/grid.15667.33
    312 schema:familyName Bonaldi
    313 schema:givenName Tiziana
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225454106.40
    315 rdf:type schema:Person
    316 sg:person.012557172167.30 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
    317 schema:familyName Vinolo
    318 schema:givenName Marco Aurélio Ramirez
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012557172167.30
    320 rdf:type schema:Person
    321 sg:person.01322676206.52 schema:affiliation https://www.grid.ac/institutes/grid.15667.33
    322 schema:familyName Cuomo
    323 schema:givenName Alessandro
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322676206.52
    325 rdf:type schema:Person
    326 sg:person.01351273542.97 schema:affiliation https://www.grid.ac/institutes/grid.411249.b
    327 schema:familyName Ferreira
    328 schema:givenName Caroline Marcantonio
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351273542.97
    330 rdf:type schema:Person
    331 sg:person.014063362571.01 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    332 schema:familyName Hajnády
    333 schema:givenName Zoltán
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014063362571.01
    335 rdf:type schema:Person
    336 sg:person.014104377270.70 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
    337 schema:familyName Corrêa
    338 schema:givenName Renan Oliveira
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014104377270.70
    340 rdf:type schema:Person
    341 sg:person.014576132211.00 schema:affiliation https://www.grid.ac/institutes/grid.494717.8
    342 schema:familyName Denizot
    343 schema:givenName Jérémy
    344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014576132211.00
    345 rdf:type schema:Person
    346 sg:person.016226144333.02 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    347 schema:familyName Kazakevych
    348 schema:givenName Juri
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016226144333.02
    350 rdf:type schema:Person
    351 sg:person.016230733076.57 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    352 schema:familyName Balázsi
    353 schema:givenName Szabina
    354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016230733076.57
    355 rdf:type schema:Person
    356 sg:person.0610771443.21 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
    357 schema:familyName Fachi
    358 schema:givenName José Luís
    359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610771443.21
    360 rdf:type schema:Person
    361 sg:person.0654337411.46 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
    362 schema:familyName Sato
    363 schema:givenName Fabio Takeo
    364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654337411.46
    365 rdf:type schema:Person
    366 sg:person.0730314033.10 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
    367 schema:familyName Stellato
    368 schema:givenName Claudia
    369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730314033.10
    370 rdf:type schema:Person
    371 sg:pub.10.1007/978-1-4939-6630-1_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025224026
    372 https://doi.org/10.1007/978-1-4939-6630-1_7
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1007/s00726-010-0668-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025365710
    375 https://doi.org/10.1007/s00726-010-0668-2
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1007/s10620-008-0601-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037162226
    378 https://doi.org/10.1007/s10620-008-0601-7
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1038/35055010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045406065
    381 https://doi.org/10.1038/35055010
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1038/bjc.2016.36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003603071
    384 https://doi.org/10.1038/bjc.2016.36
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/cr.2016.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039060709
    387 https://doi.org/10.1038/cr.2016.49
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/cr.2017.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085001187
    390 https://doi.org/10.1038/cr.2017.60
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1038/cr.2017.68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085392521
    393 https://doi.org/10.1038/cr.2017.68
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1038/nchembio.2065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001204414
    396 https://doi.org/10.1038/nchembio.2065
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1038/nchembio.2218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052104192
    399 https://doi.org/10.1038/nchembio.2218
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/nmeth.3901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032398342
    402 https://doi.org/10.1038/nmeth.3901
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1038/nprot.2016.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049695744
    405 https://doi.org/10.1038/nprot.2016.136
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1038/nrm.2016.140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009727188
    408 https://doi.org/10.1038/nrm.2016.140
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1186/1756-8935-6-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032233933
    411 https://doi.org/10.1186/1756-8935-6-27
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1002/anie.201203754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048786051
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1002/pmic.201400075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019717666
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1002/pmic.201400449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022979605
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1016/0092-8674(78)90305-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010035463
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1016/j.bbagrm.2011.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050048915
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1016/j.bmc.2011.11.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000921953
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1016/j.canlet.2009.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013983423
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1016/j.ccr.2010.10.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042891274
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1016/j.cell.2011.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009492522
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1016/j.cell.2016.05.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023287756
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1016/j.cmet.2011.02.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028381301
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1016/j.molcel.2010.01.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045543158
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1016/j.molcel.2015.02.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002362071
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1016/j.molcel.2016.03.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025835977
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1016/j.molcel.2016.03.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043128799
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1016/j.molcel.2016.03.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027761001
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1016/j.molcel.2016.10.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050660117
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1016/j.neuint.2016.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049441059
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1016/s1074-5521(02)00305-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028266129
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1016/s1535-6108(04)00114-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051297122
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1021/ac026117i schema:sameAs https://app.dimensions.ai/details/publication/pub.1000183287
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1021/bi0494471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055199751
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1021/cb3001793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021289198
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1073/pnas.92.4.1237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015308836
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1074/mcp.m700021-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045553870
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1074/mcp.m900489-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023704683
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1083/jcb.147.6.1153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046825866
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1093/emboj/cdg315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044213586
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1093/nar/27.9.2057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016307126
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1101/cshperspect.a026831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060407218
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1126/science.1234852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010986971
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1128/iai.01432-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036060202
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1128/mcb.24.8.3132-3139.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037028734
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1161/circresaha.116.303936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000286335
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1177/1087057111416004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044659057
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.3389/fmicb.2017.01732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091537031
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.3390/nu7042839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007900393
    486 rdf:type schema:CreativeWork
    487 https://www.grid.ac/institutes/grid.15667.33 schema:alternateName European Institute of Oncology
    488 schema:name Department of Experimental Oncology, Istituto Europeo di Oncologia, 20139, Milano, Italy
    489 rdf:type schema:Organization
    490 https://www.grid.ac/institutes/grid.411087.b schema:alternateName State University of Campinas
    491 schema:name Laboratory of Immunoinflammation, Institute of Biology, UNICAMP, 13083-862, Campinas, Brazil
    492 rdf:type schema:Organization
    493 https://www.grid.ac/institutes/grid.411249.b schema:alternateName Federal University of Sao Paulo
    494 schema:name Chemical Biology Graduate Program, Universidade Federal de São Paulo, 09913-03, Diadema, SP, Brazil
    495 Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo, 09913-03, Diadema, SP, Brazil
    496 rdf:type schema:Organization
    497 https://www.grid.ac/institutes/grid.418195.0 schema:alternateName Babraham Institute
    498 schema:name Biological Chemistry, Babraham Institute, CB22 3AT, Cambridge, UK
    499 Lymphocyte Signalling and Development, Babraham Institute, CB22 3AT, Cambridge, UK
    500 Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK
    501 rdf:type schema:Organization
    502 https://www.grid.ac/institutes/grid.494717.8 schema:alternateName University of Clermont Auvergne
    503 schema:name Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK
    504 Université Clermont Auvergne, Inserm U1071, INRA USC2018, M2iSH, F-63000, Clermont–Ferrand, France
    505 rdf:type schema:Organization
    506 https://www.grid.ac/institutes/grid.8356.8 schema:alternateName University of Essex
    507 schema:name Nuclear Dynamics, Babraham Institute, CB22 3AT, Cambridge, UK
    508 School of Biological Sciences, University of Essex, CO4 3SQ, Colchester, UK
    509 rdf:type schema:Organization
    510 https://www.grid.ac/institutes/grid.9983.b schema:alternateName University of Lisbon
    511 schema:name Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649-028, Lisbon, Portugal
    512 Lymphocyte Signalling and Development, Babraham Institute, CB22 3AT, Cambridge, UK
    513 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...