A dual role for the N-terminal domain of the IL-3 receptor in cell signalling View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Sophie E. Broughton, Timothy R. Hercus, Tracy L. Nero, Winnie L. Kan, Emma F. Barry, Mara Dottore, Karen S. Cheung Tung Shing, Craig J. Morton, Urmi Dhagat, Matthew P. Hardy, Nicholas J. Wilson, Matthew T. Downton, Christine Schieber, Timothy P. Hughes, Angel F. Lopez, Michael W. Parker

ABSTRACT

The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is overexpressed in acute and chronic myeloid leukaemia progenitor cells. It belongs to the type I cytokine receptor family in which the α-subunits consist of two fibronectin III-like domains that bind cytokine, and a third, evolutionarily unrelated and topologically conserved, N-terminal domain (NTD) with unknown function. Here we show by crystallography that, while the NTD of IL3Rα is highly mobile in the presence of IL-3, it becomes surprisingly rigid in the presence of IL-3 K116W. Mutagenesis, biochemical and functional studies show that the NTD of IL3Rα regulates IL-3 binding and signalling and reveal an unexpected role in preventing spontaneous receptor dimerisation. Our work identifies a dual role for the NTD in this cytokine receptor family, protecting against inappropriate signalling and dynamically regulating cytokine receptor binding and function. More... »

PAGES

386

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-017-02633-7

DOI

http://dx.doi.org/10.1038/s41467-017-02633-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100570891

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29374162


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "COS Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cercopithecus aethiops", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallography, X-Ray", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HEK293 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-3 Receptor alpha Subunit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Dynamics Simulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Domains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "St Vincents Institute of Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.1073.5", 
          "name": [
            "Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent\u2019s Institute of Medical Research, 3065, Fitzroy, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Broughton", 
        "givenName": "Sophie E.", 
        "id": "sg:person.01107516255.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107516255.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Cancer Biology", 
          "id": "https://www.grid.ac/institutes/grid.470344.0", 
          "name": [
            "The Centre for Cancer Biology, SA Pathology and the University of South Australia, 5000, Adelaide, SA, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hercus", 
        "givenName": "Timothy R.", 
        "id": "sg:person.01153762134.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153762134.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Vincents Institute of Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.1073.5", 
          "name": [
            "Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent\u2019s Institute of Medical Research, 3065, Fitzroy, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nero", 
        "givenName": "Tracy L.", 
        "id": "sg:person.01222075334.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222075334.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Cancer Biology", 
          "id": "https://www.grid.ac/institutes/grid.470344.0", 
          "name": [
            "The Centre for Cancer Biology, SA Pathology and the University of South Australia, 5000, Adelaide, SA, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kan", 
        "givenName": "Winnie L.", 
        "id": "sg:person.0721177464.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721177464.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Cancer Biology", 
          "id": "https://www.grid.ac/institutes/grid.470344.0", 
          "name": [
            "The Centre for Cancer Biology, SA Pathology and the University of South Australia, 5000, Adelaide, SA, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barry", 
        "givenName": "Emma F.", 
        "id": "sg:person.01150177522.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150177522.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Cancer Biology", 
          "id": "https://www.grid.ac/institutes/grid.470344.0", 
          "name": [
            "The Centre for Cancer Biology, SA Pathology and the University of South Australia, 5000, Adelaide, SA, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dottore", 
        "givenName": "Mara", 
        "id": "sg:person.01077736153.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077736153.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent\u2019s Institute of Medical Research, 3065, Fitzroy, VIC, Australia", 
            "Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 3010, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shing", 
        "givenName": "Karen S. Cheung Tung", 
        "id": "sg:person.014111134073.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014111134073.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Vincents Institute of Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.1073.5", 
          "name": [
            "Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent\u2019s Institute of Medical Research, 3065, Fitzroy, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morton", 
        "givenName": "Craig J.", 
        "id": "sg:person.01301624707.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301624707.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Vincents Institute of Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.1073.5", 
          "name": [
            "Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent\u2019s Institute of Medical Research, 3065, Fitzroy, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dhagat", 
        "givenName": "Urmi", 
        "id": "sg:person.01122566322.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122566322.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CSL (Australia)", 
          "id": "https://www.grid.ac/institutes/grid.1135.6", 
          "name": [
            "CSL Limited, 3010, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hardy", 
        "givenName": "Matthew P.", 
        "id": "sg:person.01231555762.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231555762.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CSL (Australia)", 
          "id": "https://www.grid.ac/institutes/grid.1135.6", 
          "name": [
            "CSL Limited, 3010, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilson", 
        "givenName": "Nicholas J.", 
        "id": "sg:person.0604704414.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604704414.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "IBM Research - Australia", 
          "id": "https://www.grid.ac/institutes/grid.481553.e", 
          "name": [
            "IBM Research Australia, Level 5, 204 Lygon Street, 3053, Carlton, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Downton", 
        "givenName": "Matthew T.", 
        "id": "sg:person.01122035427.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122035427.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "IBM Research - Australia", 
          "id": "https://www.grid.ac/institutes/grid.481553.e", 
          "name": [
            "IBM Research Australia, Level 5, 204 Lygon Street, 3053, Carlton, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schieber", 
        "givenName": "Christine", 
        "id": "sg:person.0713340341.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713340341.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "South Australian Health and Medical Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.430453.5", 
          "name": [
            "South Australian Health and Medical Research Institute and University of Adelaide, 5000, Adelaide, SA, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hughes", 
        "givenName": "Timothy P.", 
        "id": "sg:person.014243130677.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014243130677.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Cancer Biology", 
          "id": "https://www.grid.ac/institutes/grid.470344.0", 
          "name": [
            "The Centre for Cancer Biology, SA Pathology and the University of South Australia, 5000, Adelaide, SA, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopez", 
        "givenName": "Angel F.", 
        "id": "sg:person.0721235453.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721235453.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent\u2019s Institute of Medical Research, 3065, Fitzroy, VIC, Australia", 
            "Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 3010, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parker", 
        "givenName": "Michael W.", 
        "id": "sg:person.01303175270.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303175270.57"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1107/s0907444910007493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000235100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444910007493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000235100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.36.22630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000956264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2011.047894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003991130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci.insight.86131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004755485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci.insight.86131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004755485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-03-0852", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004844104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(97)76066-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004907170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0263-7855(96)00018-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005898005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2014.06.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006842196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(80)90515-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007065635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pro.2072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007157542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bjh.12978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008407630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s2053230x14002593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008551373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2014.111740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009396656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2015.08.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010116240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.05.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010954840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2014.128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011662516", 
          "https://doi.org/10.1038/leu.2014.128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2014.128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011662516", 
          "https://doi.org/10.1038/leu.2014.128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012171825", 
          "https://doi.org/10.1038/sj.leu.2401903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012171825", 
          "https://doi.org/10.1038/sj.leu.2401903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bjh.12282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013278415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.06.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013868051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2010.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014010860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444906045975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016114112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0050375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016739651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10428190701799035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018719390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444904019158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020281098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2009.04.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021225281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-2070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021512475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0909049502015170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022230728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.24.11842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022704594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-016-1644-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024003995", 
          "https://doi.org/10.1007/s00439-016-1644-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-016-1644-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024003995", 
          "https://doi.org/10.1007/s00439-016-1644-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-472x(99)00118-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026249712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m808197200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026629360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.16.6.3035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026798350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2014-04-566737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026864480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1041400219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028455591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ct300400x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029039064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0074376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030072085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030411438", 
          "https://doi.org/10.1038/onc.2011.204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2011.08.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031847251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444911001314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032555428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2016.05.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032619145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exphem.2003.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033615042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471721204.ch14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033997585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.9.3779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035599535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2012.01164.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035676994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036269489", 
          "https://doi.org/10.1038/nature10975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.1306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037044962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcc.20289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040543339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcc.20289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040543339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.42.25999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042334035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444905024984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043970233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-02-0540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046876783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cytogfr.2013.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047443816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.12.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048155900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bcmd.1998.0184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048416437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2001.5907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049055132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050126776", 
          "https://doi.org/10.1038/nsmb977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050126776", 
          "https://doi.org/10.1038/nsmb977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050126776", 
          "https://doi.org/10.1038/nsmb977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-12-475194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052011799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(03)00389-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052539209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.445869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058023889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1549776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062490342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2014-05-575704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064122650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074517573", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074684089", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079343524", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1994.tb06848.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082582509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082854093", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2017.06.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086123507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/bloodadvances.2016002931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100454359"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is overexpressed in acute and chronic myeloid leukaemia progenitor cells. It belongs to the type I cytokine receptor family in which the \u03b1-subunits consist of two fibronectin III-like domains that bind cytokine, and a third, evolutionarily unrelated and topologically conserved, N-terminal domain (NTD) with unknown function. Here we show by crystallography that, while the NTD of IL3R\u03b1 is highly mobile in the presence of IL-3, it becomes surprisingly rigid in the presence of IL-3 K116W. Mutagenesis, biochemical and functional studies show that the NTD of IL3R\u03b1 regulates IL-3 binding and signalling and reveal an unexpected role in preventing spontaneous receptor dimerisation. Our work identifies a dual role for the NTD in this cytokine receptor family, protecting against inappropriate signalling and dynamically regulating cytokine receptor binding and function.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-017-02633-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "A dual role for the N-terminal domain of the IL-3 receptor in cell signalling", 
    "pagination": "386", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3870a3bbf5b42ebdce421cb400ec044fdf3a52a935a4666eadc5c486cba182b6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29374162"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-017-02633-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100570891"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-017-02633-7", 
      "https://app.dimensions.ai/details/publication/pub.1100570891"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000493.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-017-02633-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-02633-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-02633-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-02633-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-02633-7'


 

This table displays all metadata directly associated to this object as RDF triples.

456 TRIPLES      21 PREDICATES      112 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-017-02633-7 schema:about N07de85ed71314bd5a6fd38b153b0b7ca
2 N216328dc0bbc46aaa9d4a2fc76b1a4f6
3 N483922a0a0c9491791bbcecbb15a6870
4 N4f3fd4c0ac6d47468aaa925af506455f
5 N6704ee6db04248929194d01e67fe935c
6 N94ea6f5a1f4841d4a3693ee8b4a77cbe
7 N9f809939c6ee43cb8deb843f33076e61
8 N9ffbac3e058d4f879115fdcbe628706e
9 Nc06b0ddf01444a1da0f1b4940de8607c
10 Nc1370ad203db4c0eb2a52751336c6cf8
11 Ncda8a0a06e674cfdb9c4b76764516485
12 Nd5156373ecb64c46aeba6d09524fe824
13 Ndf2d9f048ef844078955eae19b85e9ee
14 Nf155329a3e4c408aad9a7db3b35d7dd5
15 Nf367e831f9034d59be31e9b1c0e89e11
16 Nfa2135661088465a959c625ee537dbd3
17 anzsrc-for:06
18 anzsrc-for:0601
19 schema:author N5cd7f36a99fe48c7b19ade0be1fc801e
20 schema:citation sg:pub.10.1007/s00439-016-1644-z
21 sg:pub.10.1038/leu.2014.128
22 sg:pub.10.1038/nature10975
23 sg:pub.10.1038/nsmb977
24 sg:pub.10.1038/onc.2011.204
25 sg:pub.10.1038/sj.leu.2401903
26 https://app.dimensions.ai/details/publication/pub.1074517573
27 https://app.dimensions.ai/details/publication/pub.1074684089
28 https://app.dimensions.ai/details/publication/pub.1079343524
29 https://app.dimensions.ai/details/publication/pub.1082854093
30 https://doi.org/10.1002/0471721204.ch14
31 https://doi.org/10.1002/j.1460-2075.1994.tb06848.x
32 https://doi.org/10.1002/jcc.20289
33 https://doi.org/10.1002/jcp.1041400219
34 https://doi.org/10.1002/pro.2072
35 https://doi.org/10.1006/bbrc.2001.5907
36 https://doi.org/10.1006/bcmd.1998.0184
37 https://doi.org/10.1016/0003-2697(80)90515-1
38 https://doi.org/10.1016/0263-7855(96)00018-5
39 https://doi.org/10.1016/j.bpj.2015.08.015
40 https://doi.org/10.1016/j.cell.2007.12.030
41 https://doi.org/10.1016/j.cell.2008.05.053
42 https://doi.org/10.1016/j.cell.2011.06.048
43 https://doi.org/10.1016/j.celrep.2014.06.038
44 https://doi.org/10.1016/j.cytogfr.2013.03.002
45 https://doi.org/10.1016/j.exphem.2003.11.010
46 https://doi.org/10.1016/j.jmb.2017.06.011
47 https://doi.org/10.1016/j.stem.2009.04.018
48 https://doi.org/10.1016/j.str.2010.01.003
49 https://doi.org/10.1016/j.str.2011.08.015
50 https://doi.org/10.1016/j.str.2016.05.017
51 https://doi.org/10.1016/s0076-6879(97)76066-x
52 https://doi.org/10.1016/s0301-472x(99)00118-6
53 https://doi.org/10.1016/s1097-2765(03)00389-7
54 https://doi.org/10.1021/ct300400x
55 https://doi.org/10.1063/1.445869
56 https://doi.org/10.1073/pnas.89.24.11842
57 https://doi.org/10.1073/pnas.92.9.3779
58 https://doi.org/10.1074/jbc.271.42.25999
59 https://doi.org/10.1074/jbc.272.36.22630
60 https://doi.org/10.1074/jbc.m808197200
61 https://doi.org/10.1080/10428190701799035
62 https://doi.org/10.1107/s0907444904019158
63 https://doi.org/10.1107/s0907444905024984
64 https://doi.org/10.1107/s0907444906045975
65 https://doi.org/10.1107/s0907444910007493
66 https://doi.org/10.1107/s0907444911001314
67 https://doi.org/10.1107/s0909049502015170
68 https://doi.org/10.1107/s2053230x14002593
69 https://doi.org/10.1111/bjh.12282
70 https://doi.org/10.1111/bjh.12978
71 https://doi.org/10.1111/j.1600-065x.2012.01164.x
72 https://doi.org/10.1126/science.1549776
73 https://doi.org/10.1128/mcb.16.6.3035
74 https://doi.org/10.1158/1078-0432.ccr-05-2070
75 https://doi.org/10.1172/jci.insight.86131
76 https://doi.org/10.1182/blood-2002-03-0852
77 https://doi.org/10.1182/blood-2005-02-0540
78 https://doi.org/10.1182/blood-2012-12-475194
79 https://doi.org/10.1182/blood-2014-04-566737
80 https://doi.org/10.1182/blood-2014-05-575704
81 https://doi.org/10.1182/bloodadvances.2016002931
82 https://doi.org/10.1371/journal.pone.0050375
83 https://doi.org/10.1371/journal.pone.0074376
84 https://doi.org/10.18632/oncotarget.1306
85 https://doi.org/10.3324/haematol.2011.047894
86 https://doi.org/10.3324/haematol.2014.111740
87 schema:datePublished 2018-12
88 schema:datePublishedReg 2018-12-01
89 schema:description The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is overexpressed in acute and chronic myeloid leukaemia progenitor cells. It belongs to the type I cytokine receptor family in which the α-subunits consist of two fibronectin III-like domains that bind cytokine, and a third, evolutionarily unrelated and topologically conserved, N-terminal domain (NTD) with unknown function. Here we show by crystallography that, while the NTD of IL3Rα is highly mobile in the presence of IL-3, it becomes surprisingly rigid in the presence of IL-3 K116W. Mutagenesis, biochemical and functional studies show that the NTD of IL3Rα regulates IL-3 binding and signalling and reveal an unexpected role in preventing spontaneous receptor dimerisation. Our work identifies a dual role for the NTD in this cytokine receptor family, protecting against inappropriate signalling and dynamically regulating cytokine receptor binding and function.
90 schema:genre research_article
91 schema:inLanguage en
92 schema:isAccessibleForFree true
93 schema:isPartOf N5f9d9427422944dbb82cc34fce7753c7
94 Nf784ee0b80bc4818a20ad60c5fe257bb
95 sg:journal.1043282
96 schema:name A dual role for the N-terminal domain of the IL-3 receptor in cell signalling
97 schema:pagination 386
98 schema:productId N5e458164803d46249a78f89f2be0347c
99 N630cbc5f98984d0a84f1984aaa8058b0
100 N66eaafa96f8b4917b03256ae4b488826
101 Nc30b8e5e42984dfd9587de48c3991632
102 Ncb5819436b7d422b84d23d23d27238ce
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100570891
104 https://doi.org/10.1038/s41467-017-02633-7
105 schema:sdDatePublished 2019-04-10T13:10
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher Na105b19bf26d46ec914e33f6e92a3c32
108 schema:url https://www.nature.com/articles/s41467-017-02633-7
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N07de85ed71314bd5a6fd38b153b0b7ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Crystallography, X-Ray
114 rdf:type schema:DefinedTerm
115 N0aa2652ca03e433d884b01f958226a31 rdf:first sg:person.01303175270.57
116 rdf:rest rdf:nil
117 N0b028943de44487fb65204832ff8d621 rdf:first sg:person.01231555762.21
118 rdf:rest N17112933d8b24d719f290009a47b44f7
119 N17112933d8b24d719f290009a47b44f7 rdf:first sg:person.0604704414.46
120 rdf:rest Ndf4968a115fc43c3a1639b2cf3400380
121 N216328dc0bbc46aaa9d4a2fc76b1a4f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Cell Line, Tumor
123 rdf:type schema:DefinedTerm
124 N2736f549792445a88b3b270ff8502bda rdf:first sg:person.0721235453.06
125 rdf:rest N0aa2652ca03e433d884b01f958226a31
126 N392c7da73ea344fc90bf696c323bf63a rdf:first sg:person.0721177464.52
127 rdf:rest Ne84f0904244d4104a0584da7ab46deff
128 N483922a0a0c9491791bbcecbb15a6870 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Cercopithecus aethiops
130 rdf:type schema:DefinedTerm
131 N4e1828f7694a4e5d90d0235e63f0bc43 rdf:first sg:person.014111134073.57
132 rdf:rest N4f468ddece534382b2f7459f69906f27
133 N4f3fd4c0ac6d47468aaa925af506455f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Interleukin-3
135 rdf:type schema:DefinedTerm
136 N4f468ddece534382b2f7459f69906f27 rdf:first sg:person.01301624707.33
137 rdf:rest Ne57bd36db65f4c14a7e769551726ad8d
138 N5cd7f36a99fe48c7b19ade0be1fc801e rdf:first sg:person.01107516255.52
139 rdf:rest Na41fbae96f65483a8e094c567cce2710
140 N5e458164803d46249a78f89f2be0347c schema:name dimensions_id
141 schema:value pub.1100570891
142 rdf:type schema:PropertyValue
143 N5f9d9427422944dbb82cc34fce7753c7 schema:issueNumber 1
144 rdf:type schema:PublicationIssue
145 N630cbc5f98984d0a84f1984aaa8058b0 schema:name pubmed_id
146 schema:value 29374162
147 rdf:type schema:PropertyValue
148 N66eaafa96f8b4917b03256ae4b488826 schema:name nlm_unique_id
149 schema:value 101528555
150 rdf:type schema:PropertyValue
151 N6704ee6db04248929194d01e67fe935c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Mutation
153 rdf:type schema:DefinedTerm
154 N94ea6f5a1f4841d4a3693ee8b4a77cbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Molecular Dynamics Simulation
156 rdf:type schema:DefinedTerm
157 N9f809939c6ee43cb8deb843f33076e61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Protein Domains
159 rdf:type schema:DefinedTerm
160 N9ffbac3e058d4f879115fdcbe628706e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Interleukin-3 Receptor alpha Subunit
162 rdf:type schema:DefinedTerm
163 Na105b19bf26d46ec914e33f6e92a3c32 schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 Na41fbae96f65483a8e094c567cce2710 rdf:first sg:person.01153762134.01
166 rdf:rest Ne9cea7c0ad9e42acb072ba3f91d583a2
167 Nc06b0ddf01444a1da0f1b4940de8607c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Animals
169 rdf:type schema:DefinedTerm
170 Nc1370ad203db4c0eb2a52751336c6cf8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Signal Transduction
172 rdf:type schema:DefinedTerm
173 Nc30b8e5e42984dfd9587de48c3991632 schema:name readcube_id
174 schema:value 3870a3bbf5b42ebdce421cb400ec044fdf3a52a935a4666eadc5c486cba182b6
175 rdf:type schema:PropertyValue
176 Ncb5819436b7d422b84d23d23d27238ce schema:name doi
177 schema:value 10.1038/s41467-017-02633-7
178 rdf:type schema:PropertyValue
179 Ncda8a0a06e674cfdb9c4b76764516485 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Binding Sites
181 rdf:type schema:DefinedTerm
182 Nd5156373ecb64c46aeba6d09524fe824 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Amino Acid Sequence
184 rdf:type schema:DefinedTerm
185 Nd96cd305549f4b22bf03e20d9c53d77c rdf:first sg:person.0713340341.51
186 rdf:rest Ne6610c898a4e45c19a3314f9de2dcabc
187 Ndf2d9f048ef844078955eae19b85e9ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name COS Cells
189 rdf:type schema:DefinedTerm
190 Ndf4968a115fc43c3a1639b2cf3400380 rdf:first sg:person.01122035427.64
191 rdf:rest Nd96cd305549f4b22bf03e20d9c53d77c
192 Ne57bd36db65f4c14a7e769551726ad8d rdf:first sg:person.01122566322.91
193 rdf:rest N0b028943de44487fb65204832ff8d621
194 Ne6610c898a4e45c19a3314f9de2dcabc rdf:first sg:person.014243130677.65
195 rdf:rest N2736f549792445a88b3b270ff8502bda
196 Ne6c6b72ae6734acda870d9fb830fc416 rdf:first sg:person.01077736153.15
197 rdf:rest N4e1828f7694a4e5d90d0235e63f0bc43
198 Ne84f0904244d4104a0584da7ab46deff rdf:first sg:person.01150177522.81
199 rdf:rest Ne6c6b72ae6734acda870d9fb830fc416
200 Ne9cea7c0ad9e42acb072ba3f91d583a2 rdf:first sg:person.01222075334.91
201 rdf:rest N392c7da73ea344fc90bf696c323bf63a
202 Nf155329a3e4c408aad9a7db3b35d7dd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Protein Binding
204 rdf:type schema:DefinedTerm
205 Nf367e831f9034d59be31e9b1c0e89e11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name HEK293 Cells
207 rdf:type schema:DefinedTerm
208 Nf784ee0b80bc4818a20ad60c5fe257bb schema:volumeNumber 9
209 rdf:type schema:PublicationVolume
210 Nfa2135661088465a959c625ee537dbd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Humans
212 rdf:type schema:DefinedTerm
213 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
214 schema:name Biological Sciences
215 rdf:type schema:DefinedTerm
216 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
217 schema:name Biochemistry and Cell Biology
218 rdf:type schema:DefinedTerm
219 sg:journal.1043282 schema:issn 2041-1723
220 schema:name Nature Communications
221 rdf:type schema:Periodical
222 sg:person.01077736153.15 schema:affiliation https://www.grid.ac/institutes/grid.470344.0
223 schema:familyName Dottore
224 schema:givenName Mara
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077736153.15
226 rdf:type schema:Person
227 sg:person.01107516255.52 schema:affiliation https://www.grid.ac/institutes/grid.1073.5
228 schema:familyName Broughton
229 schema:givenName Sophie E.
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107516255.52
231 rdf:type schema:Person
232 sg:person.01122035427.64 schema:affiliation https://www.grid.ac/institutes/grid.481553.e
233 schema:familyName Downton
234 schema:givenName Matthew T.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122035427.64
236 rdf:type schema:Person
237 sg:person.01122566322.91 schema:affiliation https://www.grid.ac/institutes/grid.1073.5
238 schema:familyName Dhagat
239 schema:givenName Urmi
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122566322.91
241 rdf:type schema:Person
242 sg:person.01150177522.81 schema:affiliation https://www.grid.ac/institutes/grid.470344.0
243 schema:familyName Barry
244 schema:givenName Emma F.
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150177522.81
246 rdf:type schema:Person
247 sg:person.01153762134.01 schema:affiliation https://www.grid.ac/institutes/grid.470344.0
248 schema:familyName Hercus
249 schema:givenName Timothy R.
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153762134.01
251 rdf:type schema:Person
252 sg:person.01222075334.91 schema:affiliation https://www.grid.ac/institutes/grid.1073.5
253 schema:familyName Nero
254 schema:givenName Tracy L.
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222075334.91
256 rdf:type schema:Person
257 sg:person.01231555762.21 schema:affiliation https://www.grid.ac/institutes/grid.1135.6
258 schema:familyName Hardy
259 schema:givenName Matthew P.
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231555762.21
261 rdf:type schema:Person
262 sg:person.01301624707.33 schema:affiliation https://www.grid.ac/institutes/grid.1073.5
263 schema:familyName Morton
264 schema:givenName Craig J.
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301624707.33
266 rdf:type schema:Person
267 sg:person.01303175270.57 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
268 schema:familyName Parker
269 schema:givenName Michael W.
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303175270.57
271 rdf:type schema:Person
272 sg:person.014111134073.57 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
273 schema:familyName Shing
274 schema:givenName Karen S. Cheung Tung
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014111134073.57
276 rdf:type schema:Person
277 sg:person.014243130677.65 schema:affiliation https://www.grid.ac/institutes/grid.430453.5
278 schema:familyName Hughes
279 schema:givenName Timothy P.
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014243130677.65
281 rdf:type schema:Person
282 sg:person.0604704414.46 schema:affiliation https://www.grid.ac/institutes/grid.1135.6
283 schema:familyName Wilson
284 schema:givenName Nicholas J.
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604704414.46
286 rdf:type schema:Person
287 sg:person.0713340341.51 schema:affiliation https://www.grid.ac/institutes/grid.481553.e
288 schema:familyName Schieber
289 schema:givenName Christine
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713340341.51
291 rdf:type schema:Person
292 sg:person.0721177464.52 schema:affiliation https://www.grid.ac/institutes/grid.470344.0
293 schema:familyName Kan
294 schema:givenName Winnie L.
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721177464.52
296 rdf:type schema:Person
297 sg:person.0721235453.06 schema:affiliation https://www.grid.ac/institutes/grid.470344.0
298 schema:familyName Lopez
299 schema:givenName Angel F.
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721235453.06
301 rdf:type schema:Person
302 sg:pub.10.1007/s00439-016-1644-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1024003995
303 https://doi.org/10.1007/s00439-016-1644-z
304 rdf:type schema:CreativeWork
305 sg:pub.10.1038/leu.2014.128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011662516
306 https://doi.org/10.1038/leu.2014.128
307 rdf:type schema:CreativeWork
308 sg:pub.10.1038/nature10975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036269489
309 https://doi.org/10.1038/nature10975
310 rdf:type schema:CreativeWork
311 sg:pub.10.1038/nsmb977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050126776
312 https://doi.org/10.1038/nsmb977
313 rdf:type schema:CreativeWork
314 sg:pub.10.1038/onc.2011.204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030411438
315 https://doi.org/10.1038/onc.2011.204
316 rdf:type schema:CreativeWork
317 sg:pub.10.1038/sj.leu.2401903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012171825
318 https://doi.org/10.1038/sj.leu.2401903
319 rdf:type schema:CreativeWork
320 https://app.dimensions.ai/details/publication/pub.1074517573 schema:CreativeWork
321 https://app.dimensions.ai/details/publication/pub.1074684089 schema:CreativeWork
322 https://app.dimensions.ai/details/publication/pub.1079343524 schema:CreativeWork
323 https://app.dimensions.ai/details/publication/pub.1082854093 schema:CreativeWork
324 https://doi.org/10.1002/0471721204.ch14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033997585
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1002/j.1460-2075.1994.tb06848.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082582509
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1002/jcc.20289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040543339
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1002/jcp.1041400219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028455591
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1002/pro.2072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007157542
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1006/bbrc.2001.5907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049055132
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1006/bcmd.1998.0184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048416437
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1016/0003-2697(80)90515-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007065635
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1016/0263-7855(96)00018-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005898005
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1016/j.bpj.2015.08.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010116240
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1016/j.cell.2007.12.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048155900
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1016/j.cell.2008.05.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010954840
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1016/j.cell.2011.06.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013868051
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1016/j.celrep.2014.06.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006842196
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1016/j.cytogfr.2013.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047443816
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1016/j.exphem.2003.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033615042
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1016/j.jmb.2017.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086123507
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1016/j.stem.2009.04.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021225281
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1016/j.str.2010.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014010860
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1016/j.str.2011.08.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031847251
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1016/j.str.2016.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032619145
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1016/s0076-6879(97)76066-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004907170
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1016/s0301-472x(99)00118-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026249712
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1016/s1097-2765(03)00389-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052539209
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1021/ct300400x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029039064
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1063/1.445869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058023889
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1073/pnas.89.24.11842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022704594
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1073/pnas.92.9.3779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035599535
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1074/jbc.271.42.25999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042334035
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1074/jbc.272.36.22630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000956264
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1074/jbc.m808197200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026629360
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1080/10428190701799035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018719390
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1107/s0907444904019158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020281098
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1107/s0907444905024984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043970233
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1107/s0907444906045975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016114112
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1107/s0907444910007493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000235100
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1107/s0907444911001314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032555428
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1107/s0909049502015170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022230728
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1107/s2053230x14002593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008551373
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1111/bjh.12282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013278415
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1111/bjh.12978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008407630
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1111/j.1600-065x.2012.01164.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035676994
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1126/science.1549776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062490342
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1128/mcb.16.6.3035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026798350
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1158/1078-0432.ccr-05-2070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021512475
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1172/jci.insight.86131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004755485
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1182/blood-2002-03-0852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004844104
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1182/blood-2005-02-0540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046876783
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1182/blood-2012-12-475194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052011799
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1182/blood-2014-04-566737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026864480
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1182/blood-2014-05-575704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064122650
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1182/bloodadvances.2016002931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100454359
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1371/journal.pone.0050375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016739651
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1371/journal.pone.0074376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030072085
431 rdf:type schema:CreativeWork
432 https://doi.org/10.18632/oncotarget.1306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037044962
433 rdf:type schema:CreativeWork
434 https://doi.org/10.3324/haematol.2011.047894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003991130
435 rdf:type schema:CreativeWork
436 https://doi.org/10.3324/haematol.2014.111740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009396656
437 rdf:type schema:CreativeWork
438 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
439 schema:name Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent’s Institute of Medical Research, 3065, Fitzroy, VIC, Australia
440 Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 3010, Parkville, VIC, Australia
441 rdf:type schema:Organization
442 https://www.grid.ac/institutes/grid.1073.5 schema:alternateName St Vincents Institute of Medical Research
443 schema:name Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent’s Institute of Medical Research, 3065, Fitzroy, VIC, Australia
444 rdf:type schema:Organization
445 https://www.grid.ac/institutes/grid.1135.6 schema:alternateName CSL (Australia)
446 schema:name CSL Limited, 3010, Parkville, VIC, Australia
447 rdf:type schema:Organization
448 https://www.grid.ac/institutes/grid.430453.5 schema:alternateName South Australian Health and Medical Research Institute
449 schema:name South Australian Health and Medical Research Institute and University of Adelaide, 5000, Adelaide, SA, Australia
450 rdf:type schema:Organization
451 https://www.grid.ac/institutes/grid.470344.0 schema:alternateName Centre for Cancer Biology
452 schema:name The Centre for Cancer Biology, SA Pathology and the University of South Australia, 5000, Adelaide, SA, Australia
453 rdf:type schema:Organization
454 https://www.grid.ac/institutes/grid.481553.e schema:alternateName IBM Research - Australia
455 schema:name IBM Research Australia, Level 5, 204 Lygon Street, 3053, Carlton, VIC, Australia
456 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...