Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Jérôme Carayol, Christian Chabert, Alessandro Di Cara, Claudia Armenise, Gregory Lefebvre, Dominique Langin, Nathalie Viguerie, Sylviane Metairon, Wim H. M. Saris, Arne Astrup, Patrick Descombes, Armand Valsesia, Jörg Hager

ABSTRACT

Thousands of genetic variants have been associated with complex traits through genome-wide association studies. However, the functional variants or mechanistic consequences remain elusive. Intermediate traits such as gene expression or protein levels are good proxies of the metabolic state of an organism. Proteome analysis especially can provide new insights into the molecular mechanisms of complex traits like obesity. The role of genetic variation in determining protein level variation has not been assessed in obesity. To address this, we design a large-scale protein quantitative trait locus (pQTL) analysis based on a set of 1129 proteins from 494 obese subjects before and after a weight loss intervention. This reveals 55 BMI-associated cis-pQTLs and trans-pQTLs at baseline and 3 trans-pQTLs after the intervention. We provide evidence for distinct genetic mechanisms regulating BMI-associated proteins before and after weight loss. Finally, by functional analysis, we identify and validate FAM46A as a trans regulator for leptin. More... »

PAGES

2084

References to SciGraph publications

  • 2001-01. Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation in INTERNATIONAL JOURNAL OF OBESITY
  • 2016-09-01. Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster in NATURE COMMUNICATIONS
  • 2014-12. Personalized weight loss strategies—the role of macronutrient distribution in NATURE REVIEWS ENDOCRINOLOGY
  • 2016-02-01. Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels in NATURE COMMUNICATIONS
  • 2007-04. Netrins: beyond the brain in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2014-04. Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity in NATURE MEDICINE
  • 2008-07. Mapping and quantifying mammalian transcriptomes by RNA-Seq in NATURE METHODS
  • 2017-02-27. Genome-wide identification of splicing QTLs in the human brain and their enrichment among schizophrenia-associated loci in NATURE COMMUNICATIONS
  • 2006-08. Cellular adhesion molecules and their relationship with measures of obesity and metabolic syndrome in a multiethnic population in INTERNATIONAL JOURNAL OF OBESITY
  • 2016-10. Next-generation genotype imputation service and methods in NATURE GENETICS
  • 2011-12. Human growth hormone receptor (GHR) expression in obesity: I. GHR mRNA expression in omental and subcutaneous adipose tissues of obese women in INTERNATIONAL JOURNAL OF OBESITY
  • 2009-06. Sequential interplay between BAG6 and HSP70 upon heat shock in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2015-04. The role of regulatory variation in complex traits and disease in NATURE REVIEWS GENETICS
  • 2000-06. Synthesis and regulation of sex hormone-binding globulin in obesity in INTERNATIONAL JOURNAL OF OBESITY
  • 2015-02. Genetic studies of body mass index yield new insights for obesity biology in NATURE
  • 2016-06. Defining the consequences of genetic variation on a proteome-wide scale in NATURE
  • 2017-02-27. Connecting genetic risk to disease end points through the human blood plasma proteome in NATURE COMMUNICATIONS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-017-02182-z

    DOI

    http://dx.doi.org/10.1038/s41467-017-02182-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1099597634

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29234017


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