Ontology type: schema:ScholarlyArticle Open Access: True
2017-12
AUTHORSWenhe Zhong, Liang Cui, Boon Chong Goh, Qixu Cai, Peiying Ho, Yok Hian Chionh, Meng Yuan, Abbas El Sahili, Linda A. Fothergill-Gilmore, Malcolm D. Walkinshaw, Julien Lescar, Peter C. Dedon
ABSTRACTPyruvate kinase (PYK) is an essential glycolytic enzyme that controls glycolytic flux and is critical for ATP production in all organisms, with tight regulation by multiple metabolites. Yet the allosteric mechanisms governing PYK activity in bacterial pathogens are poorly understood. Here we report biochemical, structural and metabolomic evidence that Mycobacterium tuberculosis (Mtb) PYK uses AMP and glucose-6-phosphate (G6P) as synergistic allosteric activators that function as a molecular "OR logic gate" to tightly regulate energy and glucose metabolism. G6P was found to bind to a previously unknown site adjacent to the canonical site for AMP. Kinetic data and structural network analysis further show that AMP and G6P work synergistically as allosteric activators. Importantly, metabolome profiling in the Mtb surrogate, Mycobacterium bovis BCG, reveals significant changes in AMP and G6P levels during nutrient deprivation, which provides insights into how a PYK OR gate would function during the stress of Mtb infection. More... »
PAGES1986
http://scigraph.springernature.com/pub.10.1038/s41467-017-02086-y
DOIhttp://dx.doi.org/10.1038/s41467-017-02086-y
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1093139655
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29215013
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adenosine Monophosphate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Allosteric Regulation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Crystallography, X-Ray",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Enzyme Assays",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glucose",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glucose-6-Phosphate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kinetics",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Metabolome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Metabolomics",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Molecular Docking Simulation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mycobacterium bovis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mycobacterium tuberculosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein Domains",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pyruvate Kinase",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Nanyang Technological University",
"id": "https://www.grid.ac/institutes/grid.59025.3b",
"name": [
"Infectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, 138602, Singapore, Singapore",
"NTU Institute of Structural Biology, Nanyang Technological University, 636921, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Zhong",
"givenName": "Wenhe",
"id": "sg:person.01315734521.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315734521.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Singapore-MIT Alliance for Research and Technology",
"id": "https://www.grid.ac/institutes/grid.429485.6",
"name": [
"Infectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, 138602, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Cui",
"givenName": "Liang",
"id": "sg:person.01041544675.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041544675.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nanyang Technological University",
"id": "https://www.grid.ac/institutes/grid.59025.3b",
"name": [
"Infectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, 138602, Singapore, Singapore",
"NTU Institute of Structural Biology, Nanyang Technological University, 636921, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Goh",
"givenName": "Boon Chong",
"id": "sg:person.0650376750.85",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650376750.85"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hong Kong University of Science and Technology",
"id": "https://www.grid.ac/institutes/grid.24515.37",
"name": [
"Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China"
],
"type": "Organization"
},
"familyName": "Cai",
"givenName": "Qixu",
"id": "sg:person.01102470320.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102470320.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Singapore-MIT Alliance for Research and Technology",
"id": "https://www.grid.ac/institutes/grid.429485.6",
"name": [
"Infectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, 138602, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Ho",
"givenName": "Peiying",
"id": "sg:person.0754371774.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754371774.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Singapore-MIT Alliance for Research and Technology",
"id": "https://www.grid.ac/institutes/grid.429485.6",
"name": [
"Infectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, 138602, Singapore, Singapore",
"Tychan Private Ltd, 80 Robinson Road, #17-02, 068898, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Chionh",
"givenName": "Yok Hian",
"id": "sg:person.01117442225.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117442225.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Scripps Research Institute",
"id": "https://www.grid.ac/institutes/grid.214007.0",
"name": [
"Institute of Quantitative Biology, Biochemistry and Biotechnology, University of Edinburgh, King\u2019s Buildings, EH9 3BF, Edinburgh, UK",
"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 92037, La Jolla, CA, USA"
],
"type": "Organization"
},
"familyName": "Yuan",
"givenName": "Meng",
"id": "sg:person.01237401466.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237401466.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nanyang Technological University",
"id": "https://www.grid.ac/institutes/grid.59025.3b",
"name": [
"NTU Institute of Structural Biology, Nanyang Technological University, 636921, Singapore, Singapore",
"School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Sahili",
"givenName": "Abbas El",
"id": "sg:person.011421630443.99",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011421630443.99"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Edinburgh",
"id": "https://www.grid.ac/institutes/grid.4305.2",
"name": [
"Institute of Quantitative Biology, Biochemistry and Biotechnology, University of Edinburgh, King\u2019s Buildings, EH9 3BF, Edinburgh, UK"
],
"type": "Organization"
},
"familyName": "Fothergill-Gilmore",
"givenName": "Linda A.",
"id": "sg:person.0746113413.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746113413.88"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Edinburgh",
"id": "https://www.grid.ac/institutes/grid.4305.2",
"name": [
"Institute of Quantitative Biology, Biochemistry and Biotechnology, University of Edinburgh, King\u2019s Buildings, EH9 3BF, Edinburgh, UK"
],
"type": "Organization"
},
"familyName": "Walkinshaw",
"givenName": "Malcolm D.",
"id": "sg:person.01101163533.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101163533.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nanyang Technological University",
"id": "https://www.grid.ac/institutes/grid.59025.3b",
"name": [
"NTU Institute of Structural Biology, Nanyang Technological University, 636921, Singapore, Singapore",
"School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Lescar",
"givenName": "Julien",
"id": "sg:person.0601645323.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601645323.84"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Massachusetts Institute of Technology",
"id": "https://www.grid.ac/institutes/grid.116068.8",
"name": [
"Infectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, 138602, Singapore, Singapore",
"Department of Biological Engineering, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA"
],
"type": "Organization"
},
"familyName": "Dedon",
"givenName": "Peter C.",
"id": "sg:person.0772755577.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772755577.30"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nature11540",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000007436",
"https://doi.org/10.1038/nature11540"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444910045749",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002186240"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1510932112",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002486539"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0263-7855(96)00018-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005898005"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.chembiol.2010.08.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006174380"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ct4008603",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006888895"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1513033112",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007778374"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m111.289033",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007943992"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0021889807021206",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012753217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444905036693",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013232159"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms12393",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016066971",
"https://doi.org/10.1038/ncomms12393"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ci3003649",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018459126"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms13302",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018608148",
"https://doi.org/10.1038/ncomms13302"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444904019158",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020281098"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m109.074310",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020916993"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444913013875",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021100089"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20030846",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023672265"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m110.212613",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024765935"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pcbi.1003159",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025562281"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-2105-9-40",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026371509",
"https://doi.org/10.1186/1471-2105-9-40"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.ppat.1003116",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028034529"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1518171112",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028467879"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ct300400x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029039064"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj2410573",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029111651"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj2410573",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029111651"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m109.079905",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032535967"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444911001314",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032555428"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444913000061",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036142611"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444904026460",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036575621"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tibs.2012.04.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037428799"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1098/rsos.140120",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037578800"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0969-2126(98)00021-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037838477"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1217157110",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037876748"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1139/o75-061",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038626226"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcc.20289",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040543339"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcc.20289",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040543339"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nchembio.1060",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041031209",
"https://doi.org/10.1038/nchembio.1060"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444910048675",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042333798"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms10111",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045601085",
"https://doi.org/10.1038/ncomms10111"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ci300363c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046844098"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.chembiol.2011.06.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048452668"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tim.2011.03.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050602997"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gkm216",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052481822"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0810961106",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053108239"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/acs.jcim.6b00115",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055098333"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bi0474923",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055198562"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bi0474923",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055198562"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bi100780t",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055203335"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bi100780t",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055203335"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1063/1.445869",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058023889"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m115.707430",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058214448"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/jvi.00378-16",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062712482"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080459278",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082126111",
"type": "CreativeWork"
}
],
"datePublished": "2017-12",
"datePublishedReg": "2017-12-01",
"description": "Pyruvate kinase (PYK) is an essential glycolytic enzyme that controls glycolytic flux and is critical for ATP production in all organisms, with tight regulation by multiple metabolites. Yet the allosteric mechanisms governing PYK activity in bacterial pathogens are poorly understood. Here we report biochemical, structural and metabolomic evidence that Mycobacterium tuberculosis (Mtb) PYK uses AMP and glucose-6-phosphate (G6P) as synergistic allosteric activators that function as a molecular \"OR logic gate\" to tightly regulate energy and glucose metabolism. G6P was found to bind to a previously unknown site adjacent to the canonical site for AMP. Kinetic data and structural network analysis further show that AMP and G6P work synergistically as allosteric activators. Importantly, metabolome profiling in the Mtb surrogate, Mycobacterium bovis BCG, reveals significant changes in AMP and G6P levels during nutrient deprivation, which provides insights into how a PYK OR gate would function during the stress of Mtb infection.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41467-017-02086-y",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2763430",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1043282",
"issn": [
"2041-1723"
],
"name": "Nature Communications",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "8"
}
],
"name": "Allosteric pyruvate kinase-based \u201clogic gate\u201d synergistically senses energy and sugar levels in Mycobacterium tuberculosis",
"pagination": "1986",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"8f82cd67205b7d1361607810840ac7b77678bf008499557170921b6af2308c48"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29215013"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101528555"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41467-017-02086-y"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1093139655"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41467-017-02086-y",
"https://app.dimensions.ai/details/publication/pub.1093139655"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T17:38",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000552.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41467-017-02086-y"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-02086-y'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-02086-y'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-02086-y'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-02086-y'
This table displays all metadata directly associated to this object as RDF triples.
377 TRIPLES
21 PREDICATES
93 URIs
35 LITERALS
23 BLANK NODES