Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Inma M. Berenjeno, Roberto Piñeiro, Sandra D. Castillo, Wayne Pearce, Nicholas McGranahan, Sally M. Dewhurst, Valerie Meniel, Nicolai J. Birkbak, Evelyn Lau, Laurent Sansregret, Daniele Morelli, Nnennaya Kanu, Shankar Srinivas, Mariona Graupera, Victoria E. R. Parker, Karen G. Montgomery, Larissa S. Moniz, Cheryl L. Scudamore, Wayne A. Phillips, Robert K. Semple, Alan Clarke, Charles Swanton, Bart Vanhaesebroeck

ABSTRACT

Mutations in PIK3CA are very frequent in cancer and lead to sustained PI3K pathway activation. The impact of acute expression of mutant PIK3CA during early stages of malignancy is unknown. Using a mouse model to activate the Pik3ca H1047R hotspot mutation in the heterozygous state from its endogenous locus, we here report that mutant Pik3ca induces centrosome amplification in cultured cells (through a pathway involving AKT, ROCK and CDK2/Cyclin E-nucleophosmin) and in mouse tissues, and increased in vitro cellular tolerance to spontaneous genome doubling. We also present evidence that the majority of PIK3CA H1047R mutations in the TCGA breast cancer cohort precede genome doubling. These previously unappreciated roles of PIK3CA mutation show that PI3K signalling can contribute to the generation of irreversible genomic changes in cancer. While this can limit the impact of PI3K-targeted therapies, these findings also open the opportunity for therapeutic approaches aimed at limiting tumour heterogeneity and evolution. More... »

PAGES

1773

References to SciGraph publications

  • 2014-02. PI3K and cancer: lessons, challenges and opportunities in NATURE REVIEWS DRUG DISCOVERY
  • 2009-07. A mechanism linking extra centrosomes to chromosomal instability in NATURE
  • 2016-01. Molecules in medicine mini-review: isoforms of PI3K in biology and disease in JOURNAL OF MOLECULAR MEDICINE
  • 2008-05. Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice in NATURE PROTOCOLS
  • 2016-01. Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis in NATURE CELL BIOLOGY
  • 2005-11. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors in NATURE GENETICS
  • 2004-04. Transgenic Mouse Line with Green-fluorescent Protein-labeled Centrin 2 allows Visualization of the Centrosome in Living Cells in TRANSGENIC RESEARCH
  • 2010-04. A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts in CELL DEATH & DISEASE
  • 2013-10. Pan-cancer patterns of somatic copy number alteration in NATURE GENETICS
  • 2007-12. Oncogenes and tumour suppressors take on centrosomes in NATURE REVIEWS CANCER
  • 2015-08-12. Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity in NATURE
  • 2005-10. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells in NATURE
  • 2012-08. Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA in NATURE GENETICS
  • 2017-12. Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate in SCIENTIFIC REPORTS
  • 2015-01. PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting in NATURE REVIEWS CANCER
  • 2008-12. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers in NATURE MEDICINE
  • 2011-05. Activated ROCK II by-passes the requirement of the CDK2 activity for centrosome duplication and amplification in ONCOGENE
  • 2013-01. Conditional activation of Pik3caH1047R in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations in ONCOGENE
  • 2015-11. Centrosomes and cancer: revisiting a long-standing relationship in NATURE REVIEWS CANCER
  • 2012-05. Absolute quantification of somatic DNA alterations in human cancer in NATURE BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-017-02002-4

    DOI

    http://dx.doi.org/10.1038/s41467-017-02002-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092832035

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29170395


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