Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Noha A. Yousri, Khalid A. Fakhro, Amal Robay, Juan L. Rodriguez-Flores, Robert P. Mohney, Hassina Zeriri, Tala Odeh, Sara Abdul Kader, Eman K. Aldous, Gaurav Thareja, Manish Kumar, Alya Al-Shakaki, Omar M. Chidiac, Yasmin A. Mohamoud, Jason G. Mezey, Joel A. Malek, Ronald G. Crystal, Karsten Suhre

ABSTRACT

Metabolomics-genome-wide association studies (mGWAS) have uncovered many metabolic quantitative trait loci (mQTLs) influencing human metabolic individuality, though predominantly in European cohorts. By combining whole-exome sequencing with a high-resolution metabolomics profiling for a highly consanguineous Middle Eastern population, we discover 21 common variant and 12 functional rare variant mQTLs, of which 45% are novel altogether. We fine-map 10 common variant mQTLs to new metabolite ratio associations, and 11 common variant mQTLs to putative protein-altering variants. This is the first work to report common and rare variant mQTLs linked to diseases and/or pharmacological targets in a consanguineous Arab cohort, with wide implications for precision medicine in the Middle East. More... »

PAGES

333

References to SciGraph publications

  • 2016-12. The Qatar genome: a population-specific tool for precision medicine in the Middle East in HUMAN GENOME VARIATION
  • 2014-10. Long term conservation of human metabolic phenotypes and link to heritability in METABOLOMICS
  • 2000-06. Deafness heterogeneity in a Druze isolate from the Middle East: novel OTOF and PDS mutations, low prevalence of GJB2 35delG mutation and indication for a new DFNB locus in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2016-08. Analysis of protein-coding genetic variation in 60,706 humans in NATURE
  • 2016-03-23. Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA in NATURE COMMUNICATIONS
  • 2015-12. Microarray analysis identifies IL-1 receptor type 2 as a novel candidate biomarker in patients with acute respiratory distress syndrome in RESPIRATORY RESEARCH
  • 1999-12. Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2) in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2012-02. A linear complexity phasing method for thousands of genomes in NATURE METHODS
  • 2012-10. Pharmacogenomics Knowledge for Personalized Medicine in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2017-04. Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites in NATURE GENETICS
  • 2009-10. Androgens in rheumatoid arthritis: when are they effectors? in ARTHRITIS RESEARCH & THERAPY
  • 2012-12. On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies in BMC BIOINFORMATICS
  • 2016-12. An exome array study of the plasma metabolome in NATURE COMMUNICATIONS
  • 2016-09. Metabolomics enables precision medicine: “A White Paper, Community Perspective” in METABOLOMICS
  • 2017-12. Large Scale Metabolic Profiling identifies Novel Steroids linked to Rheumatoid Arthritis in SCIENTIFIC REPORTS
  • 2014-05. Hypoxia and hypoxia-inducible factor 1 repress SEMA4B expression to promote non-small cell lung cancer invasion in TUMOR BIOLOGY
  • 2001. Differential expression of a novel serine protease homologue in squamous cell carcinoma of the head and neck in BRITISH JOURNAL OF CANCER
  • 2015-12. Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels in NATURE COMMUNICATIONS
  • 2001-01. Role of Common Gene Variations in the Molecular Pathogenesis of Short-Chain Acyl-CoA Dehydrogenase Deficiency in PEDIATRIC RESEARCH
  • 2013-12. Lysine metabolism in mammalian brain: an update on the importance of recent discoveries in AMINO ACIDS
  • 2016-10-12. Genomics is failing on diversity in NATURE
  • 2011-06. A genome-wide association study of metabolic traits in human urine in NATURE GENETICS
  • 2010-02. A genome-wide perspective of genetic variation in human metabolism in NATURE GENETICS
  • 1999-04. A mutation in OTOF, encoding otoferlin, a FER-1-like protein, causes DFNB9, a nonsyndromic form of deafness in NATURE GENETICS
  • 2014-06. An atlas of genetic influences on human blood metabolites in NATURE GENETICS
  • 2003-07. Genomic approaches to identifying transcriptional regulators of osteoblast differentiation in GENOME BIOLOGY
  • 2011-05. A framework for variation discovery and genotyping using next-generation DNA sequencing data in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-017-01972-9

    DOI

    http://dx.doi.org/10.1038/s41467-017-01972-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100485427

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29362361


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