DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Stephan Nothjunge, Thomas G. Nührenberg, Björn A. Grüning, Stefanie A. Doppler, Sebastian Preissl, Martin Schwaderer, Carolin Rommel, Markus Krane, Lutz Hein, Ralf Gilsbach

ABSTRACT

Storage of chromatin in restricted nuclear space requires dense packing while ensuring DNA accessibility. Thus, different layers of chromatin organization and epigenetic control mechanisms exist. Genome-wide chromatin interaction maps revealed large interaction domains (TADs) and higher order A and B compartments, reflecting active and inactive chromatin, respectively. The mutual dependencies between chromatin organization and patterns of epigenetic marks, including DNA methylation, remain poorly understood. Here, we demonstrate that establishment of A/B compartments precedes and defines DNA methylation signatures during differentiation and maturation of cardiac myocytes. Remarkably, dynamic CpG and non-CpG methylation in cardiac myocytes is confined to A compartments. Furthermore, genetic ablation or reduction of DNA methylation in embryonic stem cells or cardiac myocytes, respectively, does not alter genome-wide chromatin organization. Thus, DNA methylation appears to be established in preformed chromatin compartments and may be dispensable for the formation of higher order chromatin organization. More... »

PAGES

1667

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-017-01724-9

    DOI

    http://dx.doi.org/10.1038/s41467-017-01724-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092714925

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29162810


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