Structural basis for xenobiotic extrusion by eukaryotic MATE transporter View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Hirotake Miyauchi, Satomi Moriyama, Tsukasa Kusakizako, Kaoru Kumazaki, Takanori Nakane, Keitaro Yamashita, Kunio Hirata, Naoshi Dohmae, Tomohiro Nishizawa, Koichi Ito, Takaaki Miyaji, Yoshinori Moriyama, Ryuichiro Ishitani, Osamu Nureki

ABSTRACT

Mulitidrug and toxic compound extrusion (MATE) family transporters export xenobiotics to maintain cellular homeostasis. The human MATE transporters mediate the excretion of xenobiotics and cationic clinical drugs, whereas some plant MATE transporters are responsible for aluminum tolerance and secondary metabolite transport. Here we report the crystal structure of the eukaryotic MATE transporter from Arabidopsis thaliana, at 2.6 Å resolution. The structure reveals that its carboxy-terminal lobe (C-lobe) contains an extensive hydrogen-bonding network with well-conserved acidic residues, and their importance is demonstrated by the structure-based mutational analysis. The structural and functional analyses suggest that the transport mechanism involves the structural change of transmembrane helix 7, induced by the formation of a hydrogen-bonding network upon the protonation of the conserved acidic residue in the C-lobe. Our findings provide insights into the transport mechanism of eukaryotic MATE transporters, which is important for the improvement of the pharmacokinetics of the clinical drugs. More... »

PAGES

1633

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-017-01541-0

DOI

http://dx.doi.org/10.1038/s41467-017-01541-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092714914

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29158478


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arabidopsis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arabidopsis Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Plant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organic Cation Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Domains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenobiotics", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, 113-0032, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyauchi", 
        "givenName": "Hirotake", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Okayama University", 
          "id": "https://www.grid.ac/institutes/grid.261356.5", 
          "name": [
            "Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 700-8530, Okayama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moriyama", 
        "givenName": "Satomi", 
        "id": "sg:person.011001112653.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011001112653.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, 113-0032, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kusakizako", 
        "givenName": "Tsukasa", 
        "id": "sg:person.01137642207.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137642207.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, 113-0032, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kumazaki", 
        "givenName": "Kaoru", 
        "id": "sg:person.01257541632.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257541632.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, 113-0032, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakane", 
        "givenName": "Takanori", 
        "id": "sg:person.01044316423.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044316423.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "RIKEN SPring-8 Center, Sayo-gun, 679-5148, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamashita", 
        "givenName": "Keitaro", 
        "id": "sg:person.0624540116.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624540116.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "RIKEN SPring-8 Center, Sayo-gun, 679-5148, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirata", 
        "givenName": "Kunio", 
        "id": "sg:person.01256470305.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256470305.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RIKEN", 
          "id": "https://www.grid.ac/institutes/grid.7597.c", 
          "name": [
            "Biomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science, Wako, 351-0198, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dohmae", 
        "givenName": "Naoshi", 
        "id": "sg:person.01002040077.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002040077.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, 113-0032, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishizawa", 
        "givenName": "Tomohiro", 
        "id": "sg:person.01033506435.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033506435.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 277-8562, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Koichi", 
        "id": "sg:person.01022333176.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022333176.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Okayama University", 
          "id": "https://www.grid.ac/institutes/grid.261356.5", 
          "name": [
            "Advanced Science Research Center, Okayama University, 700-8530, Okayama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyaji", 
        "givenName": "Takaaki", 
        "id": "sg:person.0610612725.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610612725.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Okayama University", 
          "id": "https://www.grid.ac/institutes/grid.261356.5", 
          "name": [
            "Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 700-8530, Okayama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moriyama", 
        "givenName": "Yoshinori", 
        "id": "sg:person.01322341712.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322341712.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, 113-0032, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishitani", 
        "givenName": "Ryuichiro", 
        "id": "sg:person.01221724404.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221724404.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, 113-0032, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nureki", 
        "givenName": "Osamu", 
        "id": "sg:person.01043223704.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043223704.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1107/s0907444910007493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000235100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444910007493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000235100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.49.5.1865-1871.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002319938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m108777200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002510973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003844296", 
          "https://doi.org/10.1038/nature12014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506483102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005723093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tips.2006.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006578464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro3175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009238642", 
          "https://doi.org/10.1038/nrmicro3175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00090.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009364526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2006030205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009447232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2006030205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009447232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms8995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012049543", 
          "https://doi.org/10.1038/ncomms8995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1219901110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013864174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.187.5.1552-1558.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015745349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.3346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018133728", 
          "https://doi.org/10.1038/nsmb.3346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00504.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018260603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889897006766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019562892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2958.1999.01162.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019649302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444996012255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020405374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0028766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023788906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2007.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024360816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1003120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024976318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1105/tpc.106.046029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030158176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1993.1626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030443070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0812512106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030863605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909047337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032162623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909047337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032162623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-biochem-060815-014520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032964256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(73)90217-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034117293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-1033.2003.03418.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035445872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/mp/ssu063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035618225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035712479", 
          "https://doi.org/10.1038/nsmb.2687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444904026460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036575621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2007.04.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036736950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-313x.2008.03696.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038295961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1104/pp.107.097162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038472087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038980105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2006.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040537865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042208726", 
          "https://doi.org/10.1038/nature09408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042208726", 
          "https://doi.org/10.1038/nature09408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.49.5.1857-1864.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048822420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jxb/erp312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050566751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444902016657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051282549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m116.728618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058214964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/19336950.2015.1106654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058412560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.4952941", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1096150003"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Mulitidrug and toxic compound extrusion (MATE) family transporters export xenobiotics to maintain cellular homeostasis. The human MATE transporters mediate the excretion of xenobiotics and cationic clinical drugs, whereas some plant MATE transporters are responsible for aluminum tolerance and secondary metabolite transport. Here we report the crystal structure of the eukaryotic MATE transporter from Arabidopsis thaliana, at 2.6\u2009\u00c5 resolution. The structure reveals that its carboxy-terminal lobe (C-lobe) contains an extensive hydrogen-bonding network with well-conserved acidic residues, and their importance is demonstrated by the structure-based mutational analysis. The structural and functional analyses suggest that the transport mechanism involves the structural change of transmembrane helix 7, induced by the formation of a hydrogen-bonding network upon the protonation of the conserved acidic residue in the C-lobe. Our findings provide insights into the transport mechanism of eukaryotic MATE transporters, which is important for the improvement of the pharmacokinetics of the clinical drugs.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-017-01541-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6534916", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6107319", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Structural basis for xenobiotic extrusion by eukaryotic MATE transporter", 
    "pagination": "1633", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ca6cfb37f41d0a6e843ba158e6bdae3af9070e90502ba3d62e32bd1a123934b8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29158478"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-017-01541-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1092714914"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-017-01541-0", 
      "https://app.dimensions.ai/details/publication/pub.1092714914"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000548.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-017-01541-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-01541-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-01541-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-01541-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-01541-0'


 

This table displays all metadata directly associated to this object as RDF triples.

338 TRIPLES      21 PREDICATES      79 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-017-01541-0 schema:about N16a547c2bb1b4e6d9cd2e6bb8e8f2a98
2 N4936c3143daa4b6d83c9ed83e72c542c
3 N564329ac50434b10a3e7010f75256144
4 N646956a87f1b49a1900cf1a95d4a64a7
5 N72496640212f4b0683a51876986ca9a5
6 Nbec2546c7018457294ffa9d537bba689
7 Ne941f9258a6646e2aac479a70a0f6b04
8 Nf3e9c82bb1204c95bc614f9f00f7af03
9 anzsrc-for:06
10 anzsrc-for:0601
11 schema:author N7266a3e684d249d8924583495d901d3e
12 schema:citation sg:pub.10.1038/nature09408
13 sg:pub.10.1038/nature12014
14 sg:pub.10.1038/ncomms8995
15 sg:pub.10.1038/nrmicro3175
16 sg:pub.10.1038/nsmb.2687
17 sg:pub.10.1038/nsmb.3346
18 https://doi.org/10.1006/jmbi.1993.1626
19 https://doi.org/10.1016/0003-2697(73)90217-0
20 https://doi.org/10.1016/j.bcp.2007.03.004
21 https://doi.org/10.1016/j.bcp.2007.04.010
22 https://doi.org/10.1016/j.cell.2012.04.012
23 https://doi.org/10.1016/j.str.2006.01.013
24 https://doi.org/10.1016/j.tips.2006.09.001
25 https://doi.org/10.1046/j.1365-2958.1999.01162.x
26 https://doi.org/10.1046/j.1432-1033.2003.03418.x
27 https://doi.org/10.1063/1.4952941
28 https://doi.org/10.1073/pnas.0506483102
29 https://doi.org/10.1073/pnas.0812512106
30 https://doi.org/10.1073/pnas.1219901110
31 https://doi.org/10.1074/jbc.m108777200
32 https://doi.org/10.1074/jbc.m116.728618
33 https://doi.org/10.1080/19336950.2015.1106654
34 https://doi.org/10.1093/jxb/erp312
35 https://doi.org/10.1093/mp/ssu063
36 https://doi.org/10.1104/pp.107.097162
37 https://doi.org/10.1105/tpc.106.046029
38 https://doi.org/10.1107/s0021889897006766
39 https://doi.org/10.1107/s0907444902016657
40 https://doi.org/10.1107/s0907444904026460
41 https://doi.org/10.1107/s0907444909047337
42 https://doi.org/10.1107/s0907444910007493
43 https://doi.org/10.1107/s0907444996012255
44 https://doi.org/10.1111/j.1365-313x.2008.03696.x
45 https://doi.org/10.1128/aac.49.5.1857-1864.2005
46 https://doi.org/10.1128/aac.49.5.1865-1871.2005
47 https://doi.org/10.1128/jb.187.5.1552-1558.2005
48 https://doi.org/10.1146/annurev-biochem-060815-014520
49 https://doi.org/10.1152/ajpcell.00090.2006
50 https://doi.org/10.1152/ajpcell.00504.2007
51 https://doi.org/10.1371/journal.pgen.1003120
52 https://doi.org/10.1371/journal.pone.0028766
53 https://doi.org/10.1681/asn.2006030205
54 schema:datePublished 2017-12
55 schema:datePublishedReg 2017-12-01
56 schema:description Mulitidrug and toxic compound extrusion (MATE) family transporters export xenobiotics to maintain cellular homeostasis. The human MATE transporters mediate the excretion of xenobiotics and cationic clinical drugs, whereas some plant MATE transporters are responsible for aluminum tolerance and secondary metabolite transport. Here we report the crystal structure of the eukaryotic MATE transporter from Arabidopsis thaliana, at 2.6 Å resolution. The structure reveals that its carboxy-terminal lobe (C-lobe) contains an extensive hydrogen-bonding network with well-conserved acidic residues, and their importance is demonstrated by the structure-based mutational analysis. The structural and functional analyses suggest that the transport mechanism involves the structural change of transmembrane helix 7, induced by the formation of a hydrogen-bonding network upon the protonation of the conserved acidic residue in the C-lobe. Our findings provide insights into the transport mechanism of eukaryotic MATE transporters, which is important for the improvement of the pharmacokinetics of the clinical drugs.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N5562e7aa028f4414a26bdd97342382b7
61 Nb62bca9accf6468dac690c11a6a63b04
62 sg:journal.1043282
63 schema:name Structural basis for xenobiotic extrusion by eukaryotic MATE transporter
64 schema:pagination 1633
65 schema:productId N3d4d4bab067548e1b0f4d9dcee0ce982
66 N65c2d6cafeb94b208404cdc229d2c0e7
67 N75eafa10885b4860a07eebd377a47d19
68 N9f5e51f018854756b5669d3d4010c5e5
69 Nddab3611842a4d0d81ba04f24dacf63f
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092714914
71 https://doi.org/10.1038/s41467-017-01541-0
72 schema:sdDatePublished 2019-04-10T23:31
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nd87501aa8db742c98587f1a68c462cc2
75 schema:url https://www.nature.com/articles/s41467-017-01541-0
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N16a547c2bb1b4e6d9cd2e6bb8e8f2a98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Protein Domains
81 rdf:type schema:DefinedTerm
82 N1a97cf4b81a74f05a066e62a7b14cace schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
83 schema:familyName Miyauchi
84 schema:givenName Hirotake
85 rdf:type schema:Person
86 N223cf2b18715429489799e04f71b9dad rdf:first sg:person.0610612725.36
87 rdf:rest N3f23664dfc4a4c67921b5e1f41edb008
88 N3d4d4bab067548e1b0f4d9dcee0ce982 schema:name pubmed_id
89 schema:value 29158478
90 rdf:type schema:PropertyValue
91 N3f23664dfc4a4c67921b5e1f41edb008 rdf:first sg:person.01322341712.84
92 rdf:rest N7ba619ba6a25402594c79e40aa99ef59
93 N4936c3143daa4b6d83c9ed83e72c542c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Xenobiotics
95 rdf:type schema:DefinedTerm
96 N5562e7aa028f4414a26bdd97342382b7 schema:volumeNumber 8
97 rdf:type schema:PublicationVolume
98 N564329ac50434b10a3e7010f75256144 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Gene Expression Regulation, Plant
100 rdf:type schema:DefinedTerm
101 N5a743a26d3804072936800a69ad9e5c7 schema:name RIKEN SPring-8 Center, Sayo-gun, 679-5148, Hyogo, Japan
102 rdf:type schema:Organization
103 N646956a87f1b49a1900cf1a95d4a64a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Biological Transport
105 rdf:type schema:DefinedTerm
106 N65c2d6cafeb94b208404cdc229d2c0e7 schema:name dimensions_id
107 schema:value pub.1092714914
108 rdf:type schema:PropertyValue
109 N72496640212f4b0683a51876986ca9a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Organic Cation Transport Proteins
111 rdf:type schema:DefinedTerm
112 N7266a3e684d249d8924583495d901d3e rdf:first N1a97cf4b81a74f05a066e62a7b14cace
113 rdf:rest Nd089081cda1a4d4dadb176a289533769
114 N75eafa10885b4860a07eebd377a47d19 schema:name readcube_id
115 schema:value ca6cfb37f41d0a6e843ba158e6bdae3af9070e90502ba3d62e32bd1a123934b8
116 rdf:type schema:PropertyValue
117 N7ba619ba6a25402594c79e40aa99ef59 rdf:first sg:person.01221724404.09
118 rdf:rest N895b3f55ee324ad199b4422649d47785
119 N895b3f55ee324ad199b4422649d47785 rdf:first sg:person.01043223704.15
120 rdf:rest rdf:nil
121 N8d77ce15bb144fb7aa0ada25d2e81ce2 rdf:first sg:person.01257541632.51
122 rdf:rest Ncea3dc6e8a24406ca60ee104e2faddd3
123 N8eceecb401f94e55b4b0861ec56fa116 rdf:first sg:person.01256470305.03
124 rdf:rest N961f7d3de035497799f48b330f33d1b3
125 N92bb1faccc064c698cfc111ebbcb9c58 rdf:first sg:person.01022333176.34
126 rdf:rest N223cf2b18715429489799e04f71b9dad
127 N961f7d3de035497799f48b330f33d1b3 rdf:first sg:person.01002040077.62
128 rdf:rest N9eedf87af3c6458e9b2d46150ddd174a
129 N9eedf87af3c6458e9b2d46150ddd174a rdf:first sg:person.01033506435.08
130 rdf:rest N92bb1faccc064c698cfc111ebbcb9c58
131 N9ef043fb74df465197af0419bb6b25ec rdf:first sg:person.01137642207.68
132 rdf:rest N8d77ce15bb144fb7aa0ada25d2e81ce2
133 N9f5e51f018854756b5669d3d4010c5e5 schema:name doi
134 schema:value 10.1038/s41467-017-01541-0
135 rdf:type schema:PropertyValue
136 Nb62bca9accf6468dac690c11a6a63b04 schema:issueNumber 1
137 rdf:type schema:PublicationIssue
138 Nbdfdce5c6aac4b969ac9543d3730cb82 schema:name RIKEN SPring-8 Center, Sayo-gun, 679-5148, Hyogo, Japan
139 rdf:type schema:Organization
140 Nbec2546c7018457294ffa9d537bba689 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Arabidopsis Proteins
142 rdf:type schema:DefinedTerm
143 Ncea3dc6e8a24406ca60ee104e2faddd3 rdf:first sg:person.01044316423.25
144 rdf:rest Ndbce5af677fd442fa7f61929a014d22d
145 Nd089081cda1a4d4dadb176a289533769 rdf:first sg:person.011001112653.81
146 rdf:rest N9ef043fb74df465197af0419bb6b25ec
147 Nd87501aa8db742c98587f1a68c462cc2 schema:name Springer Nature - SN SciGraph project
148 rdf:type schema:Organization
149 Ndbce5af677fd442fa7f61929a014d22d rdf:first sg:person.0624540116.94
150 rdf:rest N8eceecb401f94e55b4b0861ec56fa116
151 Nddab3611842a4d0d81ba04f24dacf63f schema:name nlm_unique_id
152 schema:value 101528555
153 rdf:type schema:PropertyValue
154 Ne941f9258a6646e2aac479a70a0f6b04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Humans
156 rdf:type schema:DefinedTerm
157 Nf3e9c82bb1204c95bc614f9f00f7af03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Arabidopsis
159 rdf:type schema:DefinedTerm
160 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
161 schema:name Biological Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
164 schema:name Biochemistry and Cell Biology
165 rdf:type schema:DefinedTerm
166 sg:grant.6107319 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-017-01541-0
167 rdf:type schema:MonetaryGrant
168 sg:grant.6534916 http://pending.schema.org/fundedItem sg:pub.10.1038/s41467-017-01541-0
169 rdf:type schema:MonetaryGrant
170 sg:journal.1043282 schema:issn 2041-1723
171 schema:name Nature Communications
172 rdf:type schema:Periodical
173 sg:person.01002040077.62 schema:affiliation https://www.grid.ac/institutes/grid.7597.c
174 schema:familyName Dohmae
175 schema:givenName Naoshi
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002040077.62
177 rdf:type schema:Person
178 sg:person.01022333176.34 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
179 schema:familyName Ito
180 schema:givenName Koichi
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022333176.34
182 rdf:type schema:Person
183 sg:person.01033506435.08 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
184 schema:familyName Nishizawa
185 schema:givenName Tomohiro
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033506435.08
187 rdf:type schema:Person
188 sg:person.01043223704.15 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
189 schema:familyName Nureki
190 schema:givenName Osamu
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043223704.15
192 rdf:type schema:Person
193 sg:person.01044316423.25 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
194 schema:familyName Nakane
195 schema:givenName Takanori
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044316423.25
197 rdf:type schema:Person
198 sg:person.011001112653.81 schema:affiliation https://www.grid.ac/institutes/grid.261356.5
199 schema:familyName Moriyama
200 schema:givenName Satomi
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011001112653.81
202 rdf:type schema:Person
203 sg:person.01137642207.68 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
204 schema:familyName Kusakizako
205 schema:givenName Tsukasa
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137642207.68
207 rdf:type schema:Person
208 sg:person.01221724404.09 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
209 schema:familyName Ishitani
210 schema:givenName Ryuichiro
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221724404.09
212 rdf:type schema:Person
213 sg:person.01256470305.03 schema:affiliation Nbdfdce5c6aac4b969ac9543d3730cb82
214 schema:familyName Hirata
215 schema:givenName Kunio
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256470305.03
217 rdf:type schema:Person
218 sg:person.01257541632.51 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
219 schema:familyName Kumazaki
220 schema:givenName Kaoru
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257541632.51
222 rdf:type schema:Person
223 sg:person.01322341712.84 schema:affiliation https://www.grid.ac/institutes/grid.261356.5
224 schema:familyName Moriyama
225 schema:givenName Yoshinori
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322341712.84
227 rdf:type schema:Person
228 sg:person.0610612725.36 schema:affiliation https://www.grid.ac/institutes/grid.261356.5
229 schema:familyName Miyaji
230 schema:givenName Takaaki
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610612725.36
232 rdf:type schema:Person
233 sg:person.0624540116.94 schema:affiliation N5a743a26d3804072936800a69ad9e5c7
234 schema:familyName Yamashita
235 schema:givenName Keitaro
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624540116.94
237 rdf:type schema:Person
238 sg:pub.10.1038/nature09408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042208726
239 https://doi.org/10.1038/nature09408
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/nature12014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003844296
242 https://doi.org/10.1038/nature12014
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/ncomms8995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012049543
245 https://doi.org/10.1038/ncomms8995
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/nrmicro3175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009238642
248 https://doi.org/10.1038/nrmicro3175
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/nsmb.2687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035712479
251 https://doi.org/10.1038/nsmb.2687
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/nsmb.3346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018133728
254 https://doi.org/10.1038/nsmb.3346
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1006/jmbi.1993.1626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030443070
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/0003-2697(73)90217-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034117293
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.bcp.2007.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024360816
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.bcp.2007.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036736950
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.cell.2012.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038980105
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.str.2006.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040537865
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.tips.2006.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006578464
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1046/j.1365-2958.1999.01162.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019649302
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1046/j.1432-1033.2003.03418.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035445872
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1063/1.4952941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1096150003
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1073/pnas.0506483102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005723093
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1073/pnas.0812512106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030863605
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1073/pnas.1219901110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013864174
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1074/jbc.m108777200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002510973
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1074/jbc.m116.728618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058214964
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1080/19336950.2015.1106654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058412560
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1093/jxb/erp312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050566751
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1093/mp/ssu063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035618225
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1104/pp.107.097162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038472087
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1105/tpc.106.046029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030158176
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1107/s0021889897006766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019562892
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1107/s0907444902016657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051282549
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1107/s0907444904026460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036575621
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1107/s0907444909047337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032162623
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1107/s0907444910007493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000235100
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1107/s0907444996012255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020405374
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1111/j.1365-313x.2008.03696.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038295961
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1128/aac.49.5.1857-1864.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048822420
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1128/aac.49.5.1865-1871.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002319938
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1128/jb.187.5.1552-1558.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015745349
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1146/annurev-biochem-060815-014520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032964256
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1152/ajpcell.00090.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009364526
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1152/ajpcell.00504.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018260603
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1371/journal.pgen.1003120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024976318
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1371/journal.pone.0028766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023788906
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1681/asn.2006030205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009447232
327 rdf:type schema:CreativeWork
328 https://www.grid.ac/institutes/grid.261356.5 schema:alternateName Okayama University
329 schema:name Advanced Science Research Center, Okayama University, 700-8530, Okayama, Japan
330 Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 700-8530, Okayama, Japan
331 rdf:type schema:Organization
332 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
333 schema:name Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, 113-0032, Tokyo, Japan
334 Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 277-8562, Chiba, Japan
335 rdf:type schema:Organization
336 https://www.grid.ac/institutes/grid.7597.c schema:alternateName RIKEN
337 schema:name Biomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science, Wako, 351-0198, Saitama, Japan
338 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...