Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Eric Letouzé, Jayendra Shinde, Victor Renault, Gabrielle Couchy, Jean-Frédéric Blanc, Emmanuel Tubacher, Quentin Bayard, Delphine Bacq, Vincent Meyer, Jérémy Semhoun, Paulette Bioulac-Sage, Sophie Prévôt, Daniel Azoulay, Valérie Paradis, Sandrine Imbeaud, Jean-François Deleuze, Jessica Zucman-Rossi

ABSTRACT

Genomic alterations driving tumorigenesis result from the interaction of environmental exposures and endogenous cellular processes. With a diversity of risk factors, liver cancer is an ideal model to study these interactions. Here, we analyze the whole genomes of 44 new and 264 published liver cancers and we identify 10 mutational and 6 structural rearrangement signatures showing distinct relationships with environmental exposures, replication, transcription, and driver genes. The liver cancer-specific signature 16, associated with alcohol, displays a unique feature of transcription-coupled damage and is the main source of CTNNB1 mutations. Flood of insertions/deletions (indels) are identified in very highly expressed hepato-specific genes, likely resulting from replication-transcription collisions. Reconstruction of sub-clonal architecture reveals mutational signature evolution during tumor development exemplified by the vanishing of aflatoxin B1 signature in African migrants. Finally, chromosome duplications occur late and may represent rate-limiting events in tumorigenesis. These findings shed new light on the natural history of liver cancers. More... »

PAGES

1315

References to SciGraph publications

  • 2015-12. Clock-like mutational processes in human somatic cells in NATURE GENETICS
  • 2015-05. Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets in NATURE GENETICS
  • 2012-07. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators in NATURE GENETICS
  • 2013-04. EMu: probabilistic inference of mutational processes and their localization in the cancer genome in GENOME BIOLOGY
  • 2016-05-02. The topography of mutational processes in breast cancer genomes in NATURE COMMUNICATIONS
  • 2012-06. The landscape of cancer genes and mutational processes in breast cancer in NATURE
  • 2013-12. High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions in NATURE COMMUNICATIONS
  • 2016-10. Tissue-specific mutation accumulation in human adult stem cells during life in NATURE
  • 2017-03. A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers in NATURE GENETICS
  • 2015-02. Cell-of-origin chromatin organization shapes the mutational landscape of cancer in NATURE
  • 2016-06. Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors in NATURE GENETICS
  • 2016-07. The nature of mutations induced by replication–transcription collisions in NATURE
  • 2016-04-14. Hepatocellular carcinoma in NATURE REVIEWS DISEASE PRIMERS
  • 2016-06. Landscape of somatic mutations in 560 breast cancer whole-genome sequences in NATURE
  • 2014-09. Mechanisms underlying mutational signatures in human cancers in NATURE REVIEWS GENETICS
  • 2015-10. Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas in NATURE GENETICS
  • 2016-12. deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution in GENOME BIOLOGY
  • 2011-01. Integrative genomics viewer in NATURE BIOTECHNOLOGY
  • 2015-12. Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution in NATURE COMMUNICATIONS
  • 2013-08. Signatures of mutational processes in human cancer in NATURE
  • 2017-05-26. Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations in NATURE COMMUNICATIONS
  • 2013-07. Mutational heterogeneity in cancer and the search for new cancer-associated genes in NATURE
  • 2012-06. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma in NATURE GENETICS
  • 2016-05. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer in NATURE GENETICS
  • 2010-12. A flexible R package for nonnegative matrix factorization in BMC BIOINFORMATICS
  • 2011-05. A framework for variation discovery and genotyping using next-generation DNA sequencing data in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-017-01358-x

    DOI

    http://dx.doi.org/10.1038/s41467-017-01358-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092446353

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29101368


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