Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Silvia Bottini, Nedra Hamouda-Tekaya, Raphael Mategot, Laure-Emmanuelle Zaragosi, Stephane Audebert, Sabrina Pisano, Valerie Grandjean, Claire Mauduit, Mohamed Benahmed, Pascal Barbry, Emanuela Repetto, Michele Trabucchi

ABSTRACT

There is a growing body of evidence about the presence and the activity of the miRISC in the nucleus of mammalian cells. Here, we show by quantitative proteomic analysis that Ago2 interacts with the nucleoplasmic protein Sfpq in an RNA-dependent fashion. By a combination of HITS-CLIP and transcriptomic analyses, we demonstrate that Sfpq directly controls the miRNA targeting of a subset of binding sites by local binding. Sfpq modulates miRNA targeting in both nucleoplasm and cytoplasm, indicating a nucleoplasmic commitment of Sfpq-target mRNAs that globally influences miRNA modes of action. Mechanistically, Sfpq binds to a sizeable set of long 3'UTRs forming aggregates to optimize miRNA positioning/recruitment at selected binding sites, including let-7a binding to Lin28A 3'UTR. Our results extend the miRNA-mediated post-transcriptional gene silencing into the nucleoplasm and indicate that an Sfpq-dependent strategy for controlling miRNA activity takes place in cells, contributing to the complexity of miRNA-dependent gene expression control. More... »

PAGES

1189

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-017-01126-x

DOI

http://dx.doi.org/10.1038/s41467-017-01126-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092381510

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29084942


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459 schema:name CRCM, Marseille Protéomique, Institut Paoli-Calmettes, Aix Marseille University, INSERM, CNRS, 27 bd Leï Roure, BP 30059, 13273, Marseille, France
460 rdf:type schema:Organization
 




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